santiago, phd 🐈⬛ @santiagokique.bsky.social · 16/09/2026I had a patient with ADEM on Peds. A healthy teen living a normal life, suddenly unable to walk, speak, eat, could only recognize his mother. A former honor student now deeply cognitively impaired. Hospitalized for months and lost effectively all their muscle mass. (1/2) 100
santiago, phd 🐈⬛ @santiagokique.bsky.social · 16/09/2026NSF will no longer be giving grants to individuals based on their ideas, but pivot towards “implementing Trump’s golden age of science” www.science.org/content/arti...science.orgNSF memo implementing Trump’s ‘golden age’ of science unsettles researchersNew document emphasizes support for White House priorities over curiosity-driven ideas 001
santiago, phd 🐈⬛ @santiagokique.bsky.social · 06/09/2026We’re long past evidence mattering in this discussion but I remember when “natural evolution can’t do furin cleavage sites” was the fulcrum of lab leak discourse. Well here’s another naturally evolved furin cleavage site in beta coronavirus. www.nature.com/articles/s41...nature.comA divergent betacoronavirus with a functional furin cleavage site in South American bats - Nature CommunicationsThere is still limited data reported on virus diversity in South American bats. In this study, the authors report a divergent betacoronavirus with a functional furin cleavage site in South American ba... 010
santiago, phd 🐈⬛ @santiagokique.bsky.social · 05/09/2026After years of harping on about the “biomedical security state”, Jay Bhattacharya has signed away hundreds of millions of biomedical research dollars to the U.S.’ doomed imperial exploits www.nature.com/articles/d41...nature.comRevealed: inside the US military's plan to tap huge sums from the NIHAn agreement paves the way for hundreds of millions of dollars’ worth of projects to be transferred from the NIH’s institute for infectious diseases to the Department of Defense. 173
santiago, phd 🐈⬛ @santiagokique.bsky.social · 11/08/2026I’m not gonna discourse the term “woke 1” cuz it’s pointless but I wrote pretty much everything I had to say about how it was crazy here: primafacie.substack.com/p/spare-the-...primafacie.substack.comspare the rod 1reviewing institutional discipline from George Floyd in 2020 to Palestine in 2023 000
Reposted by santiago, phd 🐈⬛santiago, phd 🐈⬛ @santiagokique.bsky.social · 21/05/2026He also shared an interesting story I didn’t know about: his work as a research fellow devising the first treatment for GPA (then called Wegener’s polyangiitis). A very simple idea grounded in solid understanding of basic biology. At the time he was an NIH fellow, … www.nejm.org/doi/full/10....nejm.orgCyclophosphamide Therapy of Severe Systemic Necrotizing Vasculitis | NEJMWe studied 17 patients with severe systemic necrotizing vasculitis over an 11-year-period. Sixteen patients were treated daily with cyclophosphamide (2 mg per kilogram per day), and one was treated... 1122
santiago, phd 🐈⬛ @santiagokique.bsky.social · 31/07/2026Re-upping this bc this man whose dedicated his entire life to public service is being dragged through the mud by the dumbest and worst faith people on earth to provide a side-show for their rapidly evaporating political base of rabid conspiracists 191
santiago, phd 🐈⬛ @santiagokique.bsky.social · 16/07/2026Imagine not being able to accrue your clinical trial bc a mob of degen gamblers w/ no knowledge of medicine, biology, pharma, or trials is split 60/40 against hitting your endpoints www.statnews.com/2026/07/16/k... via @statnews.comstatnews.comKalshi comes for biopharma, with prediction markets for clinical trials and FDA approvalsPrediction markets have permeated the worlds of sports, politics, and reality television shows. Now, the biopharma industry could be next. 010
santiago, phd 🐈⬛ @santiagokique.bsky.social · 28/06/2026tf is this dawg if you need a laser to call an offsides it’s not offside. Paid for by Big Ronaldo 032
santiago, phd 🐈⬛ @santiagokique.bsky.social · 27/06/2026I think a good metaphor for biology amid the “can we just compute biology” discourse is trying to deduce the existence and specific rules of the game of futbol from a table of the different kinds of shoes worn by everyone inside a stadium at any given time 110
santiago, phd 🐈⬛ @santiagokique.bsky.social · 29/05/2026From the MIT president, Sally Kornbluth, a good distillation of the current mood in science: technically, it has never been a more exciting time to be in biomedical research; politically and economically, everyone is at the lowest they’ve ever been. www.statnews.com/2026/05/27/s...statnews.comMIT president: Why so many optimistic scientists are losing heart“This erosion of our strength is a loss for the nation,” writes MIT President Sally Kornbluth. 010
