Sign in

Tim Triche, Jr.🔰

@timtriche.bsky.social
5.9K followers 1.7K following 7.2K posts

Executive panhandler, trichelab.vai.org Posts may contain trace quantities of blood🩸, chromatin 🧬 & stats 🧮 scholar.google.com/citations?user=A… Views expressed are my own (but for the right price they can be yours!)

PostsRepliesMedia
Reposted by Tim Triche, Jr.🔰
Claudio Cantù @claudiocantu81.bsky.social · 6h
CUT&ID does Genomics+Proteomics in one shot via the fusion protein Lazarus Out @narjournal.bsky.social Unstoppable @annanordin.bsky.social is thinker+executor Get in touch if you wish to try it—plasmid soon @addgene.bsky.social 🙏 @liu.se @scilifelab.se @kawresearch.bsky.social @cancerfonden
187
Reposted by Tim Triche, Jr.🔰
Addgene @addgene.bsky.social · 01/09/2026
Nick! Shred! Cut! Read about the latest prime editors from David Liu Broad Institute, RNA-targeted cell killing with Cas12a2 from Yang Liu @utah.edu & Doudna Lab, CoCUT&Tag chromatin mapping from Derek Janssens @vai.org, and more in our latest Hot Plasmids:
twp.ai
blog.addgene.org
Hot Plasmids: September 2026
043
Reposted by Tim Triche, Jr.🔰
Jenna Norton @jenna-m-norton.bsky.social · 26/08/2026
Insights from inside NIH on the proposal to hide scores and instead bin applications into broad score categories. Please read and comment on the RFI. 27unihted.substack.com/p/nih-wants-... Link to RFI: rfi.grants.nih.gov?s=6a2b1c22c3...
27unihted.substack.com
NIH wants to shroud peer review scores. Here’s what you can do about it.
Authored by anonymous current and former NIH workers with experience in peer review
12627
Reposted by Tim Triche, Jr.🔰
Ted Pavlic (he/him/his) @tedpavlic.bsky.social · 24/08/2026
If you teach power analysis to undergrads or your grad students need a review, this widget may help. Includes a description and visualizations of power analyses for multiple tests, high-resolution OC charts, and sample code for #MATLAB, #Rstats, and #Python. #stats tpavlic.github.io/asu-simulati...
tpavlic.github.io
Power Explorer—statistical power by simulation and by formula
Statistical power made manipulable: watch the null and alternative sampling distributions separate as the sample size grows, estimate power by Monte Carlo simulation and check it against the exact ans...
1449
Reposted by Tim Triche, Jr.🔰
Bioconductor @bioconductor.bsky.social · 17/08/2026
📢Bioconductor will hold a hands-on Orchestrating Microbiome Analysis with Bioconductor workshop in Addis Ababa this September. 📅 21–25 September 2026 📍 BETin, Addis Ababa, Ethiopia Register to attend: bit.ly/4xvDUsf Learn more about this workshop: bit.ly/4xB6GYC
Workshop poster for "Orchestrating Microbiome Analysis with Bioconductor" — a week-long, free R-focused training in Addis Ababa (BETin) 21–25 Sep 2026, 9:00 AM–4:30 PM, with QR code to register and partner logos at the bottom.
145
Reposted by Tim Triche, Jr.🔰
vincentholst.bsky.social @vincentholst.bsky.social · 13/08/2026
In 2023, @nature.com published 'Papers and patents are becoming less disruptive over time', receiving world-wide media attention. Our Matters Arising, published after a 32 month delay (more on that soon), shows that the reported decline can largely be attributed to dataset artefacts. 🧵
The average CD_5 index per year for Web of Science. The original Park et al. decline (top curve) becomes essentially flat (bottom curve) when removing papers with CD_5=1. Those papers largely correspond to dataset artefacts.
9351173
Reposted by Tim Triche, Jr.🔰
Adam Phillippy @aphillippy.bsky.social · 06/08/2026
🎯 Goodhart’s law: if you make a list of variants the target, people will get really good at calling those variants. But those variants are not a genome! As a result, we’ve been stuck trying to read genomes under the lamppost of short reads [4/15]
1357
Reposted by Tim Triche, Jr.🔰
American Society of Hematology @ash.hematology.org · 21/02/2026
While adult AML treatment options continue to expand, access to novel therapies for children is frustratingly slow. A new article in The Hematologist examines the clinical trial and regulatory barriers shaping pediatric AML drug development. ashpublications.org/... #HemeSky#MedSky
0101
Tim Triche, Jr.🔰 @timtriche.bsky.social · 05/08/2026
@slotkin.senate.gov Heyo, now would be a good time to reiterate that beating Florida Mike (again) has to be a top priority for Michigan democrats
021
Reposted by Tim Triche, Jr.🔰
Thomas Lumley @tslumley.bsky.social · 30/07/2026
Watch @nrennie.bsky.social's Ihaka Lecture about data viz and creativity on YouTube if you missed the live/streamed version tonight youtube.com/live/fAiyiE8...
