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Iannacone Lab

@iannaconelab.bsky.social
359 followers 83 following 67 posts

Our lab at San Raffaele Scientific Institute & University (@unisr.bsky.social) seeks to dissect the complex dynamics of immune responses to pathogens and tumors

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Hannah Isles @hannah-isles.bsky.social · 02/09/2026
Interesting link between aging, serotonin, platelets and COVID-19 severity. A new study in Science Immunology from @iannaconelab.bsky.social and colleagues identifies platelet-derived serotonin as a driver of age-related lung pathology following SARS-CoV-2 infection. www.science.org/doi/10.1126/...
science.org
Platelet-derived serotonin drives age-related lung pathology in SARS-CoV-2 infection
In aging hosts, platelet serotonin fuels lung-damaging clots, leading to enhanced respiratory distress in the context of COVID-19.
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Iannacone Lab @iannaconelab.bsky.social · 29/08/2026
Great story! Proud to have contributed a little
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Iannacone Lab @iannaconelab.bsky.social · 28/08/2026
Hot off the press in Science Immunology: why COVID-19 hits older hosts harder. t.co/ByhneIMPSm Aged platelets (mouse and human) release more serotonin on activation → procoagulant platelets → fibrin in the lung → respiratory failure. 1/2
science.org
Platelet-derived serotonin drives age-related lung pathology in SARS-CoV-2 infection
In aging hosts, platelet serotonin fuels lung-damaging clots, leading to enhanced respiratory distress in the context of COVID-19.
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UniSR @unisr.bsky.social · 03/08/2026
The immune system does not behave in the same way in every tissue. Discover how the first UniSR – @tsinghuauniversity.bsky.social symposium is advancing research into cancer immunotherapy, neuroimmune interactions and immune memory. 👉Read more: blog.unisr.it/en/immunolog... @iannaconelab.bsky.social
blog.unisr.it
Immunology Research: Findings from UniSR-Tsinghua
Immunology research from the UniSR-Tsinghua symposium reveals new cancer immunotherapy targets and deepens the brain-immune system dialogue.
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Iannacone Lab @iannaconelab.bsky.social · 24/07/2026
🔬 Recruiting a Physician Scientist PhD student (San Raffaele, Milan) via AIRC-Cariplo-SEMM-UniMi program. Project: reprogramming tumor endothelium to restore anti-tumor immunity in liver cancer. Keep 20% clinical work. Deadline Sept 16. Apply: tinyurl.com/3vcp27dp #AIRC
tinyurl.com
Application-phd-program-physician - SEMM - European School of Molecular Medicine
< Residency/PhD Program < How to Apply PhD Program in Systems Medicine for Physician Scientists Application Area 2026 PhD RECRUITMENT PHYSICIAN SCIENTIST – CALL NOW OPEN CHECK ELIGIBILITY CRITERIA AVA...
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Iannacone Lab @iannaconelab.bsky.social · 20/07/2026
Great science and fun at our lab's annual retreat, bringing together my team with @mirelakuka.bsky.social, Marco De Giovanni, and Donato Inverso's teams. Thanks to @lozanzi.bsky.social and Stefano Sammicheli for inspiring lectures and great questions. Proud of what we've built together.
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Iannacone Lab @iannaconelab.bsky.social · 14/07/2026
In vista della Giornata Mondiale dell'Epatite (28 luglio), abbiamo raccontato a UniSR le due strategie complementari su cui lavoriamo per la cura funzionale dell'epatite B cronica 🔗 blog.unisr.it/cura-funzion...
blog.unisr.it
Cura funzionale epatite B cronica: le nuove strategie
Antivirali di nuova generazione e immunoterapia: le strategie con cui UniSR e IRCCS San Raffaele affrontano la cura funzionale dell'epatite B cronica.
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Iannacone Lab @iannaconelab.bsky.social · 14/07/2026
Huge congrats to Dr. Valentina Venzin, former PhD student in my lab, for being awarded the EFIS ACTERIA Doctoral Thesis Prize in Immunology! Her discovery of a liver-intrinsic CD4-to-CD8 T cell rescue circuit via IL-27 was a really elegant piece of work. So proud of her! www.efis.org/news/the-fon...
efis.org
ACTERIA Prizes awarded by EFIS
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UniSR @unisr.bsky.social · 08/07/2026
Exciting news😀LiveRNA, co-founded by @iannaconelab.bsky.social, has been selected for the BOOST Grant from the Paris-Saclay Cancer Cluster. The award will accelerate the development of a next-generation #mRNA #immunotherapy platform, advancing innovative cancer treatments toward the clinic.
