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David Tobin

@tobinlab.bsky.social
3K followers 1.3K following 26 posts

Scientist at Duke studying tuberculosis, host susceptibility to infection, and mycobacterial pathogenesis. Views are my own and do not represent those of my employer.

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Reposted by David Tobin
DMM Journal @dmmjournal.bsky.social · 25/09/2026
What does patient involvement in cancer research really look like? Submit an article for the EACR Science Communication Prize 2026 @helloeacr.bsky.social. Enter by 9 November via magazine.eacr.org/what-does-pa...
magazine.eacr.org
EACR Science Communication Prize 2026
Have you ever involved patients in your cancer research? We want to hear about it!
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David Tobin @tobinlab.bsky.social · 19/09/2026
Smith and Tobin lab contingent at a fantastic mycobacterial infection meeting at @pasteur.fr Inspiring to hear and see all the exciting work going on and be a part of this community in very strange times for research and public health.
Duke scientists from the Tobin and Smith labs in front of a mural at the Pasteur Institutr
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Michael Baym @baym.lol · 13/09/2026
Ten years ago Tami, Roy, and I released a movie we made of antibiotic resistance evolving in real time. I thought maybe a couple thousand people tops would see it. I couldn't have imagined it would be seen millions of times, and be taught from middle school through the graduate level worldwide
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Michael Clemens @mclem.org · 12/09/2026
The US President's new proposal to tax international students has been approved by the White House for release this week. It's an unprecedented $100,000 tax on int'l grads who stay to work after graduation on Optional Practical Training (most grads do), a crucial bridge to remaining by any channel.
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Zebrafish Disease Models Society (ZDMS) @zdmsociety.bsky.social · 13/09/2026
We are excited to offer a VIRTUAL option for #ZDM19 once again! Virtual Registration will give you access to all live ZDM19 talks as well as the recordings 🐟 #zebrafish Renew your membership and register today: www.zdmsociety.org/zdm19-regist... View the agenda: www.zdmsociety.org/monday-septe...
Logo for the Zebrafish Disease Models Society annual conference ZDM19 in Oxford, UK. Now available online.
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Olivier Neyrolles @oneyrolles.bsky.social · 13/09/2026
𝐓𝐰𝐨 𝐬𝐭𝐮𝐝𝐢𝐞𝐬, 𝐨𝐧𝐞 𝐬𝐭𝐨𝐫𝐲: 𝐜𝐨𝐩𝐩𝐞𝐫, 𝐜𝐲𝐬𝐭𝐞𝐢𝐧𝐞 𝐚𝐧𝐝 𝐫𝐞𝐝𝐨𝐱 𝐚𝐝𝐚𝐩𝐭𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝑴. 𝒕𝒖𝒃𝒆𝒓𝒄𝒖𝒍𝒐𝒔𝒊𝒔 Our new @mbio.bsky.social paper shows that copper reaches intracellular M. tuberculosis and strongly induces CysK2, a cysteine synthase linking copper sensing to redox adaptation and persistence. 📖 shorturl.at/PSDbk
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Diversify Microbiology @diversifymicro.bsky.social · 11/09/2026
UNC Greensboro Department of Biology is hiring for three positions this year including one in microbiology! spartantalent.uncg.edu/postings/35918
spartantalent.uncg.edu
Assistant Professor Microbiology
The Department of Biology at UNC Greensboro (UNCG) seeks an individual with a strong record of accomplishment in microbiology broadly defined for a tenure-track faculty position at the rank of Assista...
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Harmit Singh Malik @harmitmalik.bsky.social · 10/09/2026
Reposting this ongoing search (any discipline of biology) for an Assistant to Associate level colleague in the Division of Basic Sciences at Fred Hutch. Great city, great colleagues, great core facilities, great trainees.
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Jim Sun, PhD @sunlab.bsky.social · 09/09/2026
We are looking for a postdoctoral fellow to join the team @ubcmicroimmuno.bsky.social @science.ubc.ca to study TB pathogenesis and host-directed therapy! Please help disseminate amongst your network. ubc.wd10.myworkdayjobs.com/ubcfacultyjo...
ubc.wd10.myworkdayjobs.com
Postdoctoral Research Fellow - Host-Pathogen Interactions & Host-Directed Therapeutics
Academic Job Category Faculty Non Bargaining Job Title Postdoctoral Research Fellow - Host-Pathogen Interactions & Host-Directed Therapeutics Department Research I Sun I Department of Microbiology...