youtube.com
Ihaka Lecture Series 2026 #2 - When Creativity Meets Code
YouTube video by University of Auckland | Waipapa Taumata Rau
03110
Reposted by Tim Triche, Jr.🔰
Max Blau @maxblau.bsky.social · 23/07/2026
So if you’re not an investigative reporter, how can you know if the people picking your fruit are being mistreated? I spoke with experts who said the gold standard for preventing worker abuse is the Fair Food Program: www.propublica.org/article/h-2a...
propublica.org
Employers Have Exploited and Abused H-2A Farmworkers for Years. It Doesn’t Have to Be That Way.
The seasonal visa program has failed to protect migrant farmworkers from wage theft, forced labor, violence and death. Experts, lawyers and advocates say there are ways to reduce and even stop the har...
118463
Reposted by Tim Triche, Jr.🔰
Mara Averick @dataandme.bsky.social · 23/07/2026
Not every open-source project wants more contributors right now, and that's fine. Four shapes maintainers run — walled castle, clique, university, hippie commune — and your `CONTRIBUTING.md` is saying the quiet part out loud. No wrong answer, just an honest one. blog.stdlib.io/do-you-want-...
blog.stdlib.io
Do you WANT contributors?
Four ways to run an open-source project—castle, clique, university, commune—and which one you're really running.
36617
Reposted by Tim Triche, Jr.🔰
Costa Samaras @costasamaras.com · 19/07/2026
Could Excel be conscious? We surveyed more than Jan 1 1900 people to find out.
114137722879
Tim Triche, Jr.🔰 @timtriche.bsky.social · 19/07/2026
My proposed minister for AI
static.klipy.com
Cat and Dog: Fighting In Style
Alt: Roomba cat
081
Reposted by Tim Triche, Jr.🔰
Richard Sever @richardsever.bsky.social · 06/07/2026
“move from preprint to peer-reviewed publication leaves the central claims of most abstracts intact, indicating preprints are a reliable source…papers that were never posted as preprints were retracted at roughly twice the rate of those that were…” www.biorxiv.org/content/10.6...
biorxiv.org
Tracking claim changes from preprint to publication across 72,644 biomedical studies using large language models
Preprints now disseminate a large share of biomedical research before peer review. Because they have not yet passed peer review, some scientists regard preprint claims as unverified or potentially unr...
611158
Reposted by Tim Triche, Jr.🔰
Adam Bonica @adambonica.bsky.social · 03/07/2026
Earlier this year, I made the grounded case for why we should still believe in the promise of America. Today’s America is something we inherited. But tomorrow’s is still for us to make. America’s problems are solved problems. The blueprints exist. Better days are ahead.
open.substack.com
The Wall Looks Permanent Until It Falls
On the optimism of preparation in a time of democratic decay.
58227
Reposted by Tim Triche, Jr.🔰
Derek Lowe @dereklowe.bsky.social · 29/06/2026
One prominent group has been totally silent about the Trump administration’s latest attempt to grab control of all federal science funding. That’s the biopharma companies, and their suddenly shy, quiet CEOs. Here’s the calculation they’re making:
science.org
Speaking Up: Who Is, and Who Isn't
45424
Reposted by Tim Triche, Jr.🔰
Lior Pachter @lpachter.bsky.social · 26/06/2026
Can you share the code used to generate the scores?
0124
Tim Triche, Jr.🔰 @timtriche.bsky.social · 20/06/2026
This is a softball #3PerfectSongs (In no particular order because they’re all perfect) 1. Stevie Wonder, “Higher Ground” 2. Lera Lynn, “Wolf Like Me” (featuring Shovels & Rope) 3. Etta James, “At Last”
010
Tim Triche, Jr.🔰 @timtriche.bsky.social · 15/05/2026
@anshulkundaje.bsky.social are you planning to release weights for the model? I quite appreciated the inclusion of both correct and incorrect reasoning traces in the comparisons here.
