Sign in

Xin Jin

@xinjin.bsky.social
490 followers 263 following 49 posts

Building neurotech to study how genes and physiology impact brain function 🧬 🧠 Associate Professor, Scripps Research | Freeman Hrabowski Scholar, HHMI

PostsRepliesMedia
Xin Jin @xinjin.bsky.social · 19/06/2026
Excited to share Keystone on Neurodevelopmental Disorders in Colorado Jan 2027! ⛷️ with Tom Nowakowski, Stephan Sanders & Joe Zhou 🌟Amazing lineup keynotes from Allyson Berent & Huda Zoghbi! ⏰Abstracts/scholarship due 9/24, Poster abstract due 9/29 Join us: keystonesymposia.org/conferences/...
040
Reposted by Xin Jin
Ardem Patapoutian @ardemp.bskyverified.social · 10/04/2026
These rankings are kinda silly… but hey, we’re #1 🍾🥂🥳
0121
Xin Jin @xinjin.bsky.social · 09/04/2026
Form follows function, or function dictates form? 📢Preprint: we build Perturb-CLEAR, in vivo screen of neuroanatomy! Disease perturbations produce selective morphology-RNA changes that RNA impact alone cannot predict. Was led by the invincible grad student Boli Wu! www.biorxiv.org/content/10.6...
4328
Reposted by Xin Jin
Alejandro Montenegro @aemonten.bsky.social · 09/04/2026
Xin Jin FTW! "We developed Perturb-CLEAR, which integrates pooled CRISPR screening and whole-mount imaging to quantify brain-wide cytoarchitecture, and paired it with Perturb-seq to link structural phenotypes to transcriptomic changes." www.biorxiv.org/content/10.6...
1173
Reposted by Xin Jin
supriyasri.bsky.social @supriyasri.bsky.social · 02/04/2026
Thrilled to announce Critical Mass Ventures, a philanthropic initiative bridging science, capital, and community to close the gap between lifespan and healthspan. Our inaugural postdoc fellowship is now open. 🔬 criticalmassventures.co #ScienceSky #AcademicSky #Healthspan #Longevity #Postdoc
criticalmassventures.co
Critical Mass Ventures
084
Reposted by Xin Jin
Cedric Boeckx @cedricboeckx.bsky.social · 19/03/2026
“Genome-scale functional mapping of the mammalian whole brain with in vivo Perturb-seq” Truly impressive work by @xinjin.bsky.social 🤯🧪🧬🧠 www.biorxiv.org/content/10.6...
biorxiv.org
032
Xin Jin @xinjin.bsky.social · 17/03/2026
Excited to introduce @perturb.ai, a company I co-founded to rethink drug discovery. Biology is complex, and disease unfolds across genes, cell types, and tissues. We’re powering AI with the causal logic of human genetics www.perturb.ai/news
perturb.ai
News | Explore Cutting-Edge Gene Editing Technologies — PerturbAI
Discover the latest updates and breakthroughs in gene editing with PerturbAI's news on CRISPR innovations and collaborations. Stay informed today.
0113
Xin Jin @xinjin.bsky.social · 17/03/2026
Excited to share: enhanced capture in vivo multiome Perturb-seq! Worried about low gRNA recovery and wasting sequencing on cells that can’t assign a perturbation? We engineered gRNA transcripts to stay in the nucleus, enabling efficient multiomic Perturb-seq! www.biorxiv.org/content/10.6...
1174
Reposted by Xin Jin
Scripps Research @scripps.edu · 17/02/2026
Assoc. Prof. @xinjin.bsky.social has been named a 2026 Sloan Research Fellow by the @sloanfoundation.bsky.social, recognized for pioneering in vivo Perturb-seq—a gene-editing approach combining CRISPR technology and single-cell RNA analysis to uncover how genetic variation shapes brain development.
ow.ly
Xin Jin receives prestigious Sloan Research Fellowship - Scripps Research Magazine
Xin Jin, an associate professor at Scripps Research and a Freeman Hrabowski Scholar at Howard Hughes Medical Institute, has been awarded a Sloan Research Fellowship for her exceptional research and le...
