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tafesselab.bsky.social

@tafesselab.bsky.social
107 followers 43 following 38 posts
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tafesselab.bsky.social @tafesselab.bsky.social · 29/09/2026
Please come join us!
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Giovanni D’Angelo @giodang.bsky.social · 23/09/2026
#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics #neuroscience #BrainAtlas
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Jonathan Pruneda @jnpruneda.bsky.social · 22/08/2026
WE'RE HIRING! Thanks to some recent successes with NIH funding, we're seeking two new postdoctoral scholars to join our team. See below for details. Please share widely and feel free to reach out with any questions!
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Kimberly Beatty @beattylab.bsky.social · 02/09/2026
Work from my team. The more I understand M. abscessus, the more convinced I am that treatment can't ignore its extended spectrum beta-lactamase. That is a very active enzyme!! Chemoproteomic Elucidation of β-Lactam Drug Targets in Mycobacterium abscessus pubs.acs.org/aidcbc/artic...
pubs.acs.org
Chemoproteomic Elucidation of β-Lactam Drug Targets in Mycobacterium abscessus
Abstract. The pathogen Mycobacterium abscessus (Mab) can cause severe and difficult-to-treat chronic lung infections. Despite the rising incidence and clin
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tafesselab.bsky.social @tafesselab.bsky.social · 04/08/2026
To understand what a lipid does, we need to know its partners. Which proteins bind lipids and how can we capture those interactions? Our new Nature Protocols paper provides a practical, step-by-step guide to identifying lipid-binding proteins. 🧵
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tafesselab.bsky.social @tafesselab.bsky.social · 09/07/2026
Excited to share our latest paper where we report an MR1-specific nanobody that blocks MR1-mediated T-cell activation. Congrats to Tim Bates, Corinna from David Lewinsohn’s lab, and thanks to @jburkevic.bsky.social for HDX-MS support! @ohsunews.bsky.social academic.oup.com/jimmunol/art...
academic.oup.com
An MR1-specific nanobody capable of blocking MR1T cell activation
Abstract. MR1 is a non-polymorphic, ubiquitously expressed, MHC class I-like antigen-presenting molecule that presents small-molecule metabolites to T cell
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Mikko Taipale @miketilapia.bsky.social · 30/06/2026
Our evil ORFeome paper is out! In collaboration with @alex-stark.bsky.social, we screened ~4,000 viral proteins and secreted effectors from bacteria and parasites, covering hundreds of diverse pathogens, for phenotypes in human cells.
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tafesselab.bsky.social @tafesselab.bsky.social · 30/06/2026
Job alert!  We’re hiring a Postdoctoral Fellow to develop nanobody-based spatial biology approaches to study TB granulomas. Please help spread the word! @microbiologysociety.org @aai.org @ascbiology.bsky.social @ohsunews.bsky.social @embo.org
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tafesselab.bsky.social @tafesselab.bsky.social · 04/05/2026
We’re hiring! Our department is recruiting for a tenure-track faculty position. We seek outstanding candidates working broadly in molecular microbiology, immunology, and host–pathogen interactions. Please share widely! @jnpruneda.bsky.social @rauchlab.bsky.social www.nature.com/naturecareer...
nature.com
Faculty Position in Molecular Microbiology and Immunology - Portland, Oregon job with Oregon Health & Science University (OHSU) - Molecular Microbiology and Immunology | 12858852
The Department of Molecular Microbiology and Immunology at OHSU invites applications for a tenure-track Assistant or Associate Professor position.
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Bella Rauch @rauchlab.bsky.social · 28/04/2026
Wan’t to be faculty at a collegial host-pathogen focused department in a beautiful bikable city with amazing food? This link is for you: facultycareers-ohsu.icims.com/jobs/39006/a...
A picture of the portland waterfront during cherry blossom time
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Bella Rauch @rauchlab.bsky.social · 23/04/2026
🚨Preprint alert ! Alexis Gibson, a @hhmi-science.bsky.social Hannah Grey fellow, reports on our fun collaboration with PNNL. We used standard label-free MS to analyze caspase cleavage products in primary intestinal epithelial cells post inflammasome activation. www.biorxiv.org/content/10.6... 1/2
biorxiv.org
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André Nadler @nadlerlab.bsky.social · 23/03/2026
It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density. Lipid-CLEM, now out in @natcellbio.nature.com brought to you by @mathilda95.bsky.social changes that: www.nature.com/articles/s41...
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tafesselab.bsky.social @tafesselab.bsky.social · 05/03/2026
PacTB is back in Portland on April 8–9, 2026! West Coast TB folks (Bay Area, WA, Vancouver)—especially grad students & postdocs—please join us! Great chance to present + network. Abstract deadline: TODAY Registration deadline: Apr 1 www.eventbrite.com/e/pactb-2026...
eventbrite.com
PacTB 2026
TB research talks, posters & networking on the West Coast. Meet peers, discover cutting-edge projects, and advance TB research together.
