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David Gonzalez-Martinez

@davidgonzmar.bsky.social
15 followers 27 following 0 posts

UPenn Bioengineering | cell Signaling, RTK fusions, synthetic biology

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Reposted by David Gonzalez-Martinez
Lukasz Bugaj @bugajlab.bsky.social · 17/12/2025
🚨Preprint 2/2: Several studies implicate condensates in RTK fusion onco-signaling. So we were surprised to find that condensates are entirely dispensable😮(!). A study from proteins to mice, by dynamic duo @davidgonzmar.bsky.social and @trmumford.bsky.social. www.biorxiv.org/content/10.6... 👇
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Reposted by David Gonzalez-Martinez
Lukasz Bugaj @bugajlab.bsky.social · 16/12/2025
🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle. Led by superb PhD student Carol Gao. www.biorxiv.org/content/10.1... Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
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