iiinova — where your digital self keeps evolving

Nik Joshi @joshilabyale.bsky.social · 02/10/2025

Happy to announce the publication using advanced models to understand how T cells mediate efficient immunoediting in early sarcomas. This was a collaboration between Julie Cheung and Brian Hunt in the lab Thanks to Cancer Cell for publishing our work. www.cell.com/cancer-cell/...

cell.com

Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas

Cheung et al. describe efficient T cell control of nascent neoantigen+ and nearby neoantigen-negative sarcoma cells, underlying a ∼50% reduction in tumor penetrance. This otherwise imperceptible immun...

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Kara Marshall @karalmarshall.bsky.social · 03/05/2025

Gave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig

youtu.be

Kara Marshall PHD-History of Science in America - Trilogy at Tehaleh 04/27/25

YouTube video by Steve Lawson

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King Lab at McGill University @kinglabmcgill.bsky.social · 22/04/2025

I am very excited to share our article on IFNg, stroma and disease tolerance during intestinal helminth infection published today in Cell. This work was lead by the amazing @susanwestfall.bsky.social and supported by many international collaborators. www.sciencedirect.com/science/arti...

sciencedirect.com

A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection

Type 1 immunity mediates host defense through pathogen elimination, but whether this pathway also impacts tissue function is unknown. Here, we demonst…

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Nik Joshi @joshilabyale.bsky.social · 11/04/2025

I do not understand how in 2025 we don’t have a calendar/email program that automatically sets up out of office email. There should be an option in any event where you can click and it turns on OOO message that you’ve set up and including the start and end date (if you want).

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Rachael Sirianni, PhD @docsirianni.bsky.social · 27/03/2025

They are cutting cancer research. They are cutting cancer research. They can deny it all they want, but they are cutting cancer research. These are the cuts being made the DoD CDMRP cancer funding mechanism www.fightcancer.org/sites/defaul...

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Josh Marshall @joshtpm.bsky.social · 27/03/2025

The situation at the NIH and for all biomedical and cancer cure research in the United States is MUCH MUCH WORSE than you realize.

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Nik Joshi @joshilabyale.bsky.social · 26/03/2025

It’s a bit surprising to me we’re not hearing about foundations stepping up to fill the gap on cancelled grants. These are vetted and ongoing research programs where money can make an immediate impact. Especially for mission aligned goals. Maybe it’s occurring behind the scenes.

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Gregg Gonsalves @gregggonsalves.bsky.social · 22/02/2025

Does your child want to go to college, want to go to med or grad school? The new cures for diseases, new technologies that we depend on come out of universities. #Trump, #Musk, #Vought are now killing higher education. If you haven't been paying attention, this would be a good time to wake up.

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Senator Lisa Blunt Rochester @bluntrochester.senate.gov · 21/02/2025

These NIH funding cuts threaten research happening in Delaware on heart disease, cancer, diabetes, stroke recovery, & more. This is what this administration is focused on. Not lowering your household costs.

delawarebusinesstimes.com

Delaware’s innovation pipeline could be at risk with new NIH funding policy

With a proposed cap on indirect costs for NIH grants, Delaware's life science sector could be hit the next generation of start-ups and researchers.

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Rod Rahimi @rodrahimi.bsky.social · 22/02/2025

Summary of the infuriating blockade of US medical research “This crisis...has already consumed one funding cycle” Carole LaBonne said. “But if this block to publishing in the register continues on much longer, it’s going to swallow two funding cycles, and that will put many labs out of business.”🧪⚕️

nytimes.com

Trump Administration Stalls Scientific Research Despite Court Ruling (Gift Article)

Using an arcane law, officials have effectively delayed funding from the National Institutes of Health, leaving medical studies in jeopardy.

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Jen Mercieca @jenmercieca.bsky.social · 21/02/2025

I've been seeing lots of super compelling videos of park rangers and federal lawyers and other federal workers telling their stories. Talking about what they did at their job, how it helped the American people, and why they want to keep doing those jobs. This is the way.