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Michael Glickman @michaelglickman.bsky.social · 07/09/2026
Interesting article about SigD/RsdA in M. abscesus. Some over lap with TB regulon and function, but also many differences. It will be interesting to see if the proteolytic processing of RsdA is also by a Rip1 S2P. Nice work! 🦠https://dx.plos.org/10.1371/journal.pgen.1012286
dx.plos.org
The SigD regulon of Mycobacterium abscessus determines cell envelope composition and antibiotic susceptibility
Author summary Mycobacterium abscessus is an increasingly important bacterial pathogen that causes difficult-to-treat infections because it is naturally resistant to many antibiotics. A major contribu...
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Abby Dernburg @adernburg.bsky.social · 07/09/2026
Agreed - some of the potential damage overlaps with what the OMB proposal is attempting to impose, but this proposal would create some distinct additional problems that are worth addressing head-on.
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David Tobin @tobinlab.bsky.social · 07/09/2026
Given how NIH analyzed and presented feedback for the RFI around PI caps for # of awards (percent in favor, percent opposed was the top-line analysis) I suspect it’s important to respond in large numbers to this proposal. Can likely reuse many of the concerns about the broader OMB proposed rule.
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International Zebrafish Society @izfs.bsky.social · 03/09/2026
US Zebrafish PIs: Your input is critical! An NIH R24 grant has been obtained to develop 60 small epitope tag knock-in genes as a resource for the zebrafish community. Please submit your input by Sep 18: upenn.co1.qualtrics.com/jfe/form/SV_... #EpitopeTag #ZebrafishResource #ZebrafishSurvey
upenn.co1.qualtrics.com
Qualtrics Survey | Qualtrics Experience Management
The most powerful, simple and trusted way to gather experience data. Start your journey to experience management and try a free account today.
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Matt Scaglione @mattscaglione.bsky.social · 02/09/2026
dicty.org is live, a rebuilt dictyBase. 13,892 gene records, 20 genomes, BLAST, enrichment, CRISPR and primer design, and the full Dicty Stock Center orderable from the site. Lots of new features to check out. This is a public beta, tell us what to fix. @dictybase.bsky.social #Dictyostelium
dicty.org
dictyBase — Dictyostelium genomes, genes & tools
Searchable Dictyostelium gene records with AlphaFold structures and RNA-seq expression, 20 sequenced dictyostelid genomes, a genome browser, BLAST, and GO-enrichment analysis.
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sarasuliman.bsky.social @sarasuliman.bsky.social · 30/08/2026
For innate T cell enthusiasts, happy to share our preprint: www.biorxiv.org/content/10.6.... We show that mycobacterial lipid–reactive CD1b-specific T cells transcriptionally resemble conventional CD4 T cells more than other innate-like T cells, challenging how we classify these T cells. #CD1b #GEM
biorxiv.org
| bioRxiv
bioRxiv - the preprint server for biology, operated by openRxiv, a nonprofit organization dedicated to advancing scientific communication
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David Tobin @tobinlab.bsky.social · 29/08/2026
Interesting new RNF213 story from Mary Dickinson and Jörn Coers @coerslab.bsky.social showing xenophagy-independent role for RNF213 in cell autonomous immune defense: antimicrobial lysis of inclusions and host cell death after release.
pnas.org
RNF213-dependent lytic destruction of Chlamydia-containing vacuoles activates host cell death pathways | PNAS
The cytokine gamma-interferon promotes antimicrobial cell-autonomous immunity by inducing hundreds of interferon-stimulated genes (ISGs). Among the...
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Aaron Quinlan (he/him) @aaronquinlan.bsky.social · 28/08/2026
I am delighted to announce that The Department of Human Genetics at the University of Utah is continuing a multi-year recruiting initiative for multiple tenure-track faculty positions at the rank of Assistant Professor. Please share and consider applying! utah.peopleadmin.com/postings/208...
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David Tobin @tobinlab.bsky.social · 28/08/2026
New facets of eicosanoid signaling in TB: crosstalk with a specialized population of granuloma-associated fibroblasts. Happy to share new work led by Erika Hughes, with @charliejpyle.bsky.social and many other wonderful collaborators not on BlueSky.
cell.com
Host eicosanoid signals define a granuloma fibroblast population that coordinates mycobacterial containment
Hughes et al. find that the TB susceptibility gene lta4h contributes to the recruitment and differentiation of a discrete set of fibroblasts that populate the periphery of mycobacterial granulomas in ...
