Candida endophthalmitis and chorioretinitis are uncommon but potentially devastating complications of candidemia, associated with significant risks of vision loss and long-term morbidity. Effective ma...

Ilan S Schwartz, Alessandro C Pasqualotto; Histoplasma antigen screening in advanced HIV disease, Clinical Infectious Diseases, , ciaf238, https://doi.org/

A prospective observational study of human immune responses to vaccination after early-life antibiotic exposure shows that neonatal exposure reduces the immune response to several vaccine antigens and...

Liver X receptor drives epithelial Areg-mediated intestinal regeneration, while preventing tumour growth through adaptive immune responses.

Two finger-stick blood tests to triage people with symptoms of pulmonary tuberculosis by measuring 3 host proteins (multibiomarker test) or 3 host RNA tran

Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain. In a multicenter, non...

In this manuscript for the “Highlights of 2024” series, this is me trying to summarize recent discoveries regarding the emerging regulatory and effector roles of γδ T cells during sepsis, both in hum....

Targeted protein degradation has so far been rarely applied as an antiviral strategy. Here, the authors report that macrocycle-based PROTACs targeting host protein cyclophilin A, exploited during vira...

The UK launches mSCAPE, a world-first metagenomics initiative by UKHSA to enhance health security through rapid pathogen detection and surveillance.

AbstractBackground. The impact of antimicrobial resistance (AMR) on death at the patient level is challenging to estimate. We aimed to characterize AMR-att

Nature Immunology - In this Review, Herro and Grimes summarize the most recent key findings surrounding protective versus pathogenic functions of neutrophils, elaborating on phenotype-specific...

Up to one-third of women receive antibiotics during pregnancy. Pietrasanta et al. show that antibiotic treatment of pregnant mice reduces the amount of breast milk antibodies (SIgA) and alters the neo...

Collaborations between ophthalmologists and infectious disease specialists are critical for optimizing care of many patients with eye infections. We review

Our findings propose a causal relationship between reduced IL-6 signalling and lower risk of tuberculosis, akin to the effect seen in other IL-6 mediated diseases. This study suggests that IL-6 antago...

eaks of Fusarium solani meningitis during 2022–2023 were associated with epidural anesthesia in two distant cities in Mexico (Durango and Matamoros). The initial etiological agent identification was d...

Objective.  —To establish (1) the prevalence of positive penicillin skin tests among outpatients with well-defined but variable history of penicillin allergy and (2) the reproducibility, safety, a...

Steroid hormone levels vary greatly among individuals, between the sexes, with age, and across health and disease states. Nevertheless, what drives variance in steroid hormones and, globally, how ster...

Vulvovaginal candidiasis is the most common fungal disease in humans. MacAlpine and Lionakis synthesize the host, microbiome, and fungal factors that alter susceptibility to acute and recurrent vagina...

Urinary tract infections (UTIs) have a significant impact on quality of life for patients and present complex management issues that challenge healthcare systems. Recognizing these challenges, dedicat...

Before a new test can be routinely used in your laboratory, its reliability must be established in the laboratory where it will be used. International…

Difficulties can be encountered when translating research between cells from animals and humans because of gene expression differences. Here the authors perform an integrative transcriptomic analysis ...