4404
Xin Jin @xinjin.bsky.social · 05/02/2026
It was such an amazing visit at Utah Neuroscience! I learn from such a diverse crowd of neuroscientists doing super cutting edge works in many fields - and their trainees who are engaging and thoughtful. Campus view is unbelievable! Thank you @jasonsynaptic.bsky.social for having me!
0121
Reposted by Xin Jin
HHMI @hhmi-science.bsky.social · 18/11/2025
Calling all rising juniors & seniors: Interested in biological or biomedical research? Applications for our ’26 Summer Undergraduate Research Experience Program are now open! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: bit.ly/CechFellows
bit.ly
Summer Undergraduate Research Experience | HHMI
The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.
07089
Reposted by Xin Jin
Scripps Research @scripps.edu · 10/10/2025
The NIH has awarded a $14.2M Director’s Transformative Research Award to a team led by Nobel Prize-winning neuroscientist @ardemp.bskyverified.social, Prof. @liye-tsri.bsky.social and Assoc. Prof. @xinjin.bsky.social to map interoception and build the first atlas of this hidden sixth sense.
scripps.edu
Scripps Research-led team receives $14.2M NIH award to map the body’s “hidden sixth sense”
012425
Xin Jin @xinjin.bsky.social · 08/10/2025
Coming to #SfN2025 in San Diego? Come join our Neuroscience Symposium a day before on Nov 13! Hear from a fantastic speaker lineup and interact with vibrant audience in our community and beyond. Free registration link: www.eventbrite.com/e/dorris-neu...
062
Xin Jin @xinjin.bsky.social · 02/10/2025
Actively hiring! Video made by Sora-2 but the job post is 100% real. Apply here: hhmi.wd1.myworkdayjobs.com/en-US/Extern...
1168
Xin Jin @xinjin.bsky.social · 13/09/2025
First time bringing my fantastic students to the HHMI Science Meeting and they absolutely shined at the session! ✨ It remains one of the most stimulating mtg — I’m science-starstruck every 10 min. We’re grateful for the chance to spark new collaborations that will take our technologies further
1150
Reposted by Xin Jin
The Rockefeller University @rockefeller.edu · 18/08/2025
We are deeply saddened to share that our friend and colleague Jim Hudspeth passed away on Saturday. We will remember and continue to be inspired by Jim’s integrity, his humility, and his unwavering commitment to discovery.
rockefeller.edu
A. James Hudspeth, neuroscientist who unlocked secrets of hearing, has died - News
A. James Hudspeth, a Rockefeller neuroscientist who discovered how sound waves are converted into electrical signals in the ear's cochlea, died Saturday at his home in Manhattan. A pioneering scientist and dedicated mentor, he was the university's F.M. ...
27333
Reposted by Xin Jin
Sten Linnarsson @sten.linnarsson.org · 25/06/2025
A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
2116109
Reposted by Xin Jin
🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 02/08/2025
Terence Tao (@teorth.bsky.social) has written a thread on Mastodon about the impact of the federal grant freeze to UCLA, particularly to his own field of Mathematics. UCLA's IPAM (Institute of Pure and Applied Mathematics) could shut down entirely mathstodon.xyz/@tao/1149568...
mathstodon.xyz
Terence Tao (@tao@mathstodon.xyz)
The current administration in the US has, through various funding agencies such as the NSF and NIH, has recently suspended virtually all federal grants to my home university, UCLA (including my own p...
3292134
Reposted by Xin Jin
Max-Planck-Gesellschaft @maxplanck.de · 01/08/2025
Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.
Open Call for Expressions of Interest in Max Planck Directorships:
Expressions of interest can be submitted until 31 October 2025.