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Nik Joshi @joshilabyale.bsky.social · 21/02/2025

Well @mcuban.bsky.social every NCI grant that has been awarded over the past decade+ has been cut 20% for years, so it’s not that hypothetical of a question for cancer researchers.

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Rick Huganir @rhuganir.bsky.social · 20/02/2025

Reaching out to all Americans through the media to explain how decreasing funding of the NIH will have irreversible harm for developing therapies for all diseases. Please spread the word to your families and friends and contact your congressional representatives. www.nbcnews.com/science/scie...

nbcnews.com

Science under siege: Trump cuts threaten to undermine decades of research

Sweeping layoffs, funding freezes and executive orders have provoked outcry among federal researchers and their university partners, who fear that science itself is under siege.

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Waggoner Lab @labwaggoner.bsky.social · 20/02/2025

The attacks and uncertainty are not just crushing progress for human health, forfeiting the US leadership role in biomedical science, curtaining economic gain, and threatening many livelihoods...but breaking a pipeline of training that will be very hard to rebuild and which will haunt industry too

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Congressman Wesley Bell @repwesleybellmo.bsky.social · 19/02/2025

My family knows the pain of Alzheimer’s. It’s devastating. And now we learn Trump’s NIH cuts led to the firing of top researchers working on it --Infuriating. This isn’t “cutting waste”—it’s cutting and gutting life-saving research.

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Greg Sargent @gregsargent.bsky.social · 19/02/2025

Scoop --> Trump-Musk cuts just resulted in the firing of numerous top researchers at NIH's center for combating Alzheimer's, sources tell me. They predict big setbacks to fighting dementias. This cause was once championed by *Republicans.* Details here: newrepublic.com/article/1917...

newrepublic.com

Oops: Trump-Musk Cuts Just Wrecked an NIH Org Championed by GOPers

Republicans once lavished praise on an NIH center that deals with Alzheimer’s. Donald Trump and Elon Musk are hobbling it. What will they say now?

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Jeremy Berg @jeremymberg.bsky.social · 19/02/2025

Very important to get this word out!

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Ardem Patapoutian @ardemp.bskyverified.social · 19/02/2025

I expect that most academic biomedical researchers have considered leaving the US—if only in theory for now. What a colossal mess! Our representatives need to hear this. Please amplify so they know this matters. @levin.house.gov @repscottpeters.bsky.social @schiff.senate.gov @padilla.senate.gov

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Nik Joshi @joshilabyale.bsky.social · 19/02/2025

So angry to see this. We are volunteering our time in this system. Reviewers have better things to do than spend time reviewing grants for a system that doesn’t respect our time.

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Beth Popp Berman @epopppp.bsky.social · 18/02/2025

1/ I am seeing a lot of comments on the slashing of NIH support along the lines of “universities should just spend their huge endowments.” I’m the last person to cheer on the institutional stratification rising endowments have contributed to. But let me explain why this is not a solution.

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Nik Joshi @joshilabyale.bsky.social · 18/02/2025

My wife and I were postbac IRTAs 25 years ago. Neither would have pursued a career in research if not for this program We have PhD students in Yale Immunobiology now who also came from this NIH program including (one amazing student in my lab) This is a valuable program and has been for decades.

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Hope Jahren @realhopejahren.bsky.social · 17/02/2025

I just found out that my first book 📗, LAB GIRL 🌱🌿🌳, was challenged by a parent and subsequently removed from the shelves of the library at Walworth High School in Elkhorn, Wisconsin. So I decided to write a 🧵 on book 📚 #censorship 🚫 in American 🇺🇸 schools 🚸 1/n

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Senator Patty Murray @murray.senate.gov · 16/02/2025

Trump & Elon are putting lifesaving research on life support with a massive funding cut based on an uninformed and illegal whim. Every Senate Democrat is joining me in demanding HHS stop the political games and allow researchers to keep up their important work, uninterrupted.

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50501: The People’s Movement ❌👑 @50501movement.bsky.social · 10/02/2025

Join 50501 in a National Day of Action on Monday, February 17th. We are reclaiming President's Day - a day that is supposed to be celebrating the Presidency. Unite to limit executive overreach. Find your protest at buff.ly/417VjtT, or create one.

