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Pedro Vale

@pfvale.bsky.social
2.3K followers 1.3K following 176 posts

Ecology & Evolution of Infection Dynamics lab, Edinburgh, UK pedrovale.bio.ed.ac.uk

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Pedro Vale @pfvale.bsky.social · 12/05/2026
Evidence for balancing selection on loci associated with host use in the genome of a generalist plant parasite academic.oup.com/evlett/artic...
academic.oup.com
Evidence for balancing selection on loci associated with host use in the genome of a generalist plant parasite
Abstract. Most research on host–parasite interactions has focused on tightly coevolved species pairs, yet many parasites are generalists that infect a wide
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Pedro Vale @pfvale.bsky.social · 24/04/2026
We have some exciting new work pre-printed this week. Read on if you're interested in #behavioural responses to infection and some cool analysis of high-resolution behavioural time-series data in #Drosophila. www.biorxiv.org/content/10.6...
Experimental setup and locomotor activity across immune challenge treatments.
(A) Schematic representation of experimental setup. (B) Individual fly activity timeseries (faded
lines) and treatment mean (bold line) plotted as mean activity (number of beam breaks per
minute) over 400 hours post-infection for each treatment group (naive, injured, immune stimulated,
injured). Sample sizes per sex are annotated in each panel (F = females, M= males).
Treatment: naive (blue), injured (orange), immune stimulated (heat-killed Pe - green), infected
(live Pe – pink).
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bioRxiv Animal Behavior and Cognition @biorxiv-behav.bsky.social · 23/04/2026
Fine-scale behavioural dynamics separates adaptive sickness behaviour from injury and infection pathology www.biorxiv.org/content/10.64898/20…
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bioRxiv Ecology @biorxiv-ecology.bsky.social · 05/04/2026
Differing effects of parasite-parasite interaction types on the spatial epidemiology of co-circulating parasites www.biorxiv.org/content/10.64898/20…
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Royal Society Publishing @royalsocietypublishing.org · 30/03/2026
New research from #BiologyLetters: How do infections impact social relationships? royalsocietypublishing.org/rsbl/article... | #Behaviour #Ecology #Evolution #Epidemiology
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Pedro Vale @pfvale.bsky.social · 25/03/2026
Genetic variance and phenotypic selection on pathogen-linked oviposition choice in Drosophila doi.org/10.32942/X20...
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Pedro Vale @pfvale.bsky.social · 23/03/2026
This pre-printed article discusses insect oviposition as a tractable, mechanistically grounded model for behavioural immunity, linking individual egg-laying decisions to population level disease dynamics. 🪰🦠 doi.org/10.32942/X2W...
A drawing of fruit flies eating and laying eggs in a mix of clean and pathogen-contaminated substrates.
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EcoEvoRxiv @ecoevorxiv.bsky.social · 21/03/2026
Insect oviposition site selection as a simple system to investigate the ecology and evolution of pathogen avoidance behaviour. doi.org/10.32942/X2W962
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Ben Longdon @blongdon.bsky.social · 25/09/2025
2 job adverts on a NERC project w myself + @darrenobbard.bsky.social on “What determines the virome: ecology and the environment, evolution, or species history?” early 2026 in @uniexecec.bsky.social - Postdoc: jobs.exeter.ac.uk/hrpr_webrecr... - RA: jobs.exeter.ac.uk/hrpr_webrecr... Pls share!
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Pedro Vale @pfvale.bsky.social · 08/09/2025
*Congratulations* to former Darwin Trust-funded PhD student Arun Prakash for being awarded the Alfred Russel Wallace award from @royentsoc.bsky.social for his PhD on #immune regulation of disease #tolerance and immune #priming in #Drosophila! @edinburghbiology.bsky.social @uoe-eid.bsky.social
edinburgh-infectious-diseases.ed.ac.uk
Former PhD student wins the Alfred Wallace Award for significant contribution to the science of entomology | Edinburgh Infectious Diseases | Edinburgh Infectious Diseases
September 2025: Dr Arun Prakash, a Darwin Trust PhD student, has been retrospectively awarded the prestigious award from the Royal Entomological Society for his 2021 thesis ''Immune Regulation Of Dise...