1161195
Reposted by Xin Jin
Ardem Patapoutian @ardemp.bskyverified.social · 31/07/2025
BIG NEWS: “Senate appropriators on Thursday approved an FY26 Labor-HHS bill that included a slight bump in funding for the NIH, with a strong 26–3 bipartisan vote.” Thank you to members of the Senate Appropriations Committee on both sides of the aisle! www.axios.com/pro/health-c...
axios.com
Senate appropriators approve Labor-HHS bill with NIH bump
The vote and lawmaker comments show that most senators aren't going along with the White House's proposed 40% budget cut to NIH.
211326
Xin Jin @xinjin.bsky.social · 22/07/2025
Science and innovation drive every breakthrough. On 7/21, a nation-wide campaign kicks off to honor Apollo 11’s legacy -- tell Congress NO to research‑funding cuts. Speak up here: ProtectScienceAndInnovation.org #ProtectScience #InnovationMakesAmericaGreat
091
Reposted by Xin Jin
Alexandria Ocasio-Cortez @aoc.bsky.social · 03/07/2025
I don’t think anyone is prepared for what they just did w/ ICE. This is not a simple budget increase. It is an explosion - making ICE bigger than the FBI, US Bureau of Prisons, DEA,& others combined. It is setting up to make what’s happening now look like child’s play. And people are disappearing.
43729653537496
Reposted by Xin Jin
Mireille Kamariza @kamariza.bsky.social · 25/06/2025
Working link here! www.biorxiv.org/content/10.1...
biorxiv.org
Tre-DST: A new drug susceptibility test for Mycobacterium tuberculosis using solvatochromic trehalose probes
Tuberculosis (TB) is the most lethal cause of death from a single infectious agent. In 2024, an estimated 10 million people developed TB, nearly half a million of which were infected with drug-resista...
087
Xin Jin @xinjin.bsky.social · 20/06/2025
Honored to be an HHMI FHS! Grateful to brilliant colleagues who push me to think deeply, and to my students whose curiosity & energy make the lab a joy. My grad advisor said in genetic screens, you don’t get what you want—you get what you deserve. Hope we are deserving www.hhmi.org/programs/fre...
hhmi.org
The 2025 Freeman Hrabowski Scholars | HHMI
Freeman Hrabowski Scholars are outstanding early career faculty who have the potential to become leaders in their research fields.
16778
Xin Jin @xinjin.bsky.social · 20/06/2025
Congratulations to the 2025 McKnight cohort!
120
Reposted by Xin Jin
Ye Lab @liye-tsri.bsky.social · 20/06/2025
Congrats to @xinjin.bsky.social @tinakim-neuro.bsky.social and many others!
1113
Reposted by Xin Jin
Jason Shepherd @jasonsynaptic.bsky.social · 19/06/2025
Love seeing friends and colleagues #slay! Congrats to @moriel-z.bsky.social @utah.edu for becoming a @hhmi.org Hrabowski scholar! Also congrats to @tinakim-neuro.bsky.social @xinjin.bsky.social @doctheagrif.bsky.social www.hhmi.org/programs/fre...
hhmi.org
The 2025 Freeman Hrabowski Scholars | HHMI
Freeman Hrabowski Scholars are outstanding early career faculty who have the potential to become leaders in their research fields.
0295
Reposted by Xin Jin
Seth Blackshaw @sethblackshaw.bsky.social · 14/06/2025
Our paper on gene regulatory networks controlling hypothalamic and prethalamic development is now out in Cell Reports./1 www.cell.com/cell-reports...
cell.com
Decoding gene networks controlling hypothalamic and prethalamic neuron development
Kim et al. map gene regulatory networks of the developing mouse hypothalamus and prethalamus using single-cell multiomics, identifying regulators of regionalization and neurogenesis. They further show...
