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markesnyder.bsky.social

@markesnyder.bsky.social
109 followers 160 following 23 posts

Transplant pulmonologist, T cell biologist

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Waggoner Lab @labwaggoner.bsky.social · 17/09/2026
Spatiotemporal single-cell profiling reveals T cell clonal dynamics and phenotypic plasticity in human graft-versus-host disease @natimmunol.nature.com @elhamazizi.bsky.social @columbiauniversity.bsky.social www.nature.com/articles/s41...
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Journal of Experimental Medicine @jem.org · 17/09/2026
Upper respiratory tract #CD8⁺ tissue resident memory #Tcells protect against viral transmission. New study from Sarah E. Michalets, Jacob E. Kohlmeier and colleagues (Emory University): rupress.org/jem/article/... #InfectiousDisease #HostDefense #MucosalImmunology
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Mucosal Immunology @mucosalimmunol.bsky.social · 06/08/2026
Accumulation of mucosal and lymphoid hypo-functional granzyme K producing CD8+ effector memory T cells in idiopathic pulmonary fibrosis from @markesnyder.bsky.social www.mucosalimmunology.org/article/S193...
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markesnyder.bsky.social @markesnyder.bsky.social · 29/07/2026
Congratulations to Dr Okereke! Here she presents our work showing the accumulation of granzyme k+ cd8 T cells in the lungs and lung draining lymph nodes of patients with end stage IPF. www.mucosalimmunology.org/article/S193...
mucosalimmunology.org
Accumulation of mucosal and lymphoid hypo-functional granzyme K producing CD8+ effector memory T cells in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis is a progressive lung disease characterized by the rapid scarring of the lung parenchyma resulting in impaired gas exchange and early mortality. Current treatment options...
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ATS Assemblies @ats-assemblies.bsky.social · 07/05/2026
🌟Congratulations to Charles S. Dela Cruz, MD, PhD, ATSF, recipient of the Senior Level Peer Recognition Award of his outstanding leadership and research contributions in pulmonary and critical care medicine. Learn more: site.thoracic.org/membership/a... @ats-pitb.bsky.social
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JCI insight @insight.jci.org · 13/04/2026
Rachel A. Gottschalk @gottschalklab.bsky.social, Satarupa Ganguly @satarupa2025.bsky.social & team show lung macrophages lacking GATA2 during inflammation promote metabolic dysfunction & profibrotic gene expression in mice: doi.org/10.1172/jci....
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JCI insight @insight.jci.org · 31/01/2026
From earlier this week: Immune checkpoint inhibitor therapies for cancer can induce unintended immune related adverse events (irAEs). Here, Deepak A. Rao & team identify T cell features in pre-treatment blood samples that are associated with irAEs after ICI therapy: doi.org/10.1172/jci....
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Mucosal Immunology @mucosalimmunol.bsky.social · 30/01/2026
Integrated human and mouse single-cell profiling reveals immune-stromal niche driving silicosis www.mucosalimmunology.org/article/S193...
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Waggoner Lab @labwaggoner.bsky.social · 21/01/2026
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 @nature.com @the-de-lab.bsky.social www.nature.com/articles/s41...
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Mucosal Immunology @mucosalimmunol.bsky.social · 09/01/2026
Regulatory T cells protect against aberrant remodeling in a mouse model of pulmonary fibrosis from Michael Beers @westphillytough.bsky.social and colleagues: www.mucosalimmunology.org/article/S193...
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Pestilence @pestilence4all.bsky.social · 18/12/2025
Diminished T cell immunity during aging can have profound effects on responses to vaccines, cancer immunotherapy and infection. This article describes a unique way to enhance T cell immunity in mice, which could someday be translated to humans. #Science 🧪
nature.com
Transient hepatic reconstitution of trophic factors enhances aged immunity - Nature
Using lipid nanoparticle delivery of mRNAs to the liver in aged mice, T cell function and declining immune cues can be restored.
