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Xin Jin

@xinjin.bsky.social
493 followers 263 following 49 posts

Building neurotech to study how genes and physiology impact brain function 🧬 🧠 Associate Professor, Scripps Research | Freeman Hrabowski Scholar, HHMI

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Xin Jin @xinjin.bsky.social · 19/06/2026
Excited to share Keystone on Neurodevelopmental Disorders in Colorado Jan 2027! ⛷️ with Tom Nowakowski, Stephan Sanders & Joe Zhou 🌟Amazing lineup keynotes from Allyson Berent & Huda Zoghbi! ⏰Abstracts/scholarship due 9/24, Poster abstract due 9/29 Join us: keystonesymposia.org/conferences/...
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Xin Jin @xinjin.bsky.social · 10/04/2026
Thanks Alex! Let’s chat!!
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Ardem Patapoutian @ardemp.bskyverified.social · 10/04/2026
These rankings are kinda silly… but hey, we’re #1 🍾🥂🥳
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Xin Jin @xinjin.bsky.social · 09/04/2026
7/7 We hope Perturb-CLEAR helps connect genomics & neuroanatomy: how mutations reshape circuit-relevant cytoarchitecture in disease: multimodal data matters! Thank you Joshua Levin, William Yang, awesome collaborators & team, especially the phenomenal Boli Wu leading this! -FIN-
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Xin Jin @xinjin.bsky.social · 09/04/2026
6/7 Paired in vivo Perturb-seq revealed matched molecular phenotypes, allowing us to ask when transcriptional disruption propagates into structural remodeling. In some cases, the two modalities aligned strongly; in others, molecular change and structural outcome diverged
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Xin Jin @xinjin.bsky.social · 09/04/2026
5/7 We then applied Perturb-CLEAR to KO neurodevelopmental disorder genes and found perturbation effects were not uniform: Different genes produced distinct outcomes, with specific vulnerabilities emerging across cell types and across different parts of dendritic architecture
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Xin Jin @xinjin.bsky.social · 09/04/2026
4/7 We mapped how structure changes over time in WT neurons and related those dynamics to RNA programs, revealing coordinated and highly structured remodeling e.g. ASD risk genes were enriched in “stabilizing” program, pointing to an early postnatal window of vulnerability
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Xin Jin @xinjin.bsky.social · 09/04/2026
3/7 TLDR: we use in vivo CRISPR+whole-brain imaging to capture cytoarchitectures📸 Transcriptional signal alone does not reliably predict structural outcomes. To understand how disease genes reshape the circuit, we need multimodal readouts on molecular state + cellular form!
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Xin Jin @xinjin.bsky.social · 09/04/2026
2/7 Many of us ask how genetics reshapes the brain at the level of cellular structure. We now can profile molecular outcomes w scRNAseq at scale, but morphology - especially long-range cytoarchetecture - has remained much harder to measure systematically in pooled screens in vivo
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Xin Jin @xinjin.bsky.social · 09/04/2026
Form follows function, or function dictates form? 📢Preprint: we build Perturb-CLEAR, in vivo screen of neuroanatomy! Disease perturbations produce selective morphology-RNA changes that RNA impact alone cannot predict. Was led by the invincible grad student Boli Wu! www.biorxiv.org/content/10.6...
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Alejandro Montenegro @aemonten.bsky.social · 09/04/2026
Xin Jin FTW! "We developed Perturb-CLEAR, which integrates pooled CRISPR screening and whole-mount imaging to quantify brain-wide cytoarchitecture, and paired it with Perturb-seq to link structural phenotypes to transcriptomic changes." www.biorxiv.org/content/10.6...
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supriyasri.bsky.social @supriyasri.bsky.social · 02/04/2026
Thrilled to announce Critical Mass Ventures, a philanthropic initiative bridging science, capital, and community to close the gap between lifespan and healthspan. Our inaugural postdoc fellowship is now open. 🔬 criticalmassventures.co #ScienceSky #AcademicSky #Healthspan #Longevity #Postdoc
criticalmassventures.co
Critical Mass Ventures
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Cedric Boeckx @cedricboeckx.bsky.social · 19/03/2026
“Genome-scale functional mapping of the mammalian whole brain with in vivo Perturb-seq” Truly impressive work by @xinjin.bsky.social 🤯🧪🧬🧠 www.biorxiv.org/content/10.6...
biorxiv.org
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Xin Jin @xinjin.bsky.social · 17/03/2026
Excited to introduce @perturb.ai, a company I co-founded to rethink drug discovery. Biology is complex, and disease unfolds across genes, cell types, and tissues. We’re powering AI with the causal logic of human genetics www.perturb.ai/news
perturb.ai
News | Explore Cutting-Edge Gene Editing Technologies — PerturbAI
Discover the latest updates and breakthroughs in gene editing with PerturbAI's news on CRISPR innovations and collaborations. Stay informed today.
