Nature Microbiology, Published online: 29 September 2026; doi:10.1038/s41564-026-02476-3TRIM32-mediated SUMOylation of LAMP2A triggers classical chaperone-mediated autophagy, which viruses hijack to drive tumour growth. Peptide blockers of this modification show antitumour activity in mice model, identifying LAMP2A as a viable target.

YouTube video by The Francis Crick Institute

Radulovic et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit...

Nature Reviews Microbiology, Published online: 06 August 2026; doi:10.1038/s41579-026-01357-0This study reports that fast-growing intracellular Mycobacterium tuberculosis evades antibiotic treatment.

The slow growth displayed by Mycobacterium tuberculosis has been historically associated with pathogen’s persistence and drug tolerance. Unexpectedly, here the authors identify a rare subpopulation of...

Author summary Salmonella is a bacterium that causes a wide range of human diseases, from gastroenteritis to systemic infection. Blood stream infections are more common in young children or those who ...

Nature Communications - Not all components of the lysosome damage response pathway have been defined. Here, the authors discover that the bridge-like lipid transport protein VPS13C senses lysosomal...

The London School of Hygiene & Tropical Medicine (LSHTM) is one of the world’s leading public health universities. Our mission is to improve health and health equity in the UK and worldwide; working i...

Heffner et al. show that ANXA11 and CHMP2B, proteins encoded by ALS- and FTD-risk genes, are sequentially recruited to sites of plasma membrane damage. Membrane repair involves ANXA11-positive plug fo...

FocalPlane x ELMI2026 image competition: vote for your favourite - News

Here the authors characterize mRNA-based tuberculosis vaccine candidates BNT164a1 and BNT164b1 and show that they are immunogenic, well tolerated and efficacious in preclinical animal models.

Aktuelle Stellenanzeigen des Rudolf-Virchow-Zentrums / Current positions of the Rudolf Virchow Center

Tuberculosis treatment is challenging in part because Mycobacterium tuberculosis (Mtb) populations are phenotypically heterogeneous. Within the same infection, bacterial cells can exist in different physiological states, from actively replicating to slow-growing or non-replicating forms. To better study these processes, we developed and validated Mtb-Timer, a fluorescent reporter that enables visualization of bacterial growth dynamics. The system is based on a fluorescent protein that changes color over time: newly synthesized protein emits green fluorescence (GFP) and gradually shifts to red (DsRed) as it matures. The green-to-red fluorescence ratio, therefore, reflects bacterial replication activity. Using microscopy and flow cytometry in both in vitro cultures and infected macrophages (in cellulo), Mtb-Timer enables the quantification of distinct bacterial subpopulations and the real-time monitoring of the green-to-red fluorescence ratio and bacterial burden during treatment with first-line antibiotics.

Different nontuberculous mycobacteria (NTM) species display unique replication profiles in acidic pH in vitro which correlates to their replication within human macrophages. Inhibition of the acidic ....

In a systematic review and meta-analysis, Seyed Alireza Mortazavi and colleagues investigate urban versus rural differences in adult pulmonary tuberculosis prevalence between 2000 and 2024 in 26 low- ...

Endomembrane damage of intracellular vesicles triggers signals that activate membrane repair in mammalian cells to restore homeostasis. However, the signals that drive diverse membrane repair recruitm...

Here, the authors report metabolic activation as a potential antimicrobial strategy against Mycobacterium tuberculosis. They show that supra-physiological activation of L-histidine biosynthesis r...

"We know how to live in a world without tuberculosis. But we choose not to live in that world.

Nature Communications - Here the authors show that Plasmodium falciparum egress products disrupt endothelial barrier and activate JAK-STAT and interferon type response in a 3D blood-brain barrier...

Different nontuberculous mycobacteria (NTM) species display unique replication profiles in acidic pH in vitro which correlates to their replication within human macrophages. Inhibition of the acidic ...

YouTube video by KeystoneSymposia

Data from complementary imaging techniques were integrated into a model that resolves the dynamic exocyst ensemble and membrane architecture during exocytosis, an essential cellular pathway. Sec18 med...

Mycobacterial α-glucans target dectin-1, altering phagosomal maturation and enhancing intracellular bacterial survival.