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markesnyder.bsky.social @markesnyder.bsky.social · 06/11/2025
Imagine this: 20+ years from now. I’m a burnt out scientist, PI of a lab, but forced to work in an ancillary building, filled with reject scientists that have been shunned by the scientific community. Despite this, we end up lucking into groundbreaking fundamental scientific truths. -“Flow Horses”
fit.it
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Reposted by @markesnyder.bsky.social
Journal of Clinical Investigation @jci.org · 06/11/2025
A new mechanism helps explain idiopathic pulmonary fibrosis Preeti Yadav et al. discover crosstalk between myeloid cells and fibroblasts increases ARG1, driving pathologic collagen expression via the production of ornithine in mouse models & human tissue. www.jci.org/articles/vie...
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markesnyder.bsky.social @markesnyder.bsky.social · 02/11/2025
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Cory Booker @corybooker.com · 31/10/2025
Thank you Congressman Neguse for laying it plain.
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markesnyder.bsky.social @markesnyder.bsky.social · 24/10/2025
Great manuscript below. Would be amazing if this could be applied to transplantation tolerance. www.science.org/doi/10.1126/...
science.org
Generating functionally stable and antigen-specific Treg cells from effector T cells for cell therapy of inflammatory diseases
Antigen-specific and functionally stable Treg cells can be generated in vitro from effector/memory T cells for cell therapy of inflammatory diseases.
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markesnyder.bsky.social @markesnyder.bsky.social · 26/09/2025
www.fundresearch.org?utm_source=m...
fundresearch.org
Save Our Cures
Save Our Cures is a national advocacy campaign working to protect federal funding for biomedical research—the engine behind life-saving discoveries, advanced treatments, and the future of medicine. We...
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Senator Bernie Sanders @sanders.senate.gov · 04/09/2025
We need an HHS Secretary who respects science and does not make policy based on conspiracy theories. Vaccines are safe and effective. Kennedy is threatening the health of our kids and all Americans. He must resign.
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Reposted by @markesnyder.bsky.social
The Tennessee Holler @thetnholler.bsky.social · 22/07/2025
“What are we doing?”🔥 😳🇺🇸 Full: www.instagram.com/reel/DMa31OX...
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Waggoner Lab @labwaggoner.bsky.social · 18/07/2025
Memory CD8+ T cells have differential cytotoxic capacities across human tissues @sciimmunology.bsky.social www.science.org/doi/10.1126/...
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Waggoner Lab @labwaggoner.bsky.social · 17/07/2025
Donor-recipient SIRPα mismatch, implicated in innate allorecognition and monocyte activation, adversely affects kidney allograft survival in humans www.science.org/doi/10.1126/...
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markesnyder.bsky.social @markesnyder.bsky.social · 10/06/2025
There are a lot of terrible things happening right now, so it’s easy to lose track of page 2+ of the news, but this anti-science/anti-health/pro-idiocy move must be opposed: www.nytimes.com/2025/06/09/h...
nytimes.com
Kennedy Removes All C.D.C. Vaccine Panel Experts
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Saganism @sagan.bsky.social · 05/06/2025
Carl Sagan in 1986 on the problems with media and science literacy.
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markesnyder.bsky.social @markesnyder.bsky.social · 19/05/2025
Run in golden state park. Barely passed this cute banana slug, we were neck and neck for a few miles.
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Journal of Clinical Investigation @jci.org · 16/05/2025
Promoting regenerative responses in a pulmonary fibrosis model! Victor J. Thannickal & team discover that blocking CTLA4 in immune cells induced regeneration and reduce fibrosis in a mouse model of idiopathic pulmonary fibrosis: buff.ly/ZtmORCG
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JCI insight @insight.jci.org · 29/04/2025
2023 ASCI Emerging-Generation recipient @rramonell.bsky.social identify a novel target to manage treatment-refractory asthma by describing a significant association of airway CD8+ TEMRA cells with asthma duration: buff.ly/gmsfzyQ
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markesnyder.bsky.social @markesnyder.bsky.social · 19/04/2025
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markesnyder.bsky.social @markesnyder.bsky.social · 08/04/2025
Bottom right. Future scientist (or artist, or both) Liam Snyder. Grade 5!