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PLOS Biology @plosbiology.org · 12/08/2025
Forecasting the effects of #epidemics is complicated by a population’s pathogen exposure history. @pfvale.bsky.social @chadisaadroy.bsky.social & Mike Boots argue for the use of experimental #DiseaseEcology to better understand the consequences of variations in #infection history 🧪 plos.io/4mdDVvW
plos.io
The ghost of infections past: Accounting for heterogeneity in individual infection history improves accuracy in epidemic forecasting
Variable pathogen exposure history contributes to individual immune differences, complicating epidemic forecasting. This Essay argues that experimental disease ecology can offer powerful tools and app...
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Pedro Vale @pfvale.bsky.social · 12/08/2025
This piece on infection history as a driver of individual heterogeneity in infection outcomes was fun to think about and to write with @chadisaadroy.bsky.social and Mike Boots. Also suggest that systems like #Drosophila can offer useful tools to tackle the epidemiological consequences.
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Pedro Vale @pfvale.bsky.social · 10/07/2025
"The myth of meritocracy in science collapses under the financial sacrifices expected at every career stage. From unpaid internships and self-funded conferences to underpaid positions, these hidden costs disproportionately exclude those without generational wealth, compounded by race and gender."
dx.plos.org
Too poor to science: How wealth determines who succeeds in STEM
From student to researcher, a career in science can come with a high price tag. This Perspective explores how persistent financial barriers limit who can succeed in science, revealing how wealth shape...
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Trends in Microbiology @cp-trendsmicrobiol.bsky.social · 15/05/2025
Providencia rettgeri
dlvr.it
Providencia rettgeri
Providencia rettgeri is a rod-shaped, urease-producing, Gram-negative bacterium. It is motile, owing to the presence of flagella, which aid in its movement and colonisation of a wide range of environments. It is prevalent in hospitals and other healthcare settings, particularly on medical equipment, and therefore plays an increasingly important role in nosocomial infections. P. rettgeri produces mannose-resistant Proteus-like (MR/P) fimbriae, which allow adhesion to uroepithelial mucosal cells and to exfoliated urinary cells, contributing to its role in urinary-tract infections.
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Caroline Amoroso @cr-amo.bsky.social · 21/05/2025
Hope this primer proves helpful to anybody interested in infection avoidance. It was certainly a pleasure to write with @akgibson.bsky.social and @pfvale.bsky.social l!
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Pedro Vale @pfvale.bsky.social · 20/05/2025
This primer on infection avoidance was incredibly fun to write with @cr-amo.bsky.social and Mandy Gibson. We cover its taxonomic breadth, mechanisms and evolution, and its importance across fields as diverse as public health, conservation, and agriculture. 🧪 www.cell.com/current-biol... #SymbioSky
This figure highlights the diversity of avoidance across different species in response to pathogens and parasites. (A) Rainbow trout avoid waters with high concentrations of trematode cercariae, reducing exposure to these parasites. (B) Healthy Caribbean spiny lobsters avoid sharing dens with those infected by viruses, preventing the spread of infection within their communities. (C,D) Avoidance underlies many human public health measures such as social distancing, to minimize the risk of infectious disease contagion. (E) Oystercatchers avoid eating the largest cockles, which are likely to be infested with parasitic helminths. (F,G) Bees and ants (eusocial insects) exhibit complex social behaviours to minimize infection risks. Bees isolate or remove infected individuals from the colony, while ants restructure their social networks to reduce contact with fungal-infected foragers. (H) Sheep avoid food and water sources contaminated with feces, reducing the risk of ingesting parasites that may be present in such environments. (I,J) Caenorhabditis elegans and Drosophila melanogaster. These model organisms illustrate how detected pathogenic cues can modify behaviour and provide insights into the neurological integration of sensory perception and behavioural response to pathogens. Plants, like Saline latifolia (K), can avoid infection too, for example by flowering for shorter periods to reduce contact with fungal spores transmitted by pollinators. Root compounds of some sorghum (L) lines are associated with reduced germination of parasitic Striga seeds, demonstrating chemical avoidance strategies. (M) Crickets avoid detection by parasitic flies through the selection of variants that cannot sing, disrupting the ability of parasites to locate hosts acoustically. (N) Spongy moths show variability in larval behaviour to avoid virus-contaminated foliage. (O) Lemurs avoid water sources that have an elevated risk of fecal contamination.
