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Soragni:Lab

@alice.soragnilab.com
4.3K followers 794 following 934 posts

Of aggregation, rare cancer biology, and organoids First gen / Prof @ CU Anschutz Co-President: @TheSFPM.bsky.social Website & papers: linktr.ee/soragnilab Twitter archive: @twitter.soragnilab.com Here in a personal capacity.

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Reposted by Soragni:Lab
Mark Peifer (He, him) @peiferlabunc.bsky.social · 04/08/2026
One of the many things I love about @ascbiology.bsky.social ,my favorite scientific society, is that it recognizes there are many ways to contribute to science, including mentoring, education, outreach and advocacy. This year's Fellows represent that. 1/n www.ascb.org/society-news...
Six of the fellows--see linkNine of the fellows--see link
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Soragni:Lab @alice.soragnilab.com · 05/07/2026
Happy Fourth of July. A reminder that democracy, like science, depends on care, integrity, and collective responsibility. Let us all do our part
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Soragni:Lab @alice.soragnilab.com · 20/04/2026
Truer words were never spoken. Really important session on cancer prevention and screening with a focus on policies #AACR26
Title slide from Dr. Philip Castle reading “the best cancer is the cancer that never happens”
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Soragni:Lab @alice.soragnilab.com · 19/04/2026
First AACR Meeting ever as a non-UCLA affiliate, big changes and so excited for what’s ahead. If you see me around, stop to say hi 👋 #AACR 26
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Scott Bryan @scottygb.bsky.social · 06/04/2026
Artemis astronauts now sharing photos of the moon they have taken with their iPhones. The lights are switched off on the spaceship so they can take photos better.
The moon taken on an iPhone
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Soragni:Lab @alice.soragnilab.com · 06/04/2026
Just learned the Artemis II team is getting a better lunch than I am. Well then.. www.youtube.com/watch?v=m3kR...
youtube.com
NASA's Artemis II Live Mission Coverage (Official Broadcast)
YouTube video by NASA
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Soragni:Lab @alice.soragnilab.com · 31/03/2026
Cancer research, dismantled. Only *35* grants awarded so far in FY26. NCI stats for new and competitive grant renewals from: grant-witness.us/funding_curv...
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Soragni:Lab @alice.soragnilab.com · 27/03/2026
There is barely any money going out the door as is
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Alex Holehouse @alexholehouse.bsky.social · 12/02/2026
Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now? www.nature.com/articles/s41... More functional data, many thousands of words removed, and a few other updates from last year's preprint.
nature.com
Sequence and chemical specificity define the functional landscape of intrinsically disordered regions - Nature Cell Biology
Langstein-Skora, Schmid, Huth et al. propose that intrinsically disordered region functionality can be driven by the interplay between linear binding motifs and contextual chemical characteristics suc...
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Michael F. Wells @mfwells.bsky.social · 03/03/2026
We're hiring villagers! We are looking for a lab technician to help us discover how gene-by-environment interactions shape the developing brain via in vitro cell villages. Please DM me or visit our website at mfwellslab dot com for more info. Deadline to apply is March 11th: tinyurl.com/34seyjaj
uclahealthcareers.org
Laboratory Assistant II - Human Genetics - UCLA Health Careers - Job #29031 - Los Angeles, CA
Take a look at a great career opportunity where you can make a real difference at UCLA Health
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Soragni:Lab @alice.soragnilab.com · 03/03/2026
On the side of small gripes: I'll never find reasonable to be asked to be online at 5am to review grants especially now that paylines are gone-and so are grants. It's unreasonably burdensome for all, even more so for those getting children ready for/to school. If the goal is inclusion, 5am is not it
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Eric Topol @erictopol.bsky.social · 01/03/2026
That's right. Worse than Pointless www.nytimes.com/2026/02/23/o...
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Eric Holthaus @ericholthaus.com · 01/03/2026
This is a graph of the death of US science.
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Soragni:Lab @alice.soragnilab.com · 28/02/2026
It's a tragedy. I hope no one thinks that we are over the hump. This is quite literally how federally supported science goes extinct.
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Max Kozlov @maxkozlov.bsky.social · 27/02/2026
Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers. The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇
nature.com
White House stalls release of approved US science budgets
The US Congress rejected sweeping cuts to science agencies. But the NIH, the NSF and NASA have had their spending slowed.
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Irene Gallego Romero @ee-reh-neh.bsky.social · 28/02/2026
Finally, today's offering! www.biorxiv.org/content/10.6... This began life as a very different project which failed because we couldn't agree on defining eqtl sharing across cohorts. So two young members of the lab dug deeply into this - first @ijbeasley.bsky.social, then @patrickgibbs.bsky.social
biorxiv.org
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Richard Sever @richardsever.bsky.social · 26/02/2026
New version of our preprint on bioRxiv about bioRxiv up. Now that’s what I call a revision – 6 years after the first version! It has new data about our progress and highlights from a massive user survey. 1/n www.biorxiv.org/content/10.1...
biorxiv.org
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CU Anschutz Cancer Center @cucancercenter.bsky.social · 25/02/2026
A nationally recognized leader in patient-derived tumor organoids and functional precision oncology has arrived at CU! Welcome, Alice Soragni, PhD (@alice.soragnilab.com) 👋 ⬇️ news.cuanschutz.edu/dbmi/alice-sora…
news.cuanschutz.edu
CU Anschutz Recruits National Leader to Launch Functional Personalized Medicine Initiative
National leader in tumor organoids Alice Soragni, PhD, launches a rapid functional precision medicine initiative at CU Anschutz within CCPM and DBMI.