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Antonio Pagán @antoniopagan.bsky.social · 19/08/2026
Stanford Medicine’s Microbiology & Immunology Department (my home department) opened a job search for a tenure-track assistant professor position. Candidates interested in any and all areas of microbiology and/or immunology are encouraged to apply. facultypositions.stanford.edu/jobs/assista...
facultypositions.stanford.edu
Assistant Professor of Microbiology & Immunology - Stanford University, California, United States
The Department of Microbiology & Immunology at Stanford University seeks applications for a tenure-track faculty position at the Assistant Professor level in the University Tenure Line. We seek ou...
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David Tobin @tobinlab.bsky.social · 15/08/2026
Cool paper and technique from Shumin Tan’s lab at Tufts to detect Mycobacterium tuberculosis transcripts in situ by HCR-FISH.
science.org
Direct bacterial transcript visualization illuminates spatiotemporal environmental adaptation of Mycobacterium tuberculosis in the lung
Spatiotemporal environmental variation results in marked heterogeneity in bacterial infection progression and disease outcome, with vital consequences for treatment success. For the globally important...
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John F. Rawls @jfrawls.bsky.social · 04/08/2026
The Rawls Lab is hiring! We are seeking a motivated research technician to support cutting-edge studies in gastrointestinal physiology using zebrafish & mice. To learn more about this hands-on & in-person position at Duke University in Durham NC, click here: careers.duke.edu/job/Durham-R...
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Alex Eve @amjeve.uk · 26/07/2026
Congratulations, @jeffreyafarrell.bsky.social, on winning the @socdevbio.bsky.social #2026SDB Elizabeth D. Hay New Investigator Award! Learn more about Jeff's science and career in his @dev-journal.bsky.social interview with @saanjbati.bsky.social.
doi.org
Transitions in development – an interview with Jeffrey Farrell
Jeffrey Farrell is an Earl Stadtman Investigator at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), USA, where he heads the Unit on Cell Specification and ...
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Michael Glickman @michaelglickman.bsky.social · 23/07/2026
Please repost! #microsky🦠 The Glickman Lab at MSK is recruiting! Projects in Mtb pathogenesis, basic biology of mycobacteria, and mycobacterial cancer therapies. See our publications here: tinyurl.com/3f386f4x Send CV and cover letter to: glickmanmycolab@gmail.com
scholar.google.com
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Zebrafish Disease Models Society (ZDMS) @zdmsociety.bsky.social · 15/07/2026
🚨 Early bird pricing for registration to #ZDM19 ends today! We hope you can join us in Oxford 🤗 More details here: www.zdmsociety.org/zdm19-regist...
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Maureen Barr @barrlab.bsky.social · 13/07/2026
341,699 comments as of yesterday. Today is the deadline. Your voice impacts the future of US research & science. Please submit a comment if you haven't already.
OMB - Docket with 341,699 comments
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Conlon Lab @bconlon.bsky.social · 02/07/2026
Loss of O-antigen due to wbbL mutations is common and associated with increased mortality in Escherichia coli bloodstream infections | Science Advances www.science.org/doi/10.1126/...
science.org
Loss of O-antigen due to wbbL mutations is common and associated with increased mortality in Escherichia coli bloodstream infections
O-antigen loss in E. coli is not benign—wbbL mutations are associated with increased septic shock and higher mortality.
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Phil Abitua @ohnolog.bsky.social · 30/06/2026
Annual killifish continue to surprise us: they make neutrophils before almost every other cell type, even before gastrulation. Neutrophils usually arise from the lateral plate mesoderm (forming in cyan), but in killifish they are already patrolling around the embryo in gold. tinyurl.com/killiphil
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 30/06/2026
Pls share: U of Washington has an opening for a tenure-track faculty position at the rank of Assistant Professor. This position is expected to specialize in molecular virology or bacteriology. Here is a link: microbiology.washington.edu/index.php/ne...
microbiology.washington.edu
Micro is Hiring! | UW Microbiology
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Valeria Reyes Ruiz @reyesruiz.bsky.social · 25/06/2026
Our lab is hiring an enthusiastic and motivated research specialist to study host-pathogen interactions in the context of S. aureus infection. For more information, see below: Lab website: www.reyesruizlab.org jobs.wisc.edu/jobs/researc...
jobs.wisc.edu
Research Specialist - Madison, Wisconsin, United States
Current Employees: If you are currently employed at any of the Universities of Wisconsin, log in to Workday to apply through the internal application process.Job Category:Academic StaffEmployment Type...
