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🪾santiago, phd 🐈‍⬛

@santiagokique.bsky.social
615 followers 924 following 2K posts

Vnzln 🇻🇪 MD/PhD candidate @ Stanford 🌲 I study telomere biology in health and disease; I write about science and politics blogs @ primafacie.substack.com

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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 16/09/2026
I had a patient with ADEM on Peds. A healthy teen living a normal life, suddenly unable to walk, speak, eat, could only recognize his mother. A former honor student now deeply cognitively impaired. Hospitalized for months and lost effectively all their muscle mass. (1/2)
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 16/09/2026
NSF will no longer be giving grants to individuals based on their ideas, but pivot towards “implementing Trump’s golden age of science” www.science.org/content/arti...
science.org
NSF memo implementing Trump’s ‘golden age’ of science unsettles researchers
New document emphasizes support for White House priorities over curiosity-driven ideas
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 13/09/2026
Who’s 32 year-old 10 year-old is this
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 06/09/2026
Paul Verhoeven is a prophet
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 06/09/2026
We’re long past evidence mattering in this discussion but I remember when “natural evolution can’t do furin cleavage sites” was the fulcrum of lab leak discourse. Well here’s another naturally evolved furin cleavage site in beta coronavirus. www.nature.com/articles/s41...
nature.com
A divergent betacoronavirus with a functional furin cleavage site in South American bats - Nature Communications
There is still limited data reported on virus diversity in South American bats. In this study, the authors report a divergent betacoronavirus with a functional furin cleavage site in South American ba...
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 05/09/2026
After years of harping on about the “biomedical security state”, Jay Bhattacharya has signed away hundreds of millions of biomedical research dollars to the U.S.’ doomed imperial exploits www.nature.com/articles/d41...
nature.com
Revealed: inside the US military's plan to tap huge sums from the NIH
An agreement paves the way for hundreds of millions of dollars’ worth of projects to be transferred from the NIH’s institute for infectious diseases to the Department of Defense.
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 11/08/2026
I’m not gonna discourse the term “woke 1” cuz it’s pointless but I wrote pretty much everything I had to say about how it was crazy here: primafacie.substack.com/p/spare-the-...
primafacie.substack.com
spare the rod 1
reviewing institutional discipline from George Floyd in 2020 to Palestine in 2023
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 21/05/2026
He also shared an interesting story I didn’t know about: his work as a research fellow devising the first treatment for GPA (then called Wegener’s polyangiitis). A very simple idea grounded in solid understanding of basic biology. At the time he was an NIH fellow, … www.nejm.org/doi/full/10....
nejm.org
Cyclophosphamide Therapy of Severe Systemic Necrotizing Vasculitis | NEJM
We studied 17 patients with severe systemic necrotizing vasculitis over an 11-year-period. Sixteen patients were treated daily with cyclophosphamide (2 mg per kilogram per day), and one was treated...
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 31/07/2026
Re-upping this bc this man whose dedicated his entire life to public service is being dragged through the mud by the dumbest and worst faith people on earth to provide a side-show for their rapidly evaporating political base of rabid conspiracists
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 16/07/2026
Imagine not being able to accrue your clinical trial bc a mob of degen gamblers w/ no knowledge of medicine, biology, pharma, or trials is split 60/40 against hitting your endpoints www.statnews.com/2026/07/16/k... via @statnews.com
statnews.com
Kalshi comes for biopharma, with prediction markets for clinical trials and FDA approvals
Prediction markets have permeated the worlds of sports, politics, and reality television shows. Now, the biopharma industry could be next.
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 28/06/2026
tf is this dawg if you need a laser to call an offsides it’s not offside. Paid for by Big Ronaldo
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 27/06/2026
I think a good metaphor for biology amid the “can we just compute biology” discourse is trying to deduce the existence and specific rules of the game of futbol from a table of the different kinds of shoes worn by everyone inside a stadium at any given time
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 29/05/2026
From the MIT president, Sally Kornbluth, a good distillation of the current mood in science: technically, it has never been a more exciting time to be in biomedical research; politically and economically, everyone is at the lowest they’ve ever been. www.statnews.com/2026/05/27/s...
statnews.com
MIT president: Why so many optimistic scientists are losing heart
“This erosion of our strength is a loss for the nation,” writes MIT President Sally Kornbluth.
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 23/05/2026
This is facts I saw 2 pheos in one week on endocrine surgery lol
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Good Trailcams @goodtrailcams.bsky.social · 21/05/2026
