Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...

ID: 4897. Title: Postdoctoral Research Associate . Application Deadline:

Conventional human pluripotent stem cells (hPSCs) are widely used to study early embryonic development, generate somatic cells, and model diseases, with differentiation potential aligned to a post-imp...

Zhang and colleagues identify the transcription factor GABPA as a regulator of zygotic genome activation, epiblast formation and naive pluripotency establishment.

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Nature Cell Biology - Liu, Xie and colleagues profile putative cis-regulatory elements in mouse oocytes and pre-implantation embryos. They further validate putative enhancers in oocytes and...

As an Editor of the journal Development, I often hear complaints about peer review. We all know the problems – from lengthy review times to requests for seemingly unnecessary experiments. I a…

The chick embryo is a classical model system commonly used in developmental biology due to its amenability to gene perturbation experiments. Pairing t…

The 2025 Gordon Research Conference on Developmental Biology will be held in Pomona, California. Apply today to reserve your spot.

ChIP-DIP (ChIP done in parallel) is a highly multiplex assay for protein–DNA binding, scalable to hundreds of proteins including modified histones, chromatin regulators and transcription factors, offe...

The paternal preconception environment has been implicated as a modulator of phenotypic traits and disease risk in F1 offspring. However, the prevalence and mechanisms of such intergenerational epigen...

Stem cell-based models of the human embryo promise to transform the study of human embryogenesis. In this review, we discuss our current knowledge of the first 2 weeks of human embryo development and ...

Enhancers play an essential role in developmental processes by orchestrating the spatial and temporal regulation of gene expression. However, mapping the location of these regulatory elements in the g...

The human placenta, a unique tumor-like organ, is typically thought to exhibit rare aneuploidy associated with adverse pregnancy outcomes. Discrepancies in reported aneuploidy prevalence in placenta l...

The principal objective of DANIO-ReCODE is to provide world-class doctoral training to a new generation of early-career researchers interested in understanding the complex and multilayered process of ...