iiinova — where your digital self keeps evolving

Reposted by Steven Boeynaems

WALIIAnhydro @waliianhydro.bsky.social · 29/09/2026

Invited Speaker Dr. Olivia Carmo will be giving a talk on “Unfurling Mechanisms of Desiccation Tolerance: An Ultrastructural Perspective” at the 2nd virtual WALII Symposium. Register to hear the talk & submit an abstract to present: walii.science/2nd-virtual-...

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H. B. Beryl Rappaport @hbrappap.bsky.social · 22/09/2026

Our description of fire amoeba, 𝘐𝘯𝘤𝘦𝘯𝘥𝘪𝘢𝘮𝘰𝘦𝘣𝘢 𝘤𝘢𝘴𝘤𝘢𝘥𝘦𝘯𝘴𝘪𝘴, is now online at Cell! Thanks @oliverio.bsky.social and amazing team for questioning the limits of eukaryotes! 🔥 www.cell.com/cell/fulltex...

cell.com

A geothermal amoeba sets a new upper temperature limit for eukaryotes

The amoeba Incendiamoeba cascadensis demonstrates that eukaryotic life can withstand temperatures beyond what was thought possible and sheds light on molecular strategies for survival in extreme heat.

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Anita Donlic @anitadonlic.bsky.social · 16/09/2026

🎉 I'm thrilled to announce that the Ðonlić Lab has officially opened this month in the BMB department @wusm-bmb.bsky.social at @washumedicine.bsky.social! The lab will study how condensates shape RNA interactions, therapeutic activity, and disease progression. And - we're hiring! 👇

donliclab.com

Đonlić Lab

Decoding cellular biochemistry from microscopy: chemical tools, RNA biophysics, and machine learning in condensates.

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Michael Baym @baym.lol · 13/09/2026

Ten years ago Tami, Roy, and I released a movie we made of antibiotic resistance evolving in real time. I thought maybe a couple thousand people tops would see it. I couldn't have imagined it would be seen millions of times, and be taught from middle school through the graduate level worldwide

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Nicholas M Tran @nmtranlab.bsky.social · 10/09/2026

Our lab is recruiting! If you are interested in learning about retinal ganglion cell resilience and regeneration please see the Research Assistant I position listing below. We are looking for a candidate with experience in either mouse research or stem cell culture. jobs.bcm.edu/job/Research...

jobs.bcm.edu

Research Assistant I - Molecular & Human Genetics

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WALIIAnhydro @waliianhydro.bsky.social · 08/09/2026

Meet the speakers of the 2nd Annual WALII Symposium: Exploring Life Without Water, happening Thursday, Nov 12! 💧 To Learn More and Register for the Symposium: walii.science/2nd-virtual-...

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Delarue Research @delarueresearch.bsky.social · 06/09/2026

Our collaborative paper, with Daria Bonazzi and @dumenillab.bsky.social is finally out in Nat Comms! Using microfluidic confiners, amazing Laure Leblanc found that confined growth of E. coli uncouples growth and division, as well as pressure and biomass production. tinyurl.com/4zdwrp39

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Josh Riback @superscijew.bsky.social · 26/08/2026

New #RibackLab preprint! The nucleolus's biophysical properties aren't fixed—they're tuned to energy availability. Under nutrient limitation, nucleoli hibernate: stronger interactions, slower rRNA transport, rapid reversal upon refeeding. Led by incredible postdoc @evdokiiap.bsky.social 🧵👇

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Steven Boeynaems @boeynaemssteven.bsky.social · 26/08/2026

First preprint from the lab spearheaded by our first grad student @sovannytaylor.bsky.social! We discovered "lipoprotein hitchhiking" as a novel cell penetrance mechanism of killer peptides that has convergently arisen across 600 million years of animal and in human disease. 1/n

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WALIIAnhydro @waliianhydro.bsky.social · 25/08/2026

Save the Date! The 2nd Annual WALII Symposium is happening on November 12, 2026! Join us to hear from these four outstanding invited speakers! More details coming soon! #WALIISymposium #Science #LifeWithoutWater #DesiccationTolerance

Four symposium speakers’ portraits with names, affiliations, event date (Nov 12, 2026), and times for the 2nd WALII Symposium are shown against a desert background.

