Register for in-person Register for online The 2026 Loke CTR annual meeting theme, “Epigenetics of embryogenesis and placentation” brings together leading clinical and basic scientists to explore…

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Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection. However, much of DRT family diversity remains ...

Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.

Hi all We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? The position is in the Instit...

DNA methylation loss at transposable elements (TEs) can affect neighboring genes and be epigenetically inherited in plants, yet the determinants and significance of this additional system of inheritan...

Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

In Drosophila, the cephalic furrow counteracts mechanical stress as the developing head and the trunk tissues meet, providing evidence for how mechanical forces influence the evolution of morphog...

It is time to admit that America is no longer a functioning democracy

Nature Biotechnology - Children with rare genetic diseases get CRISPR Cures center

A novel multistep strategy reveals how parent-of-origin effects shape complex traits in large-scale biobanks.

Join with us to sign our Citizens' Petition to the US Congress to choose the people over Trump and Impeach RFK Jr Now!

imageimageIn spermatogenesis, loss of promoter DNA methylation reactivates retrotransposons in patterns shaped by chromatin modifications and the binding of DNA methylation-sensitive transcription fac...

In aging female mice, genes on the second X chromosome become active again. This could be an explanation for sex differences in aging humans regarding disease.

Le ministre de la recherche a dit sa « préoccupation », mercredi, après cette décision des autorités américaines. Le chercheur du CNRS aurait subi un contrôle aléatoire à son arrivée, avant que son ordinateur et son téléphone ne soient fouillés.

Participez à l'étude sur le dépistage du cancer du poumon en Ile-de-France pilotée par l'Institut Curie, en partenariat avec l'Institut Mutualiste Montsouris et le Centre de Santé du Square de la Mutu...

Naive pluripotent stem cells (PSCs) are counterparts of early epiblast in the mammalian embryo. Mouse and human naive PSCs differ in self-renewal requ…

The National Institutes of Health under President Donald Trump announced this month that it was cutting payments covering overhead costs for research institutions that receive its grants.

Structures reveal that histone H3K36me3 and H3K4me3 modifications reduce Polycomb repressive complex 2 (PRC2) function through the inhibition of histone tail engagement and antagonistic binding to the...

Response to tebentafusp is variable in patients with metastatic uveal melanoma. Here, the authors use droplet digital PCR to detect ctDNA and show that ctDNA positivity was associated with shorter ove...

Transposable element exonization by unannotated splicing events produces stable protein isoforms with acquired functions that are subject to evolutionary selection.

X-chromosome inactivation (XCI) contributes to sex bias in T cell immunity, but data on profiling XCI during human T cell development is still lacking. Here, the authors leverage allele-specific expre...