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Lee Grimes Lab

@leegrimeslab.bsky.social
724 followers 597 following 38 posts

🏳️‍🌈Molecular Oncology 🧬Hematology 🩸and Immunology at Cincinnati Children's Hospital. interested in understanding how ancestry affects cancer genetics and clinical outcomes. www.cincinnatichildrens.org/researc…

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Lee Grimes Lab @leegrimeslab.bsky.social · 24/04/2026
MYELOID2026 agenda and menus are up. www.myeloidmeeting.org
myeloidmeeting.org
HOME - FIFTEENTH INTERNATIONAL WORKSHOP ON MOLECULAR ASPECTS OF MYELOID STEM CELL DEVELOPMENT AND LEUKEMIA.
The Myeloid Meeting is a premier conference in Cincinnati, Ohio, advancing research, treatment, and collaboration in myeloid malignancies, including CH, MDS, and AML
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Lee Grimes Lab @leegrimeslab.bsky.social · 03/02/2026
Is your funding for hematology research "Between a rock and a hard place" #fightforhematology funds from ASH members and fans now provide a new program: A R C H hematology.org/awards/caree... NOTE: Are you doing well? .....your donations go 100% to lab support in the ARCH program.
hematology.org
Key Information - Hematology.org
Key Information
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Lee Grimes Lab @leegrimeslab.bsky.social · 06/12/2025
Me and Disney hematologists
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Lee Grimes Lab @leegrimeslab.bsky.social · 25/11/2025
Registration is now live for MYELOID2026. Please re-post. www.myeloidmeeting.org
myeloidmeeting.org
FIFTEENTH INTERNATIONAL WORKSHOP ON MOLECULAR ASPECTS OF MYELOID STEM CELL DEVELOPMENT AND LEUKEMIA
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Lee Grimes Lab @leegrimeslab.bsky.social · 22/10/2025
Postdoc Kyle Ferchen figured out how to integrate CITE-seq, TEA-seq and InfinityFlow to link cell surface markers, gene expression, and chromatin accessibility to underlying gene regulatory networks (GRNs). Clusters, gene expression and GRN edges are searchable here: altanalyze.org/MarrowAtlas/...
altanalyze.org
Bone Marrow Single-Cell Atlas Portal
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Lee Grimes Lab @leegrimeslab.bsky.social · 22/10/2025
New “discrete state” model of hematopoiesis published in Nature Immunology. rdcu.be/eL8oO We propose a hierarchical model of hematopoiesis where stable “discrete states” serve as key regulatory nodes.
rdcu.be
A unified multimodal single-cell framework reveals a discrete state model of hematopoiesis in mice
Nature Immunology - Grimes and colleagues integrate multiomic features to create a framework that allows the isolation of discrete cell states across hematopoiesis and exploit the underlying gene...
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American Society of Hematology @ash.hematology.org · 19/08/2025
With potential NIH budget cuts and funding freezes putting vital work at risk, the ASH Bridge Grant is helping researchers, and their discoveries stay on track to improve patient care. #Fight4Hematology
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American Society of Hematology @ash.hematology.org · 19/08/2025
This year the ASH Bridge Grant is funding 25 scientists with $3.75M, 5X more than last year, to keep hematology research moving forward. Congratulations to the recipients! bit.ly/3HJ51Ma #HemeSky #MedSKy #ASHAwards
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Lee Grimes Lab @leegrimeslab.bsky.social · 16/07/2025
ASH Seeks Fundamental Discovery Science Abstracts for #ASH25 IF the quality is there, the fundamental basic science poster and presentations will E X P A N D at ASH25. Its an experiment! Submit your cool basic science before August 5, 2025, at 11:59 p.m.