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Tcellogic (Sue Kaech) @tcellogic.bsky.social · 15/02/2025

Speak up!!! Please email & call you Congress Reps today to oppose these cuts to NIH-especially if you are a scientist living in a red state. Here’s where to find them: www.congress.gov/members/find...

congress.gov

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Barb McQuade @barbmcquade.bsky.social · 14/02/2025

NIH funding at @UMich supports important medical research, such as extending the life of organs waiting for transplant, advancing treatments for cerebral palsy, and sustaining experimental genetic trials for children with brain cancer.

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Waggoner Lab @labwaggoner.bsky.social · 13/02/2025

KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection www.science.org/doi/10.1126/... @science.org @nikjoshilabyale.bsky.social

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Nik Joshi @joshilabyale.bsky.social · 10/02/2025

“I mean, if the [NSF] success rate drops to 10%, why bother even applying?” says one higher education lobbyist. “Researchers may decide to leave the United States if they can’t get funding here.” 😬 www.science.org/content/arti...

science.org

‘My boss was crying.’ NSF confronts potentially massive layoffs and budget cuts

Trump could propose slashing agency’s budget by two-thirds

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Sen. Adam Schiff @schiff.senate.gov · 08/02/2025

Trump & Musk are making massive cuts to the National Institutes of Health. I know there is a lot going on right now, but this is one of worst things they have done so far, will affect cancer research and trials, the search for cures, innovation and competitiveness, our universities. Your lives.

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Ross Levine MD @rosslevinemd.bsky.social · 08/02/2025

I believe that most of our society values science and scientists. We need to continue to communicate our findings and value to the public and advocate for increased research funding, especially for young investigators->they are the future.

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Sarah Tishkoff, PhD @sarahtishkoff.bsky.social · 08/02/2025

Apologies for this long post I put together to explain to non-scientists the impact of NIH cuts: Last night, an “atomic bomb” was dropped on the biomedical science community. We were informed that effective immediately, indirect costs on NIH grants (both current and future) would be fixed at 15%.

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Sri Kosuri @srikosuri.bsky.social · 08/02/2025

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

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Glen O'Hara @gsoh31.bsky.social · 08/02/2025

If the UK was really, really smart, it would now plough tens of billions into research centres and take in all the American academics fleeing the US. Spoiler: the UK is not smart. 🇬🇧

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Mia Farrow @miafarrow.bsky.social · 08/02/2025

NIH has cut billions of dollars in biomedical funding, effective immediately The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease. www.washingtonpost.com/health/2025/...

washingtonpost.com

NIH cuts billions of dollars in biomedical funding, effective immediately

The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.

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E John Wherry @ejohnwherry.bsky.social · 08/02/2025

YES. Need to say this loudly and often! This 2.46x is also the short-term ROI. Long-term ROI (more difficult to estimate) may ~10x. Highest for any gov't spending. And the source of discoveries necessary for all new drugs (industry important too but without NIH funded science there's no foundation)

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Nik Joshi @joshilabyale.bsky.social · 08/02/2025

I feel dumb for not realizing this sooner, but everyone should delete the X app from our phones. It gives Twitter a ton of access to personal info including purchases, location, contact info, contacts, search history, identifiers. Not sure if that’s just while using the app, but what if it’s not?

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Alondra Nelson @alondra.bsky.social · 08/02/2025

Research universities are often the largest employers in their region. They are often the primary health care providers to communities. This funding shift will not only reduce US research leadership, it will put working people out of work and reduce healthcare access.

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Tim Clancy @viewfromarchstreet.com · 08/02/2025

On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...

grants.nih.gov

NOT-OD-24-110: Notice of Legislative Mandates in Effect for FY 2024

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Legislative Mandates in Effect for FY 2024 NOT-OD-24-110. NIH

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Jeremy Berg @jeremymberg.bsky.social · 08/02/2025

Indirect rates are not determined by NIH. Instead, they are the product of elaborate negotiations between each institution and the “cognizant federal agency” according to an Office of Management and Budget document, Circular A-21. 1/n

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