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Fusion Conferences @fusionconf.bsky.social · 09/06/2026
The countdown is on - Just 31 days until #CancerImmuno 2026! ⏳AND there's still time to join us! If you're interested in attending, please contact felicity@fusion-conferences.com for more information. 🔗Conference Website: bit.ly/4vAsVgd #FusionImmunology #FusionCancerResearch
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Iannacone Lab @iannaconelab.bsky.social · 03/05/2026
Pleased to have contributed to this new @science.org paper on how lymphoid tissue chemokines limit CD8⁺ T cell priming duration to preserve T cell functionality. Congrats to Lukas Altenburger and Jens Stein! t.co/K9Cmt8yO9C
t.co
https://www.science.org/doi/10.1126/science.adq2080
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European Journal of Immunology @eurjimmunol.bsky.social · 28/04/2026
📣 Join us on a journey through Treg time! Celebrating the 2026 Day of Immunology with a featured EJI collection on Tregs — highlighting landmark work on immune tolerance, including foundational contributions from Shimon Sakaguchi and colleagues. A must-read for ECRs and beyond! bit.ly/4mXCa75
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EFIS_Immunology @efis-immunology.bsky.social · 15/04/2026
📢Travel Grant Opportunity for #ECRs 🙌Proud to announce that #EFIS, together with the @eurjimmunol.bsky.social, is offering 5 travel grants (€1,000 each) to support attendance at the GRC! 💡Grants will be awarded based on scientific merit, career stage + inclusion criteria. ⏰Deadline: 1 May 2026
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Thiago Carvalho @cyrilpedia.bsky.social · 16/04/2026
With @hiroshi-ichise.bsky.social, closing the @ccii-kyoto.bsky.social workshop on advanced imaging and image analysis in Kyoto. Thanks to Guolan Lu (Stanford), @iannaconelab.bsky.social, Andrea Radtke (Leica), Yuki Sugiura (CCII), and Johanne T. Jacobsen for great lectures and practicals!
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Center for Cancer Immunotherapy and Immunobiology @ccii-kyoto.bsky.social · 13/04/2026
Matteo Iannacone @iannaconelab.bsky.social gave a tour de force presentation on liver immunity, hosted by @hiroshi-ichise.bsky.social as part of the CCII workshop on Advanced Tissue Imaging & Image Analysis #Immunology #TissueImmunity www.ccii.med.kyoto-u.ac.jp/en/event/eve...
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Waggoner Lab @labwaggoner.bsky.social · 09/04/2026
Review @natrevimmunol.nature.com @gustaveroussy.fr @iannaconelab.bsky.social Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers www.nature.com/articles/s41...
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Iannacone Lab @iannaconelab.bsky.social · 08/04/2026
Great fun to write this review on Kupffer cells with Florent Ginhoux and Paul Kubes, covering origin, diversity and roles in immunity and metabolism, now out in @natrevimmunol.nature.com. Huge credit to Bruna Araujo David, Francesco Andreata and Camille Blériot for driving this work. t.co/rGpmTMRddV
t.co
https://rdcu.be/fckoZ
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Iannacone Lab @iannaconelab.bsky.social · 02/04/2026
Neutralizing antibodies are not the whole story. In our Comment in Nature Reviews Immunology, we highlight an alternative mode of protection: 👉 T cells can eliminate infection at its earliest stage — before it becomes detectable We term this “abortive infection” 🔗 rdcu.be/fbq8p Thread 1/4
rdcu.be
Abortive infection: T cells as early, antibody-independent defenders
Nature Reviews Immunology - Neutralizing antibodies are widely viewed as the frontline of antiviral defence. Yet emerging evidence reveals that T cells can terminate infection before it is...
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Iannacone Lab @iannaconelab.bsky.social · 01/03/2026
Excited to organize @keystoneSymposia.bsky.social Tissue and Spatial Immunology with @leilaakkari.bsky.social and Hai Qi in February 2027! Join us to explore emerging research in Banff! keysym.us/KSSpatialImmune27 #KSSpatialImmune27
keysym.us
Tissue and Spatial Immunology | Keystone Symposia
Join us at the Keystone Symposia on Tissue and Spatial Immunology, February 2027, in Banff, with field leaders!