13812
Reposted by Xin Jin
Stefano Cacciatore @tkcaccia.bsky.social · 02/06/2025
KODAMA goes spatial. doi.org/10.1101/2025... #spatialtranscriptomics #visium #visiumhd #seurat #giotto
01515
Xin Jin @xinjin.bsky.social · 02/06/2025
It was fantastic to share some unpublished work with the Klingenstein family, especially on the same panel with my friend @justuskebschull.bsky.social! Grateful for the opportunity and inspiring talks all around from our cohort
0161
Reposted by Xin Jin
Chanda Prescod-Weinstein 🌌 @chanda.blacksky.app · 29/05/2025
The bipartisan framing of Chinese people as dangerous to the United States has been building up for years and has created this deeply racist and xenophobic opening for the Trump administration. I stand with my Chinese colleagues and all of our Chinese students. 🧪
washingtonpost.com
Trump administration to crack down on Chinese visas, applicants, Rubio says
Rubio said the State and Homeland Security departments will work to “aggressively revoke” visas of Chinese students in the United States, “including those with connections to the Chinese Communist Par...
17858248
Reposted by Xin Jin
Gary Schroth @genomics-guy.bsky.social · 29/05/2025
This administration is so stupid.
031
Reposted by Xin Jin
allen institute @alleninstitute.org · 21/05/2025
We've launched the Armamentarium, a new toolkit for targeted gene delivery to the brain and spinal cord. This #OpenScience resource was made possible thanks to support from the NIH BRAIN Initiative and teamwork with our collaborators. 🧠📈 www.nih.gov/news-events/...
nih.gov
Scientists design gene delivery systems for cells in the brain and spinal cord
NIH-funded breakthrough could enable targeted therapies for many neurological disorders.
06627
Reposted by Xin Jin
Kara Marshall @karalmarshall.bsky.social · 17/05/2025
Excellent interview with @baym.lol. This is all so destructive and senseless. Please share to spread the word.
032
Reposted by Xin Jin
Cedric Boeckx @cedricboeckx.bsky.social · 16/05/2025
New preprint alert 📣 #Cerebellum, organoid, autism & brain evolution 🧪 🧫🧠🧬 Collaboration with G. Testa; fruit of years of work by smart students, led by postdoc Davide Aprile. Organoids to understand better the developmental basis of autism (focus: CHD8) & sapiens brain evolution (focus: CADPS2) 🧵
biorxiv.org
Benchmarking cerebellar organoids to model autism spectrum disorder and human brain evolution
While cortical organoids have been used to model different facets of neurodevelopmental conditions and human brain evolution, cerebellar organoids have not yet featured so prominently in the same cont...
55926
Reposted by Xin Jin
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 09/04/2025
Great article by @nobelprize.bsky.social laureate @ardemp.bskyverified.social outlining the health, economic and national security benefits of US biomedical research, and the devastation of government efforts to destroy our leading edge. www.cnn.com/2025/04/09/h...
cnn.com
Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN
Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...
211549
Xin Jin @xinjin.bsky.social · 14/05/2025
Thrilled to share 2 reviews from the lab: 🧬Annual Review Functional Neurogenomics annualreviews.org/content/jour... 🧠Current Opinion high-throughput analysis of corticogenesis authors.elsevier.com/sd/article/S... Thanks to my labbies and the field—we were honored to showcase your work! #WeAreHiring
annualreviews.org
0145
Reposted by Xin Jin
David Malakoff @davidmalakoff.bsky.social · 13/05/2025
Another scoop from Jeff Mervis (@policyhound.bsky.social): NSF's ~1400 grant terminations have disproportionately affected PIs from groups underrepresented in science: women, racial & ethnic minorities, & those with disabilities. 1/3 www.science.org/content/arti...