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Xin Jin @xinjin.bsky.social · 17/03/2026
Led by the invincible Xinhe Zheng with long-time collaborator Joshua Levin, Kwanho Kim, Sean Simmons, and everyone on the team who made this possible. Constructs available on Addgene soon
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Xin Jin @xinjin.bsky.social · 17/03/2026
We applied this to disease genes in the developing cortex and profiled >85,000 neurons. Broadly expressed genes show high cell-type-specific RNA and ATAC effects, revealing regulatory programs invisible to bulk or unimodal assays. Toward causal gene regulatory models in complex tissues!
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Xin Jin @xinjin.bsky.social · 17/03/2026
With this approach, we can: • anchor gRNA-derived transcripts at the nuclear membrane • capture gRNAs directly during sn-multiome preparation • read out RNA and ATAC jointly in CRISPR screens in vivo
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Xin Jin @xinjin.bsky.social · 17/03/2026
Excited to share: enhanced capture in vivo multiome Perturb-seq! Worried about low gRNA recovery and wasting sequencing on cells that can’t assign a perturbation? We engineered gRNA transcripts to stay in the nucleus, enabling efficient multiomic Perturb-seq! www.biorxiv.org/content/10.6...
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Scripps Research @scripps.edu · 17/02/2026
Assoc. Prof. @xinjin.bsky.social has been named a 2026 Sloan Research Fellow by the @sloanfoundation.bsky.social, recognized for pioneering in vivo Perturb-seq—a gene-editing approach combining CRISPR technology and single-cell RNA analysis to uncover how genetic variation shapes brain development.
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Xin Jin receives prestigious Sloan Research Fellowship - Scripps Research Magazine
Xin Jin, an associate professor at Scripps Research and a Freeman Hrabowski Scholar at Howard Hughes Medical Institute, has been awarded a Sloan Research Fellowship for her exceptional research and le...
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Xin Jin @xinjin.bsky.social · 05/02/2026
It was such an amazing visit at Utah Neuroscience! I learn from such a diverse crowd of neuroscientists doing super cutting edge works in many fields - and their trainees who are engaging and thoughtful. Campus view is unbelievable! Thank you @jasonsynaptic.bsky.social for having me!
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HHMI @hhmi-science.bsky.social · 18/11/2025
Calling all rising juniors & seniors: Interested in biological or biomedical research? Applications for our ’26 Summer Undergraduate Research Experience Program are now open! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: bit.ly/CechFellows
bit.ly
Summer Undergraduate Research Experience | HHMI
The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.
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Scripps Research @scripps.edu · 10/10/2025
The NIH has awarded a $14.2M Director’s Transformative Research Award to a team led by Nobel Prize-winning neuroscientist @ardemp.bskyverified.social, Prof. @liye-tsri.bsky.social and Assoc. Prof. @xinjin.bsky.social to map interoception and build the first atlas of this hidden sixth sense.
scripps.edu
Scripps Research-led team receives $14.2M NIH award to map the body’s “hidden sixth sense”
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Xin Jin @xinjin.bsky.social · 08/10/2025
Coming to #SfN2025 in San Diego? Come join our Neuroscience Symposium a day before on Nov 13! Hear from a fantastic speaker lineup and interact with vibrant audience in our community and beyond. Free registration link: www.eventbrite.com/e/dorris-neu...
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Xin Jin @xinjin.bsky.social · 02/10/2025
Actively hiring! Video made by Sora-2 but the job post is 100% real. Apply here: hhmi.wd1.myworkdayjobs.com/en-US/Extern...
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Xin Jin @xinjin.bsky.social · 13/09/2025
And to my Freeman Hrabowski Scholar cohort: what an inspiring group to be part of. Every talk was effortlessly pitch-perfect, and your brilliance gives the most healthy dosage and best kind of imposter-syndrome fuel #FHS25Strong
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Xin Jin @xinjin.bsky.social · 13/09/2025
First time bringing my fantastic students to the HHMI Science Meeting and they absolutely shined at the session! ✨ It remains one of the most stimulating mtg — I’m science-starstruck every 10 min. We’re grateful for the chance to spark new collaborations that will take our technologies further
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The Rockefeller University @rockefeller.edu · 18/08/2025
We are deeply saddened to share that our friend and colleague Jim Hudspeth passed away on Saturday. We will remember and continue to be inspired by Jim’s integrity, his humility, and his unwavering commitment to discovery.
rockefeller.edu
A. James Hudspeth, neuroscientist who unlocked secrets of hearing, has died - News
A. James Hudspeth, a Rockefeller neuroscientist who discovered how sound waves are converted into electrical signals in the ear's cochlea, died Saturday at his home in Manhattan. A pioneering scientist and dedicated mentor, he was the university's F.M. ...
