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Michelle Percharde

@mpercharde.bsky.social
801 followers 581 following 66 posts

Transposons, chromatin, development. Group leader @ the MRC LMS in London and UKRI FLF. Mum of 2, she/her. Www.perchardelab.com

PostsRepliesMedia
Reposted by Michelle Percharde
Kurianlab @kurianlab.bsky.social · 09/05/2026
www.cell.com/molecular-ce... check this beautiful paper
cell.com
Alu repeat-containing RNAs spatially organize actively transcribed genomic regions around nuclear speckles
Liu et al. identify nuclear speckle-enriched Alu repeat-containing RNAs that facilitate the organization of actively transcribed genes at speckles by binding Alu sequences and promoting speckle assemb...
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Reposted by Michelle Percharde
Lori Passmore @lapassmore.bsky.social · 25/02/2026
We are excited to be recruiting a new tenure track group leader in the Structural Studies Division at MRC LMB! It is an amazing place to start your own lab. @mrclmb.bsky.social Please get in touch if you have any questions. www.nature.com/naturecareer...
nature.com
Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Cambridge, Cambridgeshire (GB) job with MRC Laboratory of Molecular Biology (LMB) | 12854636
Research Group Leader Tenure Track Starting Salary £67,979 to £76,868 per annum MRC Laboratory of Molecular Biology, Cambridge, UK The MRC Laborato...
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Reposted by Michelle Percharde
Miguel Branco @brancolab.bsky.social · 02/02/2026
New preprint from the lab! We dig into the regulatory roles of TEs in the mouse placenta, with some surprising findings. Led by the awesome @smamante.bsky.social. Particular kudos to him for navigating the many twists and turns of the project.
biorxiv.org
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Michelle Percharde @mpercharde.bsky.social · 22/12/2025
🚨Our story is published! Same bones but + dissection of MERVL’s role integrating signals from #ZGA factors, & + about pathological DUX4 activation of NOXA #TEsky. Thanks to all revs for their helpful comments improving the ms. Even #rev3 - until they ghosted us 😜 www.science.org/doi/epdf/10....
science.org
CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency, and cell death
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Michelle Percharde @mpercharde.bsky.social · 02/12/2025
Very excited to be part of this prestigious programme, thank you @embo.org !
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Reposted by Michelle Percharde
EMBO @embo.org · 02/12/2025
Congratulations to the new cohort of 28 EMBO Young Investigators! They are joining an international network of more than 800 life scientists – Welcome! Read the press release here: www.embo.org/press-releases/twenty-…
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Michelle Percharde @mpercharde.bsky.social · 27/11/2025
🚨Post open in our lab! Come work on some cool themes involving metabolism, chromatin, early development 🤓. Pls RT
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Reposted by Michelle Percharde
MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 20/11/2025
📣 We’re hiring 6 new Team Science postdocs! Our Team Science approach brings together interdisciplinary researchers to tackle questions no single field can solve alone. Find out more and download our brochure below
lms.mrc.ac.uk
MRC Postdoctoral Research Scientists x 6 - MRC Laboratory of Medical Sciences
Team Science Project
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Michelle Percharde @mpercharde.bsky.social · 16/11/2025
#TEsky
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Reposted by Michelle Percharde
MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 14/11/2025
Register now for our one-day symposium at the MRC Laboratory of Medical Sciences on environmental and metabolic control of early development on 4 December 2025! Spaces are limited, register here: www.symposia.org.uk/courses/stem...
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Michelle Percharde @mpercharde.bsky.social · 10/11/2025
Spaces filling up for our @bsdb.bsky.social GRT symposium @mrc-lms.bsky.social on environment, metabolism and stem cell development 4th Dec 2025! Updated poster with talk titles below. Register here: www.symposia.org.uk/courses/stem... Looking forward to seeing you there!
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Reposted by Michelle Percharde
MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 09/10/2025
We are launching 11 new #PhD opportunities today! If you would like to contribute to the research at the LMS apply today! #medicalscience #lifescience
lms.mrc.ac.uk
Studentships and PhD training
We have two core PhD programmes - traditional and transdisciplinary. Our PhD students are registered with Imperial and are embedded in our dedicated research facility.
