How the BRCA1-A complex finds and removes ubiquitin signals at DNA breaks remains unknown. Here the authors show that ARISC–RAP80 binds K63-linked ubiquitin chains through multiple subunits and non-ca...

Cytoplasmic lattices (CPLs) are filamentous assemblies essential for mammalian embryonic development. They are known to regulate organelle organization, spindle assembly, and protein homeostasis, but ...

Abstract. Transcription elongation by RNA polymerase II is a tightly regulated process that requires coordinated interactions between transcription elongat

A lab operating system and AI agent for structured molecular and structural biology workflows.

Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional ...

Compound-mediated targeted protein degradation through the recruitment of Ub ligases is an emerging field. Here, the authors determine key structural and biochemical principles for harnessing SCF-FBXO...

Target-directed microRNA degradation is driven by the atypical ZSWIM8–CUL3 E3 ubiquitin ligase that uses a two-RNA-factor authentication mechanism to specifically recognize AGO–miRNA–trigger...

Molecular biologist Matthias Muhar becomes part of the MPI-CBG faculty

MicroRNAs direct downregulation of target mRNAs. Sometimes, however, this regulatory paradigm inverts, and a target RNA triggers the degradation of a microRNA. This target-directed microRNA degradatio...

Nature Reviews Molecular Cell Biology, Published online: 31 October 2025; doi:10.1038/s41580-025-00919-zIn this Tools of the Trade article, Kiss (Schulman lab) discusses the development of UbiREAD, a method that delivers in vitro-ubiquitinated protein reporters into cells to systematically assess how different ubiquitin chain configurations affect protein stability and degradation.

Membrane proteins are essential for any cell but difficult to fold. Here, the authors show that the EMC acts as a chaperone for membrane proteins. They dissect client recognition and provide a molecul...

Freeman Hrabowski Scholars are outstanding early career faculty who have the potential to become leaders in their research fields.

Using biochemistry, chemical biology, and cryo-EM, Maiwald et al. elucidate how TRIP12 forms K29 linkages and K29/K48-linked branched ubiquitin chains, revealing a mechanism for polyubiquitylation sha...