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 21/05/2026
Dr. Fauci came to Stanford for Medicine grand rounds and shared a few reflections I thought were worth passing on: The first was about Operation Warp Speed and the current state of the NIH. As you’ll recall the first mRNA vax was developed at record speed. Fauci atttributes that success to 4 factors
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 15/05/2026
New blog post about that Science paper from a couple of weeks ago that tested LLMs against ED physicians in a retrospective “trial” of differential diagnosis open.substack.com/pub/primafac...
open.substack.com
AI performs at the level of an intern?
RE: "Performance of a large language model on the reasoning tasks of a physician." Science 2026
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 15/05/2026
New blog post about that Science paper from a couple of weeks ago that tested LLMs against ED physicians in a retrospective “trial” of differential diagnosis open.substack.com/pub/primafac...
open.substack.com
AI performs at the level of an intern?
RE: "Performance of a large language model on the reasoning tasks of a physician." Science 2026
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 26/04/2026
Good Op-Ed this week from first-year medical students re: the recently announced DOJ investigation into Stanford admissions stanforddaily.com/2026/04/19/d...
stanforddaily.com
The DOJ is targeting Stanford Medicine's nonexistent problem
Akeke and Zhang defend against the DOJ's investigation into Stanford Medicine and advocate for the importance of diversity consideration in admissions.
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 25/04/2026
this 100% AI generated image is spooking folks rightfully concerned about research integrity. Yes, it’s very realistic albeit too clean. My humble proposal: perfect use case for blockchain. Gel reader generates token when image canned with “for pub” setting, tracked through editors/Illustrator
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James Goodwin @jamesgoodwin.bsky.social · 05/04/2026
I have to read this one in short spurts. It is killing me. www.nytimes.com/2026/04/04/b...
nytimes.com
Trump Slashed Science Funding. Now the U.S. Could Face a Costly Brain Drain.
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 04/04/2026
www.statnews.com/2026/04/03/p...
statnews.com
My patient would rather take a peptide than a statin. That reveals an uncomfortable truth in medicine
“The volume of evidence behind a therapy has become inversely correlated with public trust in it,” writes Vikas Patel.
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Kathleen Bachynski @bachynski.bsky.social · 04/04/2026
“For weeks, the FDA has been asking a raw-dairy farm in California to recall its Cheddar cheese, which the agency has linked to nine E. coli illnesses in California, Texas and Florida. On Thursday, the dairy farm, Raw Farm LLC, finally complied, though it said it was doing so “under protest”
nytimes.com
‘Under Protest,’ Raw Dairy Farm Recalls Cheddar Linked to 9 E. Coli Cases
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 29/03/2026
The 2020s? You mean first decade of the Iran war?
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 26/03/2026
The Trump admin is launching an “investigation” into “racial discrimination” in medical school admissions at 3 schools, including ours. In light of this, reposting one of my old blog posts about the longstanding obsession around race and merit in medicine substack.com/@primafacie/...
substack.com
santiago e sanchez (@primafacie)
In light of the scotus ruling, re-sharing my post on the myth of meritocracy and the conservative crusade against AA https://open.substack.com/pub/primafacie/p/best-and-brightest?r=1wbx1d&utm_medium=...
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skáld @danglinghemmie.bsky.social · 20/03/2026
the fundamental issue with american education, deeply infecting both parties, is thinking that learning is primarily about children consuming content that is being delivered and being graded on how well they retain it, rather than learning being a process that teaches a student *how to learn*
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Kat Stafford @katstafford.bsky.social · 18/03/2026
EXCLUSIVE: Vaccination rates among young children in Michigan dropped sharply during the first year of the Trump administration, providing an early indication of how vaccine-skeptic Health Secretary Robert F. Kennedy Jr. is influencing immunization practices. www.reuters.com/business/hea...
reuters.com
Child vaccination rate drops sharply in Michigan under RFK Jr's influence
Vaccination rates among young children in Michigan dropped sharply during the first year of the Trump administration, a Reuters analysis of state data shows, providing an early indication of how vacci...
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Kristian G. Andersen @kgandersen.bsky.social · 17/03/2026
I'm glad to see this being covered - because, frankly, this is a death-blow to collaborative science - however, the assumption of good faith in any of these decisions by reporters is mind-boggling. This is happening for one reason - to assure top-down control of what gets funded and what does not.
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 13/03/2026
Love 2 have spent the last 10 years of my life training to be a physician scientist! Only 6 more years to go!
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 12/03/2026
this is somehow the most podcast brained thing this admin has done