100
Tim Triche, Jr.🔰 @timtriche.bsky.social · 26/04/2026
Lookit, IKYK. Best Carpenter movie evar
media.tenor.com
a billboard for fox & friends shows a woman and two men
Alt: I have come here to chew bubblegum and kick ass. AND I”M ALL OUT OF ASS!!1
050
Tim Triche, Jr.🔰 @timtriche.bsky.social · 25/04/2026
Hmm, is there a way to soft-release a print of a paper for public review, Jay? Like an economics working paper. Some sort of a pre-print mechanism, if you will. 🤔 PubMed could index these, with a clear “NOT PEER REVIEWED” indication. What do you think @richardsever.bsky.social ? Madness, I guess
262
Reposted by Tim Triche, Jr.🔰
Eduardo Amorim @cegamorim.bsky.social · 22/04/2026
The largest and most diverse collection of Indigenous American genomes 👉🏻 “The evolutionary history and unique genetic diversity of Indigenous Americans” @macscastro.bsky.social @hunemeier.bsky.social @chiarabarbieri.bsky.social @jrockdrigo.bsky.social 🔗 www.nature.com/articles/s41...
25628
Reposted by Tim Triche, Jr.🔰
Kris Willis @kawillis.bsky.social · 07/04/2026
I’ve had a lot of people ask me about what I hope to accomplish with @wp-institute.bsky.social and the truth is, it’s this. I’ve come to the conclusion that the only way for American science to survive is for us to burn a way through. open.substack.com/pub/eatingpo...
open.substack.com
Trial by Fire: Crisis Engineering
A new book shows how to turn a crisis into the change you've been waiting for
121
Reposted by Tim Triche, Jr.🔰
Quanta Magazine @quantamagazine.org · 19/03/2026
The central limit theorem is a mathematical truth so powerful that it often strikes newcomers as impossible, like a magic trick of nature. Through it, the most random chaos can lead to striking predictability.
quantamagazine.org
The Math That Explains Why Bell Curves Are Everywhere | Quanta Magazine
The central limit theorem started as a bar trick for 18th-century gamblers. Now scientists rely on it every day.
03416
Tim Triche, Jr.🔰 @timtriche.bsky.social · 08/02/2026
Without naming your job, tell me something you say over and over again at work. “Immunity is complicated, you heard it here first” (Alternatively, “finished is better than perfect”)
050
Reposted by Tim Triche, Jr.🔰
Joy Franco, PhD @engineeringjoy.bsky.social · 21/01/2026
Your written protocols and lab notebooks are a love letter to your future self (whether it’s you or a future lab member). Please be kind. Here are some critical things I have frequently noticed missing: (feel free to add yours in thread 🧵)
2199
Reposted by Tim Triche, Jr.🔰
Heng Li @lh3lh3.bsky.social · 14/01/2026
I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated!
hlilab.github.io
HLi Lab - Vacancies
Openings
14363
Reposted by Tim Triche, Jr.🔰
ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · 16/01/2026
Ok, I got my own answer, use html coding to get formatting into your personal statement part: www.markdownguide.org/basic-syntax/
markdownguide.org
Basic Syntax | Markdown Guide
The Markdown elements outlined in the original design document.
142
Tim Triche, Jr.🔰 @timtriche.bsky.social · 01/01/2026
Brianna Bribel's biology videos are amazing, you should follow her @bumblingbiochemist.bsky.social in 2026.
1102
Tim Triche, Jr.🔰 @timtriche.bsky.social · 01/01/2026
Works for me. I’ll make this my major objective in 2026
Compassionate
271
Tim Triche, Jr.🔰 @timtriche.bsky.social · 27/12/2025
The Uncanny Valley of biology: good for pulling in expensive program grants, largely useless for understanding life itself
1104
Reposted by Tim Triche, Jr.🔰
Heng Li @lh3lh3.bsky.social · 22/12/2025
Thanks to the AWS Open Data program, this dataset along some derived data is also openly accessible via @AWSCloud at openhgl.s3.us-east-1.amazonaws.com/index.html
openhgl.s3.us-east-1.amazonaws.com
S3 Bucket Browser
1226
Tim Triche, Jr.🔰 @timtriche.bsky.social · 06/12/2025
BCD, right on schedule. I don’t think we will regret sending our work to this fine journal. Great work @dblipka.bsky.social and @mphartmann.bsky.social … I didn’t have time to read the PDF but I’m assuming it evolved a bit during review? It was exciting even before😁
280
Reposted by Tim Triche, Jr.🔰
Heng Li @lh3lh3.bsky.social · 03/12/2025
579 high-quality human genomes from @humanpangenome.bsky.social, Arab Pangenome and individual papers (CHM13, CN1, KSA001, I002C, YAO and KOREF1). Sequences available in the AGC format (3.7GB) and FM-index in the ropebwt3 format (20.3GB). For details, see github.com/lh3/human-asm
github.com
GitHub - lh3/human-asm: A collection of high-quality human genomes
A collection of high-quality human genomes. Contribute to lh3/human-asm development by creating an account on GitHub.
