This report describes 48 confirmed cases and one probable case of C. bantiana in clinical samples from 2009–2026.

Benznidazole 150 mg once daily for 30 days showed non-inferior efficacy and the lowest rate of drug-related adverse events among the regimens tested, supporting its adoption as the preferred benznidaz...

The state’s outbreak is the largest in the U.S.

AbstractIntroductionExcept for their role in bacterial endocarditis, non-pneumococcal Streptococcus mitis group (SMG) bacteria have traditionally been regarded as commensals of the oropharynx. Widespread adoption of matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry has increased identification of these organisms and has led to increased concern about their clinical significance. We evaluated SMG bacteremia in a large multicenter cohort to characterize associated clinical syndromes and better define their clinical relevance.MethodsWe performed a retrospective review of all adult patients from 2017 to 2025 who had SMG bacteremia at three hospitals within the Texas Medical Center. SMG bacteremia was defined as isolation of S. mitis, S. mitis/oralis, or S. mitis group as determined by MALDI-TOF. Clinical syndromes were identified through chart review and assigned using consistent classification approaches informed by physician documentation, imaging, and microbiologic data.ResultsAmong 253 patients, neutropenia-associated bacteremia was most common (29.6%) followed by pneumonia (9.5%), infective endocarditis (8.7%), skin, soft tissue, or bone infections (7.9%), and other identified sources (12%). No clear source was identified in 9.5% of cases. Only 22.9% were classified as contaminants. High-grade bacteremia was common, with 47% of cases having ≥ 3 positive blood culture bottles. In contrast, patients in whom SMG was regarded as contaminant nearly always had only a single bottle positive.ConclusionSMG bacteremia was associated with a broad spectrum of clinical syndromes, with most isolates being regarded as representing clinically significant infection.

U.S. Immigration and Customs Enforcement has stopped publicly revealing where it is holding most detainees who are subject to final deportation orders, in a move that has made it harder for lawyers an...

A retrospective study of 225 patients across Cook County Department of Health clinics found that the novel 1-month 1HP regimen (isoniazid plus rifapentine) for latent TB infection had a completion rat...

ICE owes millions in unpaid bills to hospitals and, in some cases, detainees themselves have been directly billed for care, records show.

As kids go back to school, Florida leaders hope to strip away vaccine mandates, clashing with some of President Donald Trump’s recommendations.

As kids go back to school, Florida leaders hope to strip away vaccine mandates, clashing with some of President Donald Trump’s recommendations.

Pennsylvania Department of Health Confirms Two Measles-Associated Deaths

USAID funding has significantly contributed to the reduction in adult and child mortality across low-income and middle-income countries over the past two decades. Our estimates show that, unless the a...

A 39-year-old man sustained facial lacerations from the body of a roe deer (Capreolus capreolus) and shattered glass after the animal, first struck by an oncoming vehicle, broke through his windshield...

Over the past two generations, the boundaries of the classical world have been stretched to the steppe frontier of China...

This report describes identification of blacklegged ticks during community-based tick surveillance at a residential property in North Carolina.

If Netanyahu is ousted in October’s balloting, don’t expect peace to break out, but the worst violence might be reined in.

Hundreds of people gathered outside a federal immigration office Sunday morning to show support for Haitian immigrants from Springfield who were called to report for immigration check-ins.