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Lee Grimes Lab @leegrimeslab.bsky.social · 10/06/2025
ASH is committing more than $12 million to address research funding challenges and support the next generation of hematologists. Learn more: ow.ly/sK3050W735W
ow.ly
ASH Commits More than $12 Million to Address Research Threats - Hematology.org
ASH Commits More than $12 Million to Address Research Threats
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Lee Grimes Lab @leegrimeslab.bsky.social · 10/06/2025
ASH has made an unprecedented investment of more than $12 million. Including ~$9 million increase in award funding. Total awards commitment of more than $20 million over the next 12 months....providing support for an additional 600+ awardees at all career stages. @ash.hematology.org
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Lee Grimes Lab @leegrimeslab.bsky.social · 10/06/2025
ASH Bridge Award direct cost floor was already raised to $500K/yr. Now the number of applications funded is dramatically increasing, with a rapid turn around...and a brand new additional cycle this year. @ash.hematology.org
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Lee Grimes Lab @leegrimeslab.bsky.social · 10/06/2025
Are you concerned about how to get your trainees to ASH2025 in Orlando? Massive increase in trainee travel awards for those giving poster or oral presentations. Submit those abstracts and find out! @ash.hematology.org
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Lee Grimes Lab @leegrimeslab.bsky.social · 10/06/2025
Coming soon.....news about increasing fundamental basic science representation at ASH...we are running an experiment!....hope you will participate in ASH2025. @ash.hematology.org
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Lee Grimes Lab @leegrimeslab.bsky.social · 07/06/2025
Feeling like the worst “Rainy Day” has hit your hematology lab? ASH is deploying some significant umbrellas. More details soon! Watch @ash.hematology.org
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Lee Grimes Lab @leegrimeslab.bsky.social · 09/05/2025
If you are invited to review abstracts for ASH2026 in a basic science category, please know that I reviewed these sections and pushed for you to do this work. PLEASE HELP ME OUT. We want to increase the quality and representation of basic science at ASH.
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Nathan Salomonis @nathansalomonis.bsky.social · 08/05/2025
New in STM, check out our integrative bulk & single-cell long-read analysis to discover and test new therapies in leukemia. We developed OncoSplice, to define new splicing defined subtypes and predict regulators. PRMT5 inhibition partially rescued mis-splicing & inhibited leukemic growth. More soon!
science.org
Splicing regulatory dynamics for precision analysis and treatment of heterogeneous leukemias
Broad dysregulated splicing in AML partially phenocopies splicing factor mutations, is prognostic, and can be pharmacologically reversed.
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Reposted by Lee Grimes Lab
Tim Stearns @stearnslab.bsky.social · 04/03/2025
The first NIH posting to the Federal Register since the inauguration appeared today. It lists several study section meetings. Great news! www.federalregister.gov/documents/20...
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Doctor Dom, D.O., M.S. 🍉✊🏾🌹 @doctor-dom.medsky.social · 20/02/2025
"A freeze on meetings of expert panels that peer review grant proposals at the NIH is kicking in this week ... Trump barred NIH from posting new Federal Register notices, which means any study section not advertised before then cannot take place." #medsky 🧪 www.science.org/content/arti...
science.org
Trump Tracker: Firings, lawsuits, and U.S. science in chaos
Follow President Donald Trump’s impact on U.S. research and science globally
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Lee Grimes Lab @leegrimeslab.bsky.social · 21/01/2025
Here is the FedEx package Linda Wolfe sent me in 2010 which included all the financials for MYELOID when it was the “Annapolis meeting” Oh my! It’s a lot more expensive these days!
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Lee Grimes Lab @leegrimeslab.bsky.social · 21/01/2025
The 15th International Workshop on Molecular Aspects of Myeloid Stem Cell Development, will be held at the Jarson-Kaplan Theater of the Aronoff Center for the Arts in Cincinnati, Ohio on May 18-21, 2026. Please hold these dates on your calendar.
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Lee Grimes Lab @leegrimeslab.bsky.social · 02/01/2025
Rebecca Black (ask your kids) came to Seacrest Studio and Grimes Lab peeps Connor and Sierra got to say hello!
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Lee Grimes Lab @leegrimeslab.bsky.social · 18/12/2024
Holiday (science) Spirit here at CCHMC in the Hildeman Lab
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Lee Grimes Lab @leegrimeslab.bsky.social · 09/12/2024
#ASH peeps at the Bollywood themed Presidential reception. #ASH24 #HemeSky
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Bailee Kain @bailee-kain.bsky.social · 06/12/2024
Is the survival disparity observed in Black AML patients linked to underlying differences in disease biology? Come learn about PHIP, a previously overlooked oncogene found in Black patients, at my talk tomorrow (12/7) at 4:30🩸 #ASH24 #AML #healthequity @leegrimeslab.bsky.social
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Lee Grimes Lab @leegrimeslab.bsky.social · 06/12/2024
Postdocs with talks get cake!! #ASH24 #HemeSky OK. They might get cake anyway, but they do have talks in 618 Saturday and Sunday!