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Jerelle Joseph @jerelleaj.bsky.social · 20/08/2026

Out now in #PRXLife “Roadmap for Condensates in Cell Biology” journals.aps.org/prxlife/abst... From our amazing discussions at #KITP last summer!

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Böke Lab @bokelab.bsky.social · 12/08/2026

What does an ovary actually look like as it ages—one oocyte at a time? We mapped >85,000 oocytes in >100 intact mouse ovaries, in 3D, across the reproductive lifespan. And the ovary turned out to be much more organized than we expected. 🧵 1/5 www.nature.com/articles/s43...

nature.com

Three-dimensional mapping of intact ovaries reveals the aging dynamics of the ovarian reserve - Nature Aging

The spatiotemporal dynamics of the depletion of the ovarian reserve remain incompletely understood. Combining whole-ovary imaging, AI and modeling, the authors mapped over 85,000 mouse oocytes and fou...

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Ali Shaib @alishaib.bsky.social · 07/08/2026

Exciting new preprint from Ignacio Vega Vásquez, Sauer lab, my team and collaborators: #Mega-ExM. From just ~20 NPCs imaged with a 10× objective on a confocal, we reconstructed the 3D structure at ~33 Å. A step toward optical structural biology in intact cells. www.biorxiv.org/content/10.6...

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WALIIAnhydro @waliianhydro.bsky.social · 07/08/2026

Mark your calendars!! We are excited to announce the date for this year's WALII Virtual Symposium on November 12, 2026! More details will be shared soon!

A 'Save the Date' graphic for the 2nd annual WALII Symposium. The text is on a brown square background over an image or dry, cracked mud and water.

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André Nadler @nadlerlab.bsky.social · 29/07/2026

Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...

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D. Allan Drummond @dadrummond.art · 29/07/2026

Got the news today that I've been promoted to Full Professor of Biochemistry & Molecular Biology at The University of Chicago. A tremendous honor, one made possible by an incredible group of trainees who I've had the pleasure of working with over the past twenty years. Best is yet to come! 🤓🔬

My bronze sculpture of a budding yeast cell, cutaway to show all the organelles and internal structures, in my open hand against a white background. My research group studies budding yeast and human cells to understand the molecular basis for how cells sense and respond to sudden changes in their environment. Now back to our regularly scheduled bug and sculpture posting!

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Christine Mayr @christinemayr.bsky.social · 28/07/2026

Jim Shorter and his postdoc Miriam wrote a beautiful preview about our most recent paper on mRNAs preventing misfolding of IDR-containing proteins. UTR-ly unexpected: RNA chaperones tame intrinsically disordered proteins: Cell www.cell.com/cell/fulltex...

cell.com

UTR-ly unexpected: RNA chaperones tame intrinsically disordered proteins

How do cells ensure that complex, multidomain proteins fold correctly? Luo et al. reveal a self-contained solution. The 3′UTR of an mRNA co-translationally chaperones the protein it encodes, preventin...

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Steven Boeynaems @boeynaemssteven.bsky.social · 03/07/2026

Such beautiful work. Just worth it for the discussion section alone, which is thought-provoking, forward-looking and Linnaeus-quoting.

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Mikko Taipale @miketilapia.bsky.social · 30/06/2026

Our evil ORFeome paper is out! In collaboration with @alex-stark.bsky.social, we screened ~4,000 viral proteins and secreted effectors from bacteria and parasites, covering hundreds of diverse pathogens, for phenotypes in human cells.

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Scott Coyle @cellraiser.bsky.social · 24/06/2026

@zjmaggiexu.bsky.social's story on suctorian trap structure adaptation is now online in @currentbiology.bsky.social , with new evolutionary analyses and modeling! This fall, Maggie will keep exploring predatory protists as a PD in @nbellono.bsky.social group; keep an eye out for her she's amazing!

sciencedirect.com

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Martin Jonikas @mjonikas.bsky.social · 11/06/2026

The algal pyrenoid fixes ~1/3 of global carbon, relying on a unique membrane-within-condensate architecture. How is this architecture built? We discovered that the protein MITH1 draws membranes into the pyrenoid condensate by promoting wetting! 🌿💧 www.biorxiv.org/content/10.6...