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Reposted by Michelle Percharde
Transposon and Cancer Epigenetics Group @deniz-lab.bsky.social · 02/10/2025
We have a new PhD studentship in the lab on the immunogenic roles of transposable elements in paediatric acute myeloid leukaemia! Come and work with us! www.colcc.ac.uk/2026-cyp-phd...
colcc.ac.uk
2026 CYP PhD Project Deniz
Uncovering the Immunogenic Landscape of Transposon-Driven Transcripts in Paediatric Acute Myeloid Leukaemia Primary supervisor: Özgen Deniz, Queen Mary University of London Secondary supervisor: Ri...
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Reposted by Michelle Percharde
Science News @scinews.bsky.social · 20/09/2025
World’s first AI-designed viruses a step towards AI-generated life. #Nature Scientists used AI to write coherent viral genomes, using them to synthesize bacteriophages capable of killing resistant strains of bacteria. www.nature.com/articles/d41...
nature.com
World’s first AI-designed viruses a step towards AI-generated life
Scientists used AI to write coherent viral genomes, using them to synthesize bacteriophages capable of killing resistant strains of bacteria.
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Michelle Percharde @mpercharde.bsky.social · 19/09/2025
Come be our head of bioinformatics at @mrc-lms.bsky.social ! Our bioinformatics team are closely involved with lots of interesting science and we love working with them. Topics inc. development, cancer, metabolism, aging, TEs (my favourite of course 😜) #TEsky lms.mrc.ac.uk/work/vacanci...
lms.mrc.ac.uk
Head of Bioinformatics - MRC Laboratory of Medical Sciences
We are recruiting for a Head of Bioinformatics to lead our Bioinformatics facility
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Reposted by Michelle Percharde
Oded Rechavi @odedrechavi.bsky.social · 31/07/2025
it appears your low-hanging-fruit phd project wasn't so risk free after all, mr. bond
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Reposted by Michelle Percharde
Helena Cocheme @cochemelab.bsky.social · 27/07/2025
Join the #LMS! Our institute is advertising for junior #GroupLeader positions in #Physiology and #Metabolism. Closing date for applications: August 31st!
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Reposted by Michelle Percharde
MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 09/07/2025
A new study, published today in Nature, reveals the hidden benefits of weight loss on fat tissue. A better understanding of how weight loss leads to health improvements at a molecular level could help inform the development of therapies for diseases such as type 2 diabetes in the future.
lms.mrc.ac.uk
Study reveals the hidden benefits of weight loss on fat tissue
Scientists from the MRC Laboratory of Medical Sciences (LMS) and Imperial College London have produced the first detailed characterisation of the changes that weight loss causes in human fat tissue by...
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Michelle Percharde @mpercharde.bsky.social · 08/07/2025
🚨Symposium alert! 🚨 Next edition of our biennial stem cell symposium is 4th Dec 2025 - focus on metabolism and development. Sponsored by @bsdb.bsky.social. Great lineup of speakers, hosted @mrc-lms.bsky.social in London. Registration is open. www.symposia.org.uk/courses/stem...
Poster for Genesis Research Trust / BSDB symposium on metabolism and stem cells
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Reposted by Michelle Percharde
Vicki Metzis @vmetzis.bsky.social · 27/06/2025
Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social
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Michelle Percharde @mpercharde.bsky.social · 26/06/2025
The Chromatin And Development lab are hiring a postdoc! Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT! lms.mrc.ac.uk/work/vacanci...
lms.mrc.ac.uk
MRC Postdoctoral Research Scientist - MRC Laboratory of Medical Sciences
The MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. LMS...
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Michelle Percharde @mpercharde.bsky.social · 26/05/2025
LTRs as dogs…can be friendly, quite helpful at times. LINEs as cats? Also pretty nice in some cases, but also will get angry and scratch out your eyes. Hmm #TEsky 🤔
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Reposted by Michelle Percharde
Annika Barber @annikabarber.bsky.social · 26/05/2025
I love the concept of domesticated transposable elements. I like that my genome has its little viral pets to feed nucleic acids and take out for transcriptional walkies. 🧬
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Reposted by Michelle Percharde
Development @dev-journal.bsky.social · 16/05/2025
In this Review, @bryonyleeke.bsky.social, Imke Staffhorst and @mpercharde.bsky.social @mrc-lms.bsky.social explore roles of the nucleolus in mammalian development, focusing on genome organisation and chromatin regulation: doi.org/10.1242/dev....
Figure 1 Nucleolar structure and rRNA gene organisation.