15823
Reposted by Tim Triche, Jr.🔰
Tim Triche, Jr.🔰 @timtriche.bsky.social · 22/10/2025
Guaranteed funding for five years and a 20% increase in a $39K base stipend if you haul in a fellowship. World class facilities and faculty in metabolism, structural biology, epigenetics, and beyond. Grand Rapids is half the cost of living of California or Boston. Apply by December 1st if interested
12214
Reposted by Tim Triche, Jr.🔰
mr. TIM @timkellogg.me · 29/11/2025
the reason why he’s doing this
N8
N8 Programs @ @N8Programs • 17h i'd always recommend using at least two hidden layers so you get access to induction heads
1
O10.
Thi 711
Mariusz Kurman v @mkurman88
贝
企
X.com
Think about it differently. If we can train a single-layer model with somewhat promising results, it indicates we're doing something fundamentally wrong with the current SOTAs
1192
Tim Triche, Jr.🔰 @timtriche.bsky.social · 22/10/2025
Guaranteed funding for five years and a 20% increase in a $39K base stipend if you haul in a fellowship. World class facilities and faculty in metabolism, structural biology, epigenetics, and beyond. Grand Rapids is half the cost of living of California or Boston. Apply by December 1st if interested
12214
Reposted by Tim Triche, Jr.🔰
Xian Chang @xian-chang.bsky.social · 02/10/2025
🦒Long read giraffe is out!🦒 Mapping long reads to pangenome graphs is ~10x faster than with GraphAligner, with veeery slightly better mapping accuracy, short variant calling, and SV genotyping than GraphAligner or Minimap2
14222
Reposted by Tim Triche, Jr.🔰
The Society for Functional Precision Medicine @thesfpm.bsky.social · 29/09/2025
We want to congratulate our President, Dr. Tony Letai, on his appointment as Director of the NCI. This announcement marks an historic moment for cancer research. Dr. Letai has been a tireless advocate and visionary leader for functional precision medicine 🧵 www.nih.gov/news-events/...
nih.gov
Secretary Kennedy Swears in Dr. Anthony Letai as Director of the National Cancer Institute
Dr. Letai will serve as NCI’s 18th director.
1116
Tim Triche, Jr.🔰 @timtriche.bsky.social · 24/09/2025
Good news for @alice.soragnilab.com, SFPM, and rare disease models. Bad news for mouse cancer enthusiasts (humans are unreliable models of mouse disease).
192
Reposted by Tim Triche, Jr.🔰
mr. TIM @timkellogg.me · 13/09/2025
DARE logo with tagline, “to not write a paper titled as a question”
172
Reposted by Tim Triche, Jr.🔰
EMBL-EBI @ebi.embl.org · 08/09/2025
Mathematical models in biology are powerful, but often hard to run, visualise, or reuse without specialist skills. Menelmacar is a new platform that makes biological models interactive and easy to explore directly in the browser: biomodels.bacpop.org 🧬💻
24311
Tim Triche, Jr.🔰 @timtriche.bsky.social · 08/09/2025
Post a perfect album from the 90s that isn’t Nirvana, Pearl Jam, Soundgarden, or Alice In Chains
the downward spiral
580
Tim Triche, Jr.🔰 @timtriche.bsky.social · 15/08/2025
What gif pops up for your name?
media.tenor.com
a man with horns and a beard has the words there are some who call me
Alt: The enchanter
570
Reposted by Tim Triche, Jr.🔰
Constantin Ahlmann-Eltze @const-ae.bsky.social · 04/08/2025
Our paper benchmarking foundation models for perturbation effect prediction is finally published 🎉🥳🎉 www.nature.com/articles/s41... We show that none of the available* models outperform simple linear baselines. Since the original preprint, we added more methods, metrics, and prettier figures! 🧵
Beeswarm plot of the prediction error across different methods of double perturbations showing that all methods (scGPT, scFoundation, UCE, scBERT, Geneformer, GEARS, and CPA) perform worse than the additive baseline.Line plot of the true positive rate against the false discovery proportion showing that none of the methods is better at finding non additive interactions than simply predicting no change.
212557