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markesnyder.bsky.social @markesnyder.bsky.social · 07/04/2025
Just got back from the Smokies! Felt amazing to get off the grid for a few seconds.
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Journal of Experimental Medicine @jem.org · 20/03/2025
De Sousa, Perkey, Le Corre, Maillard, Labrecque et al. @umontreal.ca show that fibroblastic reticular cells are the source of Notch ligands promoting the differentiation of short-lived effector CD8+ T cells. rupress.org/jem/article/... #InfectiousDisease #HostDefense #LymphocyteBiology
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Waggoner Lab @labwaggoner.bsky.social · 18/03/2025
Maintenance of graft tissue-resident Foxp3+ cells is necessary for lung transplant tolerance in mice www.jci.org/articles/vie... @jclinical-invest.bsky.social
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JCI insight @insight.jci.org · 06/03/2025
@markesnyder.bsky.social et al. flip the script on our understanding of infection and rejection after transplantation– they show that systemic NKG2D blockade can impair airway-associated Tissue resident memory T cell accumulation and reduce CLAD severity: buff.ly/61mpbwk
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Stand Up for Science! @standupforscience.net · 02/03/2025
WHERE WILL YOU BE ON MARCH 7TH!? Head to www.standupforscience2025.org/local-event-information/ or the link in our bio to find your closest event—or add one if you're hosting one! #standupforscience2025
Map of Stand Up for Science events, with official SUFS events in Red and solidarity events in Blue
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Stand Up for Science! @standupforscience.net · 12/02/2025
Welcome to the Bluesky account for Stand Up for Science 2025! Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide! #scienceforall #sciencenotsilence
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Eric Topol @erictopol.bsky.social · 02/03/2025
By itself, this is certainly not the most important issue we're confronting right now. But it's emblematic of the pervasive, destructive, anti-science efforts. Gift link www.nytimes.com/2025/02/26/c...
nytimes.com
She Lobbied for a Carcinogen. Now She’s at the E.P.A., Approving New Chemicals. (Gift Article)
Lynn Dekleva, who recently took a senior role at the agency, once led an aggressive effort by industry to block regulations on formaldehyde.
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Eric Topol @erictopol.bsky.social · 25/02/2025
A treasure chest of all of our immune system exposures and responses is hiding in our B and T cell receptors. Now that's being decoded to make diagnoses. erictopol.substack.com/p/the-first-...
erictopol.substack.com
The First Diagnostic Immunome
A Big Step Forward By Sequencing B and T Cell Receptors Plus A.I.
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markesnyder.bsky.social @markesnyder.bsky.social · 25/02/2025
Excited to share our lab’s latest publication exploring the role of tissue resident memory T cells in the development of chronic lung allograft dysfunction. Excellent work by graduate student Madeline Lipp and postdoc Kaveh Moghbeli!! insight.jci.org/articles/vie...
insight.jci.org
JCI Insight - NKG2D blockade impairs tissue-resident memory T cell accumulation and reduces chronic lung allograft dysfunction
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markesnyder.bsky.social @markesnyder.bsky.social · 20/02/2025
I realize nobody will see this, but I had to reply to a flawed argument. Hindering biomedical sciences will not just result in the status quo, things will get worse. Impairing our ability to respond to emerging pathogens and new harmful industrial by products will result in death and suffering.
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markesnyder.bsky.social @markesnyder.bsky.social · 09/02/2025
Sad news today.
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markesnyder.bsky.social @markesnyder.bsky.social · 26/01/2025
Go Bills!!! Unfortunately, I heard they already called roughing the passer on Matt Milano because he frowned during a State Farm commercial.
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markesnyder.bsky.social @markesnyder.bsky.social · 17/01/2025
Cloudy every day isn’t always bad. Pittsburgh clouds make some decent photos.
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