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Iannacone Lab @iannaconelab.bsky.social · 04/02/2026
Join us for the 2026 GRC Immunochemistry and Immunobiology "Immune Circuitry and Molecular Pathways in Tissue Homeostasis, Infection, and Disease" in beautiful Barcelona. June 28 - July 3, 2026. Great lineup of speakers! www.grc.org/immunochemis...
grc.org
2026 Immunochemistry and Immunobiology Conference GRC
The 2026 Gordon Research Conference on Immunochemistry and Immunobiology will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.
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Iannacone Lab @iannaconelab.bsky.social · 04/02/2026
Don't miss the 2026 Global Immunotalks!
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Fusion Conferences @fusionconf.bsky.social · 02/02/2026
📢Want to speak at the #CancerImmuno conference? Good news! The chairs have released additional short talk slots and extended the submission deadline to 26 February 2026! Submit your abstract for a chance to present your work alongside leading researchers in the field. 👉 Register now: bit.ly/3NRB7Iu
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European Journal of Immunology @eurjimmunol.bsky.social · 27/01/2026
📩 Submit the paper link + short statement (≤250 words) to ejied@wiley.com by 15 April 2026. The winner will be selected by EJI editors together with @yefis-immunology.bsky.social representatives. #Immunology #ImmunoSky #AcademicSky #EarlyCareerResearchers #ECR @efis-immunology.bsky.social
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European Journal of Immunology @eurjimmunol.bsky.social · 27/01/2026
🏆Nominations are OPEN for the 2026 EJI-EFIS Prize for the ECR Article of the Year! Best paper published in EJI (2025) by an early-career researcher wins €5,000 + travel grant to ECI 2027 (Florence)✈️ 🔗 Details & eligibility: bit.ly/41GeiMi 🫵 Self-nominations encouraged!
onlinelibrary.wiley.com
European Journal of Immunology: EJI-EFIS Prize for the ECR Article of the Year
EJI and EFIS are thrilled to announce a new prize honoring Early Career Researchers (ECRs) whose work is published in EJI. This initiative aims to showcase the next generation of immunologists and encourage them to submit their excellent research to EJI.
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Iannacone Lab @iannaconelab.bsky.social · 24/01/2026
Great story from the Nieswandt lab in Science: uncovering a non-classical platelet mechanism that drives inflammation via integrin- and tetraspanin-rich tethers. A fresh angle on thrombo-inflammation. Happy to be part of this work! www.science.org/doi/10.1126/...
science.org
Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation
Platelet integrin αIIbβ3 is essential for hemostasis, thrombosis, and inflammation. We found that ligation of αIIbβ3 by von Willebrand factor or fibrin under flow triggered its accumulation in plasma ...
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Iannacone Lab @iannaconelab.bsky.social · 20/12/2025
1/ New from our lab 🧪 ARTC2 blockade is widely used to protect tissue Tregs — but when is it truly essential, and for which subsets? 2/ In this @eurjimmunol.bsky.social update, we dissect the subset-specific and context-dependent effects of ARTC2 blockade on hepatic Treg recovery.
onlinelibrary.wiley.com
Optimising Recovery of Hepatic Regulatory T Cells: A Practical Guide Using ARTC2 Blockade
This is an update to the Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition), Chapter 3: 12C, by Cossarizza et al. Administration of anti-ARTC2 nanobody...
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Iannacone Lab @iannaconelab.bsky.social · 25/11/2025
Thrilled to contribute to this landmark consensus effort led by Dave Masopust and Rafi Ahmed. A major step toward clearer, shared T cell nomenclature for the field. www.nature.com/articles/s41...
nature.com
Guidelines for T cell nomenclature - Nature Reviews Immunology
This Consensus Statement clarifies the existing subset-based nomenclature for T cells. Furthermore, it proposes an alternative modular nomenclature that is designed to be brief and flexible and to avo...
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Iannacone Lab @iannaconelab.bsky.social · 23/11/2025
Honoured to see our @natimmunol.nature.com study highlighted in a thoughtful @jhepatology.bsky.social commentary on the IL-27/Kupffer cell axis in chronic HBV — a great summary of why tissue immunity matters and of our work. Paper: tinyurl.com/yt652mxa Commentary: tinyurl.com/56pke5x5
nature.com
CD4+ T cells license Kupffer cells to reverse CD8+ T cell dysfunction induced by hepatocellular priming - Nature Immunology
Here the authors show that CD4+ effector T cells prevent or reverse CD8+ T cell dysfunction by licensing Kupffer cells to trigger IL-27 production, defining a liver-specific immune circuit and a poten...
