#microglia really are the moms of the brain, always checking on the kids-But they act very different inside the house (CNS) vs outside (in culture). “Outside healthy brains, microglia…..behave differently, [Watanabe] says. We cannot publish anything without in-vivo imaging in microglia.” Cool read
biorxiv.org
Microglia extract neuronal proteolytic organelles via skoupocytosis
Neurons face unique challenges in maintaining protein homeostasis due to their tortuous morphology and extended processes. Proteolytic organelles are typically transported retrogradely towards their s...