The pathogen Streptococcus pneumoniae can adapt to diverse microenvironments in the human body. Here, De Bakker et al. study these adaptation responses, showing unusual sugar utilization and identifyi...

The authors identify a chemical cocktail to generate totipotent-like cells, which they then use to build an embryo model. This model captures a developmental spectrum from early embryogenesis to post-...

Alzheimer’s disease is a severe neurodegenerative disorder, with multifactorial mechanisms of disease development and progression. Evidence from genetic association studies, animal models, and clinica...

The RBPJ–NCOR repressor complex is identified as a negative regulator of FOXP3 expression through modulation of histone acetylation in induced regulatory T cells.

Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...

Germinal centre B cells modify their mutation rate to preserve high-affinity receptors, thereby safeguarding high-affinity B cell lineages and enhancing the outcomes of antibody affinity maturation.

Wu et al. demonstrate how neutrophils, located within the protective layers of the brain, respond to social threats and modulate psychological processes. This process is governed by testosterone in a ...

Some attendees of a packed presentation were curious about the prospect of the first ‘topological’ qubits, but left with questions unanswered.

The integration of multimodal single-cell data enables comprehensive organ reference atlases, yet its impact remains largely unexplored, particularly in complex tissues. We generated a benchmarking da...

Source code for scOMM. Contribute to mereulab/scOMM development by creating an account on GitHub.

We study sets of $δ$ tubes in $\mathbb{R}^3$, with the property that not too many tubes can be contained inside a common convex set $V$. We show that the union of tubes from such a set must have almos...

mRNA with engineered poly(A) tails produces prolonged higher levels of protein.

Imagine a cancer treatment that precisely targets malignant cells, leaving healthy ones untouched. Consider, also, a cancer treatment that corrects abnormal protein synthesis to produce healthy protei...

Maatz, Lindberg et al. identify molecular alterations and immune response changes in endomyocardial biopsies from patients with myocarditis after COVID-19 infection, after anti-COVID-19 vaccination or...

Parse has now invalidated all claims that 10x Genomics asserts against Parse products, further reinforcing Parse’s ability to drive ongoing innovation in the single cell space.

Short-lived perilesional Ly6G+ macrophages license alveolar epithelial regeneration after viral-triggered lung injury.

α/β T cells are key players in adaptive immunity. The specificity of T cells is determined by the sequences of the hypervariable T cell receptor (TCR) α and β chains. Although bulk TCR sequencing offe...

Nature Communications - Multi-omics integration is often limited by data sparsity and heterogeneity. Here, the authors develop MOSA, a method designed to augment DepMap cell line data to...

Multi-modal datasets can be beset by spurious connections due to indirect impacts propagating through an unmapped biological network. We applied Markov fields to eliminate spurious correlations in a d...

scAtlasVAE is a deep learning-based model for cross-atlas integration. Here it enables the development of a large-scale human CD8+ T cell atlas with integrated T cell receptor data.

Chitin-cellulose fibrous foam constructed by hydrogen bonding–induced self-assembly achieved efficient removal of microplastics.

Chemokine receptors control cell migration within the body. Here we reveal a novel interaction betwe

We show that target-induced proximity labelling enables isolation of first-division CD8 chimeric antigen receptor T cells that asymmetrically distribute their surface proteome and transcriptome, resul...