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Valentina Venzin @valentinavenzin.bsky.social · 20/11/2025
New review out! 😊 20 years after it’s discovery, with @iannaconelab.bsky.social we decided to bring together what we currently know about this cytokine and how it shapes CD8 T cell responses. A small contribution to make sense of a field that is moving fast 🌈 @cp-trendsimmuno.bsky.social
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Iannacone Lab @iannaconelab.bsky.social · 20/11/2025
New review out in @cp-trendsimmuno.bsky.social! With @valentinavenzin.bsky.social, we revisit IL-27 as a central regulator of CD8⁺ T cell fate — integrating insights from infection, cancer, and autoimmunity, and outlining its therapeutic potential. www.sciencedirect.com/science/arti...
sciencedirect.com
Reframing IL-27: a central regulator of CD8+ T cell immunity
Interleukin-27 (IL-27), a member of the IL-12 cytokine family, was long viewed primarily as a regulator of CD4+ T cell immunity. Subsequent studies re…
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Fusion Conferences @fusionconf.bsky.social · 17/11/2025
#CancerImmuno speaker list is live!📢 Join us in sunny Lisbon, July 2026. Register now and submit your talk to share your research. Early Bird Deadline: 15 Jan 2026 👉 Click here to register: bit.ly/4qZVqmd #FusionImmunology #FusionCancerResearch
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Immunology Podcast @immunologypodcast.com · 21/10/2025
🎤 Our next episode it out! We chat with Professor Matteo Iannacone ( @iannaconelab.bsky.social ) from @@unisr.bsky.socialabout his work understanding the generation of dysfunctional adaptive immune cells in chronic #HepatitisBVirus infection. 🎧 Listen now: bit.ly/4o2W8xa
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Iannacone Lab @iannaconelab.bsky.social · 18/10/2025
Join us for this exciting meeting! @embo.org Workshop "Pathogen Immunity and Signalling", 8-12 June, 2026, Leiden, The Netherlands meetings.embo.org/event/26-pat...
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European Journal of Immunology @eurjimmunol.bsky.social · 15/10/2025
🎉Kicking off the 50th annual SSI meeting in Stockholm! Huge thanks to @cgerlachlab.bsky.social for the warm welcome and inspiring introduction! @yssi-immunology.bsky.social @yefis-immunology.bsky.social @efis-immunology.bsky.social @swimm-immuno.bsky.social @iannaconelab.bsky.social
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European Journal of Immunology @eurjimmunol.bsky.social · 16/10/2025
🎉 Congratulations to this year's SSI Young Investigator Award winners! Meet the rising stars of Scandinavian #immunology: John, Jonna, Chris, and Asbjørn @yssi-immunology.bsky.social @yefis-immunology.bsky.social @efis-immunology.bsky.social @iannaconelab.bsky.social @romagnanilab.bsky.social
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Iannacone Lab @iannaconelab.bsky.social · 07/10/2025
Our review "From Histology to High-Resolution Mapping: The Rise of Spatial Omics in Immunology" is now online! onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
From Histology to High‐Resolution Mapping: The Rise of Spatial Omics in Immunology
Immune regulation is fundamentally spatial, shaped by tissue architecture and local cues. Spatial omics—transcriptomic, proteomic, metabolomic, lipidomic, and phosphoproteomic platforms—preserve coor...
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European Journal of Immunology @eurjimmunol.bsky.social · 07/10/2025
📣 EJI is proud to share that this year’s Nobel Prize winner, Shimon Sakaguchi, published with us on 6 October: bit.ly/46R7n4g We extend our heartfelt congratulations to Shimon for receiving the prize in recognition of his pioneering work on Tregs. #NobelPrize #Immunology #Tregs
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Iannacone Lab @iannaconelab.bsky.social · 26/09/2025
🧵 (1/2) Interested in tertiary lymphoid structures (TLSs)? Check out our latest review, where we chart how TLSs form across organs and contexts — from lung to liver, CNS, skin, gut & more — and their dual roles in protection vs. pathology.
onlinelibrary.wiley.com
Tertiary Lymphoid Structures Across Organs: Context, Composition, and Clinical Levers
Tertiary lymphoid structures (TLSs) arise in non-lymphoid tissues in response to persistent antigen stimulation and chronic inflammation. Spanning organs from lung and liver to meninges, skin, and be....