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Lee Grimes Lab @leegrimeslab.bsky.social · 06/12/2024
#ASH24 #HemeSky Celebrating the excellent leadership of Mohan Narla as this year’s President of ASH.
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Lee Grimes Lab @leegrimeslab.bsky.social · 06/12/2024
Welcome to #ASH2024 as the morning fig burns off and the meetings begin! #HemeSky
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American Society of Hematology @ash.hematology.org · 21/11/2024
Hello, #hematology community! ASH is now on BlueSky. We're here to share cutting-edge research and educational resources and connect global experts in blood diseases. Join us in advancing hematology together. Welcome, colleagues! #BloodSky #HemeSky #MedSky
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Lee Grimes Lab @leegrimeslab.bsky.social · 20/11/2024
CHMC Division of Immunobiology is hiring Assistant Professors. You can have a lab next to mine if you like.
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Lee Grimes Lab @leegrimeslab.bsky.social · 20/11/2024
Are neutrophils "good" or "bad"? Rana Herro reviews the current literature here: rdcu.be/d0Rt7
rdcu.be
The diverse roles of neutrophils from protection to pathogenesis
Nature Immunology - In this Review, Herro and Grimes summarize the most recent key findings surrounding protective versus pathogenic functions of neutrophils, elaborating on phenotype-specific...
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Lee Grimes Lab @leegrimeslab.bsky.social · 20/11/2024
Hello Postdocs who are coming to ASH 2024 in San Diego! Please join us for ASH-a-Palooza on Friday at the corner of 5th and K Streets. You will need your trainee (blue) badge to get in. @ash-hematology.bsky.social
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Lee Grimes Lab @leegrimeslab.bsky.social · 20/11/2024
Hello PhD-candidate hematology trainees who are coming to ASH 2024 in San Diego! Please join us for ASH-a-Palooza on Friday at the corner of 5th and K Streets. You will need your trainee (blue) badge to get in. @ash-hematology.bsky.social
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Lee Grimes Lab @leegrimeslab.bsky.social · 19/11/2024
If you are interested in studying AML then please consider this faculty opportunity here at CCHMC. jobs.sciencecareers.org/job/666655/a...
jobs.sciencecareers.org
Assistant, Associate, Full Professor Faculty positions Advanced Leukemia Therapies & Research Center - Cincinnati, Ohio job with Cincinnati Children's Hospital Medical | 666655
Cincinnati Children’s Hospital invites applications for tenure-track faculty positions at the Assistant, Associate, or Full Professor level.
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Lee Grimes Lab @leegrimeslab.bsky.social · 17/11/2024
First manuscript from Linde Miles Lab at CCHMC looking at clonal evolution in NPM1-mut AML at single cell resolution. Check out the pre-print here: www.biorxiv.org/content/10.1...
biorxiv.org
Genotype-immunophenotype relationships in NPM1-mutant AML clonal evolution uncovered by single cell multiomic analysis
Acute myeloid leukemia (AML) is a multi-clonal disease, existing as a milieu of clones with unique but related genotypes as initiating clones acquire subsequent mutations. However, bulk sequencing can...
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Lee Grimes Lab @leegrimeslab.bsky.social · 17/11/2024
Previous studies have shown self-reported Black patients have inferior treatment and survival outcomes compared to White patients, but why? Our work indicating that underlying genetics influence AML biology is now live at Nature Genetics. www.nature.com/articles/s41...
nature.com
Multiomic profiling identifies predictors of survival in African American patients with acute myeloid leukemia - Nature Genetics
Analysis of exomes and transcriptomes from 100 African American patients with acute myeloid leukemia identifies ancestry-related variation in mutation profiles and survival. Refined risk classificatio...
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