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Andres Floto

@andresfloto.bsky.social
247 followers 191 following 1 posts

Prof. of Respiratory Biology & Co-Director Cambridge Centre for AI in Medicine, U of Cambridge. Studying Bacteria, Innate Immunity & Antibiotic Discovery, CF/Bronchiectasis/NTM using genetics & ML

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Reposted by Andres Floto
Chris Ruis @chris3ruis.bsky.social · 14/09/2026
We have a new preprint examining the mutational signatures of hantaviruses: biorxiv.org/content/10.6... We find that mutagens and host antiviral proteins are key factors shaping hantavirus mutagenesis With @andresfloto.bsky.social and @julianparkhill.bsky.social
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Josie Bryant @josiebryant.bsky.social · 08/07/2026
Very proud of this preprint out of my lab, our first (of hopefully many) host-microbe spatial transcriptomics paper. www.biorxiv.org/content/10.6... Amazing insights into P. aeruginosa biology and chronic airway disease @cysticfibrosis.org.uk @sangerinstitute.bsky.social @asthmaandlung.org.uk
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Josie Bryant @josiebryant.bsky.social · 08/07/2026
Great collaboration with @royalpapworth.bsky.social @andresfloto.bsky.social @teichlab.bsky.social and many many colleages across @sangerinstitute.bsky.social using @10xgenomics.bsky.social technology
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VPD Heart & Lung Research Institute @vpd-hlri.bsky.social · 09/02/2026
🎥 Professor @andresfloto.bsky.social on new funding from: @wellcometrust.bsky.social @gatesfoundation.bsky.social @novonordisk.bsky.social and how VPD-HLRI research is helping reshape antibiotic discovery in the fight against antimicrobial resistance. Read more: 🔗 bit.ly/4rJy6c2
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Reposted by Andres Floto
VPD Heart & Lung Research Institute @vpd-hlri.bsky.social · 22/01/2026
Many congratulations to @andresfloto.bsky.social and team for their success in the @gatesfoundation.bsky.social @wellcometrust.bsky.social Novo Nordisk Foundation Grand Challenge for Innovations in Gram negative antibiotic discovery: gcgh.grandchallenges.org/grant/defini...
gcgh.grandchallenges.org
Defining Permissive Chemical Space in Klebsiella pneumoniae
Andres Floto with Vitor Mendes, David Spring, Aaron Weimann, Sebastian Bruchmann, and José Miguel Hernández Lobato of the University of Cambridge in the United Kingdom will experimentally define the f...
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Reposted by Andres Floto
Nature Portfolio @natureportfolio.nature.com · 17/01/2026
A paper in Nature Microbiology presents Antimicrobial Single-Cell Testing, a large-scale live-cell imaging approach that quantifies bacterial killing in real time at single-cell resolution, which can predict treatment outcomes. go.nature.com/3Nwnez8 #microsky 🧪
This is figure 1, which shows that ASCT enables high-throughput assessments of bacterial viability.
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Medicine at Cambridge @medcambridge.bsky.social · 01/12/2025
Bacteria can control what enters their cells, balancing energy and blocking antibiotics. New study in @natmicrobiol.nature.com uncovers this hidden mechanism of drug resistance: buff.ly/s3YIwyK @andresfloto.bsky.social @vpd-hlri.bsky.social @unibas.ch
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Nature Microbiology @natmicrobiol.nature.com · 26/11/2025
#NewResearch The permeability of bacterial porins is dynamically regulated by periplasmic proton and potassium concentrations, altering antibiotic resistance. #MicroSky #AMR 🦠 @andresfloto.bsky.social www.nature.com/articles/s41...
nature.com
Metabolic control of porin permeability influences antibiotic resistance in Escherichia coli - Nature Microbiology
The permeability of bacterial porins is dynamically regulated by periplasmic proton and potassium concentrations, altering antibiotic resistance.
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Medicine at Cambridge @medcambridge.bsky.social · 15/10/2025
We're seeking 2️⃣ research associates to join Professor @andresfloto.bsky.social's lab @vpd-hlri.bsky.social. You'll be part of a multidisciplinary team exploring antibiotic uptake, efflux & metabolism across multiple bacterial pathogens. Apply before 27 October: buff.ly/SqfTX3A
Image of VPD-HLRI building and text reads: Research Associate x2 (Fixed Term), Explore opportunities at Medicine at Cambridge.