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Michelle Linterman @linterman.bsky.social · 25/09/2025
Great to have this out, and such a pleasure to work together. @smguillaume.bsky.social @cristianbeccaria.bsky.social @iannaconelab.bsky.social
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Cristian G Beccaria @cristianbeccaria.bsky.social · 25/09/2025
So happy to share that our review in #ImmunolRev is finally out! 😃 We discuss how the immune system builds specialized TLSs across organs and conditions. Huge thanks to @StephanGuillaume, @iannaconelab.bsky.social & @linterman.bsky.social for this collaboration! dx.doi.org/10.1111/imr.70063
dx.doi.org
Tertiary Lymphoid Structures Across Organs: Context, Composition, and Clinical Levers
Tertiary lymphoid structures (TLSs) arise in non-lymphoid tissues in response to persistent antigen stimulation and chronic inflammation. Spanning organs from lung and liver to meninges, skin, and be...
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Fusion Conferences @fusionconf.bsky.social · 10/09/2025
Don't forget to secure your place at our new conference! Cancer Immunology: Across Space & Time 📅Date: 10 Jul - 13 Jul 2026 🌏Location: Lisbon, Portugal 📢Early Bird & Talk Submission: 15th January 2026 Don't miss out, Register now: bit.ly/3IdEwii #CancerImmuno #FusionImmunology #FusionCancerResearch
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Valentina Venzin @valentinavenzin.bsky.social · 04/09/2025
Excited to present at the next OBS immuno seminar our recent work from the @iannaconelab.bsky.social! Happy to make science open for everyone 🌈💜
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Valentina Venzin @valentinavenzin.bsky.social · 22/08/2025
@iannaconelab.bsky.social presenting our work at #IUIS @iuis-online.bsky.social in Vienna highlighting the importance of CD4 T cell mediated help in the liver! 🚀 Thanks @immunologypodcast.com for highlighting our story! @cristianbeccaria.bsky.social podcasts.apple.com/us/podcast/t...
podcasts.apple.com
IUIS 2025: Day 3
Podcast Episode · The Immunology Podcast · 08/21/2025 · 25m
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EFIS_Immunology @efis-immunology.bsky.social · 22/08/2025
🌟Cheers to the #ACTERIA Early Career Awardees! #EFIS is proud to have supported young scientists and hope Vienna inspired you with new connections, and ideas. 🤝Here’s to the next 50 years of advancing science together!💙 @yefis-immunology.bsky.social @eurjimmunol.bsky.social @iannaconelab.bsky.social
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Cristian G Beccaria @cristianbeccaria.bsky.social · 21/08/2025
Thrilled to share some of the stories we've been working on in our @iannaconelab.bsky.social at #IUIS2025 @iuis-online.bsky.social in Vienna! Excited to chat with so many friends and colleagues from around the world! @davidemarotta.bsky.social @CaitlinAAbbott
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European Journal of Immunology @eurjimmunol.bsky.social · 21/08/2025
Steffen Jung announced Andreas Radbruch as keynote speaker at #IUIS2025, highlighting his strong support for European Immunology and the importance of backing EJI and European research! Andreas presenting his newest EJI article by Schneider-Revueltas et al. onlinelibrary.wiley.com/doi/10.1002/...
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European Journal of Immunology @eurjimmunol.bsky.social · 20/08/2025
EJI & EFIS are proud to announce the brand-new ECR Article of the Year Award 🏆 Presented by EJI’s Editor-in-Chief Matteo Iannacone at #IUIS2025, this prize celebrates outstanding research by early career researchers published in EJI 🎉 Check the eligibility criteria here👇 bit.ly/3Hvn9t5
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Iannacone Lab @iannaconelab.bsky.social · 21/08/2025
Thanks for sharing @brendaraud.bsky.social and @immunologypodcast.com!
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European Journal of Immunology @eurjimmunol.bsky.social · 19/08/2025
📢 Call for papers! Our special issue on Autoimmunity & Environmental Factors is open for submission. ✅Guaranteed peer review for all #IUIS2025 participants! Contribute to advancing our understanding of how modifiable factors influence immune tolerance and autoimmunity 👉 bit.ly/3HFEgIA
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yEFIS @yefis-immunology.bsky.social · 18/08/2025
Editor-in-Chief Nadja Bakocevic presenting at #IUIS2025 Career Fair on the ways @eurjimmunol.bsky.social and @efis-immunology.bsky.social support early career researchers. ✨ Celebrating 50 years of EJI and introducing the brand-new ECR Article of the Year Prize!
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