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Pedro Vale @pfvale.bsky.social · 15/05/2025
Providencia rettgeri is a commonly employed #Drosophila pathogen. It also has an extensive AMR profile causing opportunistic infections in hospital settings. I recently realised I know less about it than I should, so here is my homework. www.sciencedirect.com/science/arti... #Microsky #MEvosky
sciencedirect.com
Providencia rettgeri
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Pedro Vale @pfvale.bsky.social · 13/05/2025
hollyyfc.github.io/lme4u/
hollyyfc.github.io
Interpretation and Diagnostics for lme4 Hierarchical Models
Interpret and diagnose linear mixed-effects models fitted with lme4. Provides tools for summarizing model output, visualizing assumptions checks, and performing hypothesis tests.
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Pedro Vale @pfvale.bsky.social · 30/04/2025
A new preprint from the lab, where we apply complex systems and machine learning approaches to identify transitions between life and infection-induced death in #Drosophila. www.biorxiv.org/content/10.1...
biorxiv.org
Detecting infection-related mortality using dynamical statistical indicators of high-resolution activity time series
Predicting transitions between health, disease, and death across biological systems remains an important challenge with significant implications for both ecological management and medical intervention...
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Pedro Vale @pfvale.bsky.social · 25/04/2025
Really excited to finally start this project with @andreadwilson.bsky.social, using #Drosophila as a model for experimental epidemiology and evolution to explore the genetic determinants and evolutionary constraints on extreme pathogen transmission phenotypes.
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Pedro Vale @pfvale.bsky.social · 09/04/2025
Hi #Drosophila folk: I'm advertising a 2-year #Postdoc, funded by a BBSRC grant on the genetic and immune determinants and evolutionary constraints underlying extreme pathogen transmission phenotypes. Deadline 29 April, details in the link below, or feel free to email: www.jobs.ac.uk/job/DMQ231/p...
jobs.ac.uk
Postdoctoral Research Associate at The University of Edinburgh
Apply now for the Postdoctoral Research Associate role on jobs.ac.uk - the leading job board for higher education jobs. View details.
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Pedro Vale @pfvale.bsky.social · 27/03/2025
An interesting, tenured, Principal Researcher position at CIBIO in Northern Portugal, focused on the study of virus-host #co-evolution, with emphasis on the #evolution of #immune system genes and the impact of emerging diseases on wildlife. www.cibio.up.pt/en/jobs/tenu...
cibio.up.pt
TENURE, 1st Edition: 2 positions- BIOPOLIS2025-15 - Job Opportunities - Cibio
The mission of the Research Centre in Biodiversity and Genetic Resources is to develop world-class research in the areas of biodiversity and evolutionary bi
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Tobias Engl @tcsengl.bsky.social · 27/03/2025
A long, long time ago, we started this review project during the first Coron lockdown, but if finally made it out into the world - Origin and function of beneficial bacterial symbioses in insects! @naturerevmicro.bsky.social
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Katerina Guschanski @kguschan.bsky.social · 25/03/2025
Dental calculus, the preserved oral microbiome, is an absolute treasure trove of information that can be interrogated across thousands of years. But how to make it work? In a new preprint, @markella-morait.bsky.social asks this questions using >30 mammalian species:
doi.org/10.1101/2025...
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Priscilla Akyaw @abenaakyaw.bsky.social · 15/03/2025
Time to give an update on the fantastic work by @taniafpaulo.bsky.social during her PhD, now published in @royalsocietypublishing.org on the evolution of resistance and disease tolerance mechanisms to oral infection in #Drosophila royalsocietypublishing.org/doi/10.1098/... #infection #immunity 🤓🎊
royalsocietypublishing.org
Evolution of resistance and disease tolerance mechanisms to oral bacterial infection in Drosophila melanogaster | Open Biology
Pathogens exert strong selection on hosts that evolve and deploy different defensive strategies, namely minimizing pathogen exposure (avoidance), directly promoting pathogen elimination (resistance) a...