Also includes logo of the University of Cambridge Department of Medicine.
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DMM Journal @dmmjournal.bsky.social · 22/07/2025
Read our #DMMEditorsChoice highlight on the Research Article by Laetitia Pinte, @martavilagonz.bsky.social, @jamesnathanlab.bsky.social, @andresfloto.bsky.social, @pcicuta.bsky.social, @vallierlab.bsky.social and colleagues. doi.org/10.1242/dmm....
Transverse section images of cultures from reporter line stained with Haematoxylin and Eosin.
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Aaron Weimann @aweimann.bsky.social · 21/07/2025
New pre-print up introducing our bacterial protein language model Bacformer, creating a unified representation of entire bacterial genomes led by @macwiatrak.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
A contextualised protein language model reveals the functional syntax of bacterial evolution
Bacteria have evolved a vast diversity of functions and behaviours which are currently incompletely understood and poorly predicted from DNA sequence alone. To understand the syntax of bacterial evolu...
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Reposted by Andres Floto
Aaron Weimann @aweimann.bsky.social · 21/07/2025
Check out Maciek's tweetorial for Bacformer with links to code, tutorials and blog post: bsky.app/profile/macw...
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Maciek Wiatrak @macwiatrak.bsky.social · 21/07/2025
💥 Excited to introduce Bacformer 🦠 - the first foundation model for bacterial genomics. Bacformer represents genomes as sequences of ordered proteins, learning the “grammar” of how genes are arranged, interact and evolve. Preprint 📝: biorxiv.org/content/10.1... 🧵 1/n
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Medicine at Cambridge @medcambridge.bsky.social · 27/06/2025
New project led by Professor @andresfloto.bsky.social‬ and Dr Sundeep Chaitanya Vedithi at @cam.ac.uk‬ has received £1.2m funding from @ukri.org‬ to develop point-of-care DNA sequencing for rapid detection of #AMR in leprosy across the Philippines. Read more: buff.ly/9UYWUBR @vpd-hlri.bsky.social‬
Photo of training in the Philippines and text reads: Cambridge-led project secures £1.2m from UKRI to pioneer same-day AMR diagnosis for leprosy in Southeast Asia

Also includes logo of Department of Medicine, University of Cambridge
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Reposted by Andres Floto
Medicine at Cambridge @medcambridge.bsky.social · 05/06/2025
One week left to join @andresfloto.bsky.social‬ 's team as a Postdoctoral Research Associate to develop new antibiotics against mycobacteria using permeability-enabled fragment-based #DrugDiscovery. This 2-year fixed-term position is based in @cambridgebrc.bsky.social‬ 🧬Apply by 12 June:
buff.ly
Postdoctoral Research Associate (Fixed Term) - Job Opportunities - University of Cambridge
Postdoctoral Research Associate (Fixed Term) in the Department of Medicine at the University of Cambridge.
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Reposted by Andres Floto
Medicine at Cambridge @medcambridge.bsky.social · 10/04/2025
📢 Few days left to apply for our PhD studentship at @vpd-hlri.bsky.social 📢 Our 3-year programme supervised by @andresfloto.bsky.social explores chemical permeability and metabolism using #ML #GenAI to guide antibiotic drug discovery. Apply by 15 April➡️ buff.ly/9oCo4ZJ
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PhD Studentship - University of Cambridge
PhD Studentship - Understanding chemical permeability and metabolism in gram-negative organisms in the Department of Medicine at the University of Cambridge.
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Medicine at Cambridge @medcambridge.bsky.social · 07/04/2025
Hear more from our Professor Eoin McKinney, @andresfloto.bsky.social & Mihaela van der Schaar on how we're unleashing the full potential of AI in health and medicine, and how Cambridge Centre for AI in Medicine puts us in the perfect position to be leaders in the field⬇️ cam.ac.uk/opinion-ai-a...
cam.ac.uk
Opinion: AI can transform health and medicine
AI has the potential to transform health and medicine. It won't be straightforward, but if we get it right, the benefits could be enormous. Andres Floto, Mihaela van der Schaar and Eoin McKinney expla...
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Aaron Weimann @aweimann.bsky.social · 27/03/2025
Exciting PhD studentship opportunity in @andresfloto.bsky.social lab on understanding chemical permeability to advance antibiotic drug discovery www.jobs.cam.ac.uk/job/50800/. Combines experimental approaches with in silico screening and generative AI.
jobs.cam.ac.uk
PhD Studentship - Understanding chemical permeability and metabolism in gram-negative organisms - Job Opportunities - University of Cambridge
PhD Studentship - Understanding chemical permeability and metabolism in gram-negative organisms in the Department of Medicine at the University of Cambridge.
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Reposted by Andres Floto
Science Magazine @science.org · 03/12/2024
#ICYMI: In a Science study, researchers present “Evo”—a #MachineLearning model capable of decoding and designing DNA, RNA, and protein sequences, from molecular to genome scale, with unparalleled accuracy. Learn more: scim.ag/41bmK6u
Evo is a genomic foundation model that enables prediction and generation tasks from the molecular to genome scale. Using an architecture based on advances in deep signal processing, Evo is trained on 7 billion parameters with a context length of 131 kilobases at single-nucleotide resolution. Evo captures two fundamental aspects of biology—the multimodality of the central dogma and the multiscale nature of evolution.
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