The molecular, cellular, and functional restoration of the axolotl thymus after de novo regeneration is described.

A de novo IL-21 mimic, 21h10, exhibits improved stability and potent antitumor activity in vivo compared with native IL-21.

Cytotoxic T lymphocyte target recognition triggers rapid nuclear polarization to the immune synapse and an early transcriptional burst of cytokines.

The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters, suggesting previously unidentified therapeutic avenues.

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Understanding the impacts of genetic abnormalities on immune responses to tumors can inform immunogenomic-based precision medicine.

Expanded CD4+ T cell clones preferentially adopt a single fate in malaria, and TR1 cells dominate and display long-term memory.

Staphylococcus aureus skin infection induces eosinophil innate immune memory to exacerbate allergen-induced airway inflammation.

Hematopoietic aging drives lung fibrosis and profibrotic macrophage influx, stalling their maturation via reduced Treg-derived IL-10.

ALT: two men are riding a bicycle with a basket on it .

Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolutio...

We review mechanisms of action underlying the function of vaccine adjuvants and knowledge gaps to be addressed.

Late last week, the Trump administration set off a frenzy in the US scientific community when the National Institutes of Health (NIH) announced that indirect cost reimbursement for federally funded re...

TCR-peptide-HLA ternary structures define molecular mechanisms of TCR cross-reactivity toward natural influenza variants.

Single-cell and spatial multiomics analyses identify breakout lesions as a hotspot for tumor-immune interactions and diversification.

Meningeal regulatory T cells restrain local interferon-γ–producing lymphocytes, thereby safeguarding parenchymal brain homeostasis.

Meningeal regulatory T cells restrain local interferon-γ–producing lymphocytes, thereby safeguarding parenchymal brain homeostasis.

Antibodies targeting the influenza hemagglutinin from potentially pandemic H5Nx viruses can be isolated from naïve individuals.

Response to donor lymphocyte infusion in AML is characterized by marrow immunological diversity and clonal expansion of CD8+ cytotoxic T cells.

Obesity disrupts cholesterol homeostasis to inhibit the accumulation of insulin-sensitizing ST2hi VAT Treg subsets.

A multiomics approach reveals immune dysregulation signatures that characterize the clinical phenotypes of human RAG deficiency.

Today in Science and science: Our Science family of journals editors’ favorite papers of 2024

Intermediate tumor-associated macrophages (TAMs) emerge first and give rise to two more differentiated TAM populations in pancreatic cancer.

Short-lived perilesional Ly6G+ macrophages license alveolar epithelial regeneration after viral-triggered lung injury.

The balance between protective and pathological immune responses shapes progression of Mycobacterium tuberculosis infection.

Macrophages are functionally heterogeneous cells essential for apoptotic cell clearance. Apoptotic cells are defined by homogeneous characteristics, ignoring their original cell lineage identity. We f...

KEAP1 promotes persistent T cell immunity and a stem-like T cell response during chronic antigen stimulation by repressing NRF2.

Intestinal macrophage LRRK2 kinase activity impairs Paneth cell function in Crohn’s disease.