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Julie Pfeiffer @jkpfeiff.bsky.social · 26/06/2026
Faculty search announcement 2026: Tenure-Track Assistant Professor in Microbiology at UT Southwestern in Dallas. We seek candidates working in microbial pathogenesis (broadly defined). Come join our community! (1/5) www.utsouthwestern.edu/departments/...
Department members sit at a very long table in the hallway eating a pre-Thanksgiving potluck feast.
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Patrick Moynihan @pmoyniha.bsky.social · 24/06/2026
New paper in collaboration with @proftracypalmer.bsky.social, @lislowe.bsky.social and many more. We show that mycobacteria produce Type VII secreted anti-bacterial protein toxins. Excited to explore this new area of mycobacterial biology. www.nature.com/articles/s41...
nature.com
A Type VII-secreted toxin enables inter-mycobacterial competition - Nature Communications
Mycobacteria have not yet been reported to engage in interbacterial competition via secretion of proteinaceous toxins. Here, Benedict et al. show that some mycobacteria can use their type-VII secretio...
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Christina Stallings @stallingslab.bsky.social · 29/05/2026
Very excited about our recent preprint- @lindashuyingxu.bsky.social and collabs discover that neutrophils repurpose their nucleolus for storage of pre-made IFN-I to be rapidly released via a nucleolar stress response that results in nucleolar extrusion and secretion. www.biorxiv.org/content/10.6...
biorxiv.org
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 23/06/2026
Our Dept of Microbiology & Immunology @Geisel School of Medicine @Dartmouth has an opening for an Assistant Professor. Looking for programs bridging multiple areas in Micro & Immuno. A great place to be! Programs: www.M2P2.org www.dartmouthbiofilm.org Job ad: apply.interfolio.com/187637
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Science Magazine @science.org · 22/06/2026
Exclusive: The National Science Foundation is trimming this year’s budgets for hundreds of its traditional basic science programs by roughly 20% to 30%, even though its overall budget is down just 3%. scim.ag/4xY2KCm
science.org
Exclusive: NSF slashes research programs to support new tech initiative, insiders say
Unexpected shift in funds has meant sharp drop in grants this fiscal year
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Matthew Lawrenz @lawrenzlab.bsky.social · 19/05/2026
The M&I Department is looking for a new faculty member with a passion for teaching graduate and medical students to join us at UofL - see the link 👇. We have a thriving collegial department in a great city. Email me if you have questions. I will also be at Microbe in June to talk more. Join us😀.
myworkday.com
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Tera Levin @teralevin.bsky.social · 30/05/2026
Easy link for comment submission: www.regulations.gov/document/OMB... Also send a copy to your congresspeople!
regulations.gov
Regulations.gov
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Patrick S. Mitchell @psmitchej.bsky.social · 25/05/2026
Thrilled to announce that the Department of Microbiology at the University of Washington, School of Medicine is hiring at the Assistant Professor level (tenure-track)! The Pacific Northwest is an awesome place to live and do science 🧪🦠. Join us! apply.interfolio.com/185622 Applications due 8/1.
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Natasha O'Brown @natashaobrown.bsky.social · 22/05/2026
For anyone who is a scientist or has benefitted from basic research on model organisms (that's EVERYONE), please take the time to leave a comment about priority 1 here: rfi.grants.nih.gov?s=6998c3a23e... by the deadline May 28! I know I wouldn't be here today without modern medicine
rfi.grants.nih.gov
Request For Information
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Charlie Pyle @charliejpyle.bsky.social · 12/05/2026
Cool new granuloma findings we just published in JCF in collaboration with Ravi Karra’s Lab, here at Duke. Tilmanocept, a cancer diagnostic, can be repurposed to identify cardiac sarcoidosis granulomas, which could be a noninvasive alternative to diagnostic biopsy! onlinejcf.com/article/S107...
onlinejcf.com
Tilmanocept Labels Granulomas in Cardiac Sarcoidosis
Sarcoidosis is a systemic, inflammatory disease defined by the presence of noncaseating granulomas in affected organs. Single-cell and spatial profiling have resolved granulomas to be highly ordered s...