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Michelle Percharde @mpercharde.bsky.social · 14/05/2025
The nucleolus....large, rather boring organelle in the nucleus? No! Our review led by @bryonyleeke.bsky.social just out @dev-journal.bsky.social, highlighting new findings on nucleoli dynamics in development, intriguing roles in chromatin organisation & more. journals.biologists.com/dev/article/...
nucleoli are dynamically reprogrammed in early mammalian development
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Michelle Percharde @mpercharde.bsky.social · 07/05/2025
Calling undergrads! Our summer internship programme @mrc-lms.bsky.social is still open if you want to try out a summer research project. Great way to get a taste of research, inc a generous stipend. Lots of interesting labs are hosting, including us ;) Closing 15/5/25. lms.mrc.ac.uk/work-and-stu...
lms.mrc.ac.uk
LMS Undergraduate Summer Programme - MRC Laboratory of Medical Sciences
Our LMS Undergraduate Summer Programme is a fantastic, fully-funded opportunity for undergraduate students to gain hands on laboratory experience to support their scientific journeys.
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Reposted by Michelle Percharde
Transposon and Cancer Epigenetics Group @deniz-lab.bsky.social · 06/05/2025
I am excited to share our lab's first review out with in Blood Cancer Journal. We discuss the impact of transposable elements on genome regulation and variation in both normal haematopoietic processes and haematological cancers. www.nature.com/articles/s41...
nature.com
Transposable elements as genome regulators in normal and malignant haematopoiesis - Blood Cancer Journal
Blood Cancer Journal - Transposable elements as genome regulators in normal and malignant haematopoiesis
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Reposted by Michelle Percharde
Barbara Pernaute @bpernaute.bsky.social · 23/04/2025
🚨🚨#Hiring! 3 year #postdoc position open in my lab @cabd-upo-csic.bsky.social to study the interplay between DNA damage responses and #preimplantation embryo development. Fully funded by EARLYFATE #ERCCoG 📆 Apply by 23rd May 2023 🔗Details below @sebioldev.bsky.social Please RT!🙏
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Reposted by Michelle Percharde
Itai Yanai @itaiyanai.bsky.social · 28/04/2025
Barbara McClintock proposed – over 40 years ago – that transposable element activity could be a response to stress, and I think that we are still only beginning to understand how right she was.
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Reposted by Michelle Percharde
Marco Trizzino @marcotrizzino.bsky.social · 07/04/2025
New preprint from my group! Here we studied the contribution of a subset of human- and hominoid-specific transposons (SVA, LTR5HS) to the evolution of human craniofacial development. We specifically focussed on cranial neural crest (CNCC) formation and migration 1/n www.biorxiv.org/content/10.1...
biorxiv.org
Human-specific transposable elements shaped the evolution of craniofacial development through regulation of neural crest migration
Craniofacial development and neural crest specification are evolutionarily conserved processes, yet subtle modifications to their gene regulatory networks drive species-specific craniofacial diversity...
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Reposted by Michelle Percharde
Joanna W Jachowicz @jjachowicz.bsky.social · 06/04/2025
Join our team as a postdoc and explore the exciting world of transposable elements and developmental biology with us! @imbavienna.bsky.social @vbcscitraining.bsky.social
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Reposted by Michelle Percharde
Pradeepa Madapura @pradeepmadapura.bsky.social · 01/04/2025
Chromatin & transcription meeting is back again. Register your interest here www.biochemistry.org/events-and-t...
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Reposted by Michelle Percharde
QMUL Centre for Epigenetics @qmulepigenetics.bsky.social · 26/03/2025
Only a couple of months left until our official QMUL Centre for Epigenetics Launch Conference! We will have an amazing list of guest speakers, including Michelle Percharde @mpercharde.bsky.social from MRC LMS, UK. Spaces are limited.
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Maxim Greenberg @maxvcg.bsky.social · 04/03/2025
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Jeremy Berg @jeremymberg.bsky.social · 16/02/2025
They have created Schrödinger’s NIH employee 2/2
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Celtic Karla @celtickarla.bsky.social · 15/02/2025
This is my science jobs feed. Do you have an opening in your Lab or Department? Did you come across a cool job opening? Just type #sciencejobs for post to appear on the feed. #neuroskyence #academicsky #womeninstem #medsky 🧠 🧪 🧬 🪰 🌱 bsky.app/profile/did:...
