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Vincent de Bakker

@vincentdebakker.bsky.social
191 followers 366 following 3 posts

Postdoc @Bernhardt Lab, Harvard Medical School | Microbiologist | Statistician

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Reposted by Vincent de Bakker
Jan-Willem Veening @veeninglab.com · 03/09/2026
Clonal does not mean uniform. #MicroSky Our new review explores how genetically identical bacteria adopt different cell states, and how that diversity shapes survival, cooperation, antibiotic responses and gene transfer. 🧵 doi.org/10.1146/annu...
doi.org
Decoding Bistability and Drivers of Phenotypic Variation in Bacteria
In a process known as phenotypic heterogeneity or phenotypic variation, bacteria can produce distinct phenotypes within an isogenic population in response to shifting environmental conditions. Noise i...
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Reposted by Vincent de Bakker
Jan-Willem Veening @veeninglab.com · 04/08/2026
New preprint! #MicroSky Led by @ayaiizuka.bsky.social & Maria Vittoria Mazzuoli, we ask what helps Staphylococcus aureus enter, survive inside and evade treatment in human monocytes. www.biorxiv.org/content/10.6...
biorxiv.org
Staphylococcus aureus Mnh1 cation–proton antiporter promotes phagocytic uptake and intracellular survival in human monocytes
While Staphylococcus aureus is predominantly an extracellular human commensal, it can also exhibit an intracellular lifestyle that enables its persistence within diverse host cell types, including mon...
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Reposted by Vincent de Bakker
Amelia McKitterick @amelia-mckitterick.bsky.social · 23/04/2026
Happy to share the finalized version of my paper on phage lysis in bacteria with unique envelopes! 🎉 Bacteriophages target membrane-anchored glycopolymers to promote host cell lysis and progeny release www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Reposted by Vincent de Bakker
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 15/03/2026
A potential role for acyl-phosphate in the coordination of phospholipid and lipopolysaccharide synthesis in Escherichia coli www.biorxiv.org/content/10.64898/20…
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Reposted by Vincent de Bakker
Jan-Willem Veening @veeninglab.com · 27/02/2026
Checkout our latest preprint which is a real lab-wide effort to map antibiotic stress signatures across the pneumococcal pangenome. All findings have also been incorporated in PneumoBrowse 2.0. www.biorxiv.org/content/10.6...
biorxiv.org
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Reposted by Vincent de Bakker
Ákos T Kovács @evolvedbiofilm.bsky.social · 26/02/2026
Join us as Assistant/Associate/Full Professor Computational Biology at Institute of Biology Leiden (IBL) / @leidenscience.bsky.social / @unileiden.bsky.social Application deadline on 15 March 2026 👇 careers.universiteitleiden.nl/job/Assistan...
careers.universiteitleiden.nl
Assistant/Associate/Full Professor Computational Biology
Assistant/Associate/Full Professor Computational Biology
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Reposted by Vincent de Bakker
Jan-Willem Veening @veeninglab.com · 20/01/2026
The @dmf-unil.bsky.social is supporting the application of a candidate for the SNSF/ERC Starting Grant (deadline 5th of May). Reach out to me if you are interested. We are collecting CV’s until the 8th of Feb. We can offer a stimulating scientific environment and help with the application/interview.
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Reposted by Vincent de Bakker
Nature Microbiology @natmicrobiol.nature.com · 19/12/2025
What is better than one? Two connected papers! #NewResearch S protein of Streptococcus pneumoniae activates PBP1a and coordinates with a wider GpsB-associated multi-protein complex to regulate peptidoglycan remodelling and cell division. #MicroSky 🦠 www.nature.com/articles/s41...
nature.com
Streptococcus pneumoniae S protein activates PBP1a to regulate peptidoglycan remodelling and cell division - Nature Microbiology
S protein interacts with and activates PBP1a during cell division, as part of a larger GpsB-associated multiprotein complex that coordinates peptidoglycan remodelling in Streptococcus pneumoniae.
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Reposted by Vincent de Bakker
Jan-Willem Veening @veeninglab.com · 19/12/2025
Now online @natmicrobiol.nature.com! www.nature.com/articles/s41...
nature.com
Pneumococcal S protein coordinates cell wall modification and repair to resist host antimicrobials - Nature Microbiology
Streptococcal S protein activates a peptidoglycan cell wall repair and modification complex to promote resistance of Streptococcus pneumoniae to lysozyme and LL-37, and increase virulence during infec...
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Reposted by Vincent de Bakker
Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 17/12/2025
Very pleased to share that our recent article with @veeninglab.com in @natcomms.nature.com was selected for the Editor's Highlights, which aims to showcase the 50 best papers recently published in the area of #microbiology & infectious diseases! www.nature.com/collections/...
nature.com
Microbiology and infectious diseases
This page highlights recent articles on all aspects of bacteriology, mycology, parasitology and virology, covering the biology of pathogens, host-pathogen ...
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Vincent de Bakker @vincentdebakker.bsky.social · 17/12/2025
Great to see that our recent paper (www.nature.com/articles/s41...) got picked to be featured among the Editors’ Highlights: www.nature.com/collections/...
nature.com
Multi-omics profiling reveals atypical sugar utilization and a key membrane composition regulator in Streptococcus pneumoniae - Nature Communications
The pathogen Streptococcus pneumoniae can adapt to diverse microenvironments in the human body. Here, De Bakker et al. study these adaptation responses, showing unusual sugar utilization and identifyi...
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Reposted by Vincent de Bakker
anna brogan @apbrogan.bsky.social · 13/12/2025
Fer’s tour de force in B. anthracis is out! Fer got Tn-seq running, built an ordered knockout library, defined all essential sporulation genes, and found a peptidoglycan deacetylase inhibitor critical for engulfment. Including our first one-by-all Alphafold screen! journals.plos.org/plosbiology/...
journals.plos.org
Identification of sporulation genes in Bacillus anthracis highlights similarities and significant differences with Bacillus subtilis
How good is Bacillus subtilis as a model for the spore-forming pathogen Bacillus anthracis? Using high throughput genetics to identify B. anthracis sporulation genes and cytological analysis of the mu...
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Vincent de Bakker @vincentdebakker.bsky.social · 25/11/2025
Happy and proud to see this one published!
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