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Graziano Martello

@grazianomartello.bsky.social
259 followers 442 following 32 posts
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Reposted by Graziano Martello
The EMBO Journal @embojournal.org · 17/03/2026
Eliminating the confounding effects of human pluripotent #stemcell co-culture with MEFs: @grazianomartello.bsky.social @leeboratory.bsky.social @jzylicz.bsky.social and collaborators describe a serum coating approach for feeder-free culture of naïve hPSCs link.springer.com/article/10.1...
link.springer.com
Serum coating enables feeder-free culture of naive human pluripotent stem cells preserving developmental potential - The EMBO Journal
Naive human pluripotent stem cells (hPSCs) represent a pre-implantation epiblast state able to efficiently differentiate into embryonic and extraembryonic pre-implantation lineages and to self-organis...
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Reposted by Graziano Martello
Nature Cell Biology @natcellbio.nature.com · 16/01/2026
🎆 Happy new year and our first 2026 issue is out! Cover: #epiblast development 👉Perspective: biological clocks 👉Review: #mitosis #CellDeath #inflammation 🔬 #chromatin #cancer #Bcells #Tcells #autophagy #organoids #mechanobiology #TranscriptionFactors #Xist & more! www.nature.com/ncb/volumes/...
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Graziano Martello @grazianomartello.bsky.social · 11/12/2025
🚨 New paper out! A human epiblast model reveals how dynamic TGF‑β signalling controls epithelial identity in early mammalian development Here is the full paper: rdcu.be/eSWEs 🧵 A twittorial: THREAD
rdcu.be
A human epiblast model reveals dynamic TGFβ-mediated control of epithelial identity during mammalian epiblast development
Nature Cell Biology - The authors optimize an in vitro human epiblast model, which they utilize to show that early TGFβ family inhibition prevents epithelial identity, whereas it is...
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Graziano Martello @grazianomartello.bsky.social · 21/01/2025
With pleasure we share our preprint reporting robust and cost-effective expansion of naive human Pluripotent Stem Cells without feeder cells. A fantastic collaborative effort with @leeboratory.bsky.social @jzylicz.bsky.social @pasquelab.bsky.social and Nicolas Rivron. tinyurl.com/5n6z9rt9
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