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 09/03/2026
It’s going to be one of those weeks where decades happen.
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 08/03/2026
MerlinID from Cornell is one of the best apps ever made. Uses your mic to listen to bird songs and tells you what birds are hanging out around you.
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 08/03/2026
this is a deeply, perhaps irredeemably sick country newrepublic.com/post/207415/...
newrepublic.com
CPAC Head Says Iranian Schoolgirls Are Better Dead Than “in a Burqa”
Leading Republicans don’t seem to care about the bombing of a girls’ school in Iran.
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 08/03/2026
www.ft.com/content/eaec...
ft.com
Ships in Gulf declare themselves Chinese to dodge attack
At least 10 vessels have changed transponder messages in apparent attempt to avoid becoming targets
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Justin Ling @justinling.ca · 07/03/2026
Local Massachusetts weekly says it's confirmed that the Pentagon was relying on Claude for strike targeting, which is how they came to bomb a girls' school. thisweekinworcester.com/exclusive-ai...
thisweekinworcester.com
Exclusive: AI Error Likely Led to Iran Girl's School Bombing
Pentagon investigators believe a bombing of a girls' school in Iran on Saturday likely resulted from inaccurate information provided by AI.
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 05/03/2026
Forbes estimates the Iran war will cost you and me between 1.25 to 6 annual NIH budgets, depending on how long it lasts. Internally, CENTCOM is anticipating the war to last until at least September.
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 04/03/2026
Event Prediction markets need to be made illegal immediately.
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 03/03/2026
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Steve Postman 🇨🇦 @steve1970peng.bsky.social · 02/03/2026
Eisenhower
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Ben Collins @bencollins.bsky.social · 28/02/2026
We killed 85 schoolgirls. We are not the good guys.
france24.com
US-Israeli strike on girls' school kills at least 85 students, Iran's judiciary says
At least 85 students have been killed in US-Israeli strikes that hit an Iranian girls' school in Hormozgan province, Iran's judiciary said on Saturday. Washington has not commented on the reported str...
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 28/02/2026
2 days ago
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Dave Itzkoff @ditzkoff.bsky.social · 28/02/2026
theonion.com/this-war-wil...
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Peter Tennant @pwgtennant.bsky.social · 25/02/2026
This recent RCT of an "AI stethoscope" claims the technology "shows promise" for diagnosing cardiovascular conditions. It does not. It is a textbook example of the risks of conducting unprincipled 'per protocol analyses'. Once again, peer review at a major medical journal has failed. 🧵 1/
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Brent Snavely @brentasnavely.bsky.social · 25/02/2026
bsky.app/profile/domi...
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Pirek ✨ @pirek.bsky.social · 24/02/2026
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Chanda Prescod-Weinstein 🌌 @chanda.blacksky.app · 20/02/2026
Holy fuck! 🧪 www.science.org/doi/10.1126/...
science.org
Mucosal vaccination in mice provides protection from diverse respiratory threats
Traditional vaccines target specific pathogens, limiting their scope against diverse respiratory threats. We describe an intranasal liposomal formulation combining toll-like receptor (TLR) 4 and 7/8 l...
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Kathleen Bachynski @bachynski.bsky.social · 20/02/2026
Today, “U.S. Representative Summer Lee, Democrat of Pittsburgh, is introducing a resolution to award Freedom House with the Congressional Gold Medal, the highest civilian honor a person or institution can receive from Congress. The resolution is being co-sponsored by Representative Mike Kelly”
nytimes.com
Black Medics, Ahead of Their Time, Gain Belated Recognition
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Olúfẹ́mi O. Táíwò @olufemiotaiwo.bsky.social · 03/08/2025
Niemöller was asked by his concentration camp cellmate why he had ever supported Hitler and the Nazis. Reportedly, this is what he had to say for himself:
Screenshot from Niemöller's Wikipedia entry, which reads:

"I find myself wondering about that too. I wonder about it as much as I regret it. Still, it is true that Hitler betrayed me. I had an audience with him, as a representative of the Protestant Church, shortly before he became Chancellor, in 1932. Hitler promised me on his word of honor, to protect the Church, and not to issue any anti-Church laws. He also agreed not to allow pogroms against the Jews, assuring me as follows: "There will be restrictions against the Jews, but there will be no ghettos, no pogroms, in Germany."

I really believed, given the widespread anti-Semitism in Germany, at that time – that Jews should avoid aspiring to Government positions or seats in the Reichstag. There were many Jews, especially among the Zionists, who took a similar stand. Hitler's assurance satisfied me at the time. On the other hand, I hated the growing atheistic movement, which was fostered and promoted by the Social Democrats and the Communists. Their hostility toward the Church made me pin my hopes on Hitler for a while."
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