Climate change is no longer a distant environmental issue—it is a growing public health challenge for San Diego. Mosquitoes are spreading faster and farther…

Li launches new lab at an exciting time for novel immunotherapeutics and vaccine innovations

Li launches new lab at an exciting time for novel immunotherapeutics and vaccine innovations

The new Rad Lab at LJI studies the cells behind our antibodies—and aims to guide the development of better vaccines, tests, and treatments.

Climate change is no longer a distant environmental issue—it is a growing public health challenge for San Diego. Mosquitoes are spreading faster and farther…

A modified Zika vaccine protected mice almost entirely through virus-killing CD8 T cells when its antibodies failed to neutralize mature virus effectively. The T-cell protection worked shortly after v...

Although routinely detected in human blood and tissue samples, immune cell doublets are typically discarded during data acquisition or analysis, often dismissed as technical artifacts arising from ex...

Following the success of the 2020-2025 IEDB Virtual User Workshops, we will once again be bringing the workshop to you, online! In 2026, the IEDB team will be hosting one virtual user workshop over th...

Following the success of the 2020-2025 IEDB Virtual User Workshops, we will once again be bringing the workshop to you, online! In 2026, the IEDB team will be hosting one virtual user workshop over th...

Sparking an immune response where microbes enter the body should not only stop a person getting sick, but also prevent them spreading the infection to others.

YouTube video by La Jolla Institute for Immunology

Team leader Erik Ehinger, Ph.D., is on a mission to help more patients benefit from cancer immunotherapies.

An experimental Zika vaccine protected mice through CD8+ T cells, offering a possible way to avoid worsening infection caused by antibody-dependent enhancement.

LJI scientists tested two Zika vaccines, both designed to work through antibodies. One protected through T cells instead—but only the vaccine that mustered both held off the virus for the long haul.

Cancer epitopes, the molecular structures recognized by T and B cells at the tumor interface, are central to understanding antitumor immunity and developing ...

Longitudinal nasopharyngeal swabs sample and reveal upper airway humoral memory generated after intranasal FluMist vaccination.

Genetic screens in immune cells enable the systematic interrogation of gene function at scale, uncovering key regulators of cell functions such as tumor cell killing and persistence. However, existing...

LJI scientists investigate how “tissue-resident” immune cells contribute to lung and autoimmune diseases.

Shane Crotty, PhD, joined the AAI Council on July 1. We spoke with him about his research, his goals for his term, and writing a biography.

The discovery that chronic inflammation is a cause of myriad illnesses could be this century's biggest medical breakthrough.

LJI scientists are the first to provide a comprehensive look at how tissue-resident memory T cells combat infections in human lung tissue

Unlike in other tissues, lung-resident memory T cell populations are not well maintained in mice. Here the authors show that this is not the case in human lungs, where tissue-resident memory T cells s...

To test this strategy, the team engineered protein immunogens that mimic key HIV envelope structures known to initiate bnAb development.

LA JOLLA, CA—HIV is globally so diverse, consisting of hundreds of thousands of different strains, that antibodies capable of blocking one strain may not recognize another. This strain variability has been one of the greatest barriers to developing a vaccine that can provide broad protection against…

Vaccine approach yields high numbers of HIV-neutralizing antibodies in non-human primates

Physician-scientist L. Benjamin Hills wins prestigious Irvington Postdoctoral Award to study immune cells in young cancer patients

Nature - Vaccination elicits HIV broadly neutralizing antibodies in primates

Nature - Vaccination elicits HIV broadly neutralizing antibodies in primates