Mitochondria are dynamic organelles that remodel their shape to regulate cell fate. Mitochondrial division involves interactions with the endoplasmic reticulum (ER), lysosomes, and trans-Golgi network...

Karl Deisseroth is leaving his mark on brain science one technique at a time.

Nature Structural & Molecular Biology, Published online: 15 June 2026; doi:10.1038/s41594-026-01821-8Veit et al. present a fluorescence microscopy platform to measure protein scramblase-mediated lipid flipflop across membranes by imaging single vesicles containing fluorescent lipid probes to quantify precise transport rates.

Mitochondria interact directly with the nuclear pore complex via VDAC1–RANBP2 binding to sustain nuclear ATP levels.

Their strategy revealed new details that open the door to designing proteins with powerful abilities that could ultimately benefit medicine and manufacturing.

Nature Reviews Molecular Cell Biology, Published online: 19 March 2026; doi:10.1038/s41580-026-00957-1Subcellular localization is important for protein function. This Review discusses advances in spatial subcellular proteomics, assesses the strengths and weaknesses of technologies that measure and control protein localization, and considers their potential uses in cell biology and medicine.

Altered metabolism is a hallmark of cancer: malignant cells re-engineer nutrient acquisition and utilization to fuel unchecked growth and survival. Beyond functioning as a simple energy powerhouse, metabolic rewiring reshapes virtually every layer of cell regulation, from chromatin architecture a...

Mast cells are immune cells that release membraneless mast cell extracellular granules (MCEGs) in response to allergic inflammation and pathogen infection. MCEGs are found to be condensates formed thr...

Our mission is to make the world a better place through the advancement of scientific knowledge.

A newly discovered acidic nanolayer that envelopes lysosomes reveals that proton gradients extend beyond the organelle lumen, identifying a nanoscale regulatory interface that links luminal pH, TMEM17...

Tan and colleagues develop DNA nanodevices to detect the pH of the lysosomal outer surface, observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in...

Tan and colleagues develop DNA nanodevices to detect the pH of the lysosomal outer surface, observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in...

Cell surface proteins are key disease biomarkers and therapeutic targets, yet high-throughput methods for aptamer discovery targeting these proteins in situ remain limited. We introduce single-cell pe...

Nature Reviews Bioengineering, Published online: 17 October 2025; doi:10.1038/s44222-025-00361-yFunctional nucleic acids (FNAs) achieve specific target recognition, molecular binding and catalytic activity by folding into defined secondary and tertiary structures. This Review focuses on two major classes of FNAs — aptamers and DNAzymes — and discusses their structural features, production strategies and engineering approaches as well as their clinical applications in diagnostics, targeted therapy and precision medicine.

Metal-organic frameworks were the next big thing in chemistry when they were invented more than three decades ago. Now, these intriguing materials are becoming commercial tools for capturing carbon dioxide and harvesting water from the air.

Nature - Being named as a Nobel laureate is the ultimate prize for many scientists, but how do other science prizes compare?