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Xu Zhou lab @ BCH & HMS

@xuzhoulab.bsky.social
477 followers 641 following 47 posts

AP @BostonChildrens @harvardmed AM @broadinstitute inflammation, tissue biology, quant.&systems immunology #1stGen #ImmigrantScientists #NewPI

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Reposted by Xu Zhou lab @ BCH & HMS
Science in Boston @scienceinboston.com · 13/10/2025
How does acidity affect #ImmuneCells? The @xuzhoulab.bsky.social at @bostonchildrens.bsky.social found that a drop in pH can suppress immune responses by disrupting a protein called #BRD4. 🥼 Abstract in @cellpress.bsky.social: bit.ly/3IZDAhP ✏️ Press release: on.bchil.org/48rhZtf
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Xu Zhou lab @ BCH & HMS @xuzhoulab.bsky.social · 19/09/2025
Super excited to see our recent @cellcellpress.bsky.social paper featured in a Life Metabolism preview! Huge thanks to Christoopher Glass @ucsdmedschool.bsky.social for the thoughtful highlight. 🔗 academic.oup.com/lifemeta/adv... #inflammation #macrophage #chromatin #pH #biomolecularcondensates
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Reposted by Xu Zhou lab @ BCH & HMS
Jonathan Kagan @jkagan1.bsky.social · 19/09/2025
TLR4 endocytosis continues to be the centerpiece of TRIF-Interferon signaling. Kasper et al report diverse structures of Bacteroides LPS and their impact on TLR4 endocytosis and signaling. Functional consequences on Treg induction in the gut. www.cell.com/cell/abstrac...
cell.com
Structure of gut microbial glycolipid modulates host inflammatory response
Structural variations in the number of acyl chains and phosphate groups of gram-negative microbial lipid A differentially modulate DC-derived IFN-β responses, which are mechanistically regulated by TL...
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Xu Zhou lab @ BCH & HMS @xuzhoulab.bsky.social · 19/09/2025
congratulations to @virusesimmunity.bsky.social @brangwynnelab.bsky.social!
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Xu Zhou lab @ BCH & HMS @xuzhoulab.bsky.social · 22/07/2025
Beyond excited to share our #NewPaper in @cellcellpress.bsky.social! Inflamed environments acidify intracellular #pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of #inflammation authors.elsevier.com/sd/article/S...
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Xu Zhou lab @ BCH & HMS @xuzhoulab.bsky.social · 22/07/2025
Been waiting for this from my dear friends: Macrophage derived growth factor promotes epithelial proliferation for repair when lung is under inflammatory damage 🔥🔥🔥 huge congrats to @ruthfranklinlab.bsky.social @rmedzhitov.bsky.social and the team! 🎉👏🏼🍾 @harvard.edu @harvardmed.bsky.social
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Reposted by Xu Zhou lab @ BCH & HMS
Ivan Zanoni @lozanzi.bsky.social · 17/07/2025
#ChromatinPower #WhatADay! After our paper @cp-immunity.bsky.social (free link 👉 authors.elsevier.com/a/1lS0g3qNrU-i…) happy for our tiny contribution to @xuzhoulab.bsky.social Medzhitov &co amazing paper @cp-cell.bsky.social showing pH controls inflammation via chromatin remodeling! Free link👇
authors.elsevier.com
ScienceDirect.com | Science, health and medical journals, full text articles and books.
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Reposted by Xu Zhou lab @ BCH & HMS
Arthur Mortha @theonlylabever.bsky.social · 18/07/2025
pH controls inflammatory response through transcriptional condensates...but how? Read all about the mechanism here -> ‪ @xuzhoulab.bsky.social www.cell.com/cell/fulltex... www.nature.com/articles/s41... www.preprintclub.com/preprint-rev... @preprintclub.bsky.social
cell.com
Regulation of inflammatory responses by pH-dependent transcriptional condensates
BRD4 functions as an intracellular pH sensor through a conserved histidine-rich intrinsically disordered region. Inflammation-associated acidification triggers a pH-dependent switch in transcriptional...
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Xu Zhou lab @ BCH & HMS @xuzhoulab.bsky.social · 22/05/2025
Thank you for those who have a conscientious!
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Reposted by Xu Zhou lab @ BCH & HMS
Shruti Naik @drshrutinaik.bsky.social · 13/03/2025
Schumer advocated for budget CR today, essentially giving White House decision making power on AMERICAS budget. Cutting Medicaid, social security, and SCIENCE would be no problem. Call and email your senator now if think this is a horrible idea, especially if you live in New York www.govtrack.us
govtrack.us
GovTrack.us
Tracking legislation and votes in the United States Congress.
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Reposted by Xu Zhou lab @ BCH & HMS
Igor Brodsky @brodskyigorlab.bsky.social · 04/03/2025
Amazing article www.sensible-med.com/p/the-nih-is...
sensible-med.com
The NIH is Being Slashed and Burned, not “Reformed”
A strong and well-argued rebuttal to NIH criticism
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Reposted by Xu Zhou lab @ BCH & HMS
ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 23/02/2025
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Reposted by Xu Zhou lab @ BCH & HMS
Jonathan Kagan @jkagan1.bsky.social · 15/02/2025
If our "academic leaders" are wondering what a real leader looks like, look no further. Who will follow Dr. Varmus? www.nytimes.com/2025/02/14/o...
nytimes.com
Opinion | American Science is Under Attack (Gift Article)
The Trump administration hobbles research and endangers the public health.
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Reposted by Xu Zhou lab @ BCH & HMS
Jonathan Kagan @jkagan1.bsky.social · 09/02/2025
The perk of a wildly successful research enterprise is knowledge--and medical innovation. The cost of successful research is the forever argument over credit for discoveries (and revenue). How about we all invest in research, so we can keep living (and arguing)?
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Reposted by Xu Zhou lab @ BCH & HMS
Jonathan Kagan @jkagan1.bsky.social · 08/02/2025
www.fiercebiotech.com/research/rep...
fiercebiotech.com
Report: Every dollar of NIH research funding doubles in economic returns
Research funded by the National Institutes of Health (NIH) generated $2.46 in economic activity for every $1 of funding in 2023, a total of $92.9 billion, according to an
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Reposted by Xu Zhou lab @ BCH & HMS
Jonathan Kagan @jkagan1.bsky.social · 08/02/2025
This is a list of blockbuster drugs in 2024. Guess how many can trace their origins to NIH funded research? All of them.
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Reposted by Xu Zhou lab @ BCH & HMS
Igor Brodsky @brodskyigorlab.bsky.social · 08/02/2025
If this is not reversed it is going to destroy the ability of universities to support biomedical research and it will completely shut down private research institutes like the Salk Institute, the Fred Hutchinson Cancer Research Center, Scripps, and many others.
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Xu Zhou lab @ BCH & HMS @xuzhoulab.bsky.social · 29/01/2025
Despite all kinds of chaos, nothing beats a hotpot celebration of Lunar New Year with my lab family! Happy the year of snake! Year of slytherin! 🎉🎊🎆🍲
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Xu Zhou lab @ BCH & HMS @xuzhoulab.bsky.social · 22/01/2025
Heroic effort by @prywes.bsky.social tackling one of the most difficult protein! 👏🏼
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Xu Zhou lab @ BCH & HMS @xuzhoulab.bsky.social · 22/12/2024
Happy holidays to everyone! Just celebrated 2024 with the amazing group of people who made me want to go to work everyday, full of surprises and excitement! Looking forward to 2025 of Zhou lab #labholiday @bostonchildrens.bsky.social @harvardmed.bsky.social
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