Xavier Trepat @xaviertrepat.bsky.social · 06/08/2026When tension increases, the nucleus escapes. New paper out in @natphys.nature.com. Check out Tom's thread for a summary 👇 03612
Reposted by Xavier Trepatepithelial mechanics fan club @epimechfc.bsky.social · 26/07/2026How do tissues safely remove cells? Join me, @marija-matejcic.bsky.social in this perspective on the past, present and future of epithelial cell extrusion 🧵 0/16 26127
Xavier Trepat @xaviertrepat.bsky.social · 17/04/2026They might need a bending moment for that… but hold my beer 🍺 010
Xavier Trepat @xaviertrepat.bsky.social · 17/04/2026Link: www.science.org/doi/10.1126/...science.orgScience | AAAS 140
Xavier Trepat @xaviertrepat.bsky.social · 17/04/2026Our latest work on shape-programmable tissues is out in @science.org. By positioning topological defects in cellular nematics, we encode frustrated 2D force fields that relax into predictable 3D shapes. Collaboration with Marino Arroyo’s lab, led by @pauguillamat.bsky.social at @ibecbarcelona.eu. 718464
Reposted by Xavier TrepatRaimon Sunyer @raimonsunyer.bsky.social · 27/03/2026Since #durotaxis was described >25 years ago, most studies report cells migrating from soft → stiff New work from my team at @ub.edu (in collaboration with D. Odde's lab) suggests we may have been missing the point all along... 🔥 Check out our new preprint here 👇 www.biorxiv.org/content/10.6...biorxiv.org 43619
Reposted by Xavier TrepatPietro Cicuta @pcicuta.bsky.social · 14/03/2026International Congress in Biological Physics, Genova, Italy, 28 June to 3 July 2026. URGENT: submission deadline 25 March. Session topics, plenary and invited speakers: www.icbp2026.org IUPAP Physics of Life medal awarded at meeting. Spread the word - and act quickly to submit your work.icbp2026.orgICBP 2026We proudly invite experts in biological physics worldwide to the International Conference on Biological Physics 2026 (ICBP 2026) in the magnificent Italian city of Genoa from June 28 to July 5, 2026 01413
Xavier Trepat @xaviertrepat.bsky.social · 27/02/2026Less than a week to submit your abstract for #EESMechanobiology. Mechanobiology across the tree of life, from HeLa cells to weird animals and plants. The submission deadline is 3 March: s.embl.org/ees26-06-bl 🗓️ 9 – 12 June 2026 033
Xavier Trepat @xaviertrepat.bsky.social · 18/02/2026Best possible lab for a PhD / postdoc! Stay tuned for future openings and wonderful science. 1133
Reposted by Xavier TrepatTheory of Living Matter Group @tlmcambridge.bsky.social · 12/01/2026🚨Our first talk this new year would be a joint theory/experiment talk by Prof. Marino Arroyo and Prof. Xavier Trepat @xaviertrepat.bsky.social describing some of their recent work together on active morphogenesis🧫. Sign up to our mailing list for a zoom link to this talk and other upcoming talks🚨 0104
Xavier Trepat @xaviertrepat.bsky.social · 15/12/2025📢 New extended abstract submission deadline: 6 January 2026! Outstanding speaker list, plus many slots for short talks by students, postdocs, and junior PIs. Join us in March in Barcelona! events.ibecbarcelona.eu/embl-ibec-co... 0108
Xavier Trepat @xaviertrepat.bsky.social · 22/10/2025📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now! events.ibecbarcelona.eu/embl-ibec-co... 06741
Reposted by Xavier TrepatBarriga Lab @eliasbarrigalab.bsky.social · 02/10/2025New Review! #devbiol #bioelectricity #CellBiology #tissueregeneration In our new @annualreviews.bsky.social piece, we explore how bioelectricity is generated, sensed & translated into responses that sculpt tissues, guide growth & enable tissue regeneration. www.annualreviews.org/content/jour...annualreviews.orgBioelectricity in MorphogenesisBioelectricity is likely as old as life itself. From the moment the first proto-cell was enclosed in a lipid bilayer, a membrane potential arose. Thus, one can expect that bioelectrical activities inf... 13916
Reposted by Xavier TrepatBuzz Baum @buzzbaum.bsky.social · 02/10/2025LMB PhD studentship available in the Baum lab to use informatics to infer cell structure from genomic data in collaboration with the brilliant Tom Williams. If you write to me and I don’t reply - try again - the spam filter is hungry… 11619