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SalehLab @salehlabparis.bsky.social · 14/03/2025
Here we go again!!! Thanks to @rubengonzalez.bsky.social a brilliant postdoc in the lab, I made my first baby steps into the aging field... Be kind and supportive 😀 I find the results totally exciting! and so much to do now! #ProudPI #LoveVirology
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Prof. Ruth Ley FRS @microbiome.bsky.social · 25/02/2025
So excited to share this latest work by @kelseyhuus.bsky.social !!! She shows that flagellin in the human gut affects whether or not people develop fever in response to vaccine, and the amount of flagellin reflects diet
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The Interactive Fly @interactivefly.bsky.social · 01/03/2025
Prakash, A., Fenner, F., Shit, B., Salminen, T. S., Monteith, K. M., Khan, I., Vale, P. F. (2024). IMD-mediated innate immune priming increases #Drosophila survival and reduces pathogen transmission. PLoS pathogens, 20(6):e1012308 journals.plos.org/plospathogen...
journals.plos.org
IMD-mediated innate immune priming increases Drosophila survival and reduces pathogen transmission
Author summary When we are vaccinated, our immune response is able to respond quickly if we are ever exposed to the same pathogen in the future. Unlike humans, the immune systems of invertebrates, suc...
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Pedro Vale @pfvale.bsky.social · 22/02/2025
What is a model organism? asm.org/Articles/202... #MicroSky #MEvoSky
asm.org
What is a Model Organism? Moving Beyond E. coli | ASM.org
For all its prominence in research, E. coli does not reflect Earth’s rich microbial diversity. Scientists are rethinking what can—and should—constitute a model organism moving forward.
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Pedro Vale @pfvale.bsky.social · 17/02/2025
"Here, we track the development of balancing selection theory over the last century and provide an accessible review of this rich collection of models." #evobio
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Carl T. Bergstrom @carlbergstrom.com · 15/02/2025
This excellent interactive tutorial on misleading data visualizations explores the idea of a "counter chart" — the graph you draw in response to refute a misleading claims flowingdata.com/projects/dis...
flowingdata.com
Defense Against Dishonest Charts
This is a guide to protect ourselves and to preserve what is good about turning data into visual things.
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Pedro Vale @pfvale.bsky.social · 14/02/2025
Live imaging of individual symbiotic bacterial cells colonizing the gut of living Drosophila melanogaster show that Lactiplantibacillus plantarum specifically recognizes the fruit fly foregut as a distinct physical niche. www.science.org/doi/full/10.... #Symbiosky #Drosophila
science.org
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bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 14/02/2025
A century of theories of balancing selection www.biorxiv.org/content/10.1101/202…
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RES Publications @respublications.bsky.social · 12/02/2025
‪The new March issue of #RESPhysEnt, Vol. 50 Issue 1, opens with an editorial: Key questions for future research in Physiological Entomology 👀doi/10.1111/phen.12481 If you’d like to submit an article on any of these key research areas, get in touch! @wybouw.bsky.social @tbuescher.bsky.social
Cover image of Physiological Entomology Vol 50 Issue 1
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Ally Phillimore @allyphillimore.bsky.social · 12/02/2025
Fieldwork opportunity: We're looking to hire a field assistant for the www.phenoweb.org project starting 1 April. Please repost. #phenology #fieldwork #birdringing
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Ben Longdon @blongdon.bsky.social · 12/02/2025
V neat: "A naturally occurring mitochondrial genome variant confers broad protection from infection in Drosophila" from Tiina Salminen, Laura Vesala @pfvale.bsky.social et al journals.plos.org/plosgenetics...
journals.plos.org
A naturally occurring mitochondrial genome variant confers broad protection from infection in Drosophila
Author summary The strength of immune response and the disease symptoms vary among individuals even when exposed to the same pathogen. Much of this variation is due to the genes directly involved in a...
