Reposted by @chinweetan.bsky.socialJoanna Groom @groomlab.bsky.social · 21/12/2025Hey "Friends" The 2025 edition of our #AwkwardLabPhoto celebrates an incredible year of growth, publications, promotions, PhD submissions and grads I feel immensely proud and grateful to be part of this team 1176
Reposted by @chinweetan.bsky.socialMillennium Science @mscience.bsky.social · 07/10/2025How do cytokines tune immune helpers? Nature Immunology study from @groomlab.bsky.social ’s lab at @wehi-research.bsky.social used @10xgenomics.bsky.social single-cell & spatial tech to map T follicular helper (TFH) cells diversity. 🔗 www.nature.com/articles/s41... #Immunology #SpatialBiology 051
Reposted by @chinweetan.bsky.socialJoanna Groom @groomlab.bsky.social · 09/10/2025Thanks @10xgenomics.bsky.social for the shout out and for making your data publicly available Why waste precious resources ($$) to reinvent data that already exists? Cool human datasets ready to go (Although now we have scratched the spatial itch, we may need to do more @chinweetan.bsky.social 🤔) 0132
Reposted by @chinweetan.bsky.socialJoanna Groom @groomlab.bsky.social · 30/09/2025"Biology is messy and sometimes we need to embrace the mess" www.nature.com/articles/s41... Huge thanks to Amy Weinmann and Danielle Chisolm for beautifully highlighting our work and the importance of our approaches @natimmunol.nature.comnature.comTFH cell programs by pathogen and species - Nature ImmunologyCD4+ T follicular helper (TFH) cells that develop in response to a range of pathogens share aspects of a common gene signature. However, cytokine environments, rather than pathogen class, shape diversity in programming potential. 1111
Reposted by @chinweetan.bsky.socialJoanna Groom @groomlab.bsky.social · 30/09/2025Thrilled to make the cover of @natimmunol.nature.com this month. A version of this warhol-inspired image has been in my head almost since we first conceived this Tfh diversity project (many, many years ago) @wehi-research.bsky.social 0204
Reposted by @chinweetan.bsky.socialWEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 24/09/2025WEHI scientists led by @groomlab.bsky.social @chinweetan.bsky.social map how Tfh cells tailor instructions based on infection type. A step toward smarter vaccines and therapies. 📄 In @natimmunol.nature.com: www.nature.com/articles/s41... 🔗 Read more: www.wehi.edu.au/news/unlocki... 073
Reposted by @chinweetan.bsky.socialCarolien van de Sandt @cvandesandt.bsky.social · 12/09/2025Great work by @chinweetan.bsky.social , @Len Dalit and @groomlab.bsky.social and her team understanding the signatures behind T folicular helper heterogeneity! ⬇️ #ImmunoSky 051
Reposted by @chinweetan.bsky.socialJoanna Groom @groomlab.bsky.social · 12/09/2025Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com www.nature.com/articles/s41... This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social Thread below...nature.comDivergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity - Nature ImmunologyDalit, Tan and colleagues provide a multiomic profile of T follicular helper (TFH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and new tools to interrog... 33916
Reposted by @chinweetan.bsky.socialJinjin Chen @jinjinchen.bsky.social · 02/04/2025Thrilled to share our latest publication! Huge thanks to the team @chinweetan.bsky.social, Melissa Davis, Ahmed Mohamed and @bhuvad.bsky.social for making this possible! Questions welcome! Would love to hear your thoughts on our approach! 041
chinweetan.bsky.social @chinweetan.bsky.social · 02/04/2025Very excited that our work is out in Bioinformatics! mastR: an R package for automated identification of tissue-specific gene signatures in multi-group differential expression analysis academic.oup.com/bioinformati... @wehi-research.bsky.social led by the talented Jinjin Chenacademic.oup.commastR: an R package for automated identification of tissue-specific gene signatures in multi-group differential expression analysisAbstractMotivation. Biomarker discovery is important and offers insight into potential underlying mechanisms of disease. While existing biomarker identific 1492
chinweetan.bsky.social @chinweetan.bsky.social · 11/03/2025Super glad to me part of this great team and work! Amazing! 030
Reposted by @chinweetan.bsky.socialJoanna Groom @groomlab.bsky.social · 11/03/2025Very excited our work out in @jem.org “Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection” @wehi-research.bsky.social led by talented (and determined) PhD student @benjbroom.bsky.social Thread below. 25622
Reposted by @chinweetan.bsky.socialJournal of Experimental Medicine @jem.org · 10/03/2025@benjbroom.bsky.social et al. @groomlab.bsky.social show that early type I interferon blockade alters CXCR3 chemokine regulation & cell location to promote an antigen-dependent CD8+ T cell transition of precursor of exhausted T cells to stem cell–like memory CD8+ T cells rupress.org/jem/article/... 02610
Reposted by @chinweetan.bsky.socialDrLachie @drlachie.bsky.social · 06/12/2024Have seen lab mates come and go but a great group to end 2024 with. I don't like it when some mention they were finishing grade 6 when I was starting in my role here though.... 2121
Reposted by @chinweetan.bsky.socialRita Strack @ritastrack.bsky.social · 06/12/2024I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...nature.comMethod of the Year 2024: spatial proteomics - Nature MethodsApproaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease. 3614170
Reposted by @chinweetan.bsky.socialJim Mansfield @jrmansfield.bsky.social · 06/12/2024#Multiomics2024 was amazing and I was very proud to be invited to speak for @standardbiology.bsky.social. Here’s the cartoon version. Huge thanks to @aruthak.bsky.social for bringing it all together. #spatialbio 1103