santiago, phd 🐈⬛ @santiagokique.bsky.social · 23/05/2026This is facts I saw 2 pheos in one week on endocrine surgery lol 121
santiago, phd 🐈⬛ @santiagokique.bsky.social · 21/05/2026Dr. Fauci came to Stanford for Medicine grand rounds and shared a few reflections I thought were worth passing on: The first was about Operation Warp Speed and the current state of the NIH. As you’ll recall the first mRNA vax was developed at record speed. Fauci atttributes that success to 4 factors 321670
Reposted by santiago, phd 🐈⬛santiago, phd 🐈⬛ @santiagokique.bsky.social · 15/05/2026New blog post about that Science paper from a couple of weeks ago that tested LLMs against ED physicians in a retrospective “trial” of differential diagnosis open.substack.com/pub/primafac...open.substack.comAI performs at the level of an intern?RE: "Performance of a large language model on the reasoning tasks of a physician." Science 2026 042
santiago, phd 🐈⬛ @santiagokique.bsky.social · 15/05/2026New blog post about that Science paper from a couple of weeks ago that tested LLMs against ED physicians in a retrospective “trial” of differential diagnosis open.substack.com/pub/primafac...open.substack.comAI performs at the level of an intern?RE: "Performance of a large language model on the reasoning tasks of a physician." Science 2026 042
santiago, phd 🐈⬛ @santiagokique.bsky.social · 26/04/2026Good Op-Ed this week from first-year medical students re: the recently announced DOJ investigation into Stanford admissions stanforddaily.com/2026/04/19/d...stanforddaily.comThe DOJ is targeting Stanford Medicine's nonexistent problemAkeke and Zhang defend against the DOJ's investigation into Stanford Medicine and advocate for the importance of diversity consideration in admissions. 031
santiago, phd 🐈⬛ @santiagokique.bsky.social · 25/04/2026this 100% AI generated image is spooking folks rightfully concerned about research integrity. Yes, it’s very realistic albeit too clean. My humble proposal: perfect use case for blockchain. Gel reader generates token when image canned with “for pub” setting, tracked through editors/Illustrator 130
Reposted by santiago, phd 🐈⬛James Goodwin @jamesgoodwin.bsky.social · 05/04/2026I have to read this one in short spurts. It is killing me. www.nytimes.com/2026/04/04/b...nytimes.comTrump Slashed Science Funding. Now the U.S. Could Face a Costly Brain Drain. 2219
santiago, phd 🐈⬛ @santiagokique.bsky.social · 04/04/2026www.statnews.com/2026/04/03/p...statnews.comMy patient would rather take a peptide than a statin. That reveals an uncomfortable truth in medicine“The volume of evidence behind a therapy has become inversely correlated with public trust in it,” writes Vikas Patel. 010
Reposted by santiago, phd 🐈⬛Kathleen Bachynski @bachynski.bsky.social · 04/04/2026“For weeks, the FDA has been asking a raw-dairy farm in California to recall its Cheddar cheese, which the agency has linked to nine E. coli illnesses in California, Texas and Florida. On Thursday, the dairy farm, Raw Farm LLC, finally complied, though it said it was doing so “under protest”nytimes.com‘Under Protest,’ Raw Dairy Farm Recalls Cheddar Linked to 9 E. Coli Cases 35826
santiago, phd 🐈⬛ @santiagokique.bsky.social · 29/03/2026The 2020s? You mean first decade of the Iran war? 000
santiago, phd 🐈⬛ @santiagokique.bsky.social · 26/03/2026The Trump admin is launching an “investigation” into “racial discrimination” in medical school admissions at 3 schools, including ours. In light of this, reposting one of my old blog posts about the longstanding obsession around race and merit in medicine substack.com/@primafacie/...substack.comsantiago e sanchez (@primafacie)In light of the scotus ruling, re-sharing my post on the myth of meritocracy and the conservative crusade against AA https://open.substack.com/pub/primafacie/p/best-and-brightest?r=1wbx1d&utm_medium=... 112
Reposted by santiago, phd 🐈⬛skáld @danglinghemmie.bsky.social · 20/03/2026the fundamental issue with american education, deeply infecting both parties, is thinking that learning is primarily about children consuming content that is being delivered and being graded on how well they retain it, rather than learning being a process that teaches a student *how to learn* 311722
Reposted by santiago, phd 🐈⬛Kat Stafford @katstafford.bsky.social · 18/03/2026EXCLUSIVE: Vaccination rates among young children in Michigan dropped sharply during the first year of the Trump administration, providing an early indication of how vaccine-skeptic Health Secretary Robert F. Kennedy Jr. is influencing immunization practices. www.reuters.com/business/hea...reuters.comChild vaccination rate drops sharply in Michigan under RFK Jr's influenceVaccination rates among young children in Michigan dropped sharply during the first year of the Trump administration, a Reuters analysis of state data shows, providing an early indication of how vacci... 613158
