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Lydia Newton

@lsnewton.bsky.social
72 followers 78 following 3 posts

Postdoc in the Sheppard Lab at Imperial 🦠

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Reposted by Lydia Newton
Towers Lab @towerslab.bsky.social · 29/09/2025
New preprint from our lab, led by our postdocs Dara Annett and Kate Morling in collaboration with Selwood Lab! We developed a modified cyclosporine, BG147, which enhances lentivector gene therapy transduction, ex vivo in HSPC and in vivo in mouse photoreceptors, by degrading IFITM3. Check it out!
biorxiv.org
A modified cyclosporine enhances lentivector transduction ex vivo and in vivo by degrading IFITM3
Intrinsic innate immune barriers have evolved to suppress viral infection and can reduce effective gene delivery in gene therapy. We have developed BG147, a novel cyclosporine A analogue, optimised vi...
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Reposted by Lydia Newton
Towers Lab @towerslab.bsky.social · 10/07/2025
We are delighted to be joining the Blizard Institute in Autumn. The Blizard Institute is an amazing place for discovery science and we're looking forward to more transformative research and collaborations. www.qmul.ac.uk/blizard/abou...
qmul.ac.uk
Blizard Institute welcomes world-leading team of virologists
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Reposted by Lydia Newton
Mohamed Elghazaly @melghazaly.bsky.social · 09/06/2025
Towers Lab attending @londoninfectionecr.bsky.social (LINE) annual symposium. Great talk lineups at the Francis Crick Institute, London. #LINE #ScienceIsCool.
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Reposted by Lydia Newton
RM @rsbmilne.bsky.social · 08/05/2025
Virtual Virology is back - our first ever phage session. Do join us...
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Reposted by Lydia Newton
Towers Lab @towerslab.bsky.social · 05/03/2025
Great seeing our recent antiviral PROTAC paper chosen by Nature Comms Editors as one of the 50 best papers in Microbiology and Infectious Diseases! www.nature.com/collections/...
nature.com
Microbiology and infectious diseases
This page highlights recent articles on all aspects of bacteriology, mycology, parasitology and virology, covering the biology of pathogens, host-pathogen ...
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Reposted by Lydia Newton
Nature Communications @natcomms.nature.com · 28/02/2025
Antiviral drug development: Small molecules inducing degradation of host protein cyclophilin A show #antiviral activity against HIV-1 & HCV @towerslab.bsky.social ‬ @lsnewton.bsky.social @claragathmann.bsky.social @jollylab.bsky.social @alessiociulli.bsky.social www.nature.com/articles/s41...
nature.com
Macrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV - Nature Communications
Targeted protein degradation has so far been rarely applied as an antiviral strategy. Here, the authors report that macrocycle-based PROTACs targeting host protein cyclophilin A, exploited during vira...
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Lydia Newton @lsnewton.bsky.social · 14/02/2025
My PhD work is now published! We designed PROTACs that degrade the viral cofactor CypA and demonstrated their antiviral activity against HIV & HCV. We anticipate broad efficacy against unrelated viruses and reduced evolution of viral resistance. They also make excellent tools to probe Cyp biology.
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Reposted by Lydia Newton
Gabi Heller @g-heller.bsky.social · 11/02/2025
Today @gogs-k.bsky.social, @tlhr.bsky.social, and I are launching @bindresearch.org, a UK-based not-for-profit research startup to deliver publicly–available tools and datasets to make intrinsically disordered proteins druggable. 🍝 💊🧲 💻 🦠
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