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Edinburgh Infectious Diseases @uoe-eid.bsky.social · 07/02/2025
Really interesting day discussing impacts of climate change on vector borne diseases workshop today. Lots of great science and discussion about exciting projects to take forwards. @keithrmatthews.bsky.social #reecelab @roslininstitute.bsky.social @amypedersen.bsky.social
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Darren Obbard @darrenobbard.bsky.social · 08/02/2025
From @blongdon.bsky.social et al! doi.org/10.1093/evle...
doi.org
Positive correlations in susceptibility to a diverse panel of viruses across Drosophilidae host species
Abstract. Our ability to predict the emergence of novel viruses relies on there being generalizable patterns in the susceptibilities of hosts to novel infe
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Pedro Vale @pfvale.bsky.social · 09/02/2025
An important study showing that prolonged exposure to higher temperatures makes #Aedes albopictus more tolerant of #viral infection - with important implications for vector-borne diseases in a warming world. #symbiosky #evovir @uoe-eid.bsky.social
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Priscilla Akyaw @abenaakyaw.bsky.social · 06/02/2025
I am very happy to see this first part of my PhD work go online now! 💃🏾 We explored alternative strategies to elicit #diseasetolerance in #Drosophila melanogaster in response to oral #infection with a natural bacterial #pathogen, #Pseudomonas entomophila. (Thread)
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Michael Brockhurst @brockhurstlab.bsky.social · 06/02/2025
🚨 Job alert 🚨 — are you interested in understanding how mobile genetic elements and defence systems shape bacterial genome evolution? 🧬 🧪 🧫 🦠 2x 5-year research positions available in experimental evolution @mermanchester.bsky.social Join us! #microsky www.jobs.manchester.ac.uk/Job/JobDetai...
jobs.manchester.ac.uk
Research Associate in Experimental Evolution:Manchester
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Pedro Vale @pfvale.bsky.social · 06/02/2025
PhD Summer School on Host-Microbe Symbioses. Awesome topic. Unbeatable location. #symbiosky #microsky #evobio gimm.idloom.events/phd-summer-s...
gimm.idloom.events
PhD Summer School on Host-Microbe Symbioses 2025
PhD Summer School on Host-Microbe Symbioses Gulbenkian Institute for Molecular Medicine (GIMM) & Católica Biomedical Research Centre (CBR) July 06 -19, 202...
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Pedro Vale @pfvale.bsky.social · 04/02/2025
This looks like an outstanding meeting, likely of interest to #Drosophila and #EvolSky 🧪communities.
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Edinburgh Infectious Diseases @uoe-eid.bsky.social · 31/01/2025
⭐ NEW PUBLICATION ⭐ A naturally occurring mitochondrial genome variant confers broad protection from infection in Drosophila @pfvale.bsky.social Read more ➡️ buff.ly/3EcXnYt
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Pedro Vale @pfvale.bsky.social · 29/01/2025
Support a fantastic society journal by submitting your insect physiology work to @royentsoc.bsky.social PHEN. In the upcoming January volume, we discuss some of the key questions for future research in physiological #entomology. #symbiosky 🐜🐝🦋🦟🧪 resjournals.onlinelibrary.wiley.com/share/YJQDXW...
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Edinburgh Infectious Diseases @uoe-eid.bsky.social · 28/01/2025
💭Check our brand new Research Focus - featuring publications from across the Edinburgh Infectious Diseases network! @pfvale.bsky.social @richardsloanlab.bsky.social @dbogaert.bsky.social @fionagreco.bsky.social Full article here ➡️ edinburgh-infectious-diseases.ed.ac.uk/news-and-eve...
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Royal Entomological Society @royentsoc.bsky.social · 27/01/2025
RES has joined Bluesky! We are excited to share fascinating science, news, events & more. To start, we’re featuring the #LargeBlueButterfly 🦋 Our #Conservation Science team recently published ground-breaking findings on the dispersal rates of this #EndangeredSpecies 🔽 buff.ly/3Wz5QLU
Large Blue butterfly, photo by David Simcox, Conservation Project Manager at the Royal Entomological Society
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Pedro Vale @pfvale.bsky.social · 24/01/2025
Looks like a tremendous amount of work from Rodrigo Cogni's group, and a very useful quantitative review of the negative effects of viral infection across insect taxa. #symbiosky #virosky #InsectEcol #infection #evolsky
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Sam Brown @brownlab.bsky.social · 17/01/2025
Hello world! I'm starting out on bluesky with a job posting - we're looking for lab research tech who shares our love of bugs. More info here brownlab.biology.gatech.edu/opportunities/
brownlab.biology.gatech.edu
Opportunities
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