Reposted by Xavier TrepatDavid Brückner @davidbrueckner.bsky.social · 27/09/2025How do cells navigate up gradients of adhesive proteins? 🤔 Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood We show that passive friction directs cells & explains complex trajectories on gradients 👉 www.nature.com/articles/s41... 17626
Reposted by Xavier TrepatDaniel J. Cohen (Princeton) @djcohen.bsky.social · 17/09/2025SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N 46627
Reposted by Xavier TrepatBenoit Ladoux @bladoux.bsky.social · 17/09/2025Happy to share our new study @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social with C. Duclut and J. Prost. on forces generated by active fluid transport in epithelia and their role in tissue dynamics. Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri! www.biorxiv.org/content/10.1...biorxiv.orgRegulation of epithelial tissue homeostasis by active trans-epithelial transportEpithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties o... 03619
Reposted by Xavier TrepatDaniel Alber @danielalber.bsky.social · 18/09/2025A ring of cells deforms into a triangular keyhole in just 15 minutes. Meet the hindgut, a model for boundary-driven morphogenesis! Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8) 36922
Reposted by Xavier TrepatBarbara Marte @barbmarte.bsky.social · 06/09/2025new out in Nature www.nature.com/articles/d41...nature.comCompression causes cancer cells to start spreadingThe switch between proliferation and invasion is triggered by mechanical force. 05923
Xavier Trepat @xaviertrepat.bsky.social · 01/09/2025These topological transitions provide epithelia with a multiscale mechanism to adapt to sustained stretch. Beautifully modelled by Marco Pensalfini and Marino Arroyo. 041
Xavier Trepat @xaviertrepat.bsky.social · 01/09/2025New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social 🙌 @IBECBarcelona www.biorxiv.org/content/10.1... 38828
Reposted by Xavier TrepatSylvain Gabriele @sgabriele.bsky.social · 25/08/2025Excited to share our new publication in Nature Physics about the mechanical memory of morphology in confined migrating cells by @kyohalie.bsky.social 🥳 Super fun collab with @davidbrueckner.bsky.social and @gcharras.bsky.social 👏🏻 Enjoy the reading www.nature.com/articles/s41...nature.comThe actin cortex acts as a mechanical memory of morphology in confined migrating cells - Nature PhysicsCells often navigate through confined spaces. Now it is shown that cells retain a mechanical memory of previous confinement events, which makes them more efficient at migrating through narrow microenv... 58726
Reposted by Xavier TrepatKate Miroshnikova @katemiro.bsky.social · 15/08/2025Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1... 25224
Reposted by Xavier TrepatJonas Neipel @neipel.bsky.social · 20/07/2025(1/10) I am excited to finally share our work on avian left/right symmetry breaking with you. We reveal a tissue-scale active torque dipole generated at the Hensen’s node, thanks to crazy experiments by Julia @juliapfanzelter.bsky.social and some analysis by me. doi.org/10.1101/2025...doi.orgAn active torque dipole across tissue layers drives avian left-right symmetry breakingUnlike in mice, frogs, and fish, left-right (L/R) body axis formation in avian embryos does not arise from the chiral beat of cilia. Instead, a counter-clockwise tissue rotation around Hensen′ node, t... 14620
Xavier Trepat @xaviertrepat.bsky.social · 08/07/2025New paper from the lab led by @marija-matejcic.bsky.social ! Supracellular force patterns driving intestinal cell extrusion. 👇 1143
Reposted by Xavier TrepatNimesh Chahare @onenimesa.bsky.social · 03/07/2025Have you ever thought about inflating tissues? Or maybe quickly deflating those inflated tissues? New #EpithelialMechanics pre-print: doi.org/10.1101/2025... 🧵 with pressure control, multiscale buckling, controlled wrinkling 78633
Xavier Trepat @xaviertrepat.bsky.social · 03/07/2025Thanks Fabrice. Indeed, two very different physical mechanisms to engineer 3D shapes. 000
Xavier Trepat @xaviertrepat.bsky.social · 03/07/2025Thanks Mark, stay tuned for @marija-matejcic.bsky.social preprint in a few days! 010
