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Massimiliano Stagi

@mstagi.bsky.social
144 followers 157 following 2 posts

Scientist 🧬 | Microscopy Enthusiast 🔬 pcwww.liv.ac.uk/~maxstagi/

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Reposted by Massimiliano Stagi
Blue Wave 🌊 2026•2028🗽 @jmzmuda.bsky.social · 23/02/2025
An #NIH-funded research team has developed an mRNA vaccine to treat pancreatic cancer. Results from the clinical trial were published this week in Nature. #pancreas #cancer #mRNA #vaccine #medsky #science #medicine #bluesky
mskcc.org
In Early-Phase Pancreatic Cancer Clinical Trial, Investigational mRNA Vaccine Induces Sustained Immune Activity in Small Patient Group
Learn how MSK researchers are deploying mRNA vaccines against pancreatic cancer.
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Reposted by Massimiliano Stagi
mitotalks.bsky.social @mitotalks.bsky.social · 03/02/2025
Time for some mito-business. Or should we say methyl-business?? Let's ask our speaker Thomas MacVicar. This thursday, usual time and place.
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Massimiliano Stagi @mstagi.bsky.social · 04/01/2025
Our new study: www.science.org/doi/10.1126/.... It provides useful tools for studying LLOME lysosomal damage.
science.org
RpH-ILV: Probe for lysosomal pH and acute LLOMe-induced membrane permeabilization in cell lines and Drosophila
The ratiometric lysosomal probe RpH-ILV enables improved pH tracking and reveals lysosomal dynamics and susceptibility to damage.
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Reposted by Massimiliano Stagi
Brett Collins @brettcollins.bsky.social · 11/12/2024
An important and beautiful structure of the native dystrophin glycoprotein complex!.
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Reposted by Massimiliano Stagi
Chris Stringer @chrisbstringer.bsky.social · 30/11/2024
‘Dark proteome’ survey reveals thousands of new human genes | Science www.science.org/content/arti...
science.org
‘Dark proteome’ survey reveals thousands of new human genes
Database confirms that overlooked segments of the genome code for a multitude of tiny proteins
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Reposted by Massimiliano Stagi
Ewa Bomba-Warczak @ebomba.bsky.social · 11/11/2024
MITOtalks have not made it here (yet) but we are excited to host two fantastic trainee talks this week on MITOchats - Alia Edington from Friedman lab at UTSW and David Eberhardt from Chaudhuri at UUtah - visit www.mitotalks.org for more info and zoom link to join! #mitochondria please share!
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Reposted by Massimiliano Stagi
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 26/11/2024
Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD. www.science.org/doi/10.1126/...
science.org
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies
Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...
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Reposted by Massimiliano Stagi
Fran Bottanelli @franbottanelli.bsky.social · 20/11/2024
Beautiful imaging on the cover but also check out the beautiful imaging inside and our story on #endosomes and #GTPase cascades
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Reposted by Massimiliano Stagi
Denise J. Cai, Ph.D. @denisejcai.bsky.social · 20/11/2024
We’re hiring tenure-track faculty focused on Systems & #ComputationalNeuroscience at the Friedman Brain Institute at Mount Sinai! We're starting to review applications so submit yours ASAP! 👇
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Reposted by Massimiliano Stagi
MedCloudInsider @medcloudinsider.bsky.social · 20/11/2024
In a move that surprised the scientific community, DeepMind released the source code and model weights for AlphaFold 3, its groundbreaking AI system for predicting molecular interactions. medcloudinsider.com/Articles/202... #ai #healthcaretech #medicaltech
medcloudinsider.com
DeepMind Releases AlphaFold 3 Code and Weights -- MedCloudInsider
In a move that surprised the scientific community, DeepMind, a division of Google parent company Alphabet focused on developing general-purpose artificial intelligence technology, has released the sou...
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Reposted by Massimiliano Stagi
Jonny Nixon-Abell @abelljonny.bsky.social · 19/11/2024
Hullooooo Cell Biology friends. If you're heading to #CellBio2024 in (hopefully!) sunny San Diego this year, then come and check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! See you there! **Please RT** 🥳
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Reposted by Massimiliano Stagi
bioRxivpreprint @biorxivpreprint.bsky.social · 19/11/2024
Phosphatidylethanolamine is a phagocytic ligand implicated in the binding and removal of microbial extracellular vesicles www.biorxiv.org/content/10.1101/202…
biorxiv.org
Phosphatidylethanolamine is a phagocytic ligand implicated in the binding and removal of microbial extracellular vesicles https://www.biorxiv.org/content/10.1101/2024.11.18.624161v1
The efficient recognition and removal of apoptotic cells by phagocytes is critical to prevent second
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Reposted by Massimiliano Stagi
htw @heniek-htw.bsky.social · 18/11/2024
Impact of #Ageing and Disuse on #Neuromuscular Junction and #Mitochondrial Function and Morphology: Current Evidence and Controversies www.sciencedirect.com/science/arti...
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Reposted by Massimiliano Stagi
htw @heniek-htw.bsky.social · 18/11/2024
Fueling neurodegeneration: metabolic insights into microglia functions jneuroinflammation.biomedcentral.com/articles/10....
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Reposted by Massimiliano Stagi
Juan S. Bonifacino @juanbonifacino.bsky.social · 17/11/2024
Here are some free/open-source sites for the preparation of scientific illustrations, including icon libraries: bioicons.com, scidraw.io, bioart.niaid.nih.gov, inkscape.org, biogdp.com, reactome.org/icon-lib
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Reposted by Massimiliano Stagi
Gabriele Corso @gcorso.bsky.social · 17/11/2024
Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!
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Reposted by Massimiliano Stagi
Sandhya Koushika @wormlockholmes.bsky.social · 16/11/2024
Evidence for heterogeneity in endosomal-origin organelles and their positions from @melikel.bsky.social No significant differences in the distance of the subpopulations from the nucleus. NPC1-positive late endosomes/lysosomes can be closely positioned to mitochondria doi.org/10.1083/jcb....
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Massimiliano Stagi @mstagi.bsky.social · 17/11/2024
Hello, world! Looking forward to connecting with new and old friends.
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Reposted by Massimiliano Stagi
Jim Hurley @jimhurley.bsky.social · 16/11/2024
Proud of new work tinyurl.com/yhz4c6ry from the lab by Zhicheng (Chen) Cui using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/ G. Napolitano,A. Esposito, and A. Ballabio.
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Reposted by Massimiliano Stagi
Fran Bottanelli @franbottanelli.bsky.social · 15/11/2024
This #fluorescencefriday I am gonna introduce some work from the lab :) We identified a new GTPase cascades that we believe drives cargo flow along post-Golgi pathways! Compartments positive for ARF1 shed ARF1 (green) to acquire Rab11 (magenta) to become recycling endosomes. Can you spot an event?
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