EFIS-IL study group T CELL CONNECT EUROPE (TCC_EUROPE)

B cell infiltration in high-grade serous ovarian cancer associates with favorable prognosis. Nathan et al. show that tumor-draining lymph nodes in patients lack active germinal center responses and instead harbor quiescent tumor-reactive memory B cells clonally linked to tumor B cells, highlighting lymph nodes as memory reservoirs supporting intra-tumoral immunity.

Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.

Join us at the Keystone Symposia on Tissue and Spatial Immunology, February 2027, in Banff, with field leaders!

We developed a 50-plex imaging protocol using the MACSima platform to characterize the microarchitecture of germinal centers in secondary lymphoid tissues. This workflow combines tissue processing, a...

EFIS-IL study group T CELL CONNECT EUROPE (TCC_EUROPE)

Nature Reviews Bioengineering, Published online: 03 November 2025; doi:10.1038/s44222-025-00371-wEarly cancer biology and detection research is limited owing to a lack of clinical samples from pre-malignant and early-stage tumours. This Review discusses engineered in vitro systems that mimic early disease stages to investigate tumour progression and identify biomarkers for early cancer detection.

#RNAexcellence Junior Group Leader Positions (f/m/d) Job advertisement no.:   089/2025 Starting date:                  As soon as possible. The con...

The Helmholtz Institute for RNA-based Infection Researchopens a call for

Tissue-resident memory CD4+ T cells (TRM) are key sentinels of the adaptive immune response that provide a rapid, robust inflammatory response upon reactivation in non-lymphoid tissues. While CD4+ TRM...

The Nobel Prize rewards science, humanism and peace efforts. This is one of the central concepts in the will of Alfred Nobel, and it also permeates the outreach activities that have been developed for the purpose of engaging, inspiring and spreading knowledge about the Nobel Prize as well as the discoveries and achievements of the laureates.

Cheung et al. describe efficient T cell control of nascent neoantigen+ and nearby neoantigen-negative sarcoma cells, underlying a ∼50% reduction in tumor penetrance. This otherwise imperceptible immun...