Xavier Trepat @xaviertrepat.bsky.social · 03/07/2025🚨 Second preprint of the week! We uncover the multiscale dynamics of active viscoelastic buckling in epithelia. We harness these mechanical instabilities for synthetic morphogenesis. Led by @onenimesa.bsky.social 🙌. Theory by Marino Arroyo etal. @ibecbarcelona.eu www.biorxiv.org/content/10.1... 47620
Xavier Trepat @xaviertrepat.bsky.social · 30/06/2025How to turn a layer of fibroblasts into a tulip 🌷? Check out our new pre-print on shape-programmable living surfaces. Led by @pauguillamat.bsky.social www.biorxiv.org/content/10.1... 411729
Reposted by Xavier Trepatepithelial mechanics fan club @epimechfc.bsky.social · 20/04/20251/14 “Epithelial” & “Mesenchymal” aren’t binary categories—they form a spectrum, or better yet, a multidimensional space. This becomes especially clear in collective cell migration, which often depends on a finely tuned degree of “mesenchymal-ness”. #cellbio #devbio #cellmigration 311540
Reposted by Xavier TrepatDenis Wirtz @deniswirtz.bsky.social · 05/04/2025Be on the lookout for a new paper from the lab: "InterpolAI: Deep learning based optical flow interpolation and restoration of biomedical images for improved 3D tissue mapping" InterpolAI interpolates and restores defective images for enhanced 3D imaging (3D histology, MRI, confocal, ssTEM) 1336
Reposted by Xavier TrepatBenoit Ladoux @bladoux.bsky.social · 14/03/2025Happy to share our new publication in @naturematerials.bsky.social on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats @luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉 www.nature.com/articles/s41... 16933
Reposted by Xavier TrepatIrene Miguel-Aliaga @irenemiguel-aliaga.bsky.social · 19/03/2025Lab’s latest: (mouse) mums grow their guts during pregnancy and lactation: www.cell.com/cell/fulltex... 1417164
Reposted by Xavier TrepatCarmelo Ferrai @carmeloferrai.bsky.social · 19/03/2025I am Absolutely delighted to share the preprint of our last collaborative efforts where we investigated the impact of sonostimulation of Mesenchymal Stem Cells. Thread -1- www.biorxiv.org/content/10.1...biorxiv.orgSonoepigenetics: Spatiotemporal Calcium Dynamics and cAMP Signaling Driven by High Frequency Nanomechanostimulation Regulates Transient Epigenetic Modifications and Early Osteogenic Commitment in Mese...Cells effectively balance and integrate numerous pathways to adapt to external signals in an attempt to regain homeostasis, although the complex nuclear mechanotransduction mechanism through which thi... 76928
Reposted by Xavier TrepatHallou Lab @halloulab.bsky.social · 17/03/2025 🚨 Paper Alert 🚨 Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!! www.nature.com/articles/s41...nature.comA computational pipeline for spatial mechano-transcriptomics - Nature MethodsThe authors present a computational framework that leverages mechanical force inference and spatial transcriptomics to enable analyses of the interplay between the transcriptomic and mechanical state. 1013953
Xavier Trepat @xaviertrepat.bsky.social · 03/03/2025Great one-day meeting on #cancer #mechanobiology in Paris (March 14th). 0218
Reposted by Xavier TrepatAlice Perucca @aliperri.bsky.social · 10/02/20251/7: New paper alert! Excited to share our co-first author paper on Micro Immune Response On-chip (MIRO) a model that recreates the tumour-stroma interface for immunotherapy testing! @oriolmb.bsky.social and I wrote this thread to break it down for you. 👇🧵 Read more: www.nature.com/articles/s41...nature.comMicro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing - Nature CommunicationsModelling the tumour immune microenvironment in vitro is a valuable tool to test immunotherapy efficiency but capturing its complexity is challenging. Here authors present a fully humanised in vitro p... 12913
Xavier Trepat @xaviertrepat.bsky.social · 07/02/2025Work conceived by Anna Labernadie during her postdoc in the lab—now running her group at CIPF—in collaboration with Alex Calon from @researchmar.bsky.social. Congrats to first authors @aliperri.bsky.social , Andrea Gómez and @oriolmb.bsky.social ! ibecbarcelona.eu/researchers-...ibecbarcelona.euResearchers develop a device that replicates tumours to study the efficacy of immunotherapy treatmentsThe Micro Immune Response On chip (MIRO) allows tumours and their environment to be replicated in order to understand their response to immunotherapy-based treatments. 1123