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Brett Collins @brettcollins.bsky.social · 21/02/2026
This is an interesting article for those beginning down the cryoEM route for structure determination from the perspective of a crystallography lab. Not giving up on crystallography yet 😜 but I honestly can't think of a single crystallography lab now that isn't also using CryoEM in some capacity.
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Soragni:Lab @alice.soragnilab.com · 21/02/2026
Nature 🤝 Ornithology .. who knew .. www.nature.com/natcities/
nature.com
Nature Cities
Nature Cities features timely and impactful cutting-edge research, opinion, and ideas relevant to urbanisation and understanding the role of cities in our ...
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Soragni:Lab @alice.soragnilab.com · 18/02/2026
This is 252 R01s, only. The math is quite devastating
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Soragni:Lab @alice.soragnilab.com · 17/02/2026
This may end up being a hot take, but two things can be true at once: the new SciENcv is a pain, and it won't really affect things too much as most reviewers (...check notes...) actually use google/google scholar/REPORTER already
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Sarah Cohen @cohenlaboratory.bsky.social · 16/02/2026
Cells come in many shapes and sizes, with diverse physiological functions. But how do #organelles and their interaction networks remodel during #differentiation of stem cells into different cell types? Here’s what we discovered about neuronal differentiation: 1/13
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Acquired Resistance to Therapy Network (ARTNet) @nciartnet.org · 13/02/2026
Congrats to all the authors! #ARTNetPublication
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 14/02/2026
Of so many things to be infuriated about, this is perhaps my biggest gripe. Pancreatic cancer patients, who face a future without hope, are being denied a potential game-changing therapy www.mskcc.org/news/can-mrn...
mskcc.org
In Early-Phase Pancreatic Cancer Clinical Trial, Investigational mRNA Vaccine Induces Sustained Immune Activity in Small Patient Group
Learn how MSK researchers are deploying mRNA vaccines against pancreatic cancer.
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Soragni:Lab @alice.soragnilab.com · 13/02/2026
Proud of this review on centering models and next gen techs to address and prevent acquired resistance in cancer. Cements the work that our working group within @nciartnet.org has done over the last couple years, glad it resonated with people
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Prasad Jallepalli, MD, PhD @prasad.bsky.social · 13/02/2026
“I consider it an unprecedented action that really violates the basic principles of a data-driven regulatory agency and the fundamentals of public health, and it’s that simple,” said Gary Nabel, former head of the National Institutes of Health’s Vaccine Research Center and chief scientist at Sanofi, who now runs a vaccine and cancer startup. “It’s a destructive precedent that will undermine the future of vaccine development and the preeminence of American research.”
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Soragni:Lab @alice.soragnilab.com · 13/02/2026
This city has a way
sunset in LA: blue, red, pink, yellow gradient sky on a dark city scape
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Soragni:Lab @alice.soragnilab.com · 12/02/2026
With so much going on, in life and country, I have not been here as much as I used to. Posting about this big career change and reading the reactions, comments, and jokes, made me feel right back at home. Y'all know me too well. This space, like Twitter in the before time, is something else
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Soragni:Lab @alice.soragnilab.com · 12/02/2026
Really nice article describing the molecular mimicry behind VITT in a very accessible manner. Original paper here: www.nejm.org/doi/full/10.... We all learned something, in this process.
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Soragni:Lab @alice.soragnilab.com · 10/02/2026
Happy to share this new, very intentional chapter. I have left UCLA after 14 years to join the University of Colorado Anschutz as Professor of Biomedical Informatics and Neurosurgery and the inaugural Marsico Chair in Excellence in Functional Precision Medicine/n news.cuanschutz.edu/dbmi/cu-ansc...
news.cuanschutz.edu
CU Anschutz Recruits National Leader to Launch Functional Personalized Medicine Initiative
CU Anschutz welcomes Alice Soragni to launch a Functional Personalized Medicine Initiative using rapid tumor organoid testing to guide treatment decisions.
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Soragni:Lab @alice.soragnilab.com · 30/01/2026
Last day at UCLA, fourteen years in the making. Very excited for what is ahead. Huge kudos to my team and our fantastic collaborators, they keep me going.
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Zen Faulkes @doctorzen.net · 10/01/2026
I have a 166,000 word, ~700 page document of how NOT OK scientists have been in the last year.