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Sten Linnarsson @sten.linnarsson.org · 25/06/2025
A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
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🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 02/08/2025
Terence Tao (@teorth.bsky.social) has written a thread on Mastodon about the impact of the federal grant freeze to UCLA, particularly to his own field of Mathematics. UCLA's IPAM (Institute of Pure and Applied Mathematics) could shut down entirely mathstodon.xyz/@tao/1149568...
mathstodon.xyz
Terence Tao (@tao@mathstodon.xyz)
The current administration in the US has, through various funding agencies such as the NSF and NIH, has recently suspended virtually all federal grants to my home university, UCLA (including my own p...
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Max-Planck-Gesellschaft @maxplanck.de · 01/08/2025
Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.
Open Call for Expressions of Interest in Max Planck Directorships:
Expressions of interest can be submitted until 31 October 2025.
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Ardem Patapoutian @ardemp.bskyverified.social · 31/07/2025
BIG NEWS: “Senate appropriators on Thursday approved an FY26 Labor-HHS bill that included a slight bump in funding for the NIH, with a strong 26–3 bipartisan vote.” Thank you to members of the Senate Appropriations Committee on both sides of the aisle! www.axios.com/pro/health-c...
axios.com
Senate appropriators approve Labor-HHS bill with NIH bump
The vote and lawmaker comments show that most senators aren't going along with the White House's proposed 40% budget cut to NIH.
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Xin Jin @xinjin.bsky.social · 22/07/2025
Science and innovation drive every breakthrough. On 7/21, a nation-wide campaign kicks off to honor Apollo 11’s legacy -- tell Congress NO to research‑funding cuts. Speak up here: ProtectScienceAndInnovation.org #ProtectScience #InnovationMakesAmericaGreat
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Alexandria Ocasio-Cortez @aoc.bsky.social · 03/07/2025
I don’t think anyone is prepared for what they just did w/ ICE. This is not a simple budget increase. It is an explosion - making ICE bigger than the FBI, US Bureau of Prisons, DEA,& others combined. It is setting up to make what’s happening now look like child’s play. And people are disappearing.
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Xin Jin @xinjin.bsky.social · 02/07/2025
Yaaaasss!!
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Mireille Kamariza @kamariza.bsky.social · 25/06/2025
Working link here! www.biorxiv.org/content/10.1...
biorxiv.org
Tre-DST: A new drug susceptibility test for Mycobacterium tuberculosis using solvatochromic trehalose probes
Tuberculosis (TB) is the most lethal cause of death from a single infectious agent. In 2024, an estimated 10 million people developed TB, nearly half a million of which were infected with drug-resista...
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Xin Jin @xinjin.bsky.social · 22/06/2025
Thanks Debby! see you soon!!
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Xin Jin @xinjin.bsky.social · 21/06/2025
Thank you Alex!
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Xin Jin @xinjin.bsky.social · 21/06/2025
Thanks Sebastian!! Hope you are well, it's been awhile!
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Xin Jin @xinjin.bsky.social · 21/06/2025
Hi-Five 🥂 Thank you Ishmail for your help rehearsing my talk - you are such an inspiration. Would love to work together!!
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Xin Jin @xinjin.bsky.social · 21/06/2025
Thanks Piali!
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Xin Jin @xinjin.bsky.social · 20/06/2025
Thanks Navin!
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Xin Jin @xinjin.bsky.social · 20/06/2025
Thanks George!
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Xin Jin @xinjin.bsky.social · 20/06/2025
Thanks Karl!!!!
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Xin Jin @xinjin.bsky.social · 20/06/2025
Thanks Sonya! we should get coffee (or stronger drinks) :)
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Xin Jin @xinjin.bsky.social · 20/06/2025
Thansk Marla! see you soon I hope?
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Xin Jin @xinjin.bsky.social · 20/06/2025
Thanks Lena - long time, we need to catch up!!
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Xin Jin @xinjin.bsky.social · 20/06/2025
thanks Joaquin!!
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Xin Jin @xinjin.bsky.social · 20/06/2025
🫡
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Xin Jin @xinjin.bsky.social · 20/06/2025
Thanks Seth! Means a lot to me
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Xin Jin @xinjin.bsky.social · 20/06/2025
Thanks Flora! Long time - catch up needed - and your lab is looking awesome!!
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