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tafesselab.bsky.social @tafesselab.bsky.social · 02/03/2026
Glad to see this news story highlighting our recent lipid interactome database, a resource we hope will help the broader scientific community. @ohsummi.bsky.social @ohsunews.bsky.social news.ohsu.edu/2026/02/25/n...
news.ohsu.edu
New database may unlock potential of lipids in treating, preventing disease
OHSU scientists lead development of so-called ‘Google maps’ for how lipids interact with proteins inside cells.
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tafesselab.bsky.social @tafesselab.bsky.social · 24/02/2026
Our paper on The Lipid Interactome is now published, and the database is open: lipidinteractome.org @ohsummi.bsky.social @ohsunews.bsky.social @nadlerlab.bsky.social @jeremybaskin.bsky.social Please RT to spread the word. doi.org/10.1093/bioi...
doi.org
The Lipid Interactome: an interactive and open access platform for exploring cellular lipid–protein interactions
AbstractSummary. Lipid–protein interactions play essential roles in cellular signaling and membrane dynamics, yet their systematic characterization has lon
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tafesselab.bsky.social @tafesselab.bsky.social · 10/02/2026
Big career update:  I’m honored and humbled to serve as Chair of the Department of Molecular Microbiology & Immunology at Oregon Health & Science University (OHSU). Looking forward to what we’ll build together! @ohsummi.bsky.social @ohsunews.bsky.social
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James Saenz @jamessaenz.bsky.social · 08/07/2025
How do lipids shape life? I explore this question in my recent talk for the Build-a-Cell 🦠 seminar series. Thanks to @kateadamala.bsky.social for hosting! Watch it here: youtu.be/JnF7hPCiSbI?...
youtu.be
Build-a-Cell seminar James Saenz: Harnessing minimal cells to understand the living membranes
YouTube video by Build-a-Cell
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tafesselab.bsky.social @tafesselab.bsky.social · 21/01/2026
It was fun writing this book chapter on methods to trace #lipid metabolism. Congrats to Alec and Helene for their effort. Thanks to @jeremybaskin.bsky.social for the invitation to contribute this chapter. @ohsunews.bsky.social @ohsummi.bsky.social www.sciencedirect.com/science/chap...
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Eric Topol @erictopol.bsky.social · 20/01/2026
Good!
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Eric Topol @erictopol.bsky.social · 17/01/2026
Can GLP-1 drugs reduce the incidence of cancer, independent of weight loss? Results from cohort studies are encouraging for many types (Figure) and clinical trials are ongoing nature.com/articles/s43...
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tafesselab.bsky.social @tafesselab.bsky.social · 12/01/2026
Excited to share our first collaborative paper of the year- a review on the emerging roles of lipids in flavivirus infection, now published in @cp-trendsmicrobiol.bsky.social. Congrats to Judah (postdoc) for spearheading the work! @ohsunews.bsky.social www.sciencedirect.com/science/arti...
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Giovanni D’Angelo @giodang.bsky.social · 19/12/2025
@tafesselab.bsky.social Ronald Schnaar Julie Saba Ashley Cowart @gioelelamanno.bsky.social @nadlerlab.bsky.social Jurgen Seibel Markus Wenk
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Giovanni D’Angelo @giodang.bsky.social · 19/12/2025
Join us for the 2026 Glycolipid & Sphingolipid Biology Gordon Research Conference (GRC). 📍 Renaissance Tuscany Il Ciocco (Italy) 🗓️ March 22 - 27, 2026 Theme: "Molecular Codes of Cell Identity and Recognition" #LipidResearch #Sphingolipids #GRC2026 #ScienceConference #Lipidtime
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Jeremy Baskin @jeremybaskin.bsky.social · 14/12/2025
Had a blast at the OHSU Chemical Biology & Physiology meeting this week! Amazing talks, great to see lab alum Brittany White-Mathieu’s developing program at UNH, reconnect with friends and collaborators, meet some of the next generation of #chembio, and explore Portland!
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Abdou Rachid Thiam @abdourachidthiam.bsky.social · 27/11/2025
And the saga continues! Our collaborative work with outstanding Justin Korfhage & Thomas Melia’s lab in PNAS shows that ATG2A transfers triglycerides and does so bidirectionally! An exciting twist in our understanding of lipid transport. Definitely worth a deep read: www.pnas.org/doi/10.1073/...
pnas.org
ATG2 is a triglyceride transfer protein | PNAS
Bridge-like lipid transfer proteins (BLTPs) are established to function in phospholipid transport between bilayers at organelle–organelle contact s...