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Genes & Development @genesdev.bsky.social · 28/01/2025
Excited to announce new editorial leadership with Professor Andrew Dillin as Editor-in-Chief and Dr. Eric Sawey as Executive Editor, expanding the journal’s scope to include exciting new areas of molecular and cellular biology. bit.ly/genesdevpr
bit.ly
The journal Genes & Development has new editorial leadership and an expanded scope
Cold Spring Harbor Laboratory Press (CSHL Press) has announced the appointment of new editorial leadership at its renowned journal, Genes & Development. Professor Andrew Dillin has been named Edit...
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Reposted by Michelle Percharde
Miguel Branco @brancolab.bsky.social · 21/01/2025
We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below. Please spread the word.
qmul-jobs.tal.net
Postdoctoral Research Associate - QMUL Jobs
ID: 4897. Title: Postdoctoral Research Associate . Application Deadline:
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Michelle Percharde @mpercharde.bsky.social · 23/01/2025
But they seem like such a good idea at the time…
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Juliane Glaser @julianeg.bsky.social · 16/01/2025
It’s official 🎉 I am excited to share that I will start my lab this spring at the Max Planck Institute for Immunobiology and Epigenetics @mpi-ie.bsky.social in beautiful Freiburg 🤩🗻☀️ I am looking forward to new collaborations and working with the fantastic community in Freiburg & its surroundings!
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Michelle Percharde @mpercharde.bsky.social · 16/01/2025
doi.org/10.1126/scia... very happy to have contributed with @bryonyleeke.bsky.social to this fascinating study from Jesus Gil’s lab @mrc-lms.bsky.social. SMARCA4 inhibition leads to repeat element dysregulation, cGAS/STING activation and enhances immune cell clearance of senescent cells
doi.org
SMARCA4 regulates the NK-mediated killing of senescent cells
SMARCA4 inhibition enhances NK-mediated killing of senescent cells and can be combined with cisplatin to treat ovarian cancer.
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Michelle Percharde @mpercharde.bsky.social · 14/01/2025
Tell me you're a science parent without saying anything...thanks for the new calculator @alexisbarr.bsky.social
photo of work desk with child's till
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Deborah Bourc’his @deborahbourchis.bsky.social · 28/11/2024
The international Curie « Noncoding Genome » course has been revamped! 👉 Dark genome in cell plasticity and heterogeneity. A session on TEs #TEsky with M.E. Torres Padilla, D.Trono and @aktast.bsky.social. Master, PhD and postdoc fellows, a week in Paris during the Spring? Apply before Feb 15th 📌
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MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 03/01/2025
New research from Steve Cutty and @alexisbarr.bsky.social published in the British Journal of Cancer shows the protein p21 promotes survival in lung cancer cells strengthening the rationale for targeting p21 as a cancer treatment. This work was also funded by @cancerresearchuk.org
lms.mrc.ac.uk
Blocking the cell cycle inhibitor p21 prevents regrowth in lung cancer cells
Blocking the activity of a protein called p21 stops lung cancer cells entering a ‘sleep-like’ state that allows them to survive chemotherapy. Blocking p21 causes more cancer cells to die and reduces t...
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Michelle Percharde @mpercharde.bsky.social · 17/12/2024
The @mrc-lms.bsky.social is recruiting for Programme Leader Track (PLT) group leaders - come work with us! Supportive and collaborative colleagues, fascinating mechanistic science, generous funding and facilities, and a new building with nice views of London 😍 shorturl.at/VuVxX
advert for group leaders at the MRC LMS in London. Closing date 13.01.25
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Michelle Percharde @mpercharde.bsky.social · 13/12/2024
I love a good reporter! TE reporters for capturing distinct hESC states. Looking forward to reading #TEsky
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Michelle Percharde @mpercharde.bsky.social · 06/12/2024
Heading home after the @embl.org PhD symposium #biologyoutsidethebox - real pleasure to talk a bit on our work #beyondthedogma on TEs & also share about being a women in science. Loads of cool talks from v.diverse topics! #dinosaurDNA . Thanks for the invite!!
Embl phd symposium
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Shifaan Thowfeequ @shifaant.bsky.social · 04/12/2024
Nice to see our latest review published in @natrevmcb.bsky.social today – a collaborative exploration of mammalian extraembryonic development with @cwhanna.bsky.social for an invaluable epigenetic focus. @srinivas-lab.bsky.social www.nature.com/articles/s41...
nature.com
Origin, fate and function of extraembryonic tissues during mammalian development - Nature Reviews Molecular Cell Biology
During mammalian embryogenesis, extraembryonic tissues are required for the patterning and morphogenesis of the embryo. This Review discusses how signalling networks and epigenetic modifications regul...
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