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Soragni:Lab @alice.soragnilab.com · 10/01/2026
I will never stop advocating for an edit button
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Soragni:Lab @alice.soragnilab.com · 10/01/2026
Making a faculty transition painful is one thing. Making it painful for trainees and lab staff is something else entirely. It is failure. It is not procedural. It is not an accident. It's a choice. You all can do better.
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Soragni:Lab @alice.soragnilab.com · 05/01/2026
Schools are back, and so am I. Happy new year everyone May this year be.. different
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Soragni:Lab @alice.soragnilab.com · 13/12/2025
Long time off this platform.. excited to be back to share that I have been elected President of the @thesfpm.bsky.social alongside @boehmjesse.bsky.social. This community has been a true home for those of us for whom patient-derived models and functional testing belong at the center of cancer care/n
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Richard Sever @richardsever.bsky.social · 06/11/2025
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n openrxiv.org/enabling-rev...
openrxiv.org
Enabling options for review: from training and transparency to author-centered AI tools - openRxiv
Peer review is widely viewed as a critical aspect of biomedical communication. Ideally, it provides authors with feedback so they can improve manuscripts and gives readers, particularly nonspecialists...
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Danielle L. Schmitt 🔬 @schmittwitt.bsky.social · 07/11/2025
I was a UC PPFP fellow when I was a postdoc at UCSD. This program is invaluable--aside from support for two years of my postdoc, I received excellent mentoring from faculty at the UCs. This fellowship set me up for success and gave me a cohort of fellow postdocs who are now UC faculty. 1/2
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Soragni:Lab @alice.soragnilab.com · 05/11/2025
What news, wow. Gone as it came, despite an (alleged?) decade of funds at hand. I guess there is still a great deal of work to do to find viable alternative paths to academia www.statnews.com/2025/11/04/a...
statnews.com
Arena BioWorks, an ambitious biomedical institute backed by billionaires, abruptly shuts down
Exclusive: Arena Bioworks, the buzzy research institute that launched with $500 million to support a decade of scientific R&D, is abruptly shutting down, STAT has learned.
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Soragni:Lab @alice.soragnilab.com · 05/11/2025
A good evening all around, finally 💪
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Jeremy Berg @jeremymberg.bsky.social · 03/11/2025
Multi-Year funding analysis, a 🧵 I have been trying to find a robust way of quantifying and understanding multi-year (forward funding). First, some background: Most NIH grants are for multiple years (2 to 5, typically). However, the are usually funded on an annual basis. 1/18
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Soragni:Lab @alice.soragnilab.com · 31/10/2025
Contributed to this piece in Cancer Discovery on the new NIH organoid effort. Amid all uncertainty, good to see real commitment to human models and standards. Organoids are central to how we study disease and test therapies- it is about time the system reflects it 🔗 aacrjournals.org/cdnews/news/...
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Edward Nirenberg @enirenberg.bsky.social · 25/10/2025
Okay so as promised... let's go through this paper and why it matters 🧵 #medsky #immunosky #idsky
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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 23/10/2025
@joann-trejo.bsky.social, @marymunson4.bsky.social and I have a commentary in @natcellbio.nature.com on recent attacks on DEI in biomedical research: "If scientific research, especially biomedical research, is meant to serve everyone, then it requires that everyone has an opportunity to participate"
nature.com
Scaling back DEI programmes and the loss of scientific talent
Nature Cell Biology - Programmes that support diversity, equity and inclusion (DEI) in science are under attack in the USA. Data indicate that diversity in the scientific workforce increases...
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Soragni:Lab @alice.soragnilab.com · 29/09/2025
What incredible news today. I feel so grateful to have worked closely with Tony over the years and to have witnessed firsthand his vision, energy, and commitment to advancing functional precision medicine. I cannot think of a steadier (and more needed) force at the NCI at this time /n
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Tomer Ullman @tomerullman.bsky.social · 24/09/2025
Dear Editor, Thank you for submitting your review request to Tomer Ullman. As you may know, we decline a substantial proportion of reviews requests without sending them out for further evaluation. After careful consideration, we regret to say we cannot offer to take on this review.
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Caitlin Vander Weele, PhD @caitvw.bsky.social · 16/09/2025
I was going to write a whole post about all this incredible work with all these amazing scientists and organizations, but I’ll just leave @stellatecomms.bsky.social design sizzle reel here. It speaks for itself. youtu.be/x2O7DkpIoCA?...
youtu.be
Stellate Communications Reel
YouTube video by Stellate Communications
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Soragni:Lab @alice.soragnilab.com · 09/09/2025
Not sure what the best way forward is. The general confusion, lack of funding, and the slow destruction of the NIH feels hopeless, if you let it. For now I'll keep circling back to science, and know very well I am privileged to be able to do so. We all got to cope somehow, it's such a long way to go
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Soragni:Lab @alice.soragnilab.com · 04/09/2025
Glad to share this podcast, it was a fun one to record! Quite the ride of a conversation too… from my beginnings in protein aggregation, to patient-derived organoids for rare cancers, with detours through twitter and the shifting world of science comms stemcellpodcast.com/ep-303-organ...
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