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Teresa O'Meara @teresaomeara.bsky.social · 11/05/2026
We are hiring @umichmicroimmuno.bsky.social ! Tenure-track assistant professor position in our Microbiology and Immunology department. We are especially looking for someone working in bacterial pathogenesis
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tafesselab.bsky.social @tafesselab.bsky.social · 04/05/2026
We’re hiring! Our department is recruiting for a tenure-track faculty position. We seek outstanding candidates working broadly in molecular microbiology, immunology, and host–pathogen interactions. Please share widely! @jnpruneda.bsky.social @rauchlab.bsky.social www.nature.com/naturecareer...
nature.com
Faculty Position in Molecular Microbiology and Immunology - Portland, Oregon job with Oregon Health & Science University (OHSU) - Molecular Microbiology and Immunology | 12858852
The Department of Molecular Microbiology and Immunology at OHSU invites applications for a tenure-track Assistant or Associate Professor position.
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Max Gutierrez @maxgg.bsky.social · 30/03/2026
‼️ A really good meeting for people working on host-pathogen interactions! Great keynote speakers this year: Raphael Valdivia and Florence Niedergang. Please repost!
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Charlie Pyle @charliejpyle.bsky.social · 30/04/2026
An interesting new study, by Clare Smith’s lab and me, here at Duke. We found that during Mtb infection, CCR6 knockout mice (on a B6 background) form necrotic pulmonary granulomas, have increased IL17 production and have sex specific differences in susceptibility. journals.asm.org/doi/10.1128/...
journals.asm.org
CCR6 is essential for effective immunity against Mycobacterium tuberculosis infection in mice | Infection and Immunity
An estimated 10.8 million people worldwide were infected with tuberculosis (TB) in 2023, and among those cases, 1.25 million people succumbed to disease (1); 90% of people who become infected with Myc...
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ASM @asm.org · 29/04/2026
ASM's Mechanism Discovery Unit, focused on advancing research into the basic principles of microbial life, has launched! The unit is led by Glen McGugan, Ph.D., & Alison Criss, Ph.D., & guided by a Scientific Advisory Council of 14 experts. Read more: asm.org/press-releas...
ASM Mechanism Discovery Unit title with headshots of the Director and Chair.
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Surfin' NuRD @surfinnurd.bsky.social · 13/04/2026
A very moving tribute to one of the founders of modern Stem Cell Biology: Gail Martin. Well worth a read. www.pnas.org/doi/10.1073/...
pnas.org
Gail R. Martin (1944–2026): Embryonic stem cell pioneer, developmental biologist, and student of Asian art and ceramics | PNAS
Gail Roberta Martin, Professor Emerita of Anatomy at the University of California, San Francisco, and one of the founding figures of modern stem ce...
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Gc Rox @gcrox.bsky.social · 14/04/2026
Postdoctoral Position (Please re-post) A funded postdoctoral position for a recent graduate to study aspects of Neisseria gonorrhoeae pathogenesis, antigenic variation, genetics, or physiology. Please contact Hank Seifert h-seifert@northwestern.edu #Microsky, #Microbiology, #MicrobialEvolution
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Mark Mandel @markjmandel.bsky.social · 30/03/2026
Apply to be an editor at an ASM Journal! Open call for editors at mBio, mSphere, mSystems, and Microbiology Spectrum. This is a very fulfilling way to share your expertise and give back to our society journals. @asm.org journals.asm.org/asm-call-for...
journals.asm.org
ASM Journals Open Calls for Editors
A list of current and upcoming open calls for editors at ASM Journals.
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Yi Feng @fengfishlab.bsky.social · 28/03/2026
As part of the ZDMS cancer RIG 2026 meet up webinars, we want to encourage ECR participants to apply for the opportunity to share their research with our community, if you are doing cool cancer research using #zebrafish please apply here eur02.safelinks.protection.outlook.com?url=https%3A...
eur02.safelinks.protection.outlook.com
Microsoft Forms
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DMM Journal @dmmjournal.bsky.social · 24/03/2026
As today is #WorldTBDay we urge you to read this powerful interview with Dr Zolelwa Sifumba highlighting how her experience as a #tuberculosis survivor, alongside her training as a medical doctor, complements her work as a patient advocate for TBProof in South Africa doi.org/10.1242/dmm....
Picture of Zolelwa Sifumba
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Michael Baym @baym.lol · 17/03/2026
Annual reminder: if you’ve been accepted to multiple graduate programs and are still deciding, please let the ones you’re definitely not going to know as soon as possible! -Someone who got into his PhD off the waitlist the day after the deadline
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