science.org
Trump officials take steps toward a radically different NSF
Efforts to shrink staff, budget, and focus have alarmed members of Congress
15407310
Reposted by Xin Jin
Michael Baym @baym.lol · 14/05/2025
Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
A screenshot of the termination notice showing "Outstanding Investigator Grants"A screenshot of the termination notice with "This award is terminated effective the date of this award, due to unsafe antisemitic actions that suggest the institution lacks concern for the safety and wellbeing of Jewish students." highlighted
145875575
Xin Jin @xinjin.bsky.social · 09/05/2025
Science has its highs, lows, low-before-highs, and occassionally ‘cowboy hat + champagne’ plot twists. Not every day is easy, but some are downright legendary. Grateful for the laughs -- with colleagues that I adore
090
Reposted by Xin Jin
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 06/05/2025
The current administration’s narrative that Harvard (and all universities) feel “entitled” to federal dollars misleads the public. Nor are these funds a “privilege” 1/n
628082
Reposted by Xin Jin
Pierre Vanderhaeghen @vanderhaeghenp2.bsky.social · 29/03/2025
EMBOMtg Paris May 6-9 @aydoganlab.bsky.social @jamesbriscoe.bsky.social @brunetlab.bsky.social @ebisuyamiki.bsky.social @mwdorr.bsky.social @beyerlab.bsky.social @franckp.bsky.social @janereznick.bsky.social @olmedo-lab.bsky.social @perez-carrasco.bsky.social meetings.embo.org/event/25-dev...
meetings.embo.org
Developmental timing across species: From mechanisms to evolutionary insights
Like choreography, development consists of a highly ordered suite of steps and transitions. Modifying developmental tempo can affect final size and composition of tissues, as well as their plasticity…
04019
Reposted by Xin Jin
Ardem Patapoutian @ardemp.bskyverified.social · 19/03/2025
A few of us at Scripps had the pleasure of having dinner with the amazing @dulaclab.bsky.social after the first of two Kuffler lectures at UCSD! Great company with Lisa Stowers, @antihebbiann.bsky.social, and @xinjin.bsky.social
1602
Reposted by Xin Jin
Rick Huganir @rhuganir.bsky.social · 15/02/2025
I have been talking to the media, Time, Fortune, NBC, etc., to explain how the onslaught on science and NIH will impact the health of all Americans. Everyone knows someone who has cancer, heart disease, or depression. Spread the word about how cutting science impacts all. time.com/7216299/nih-...
time.com
Experts Call NIH Budget Cuts an 'Apocalypse' for Science
The reductions target indirect costs that cover administrative and equipment costs.
452062904
Reposted by Xin Jin
Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 14/02/2025
We are hearing that there is a meeting of all NIH IC directors happening now. We are also hearing, from several sources, rumors about director and assistant director level removals coming soon. The impact of this wld be enormous. IC directors have all grantmaking authority for each institute. 🧪
171368396
Xin Jin @xinjin.bsky.social · 12/02/2025
Despite the trying times, thrilled to share our @natprot.bsky.social Nature Protocols on massively parallel in vivo Perturb-seq: www.nature.com/articles/s41... Grateful for the excellent primer by Christopher Bock and Eugenia Pankevich: www.nature.com/articles/s41...
nature.com
Massively parallel in vivo Perturb-seq screening - Nature Protocols
This protocol leverages tailored adeno-associated virus vectors for effective delivery of pooled CRISPR-based genetic perturbations in live animals combined with single-cell gene expression readout of...
07317
Reposted by Xin Jin
Sri Kosuri @srikosuri.bsky.social · 08/02/2025
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
841009846
Reposted by Xin Jin
Seth Blackshaw @sethblackshaw.bsky.social · 08/02/2025
To my friends and colleagues at UAB, IU, UF, FSU, UL, WashU, OSU, CWRU, etc, etc. Call both your senators and your representative. They listen. Emphasize the direct economic impact of NIH research, and the indirect impacts on pharmaceutical/biotech. Underscore its relevance to national security.
613991
Xin Jin @xinjin.bsky.social · 08/02/2025
Devastating. It's called indirect costs but there’s nothing 'indirect' about it. It covers electricity, HR, payroll, research core facilities: the kind of costs that any business would budget for as essentials. They are everything that keeps science running.
030
Reposted by Xin Jin
Society for Neuroscience @sfn.org · 06/02/2025
Federal restrictions & funding freezes threaten vital research and halts scientific progress that benefits all Americans. Join fellow #NeuroAdvocates in urging Congress to protect congressionally approved funding & ensure uninterrupted support for the scientific workforce. 👇 #NeuroSky
112396