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Anita Donlic @anitadonlic.bsky.social · 05/06/2026

Thrilled to see our Deep-Phase paper now online in @cellcellpress.bsky.social! 🎉 The final version expands Deep-Phase across labeling modalities, adds dual-condensate imaging to dissect pathway specificity, and shows greater robustness to batch effects than classical image-analysis methods.

cell.com

Deep learning of functional perturbations from condensate morphology

A deep learning method quantitatively decodes nucleolar, nuclear speckle, and viral condensate morphology to reveal underlying biochemical states. Applying this framework reveals a previously unrecogn...

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Reposted by Steven Boeynaems

Kevin Guttenplan @kevinguttenplan.bsky.social · 05/06/2026

We're moving to Boston! Excited to share that I'm starting my own lab in the Neurobiology Department at Harvard Medical School in 2027!

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Reposted by Steven Boeynaems

Kara Marshall @karalmarshall.bsky.social · 30/05/2026

Excited to share a new preprint, led by @yasmeen-hamed.bsky.social! It describes a mechanism and potential therapeutic avenue for treating the aging bladder! Thanks to the amazing collab from the Beyder lab, as well as @valeriavasquez.bsky.social, Lichtarge labs! www.biorxiv.org/content/10.6...

biorxiv.org

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Guo-Teng @gtleung.bsky.social · 17/05/2026

Four years of New-Bee, and every year the new faces still get me. New wonder, new questions, new sparks. We keep going. 🐝 Sincere thanks again to @rsb.org.uk — proud to have secured this year's Regional Events Grant on behalf of our committee.

A slide says welcome to New-Bee neuroscience at Baylor College of Medicine’s Cullen Auditorium

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Tera Levin @teralevin.bsky.social · 02/05/2026

Bacterial immune proteins have repeatedly evolved to become parts of eukaryotic immunity. But how? Our new preprint uncovers a recent horizontal transfer event & shows how eukaryotes co-opted a toxic bacterial immune protein 🦠🧪🧵 1/

Microscopy image showing yeast cells expressing a fluorescently tagged version of the amoeba TirC protein. TirC forms filaments that span the yeast cells.

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Helena Watson @helenawatson.bsky.social · 25/04/2026

Preprint 🧵! I’m really excited to introduce BIGSMALL, an interleaved multi-magnification cryo-ET scheme bridging molecular and cellular scales in a single acquisition! BIGSMALL = 𝐁road 𝐈nformation 𝐆athering 𝐒trategy by 𝐌ultiscale 𝐀cquisition of lame𝐋𝐋a www.biorxiv.org/content/10.6... (1/6)

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Furqan Fazal @furqanmfazal.bsky.social · 02/04/2026

Excited to share our @natprot.nature.com paper on using RNA proximity labeling to map subcellular RNA transcriptomes. We’ve been working in this area for a while and wanted to create a resource paper to guide the uninitiated reader. rdcu.be/fblvI

rdcu.be

APEX-seq maps transcriptome-wide subcellular RNA localization in living cells

Nature Protocols - This Protocol describes the transcriptome-wide labeling of RNAs in a particular subcellular compartment using proximity biotinylation by localized APEX2 enzyme and subsequent...

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Shyamal @shyamalm.bsky.social · 28/03/2026

Excited to share this collaborative work with Ward and Petrucelli Labs! We show that two major genetic risk factors for #neurodegeneration and cognitive decline converge on TMEM106B fibrils accumulating within lysosomes. A LOT of work packed in here 🧠🔬 Preprint: www.biorxiv.org/content/10.6...

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Moi Expósito-Alonso (MOILAB) @mexpositoalonso.bsky.social · 26/03/2026

Our new experimental evolution study across 30+ locations using the plant Arabidopsis thaliana —— we direct "see" adaptation and extinction to different climates at the genetic as it happens! Read it in Science dx.doi.org/10.1126/scie... @ucberkeleyofficial.bsky.social @hhmi-science.bsky.social

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Carter Lab @carter-lab.bsky.social · 24/03/2026

Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...

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Simon Bullock @simonbullock11.bsky.social · 18/03/2026

Delighted to announce the posting of our latest preprint, which links stress-induced relocalisation of multiple organelles by dynein to adaptive changes in gene expression in the nucleus (1/n) 🧵 www.biorxiv.org/content/10.6...

