Nature Structural & Molecular Biology, Published online: 15 June 2026; doi:10.1038/s41594-026-01821-8Veit et al. present a fluorescence microscopy platform to measure protein scramblase-mediated lipid flipflop across membranes by imaging single vesicles containing fluorescent lipid probes to quantify precise transport rates.

Mitochondria interact directly with the nuclear pore complex via VDAC1–RANBP2 binding to sustain nuclear ATP levels.

Their strategy revealed new details that open the door to designing proteins with powerful abilities that could ultimately benefit medicine and manufacturing.

Nature Reviews Molecular Cell Biology, Published online: 19 March 2026; doi:10.1038/s41580-026-00957-1Subcellular localization is important for protein function. This Review discusses advances in spatial subcellular proteomics, assesses the strengths and weaknesses of technologies that measure and control protein localization, and considers their potential uses in cell biology and medicine.

Altered metabolism is a hallmark of cancer: malignant cells re-engineer nutrient acquisition and utilization to fuel unchecked growth and survival. Beyond functioning as a simple energy powerhouse, metabolic rewiring reshapes virtually every layer of cell regulation, from chromatin architecture a...

Mast cells are immune cells that release membraneless mast cell extracellular granules (MCEGs) in response to allergic inflammation and pathogen infection. MCEGs are found to be condensates formed thr...

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A newly discovered acidic nanolayer that envelopes lysosomes reveals that proton gradients extend beyond the organelle lumen, identifying a nanoscale regulatory interface that links luminal pH, TMEM17...

Tan and colleagues develop DNA nanodevices to detect the pH of the lysosomal outer surface, observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in...

Tan and colleagues develop DNA nanodevices to detect the pH of the lysosomal outer surface, observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in...

Cell surface proteins are key disease biomarkers and therapeutic targets, yet high-throughput methods for aptamer discovery targeting these proteins in situ remain limited. We introduce single-cell pe...

Nature Reviews Bioengineering, Published online: 17 October 2025; doi:10.1038/s44222-025-00361-yFunctional nucleic acids (FNAs) achieve specific target recognition, molecular binding and catalytic activity by folding into defined secondary and tertiary structures. This Review focuses on two major classes of FNAs — aptamers and DNAzymes — and discusses their structural features, production strategies and engineering approaches as well as their clinical applications in diagnostics, targeted therapy and precision medicine.

Metal-organic frameworks were the next big thing in chemistry when they were invented more than three decades ago. Now, these intriguing materials are becoming commercial tools for capturing carbon dioxide and harvesting water from the air.

Nature - Being named as a Nobel laureate is the ultimate prize for many scientists, but how do other science prizes compare?

N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...

Nature Reviews Molecular Cell Biology, Published online: 04 August 2025; doi:10.1038/s41580-025-00873-wLysosomes degrade cellular components, and their membrane is an important signalling hub. Recent insights into the mechanisms that maintain lysosomal membrane homeostasis — including the interplay between membrane damage, repair, lysophagy and lysosome biogenesis — highlight their importance in physiology, in disease and during ageing.

Nature - Super-resolution technique works with off-the-shelf optical microscopes.

Super-resolution technique works with off-the-shelf optical microscopes.

By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the native glycocalyx has been ...

SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...

Recipients Schreiber and Schultz will each receive $500K prize for work on chemical probes, unnatural amino acids, and new therapeutics

Sharma, Jiao and colleagues report glycosylation of small RNAs within exosomes and propose a glycosylation-dependent mechanism for RNA targeting into exosomes, which may influence intercellular commun...

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