Reposted by santiago, phd 🐈⬛Kristian G. Andersen @kgandersen.bsky.social · 17/03/2026I'm glad to see this being covered - because, frankly, this is a death-blow to collaborative science - however, the assumption of good faith in any of these decisions by reporters is mind-boggling. This is happening for one reason - to assure top-down control of what gets funded and what does not. 312845
santiago, phd 🐈⬛ @santiagokique.bsky.social · 13/03/2026Love 2 have spent the last 10 years of my life training to be a physician scientist! Only 6 more years to go! 001
santiago, phd 🐈⬛ @santiagokique.bsky.social · 12/03/2026this is somehow the most podcast brained thing this admin has done 000
santiago, phd 🐈⬛ @santiagokique.bsky.social · 09/03/2026It’s going to be one of those weeks where decades happen. 010
santiago, phd 🐈⬛ @santiagokique.bsky.social · 08/03/2026MerlinID from Cornell is one of the best apps ever made. Uses your mic to listen to bird songs and tells you what birds are hanging out around you. 031
santiago, phd 🐈⬛ @santiagokique.bsky.social · 08/03/2026this is a deeply, perhaps irredeemably sick country newrepublic.com/post/207415/...newrepublic.comCPAC Head Says Iranian Schoolgirls Are Better Dead Than “in a Burqa”Leading Republicans don’t seem to care about the bombing of a girls’ school in Iran. 031
santiago, phd 🐈⬛ @santiagokique.bsky.social · 08/03/2026www.ft.com/content/eaec...ft.comShips in Gulf declare themselves Chinese to dodge attackAt least 10 vessels have changed transponder messages in apparent attempt to avoid becoming targets 110
Reposted by santiago, phd 🐈⬛Justin Ling @justinling.ca · 07/03/2026Local Massachusetts weekly says it's confirmed that the Pentagon was relying on Claude for strike targeting, which is how they came to bomb a girls' school. thisweekinworcester.com/exclusive-ai...thisweekinworcester.comExclusive: AI Error Likely Led to Iran Girl's School BombingPentagon investigators believe a bombing of a girls' school in Iran on Saturday likely resulted from inaccurate information provided by AI. 881137584
santiago, phd 🐈⬛ @santiagokique.bsky.social · 05/03/2026Forbes estimates the Iran war will cost you and me between 1.25 to 6 annual NIH budgets, depending on how long it lasts. Internally, CENTCOM is anticipating the war to last until at least September. 100
santiago, phd 🐈⬛ @santiagokique.bsky.social · 04/03/2026Event Prediction markets need to be made illegal immediately. 000
Reposted by santiago, phd 🐈⬛Steve Postman 🇨🇦 @steve1970peng.bsky.social · 02/03/2026Eisenhower 365156665863
Reposted by santiago, phd 🐈⬛Ben Collins @bencollins.bsky.social · 28/02/2026We killed 85 schoolgirls. We are not the good guys.france24.comUS-Israeli strike on girls' school kills at least 85 students, Iran's judiciary saysAt least 85 students have been killed in US-Israeli strikes that hit an Iranian girls' school in Hormozgan province, Iran's judiciary said on Saturday. Washington has not commented on the reported str... 453168566432
Reposted by santiago, phd 🐈⬛Dave Itzkoff @ditzkoff.bsky.social · 28/02/2026theonion.com/this-war-wil... 433635813
Reposted by santiago, phd 🐈⬛Peter Tennant @pwgtennant.bsky.social · 25/02/2026This recent RCT of an "AI stethoscope" claims the technology "shows promise" for diagnosing cardiovascular conditions. It does not. It is a textbook example of the risks of conducting unprincipled 'per protocol analyses'. Once again, peer review at a major medical journal has failed. 🧵 1/ 8435185
Reposted by santiago, phd 🐈⬛Brent Snavely @brentasnavely.bsky.social · 25/02/2026bsky.app/profile/domi... 163
Reposted by santiago, phd 🐈⬛Chanda Prescod-Weinstein 🌌 @chanda.blacksky.app · 20/02/2026Holy fuck! 🧪 www.science.org/doi/10.1126/...science.orgMucosal vaccination in mice provides protection from diverse respiratory threatsTraditional vaccines target specific pathogens, limiting their scope against diverse respiratory threats. We describe an intranasal liposomal formulation combining toll-like receptor (TLR) 4 and 7/8 l... 9461157
Reposted by santiago, phd 🐈⬛Kathleen Bachynski @bachynski.bsky.social · 20/02/2026Today, “U.S. Representative Summer Lee, Democrat of Pittsburgh, is introducing a resolution to award Freedom House with the Congressional Gold Medal, the highest civilian honor a person or institution can receive from Congress. The resolution is being co-sponsored by Representative Mike Kelly”nytimes.comBlack Medics, Ahead of Their Time, Gain Belated Recognition 3259
Reposted by santiago, phd 🐈⬛Olúfẹ́mi O. Táíwò @olufemiotaiwo.bsky.social · 03/08/2025Niemöller was asked by his concentration camp cellmate why he had ever supported Hitler and the Nazis. Reportedly, this is what he had to say for himself: 633084985