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Liam Holt @liamholt.bsky.social · 05/03/2026

We have a new paper out today from superstar Nora Herzog! A virus that fluidizes the nucleus to enable replication! Check it out here: lnkd.in/e-xV8acK This was an amazing collaboration with Ian Mohr and Angus Wilson

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Emma Chory, Ph.D. @chorye.bsky.social · 04/03/2026

Evolution navigated billions of challenges to get to us to where we are today. Directed evolution compresses this to a 1D axis. Imagine if you could sample 200 dimensions at once, with data to boot 📈 First @chorylab.bsky.social PACE preprint on our new system to tackle this: bit.ly/turboprance

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Alex Holehouse @alexholehouse.bsky.social · 19/02/2026

Papers are like buses... You wait for ages, then two come along at once. Huge congrats to @bornanovak.bsky.social and @jefflotthammer.bsky.social for pushing and driving every aspect of this work, preprinted ~1 year ago to the day (Friday before BPS), now published! www.nature.com/articles/s41...

nature.com

Accurate predictions of disordered protein ensembles with STARLING - Nature

The deep learning model STARLING can generate accurate ensembles of intrinsically disordered regions of proteins using only protein sequence as input.

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Alex Holehouse @alexholehouse.bsky.social · 12/02/2026

Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now? www.nature.com/articles/s41... More functional data, many thousands of words removed, and a few other updates from last year's preprint.

nature.com

Sequence and chemical specificity define the functional landscape of intrinsically disordered regions - Nature Cell Biology

Langstein-Skora, Schmid, Huth et al. propose that intrinsically disordered region functionality can be driven by the interplay between linear binding motifs and contextual chemical characteristics suc...

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James Barrett @james-r-barrett.bsky.social · 30/01/2026

How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algae—the pyrenoid—to find out… 🧵 Preprint here!: www.biorxiv.org/content/10.6... @cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social #Rubisco #PhaseSeparation #Condensates #Pyrenoid

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Magnus Kjærgaard @proteinmagnus.bsky.social · 02/02/2026

Does targeting enzymes and substrates in a condensate lead to rate enhancement? No. Here, we investigate how the condensate environment can inhibit an enzyme reaction. Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates. doi.org/10.64898/202...

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Ryan Flynn @raflynn5.bsky.social · 28/01/2026

Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX

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Marvin Tanenbaum @marvintanenbaum.bsky.social · 28/01/2026

Now out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake! rdcu.be/e1bBW

rdcu.be

Pre-assembly of biomolecular condensate seeds drives RSV replication

Nature - Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.

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Thomas Norman @normanlab.bsky.social · 20/01/2026

New preprint on technologies to scale up CRISPR screens. We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells. We also introduce an approach for cloning lentiviral libraries with billions of elements.

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Nature Portfolio @natureportfolio.nature.com · 17/01/2026

A paper in Nature Microbiology presents Antimicrobial Single-Cell Testing, a large-scale live-cell imaging approach that quantifies bacterial killing in real time at single-cell resolution, which can predict treatment outcomes. go.nature.com/3Nwnez8 #microsky 🧪

This is figure 1, which shows that ASCT enables high-throughput assessments of bacterial viability.

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Lukasz Bugaj @bugajlab.bsky.social · 17/12/2025

🚨Preprint 2/2: Several studies implicate condensates in RTK fusion onco-signaling. So we were surprised to find that condensates are entirely dispensable😮(!). A study from proteins to mice, by dynamic duo @davidgonzmar.bsky.social and @trmumford.bsky.social. www.biorxiv.org/content/10.6... 👇

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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 15/12/2025

The vault associates with membranes in situ www.biorxiv.org/content/10.64898/20…

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Waggoner Lab @labwaggoner.bsky.social · 04/12/2025

VAPB is a critical regulating factor in cGAS-STING–mediated innate immune responses www.science.org/doi/10.1126/...

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Biozentrum, University of Basel @biozentrum.unibas.ch · 02/12/2025

🧪An international study led by Prof. Roderick Lim has discovered that nuclear pore complexes—gateways in the nuclear membrane—are not rigid or gel-like as once thought. Instead, their interiors are constantly moving and rearranging. @unibas.ch @snsf.ch 👉 www.biozentrum.unibas.ch/news/detail/...

biozentrum.unibas.ch

Shapeshifting gates guard the cell nucleus

An international study led by the University of Basel has discovered that nuclear pore complexes – tiny gateways in the nuclear membrane – are not rigid or gel-like as once thought. Their interiors ar...

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