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Why the link between immune infiltration and tumor control varies so strongly across tissues remains unresolved. We propose the “immunometabolic gatekeeping” framework, whereby tissue-intrinsic metabolic activity and waste-handling capacity shape anti-tumour immunity. In high-flux tissues, metabolic stress impairs immune surveillance, decoupling infiltration from control and allowing tumor outgrowth. This framework explains cancer paradoxes—including T cell prognostic heterogeneity, hereditary and pediatric tumor tropisms, sex-biased tumor incidence, and cancer-resistant species—and suggests metabolism-aware strategies for cancer prevention and immunotherapy.

Fercoq, Cairns, et al. show that mammary tumors induce β2-integrin-dependent neutrophil slowing in lung capillaries, reducing local perfusion in the pre-metastatic niche. Restoring integrin activity n...

PhD Project - Developing machine learning methods to infer the evolution of haematological cancers at Imperial College London, listed on FindAPhD.com

Cancer evolution is a multi-faceted process and a major clinical challenge. Indeed, tumors constantly change as they progress through multiple mechanisms, the understanding of which is critical to an…

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Classical models of cancer focus on tumour-intrinsic genetic aberrations and immune dynamics and often overlook how the metabolic environment of healthy tissues shapes tumour development and immune ef...

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

Indiana University Bloomington (IUB) is engaged in a multi-year initiative to increase the breadth and scope of its faculty in biomedical engineering. We are inviting applications for multiple tenure-...

We are seeking to appoint exceptional early-career scientists, including clinician scientists, as Group Leaders to develop bold, innovative, and high-impact research programmes.

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Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

Alexander Raven, an early career researcher from the School of Cancer Sciences, has been awarded one of UK Research and Innovation’s (UKRI) flagship Future Leaders Fellowships.

The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a

Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

Nature - Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

Metastatic disease and therapy resistance pose significant challenges in the treatment of breast cancer. Recent studies by Rozalén et al. and Petroni …

Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.