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tafesselab.bsky.social @tafesselab.bsky.social · 18/11/2025
Beautiful work! Congrats @abdourachidthiam.bsky.social and the team!
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John Burke @jburkevic.bsky.social · 05/11/2025
Cool new paper (www.jbc.org/article/S002... from my lab spearheaded by graduate students Sushant @sushantsuresh.bsky.social and Alex @alexlouiseshaw.bsky.social . This was a very cool collaboration with the Scott Hansen, Jennifer Cobb, Tamas Balla labs
jbc.org
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James Olzmann @olzmannlab.bsky.social · 29/10/2025
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. www.nature.com/articles/s41...
nature.com
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
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Jeremy Baskin @jeremybaskin.bsky.social · 28/10/2025
#ACSChemBio and #Biochemistry invite submissions to a special issue on Lipids and Lipidation guest edited by @chembiobryan.bsky.social and me! Find details in the #CallforPapers and submit your exciting findings to one of these journals by May 31, 2026. axial.acs.org/chemical-bio... #lipidtime
axial.acs.org
Call for Papers: Lipids and Lipidation | ACS Publications Chemistry Blog
This Special Issue in _ACS Chemical Biology_ will highlight the latest advancements and perspectives in the chemical biology of lipids and lipidation. Submit your manuscript by May 31, 2026.
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Holthuis Lab @holthuislab.bsky.social · 25/10/2025
Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...
biorxiv.org
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair
Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,...
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Gioele La Manno @gioelelamanno.bsky.social · 16/10/2025
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...
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tafesselab.bsky.social @tafesselab.bsky.social · 12/08/2025
Have you published lipid-protein interactome data? Please let us know, we’d love to include it in the repository. The goal is to build a centralized hub for the scientific community. Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
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Heran Darwin, PhD @heran.bsky.social · 07/10/2025
We're hiring! Check out our ad and please re-post or forward to interested #Microbiology parties: apply.interfolio.com/174783
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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James Saenz @jamessaenz.bsky.social · 24/09/2025
🌶️ Lipids bring the heat 🔥 Lipids don’t just shape membranes, they influence cellular metabolism. We show that tuning lipidome composition strongly alters metabolic heat flow in the minimal cell JCVI-Syn3B 🦠 Fantastic collaboration with Karim Fahmy’s lab (HZDR) 🎉 www.biorxiv.org/content/10.1...
biorxiv.org
Metabolic heat flow from the minimal cell JCVI-Syn3B reveals the lipidome-dependence of growth and metabolism
The cell membrane facilitates interactions with the environment and serves as an organizational platform for coordinating cellular processes, with lipids playing a central role in determining membrane...
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André Nadler @nadlerlab.bsky.social · 21/08/2025
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...
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tafesselab.bsky.social @tafesselab.bsky.social · 21/08/2025
Indeed, this is a fantastic work from the lab of @nadlerlab.bsky.social. Congratulations André and the team!
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tafesselab.bsky.social @tafesselab.bsky.social · 12/08/2025
Have you published lipid-protein interactome data? Please let us know, we’d love to include it in the repository. The goal is to build a centralized hub for the scientific community. Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
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King Lab @kinglabipd.bsky.social · 01/08/2025
🚨 new paper alert 🚨 Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances! This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...
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Levental Lab @leventallab.bsky.social · 18/07/2025
Great news!! Does anyone know what bill will determine NIH funding levels?
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tafesselab.bsky.social @tafesselab.bsky.social · 02/07/2025
Promoted to Full Professor with tenure! This wouldn’t have been possible without the incredible trainees, past & present, who made the science & the journey meaningful. Grateful to my mentors, colleagues, & collaborators. Excited for what’s next- here to the future! 🙌
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tafesselab.bsky.social @tafesselab.bsky.social · 19/06/2025
Excited to share our new preprint 🥳. We dev’ed a high-affinity nanobody that binds MR1 & blocks MR1-restricted T cell activation, a powerful tool to dissect MR1 biology in infection, inflammation & cancer. @jburkevic.bsky.social @ohsunews.bsky.social www.biorxiv.org/content/10.1...
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tafesselab.bsky.social @tafesselab.bsky.social · 10/06/2025
It’s finally out! Started this project as a PhD student in the @holthuislab.bsky.social lab & finished by my PhD student. Full-circle moment and the end of an era. 😊 Thanks to Gaelen and everyone who made this happen. @ohsummi.bsky.social @ohsunews.bsky.social pubmed.ncbi.nlm.nih.gov/40473211/
pubmed.ncbi.nlm.nih.gov
Characterization of C. elegans sphingomyelin synthases through heterologous expression - PubMed
Sphingomyelin (SM) is a major component of mammalian cell membranes and particularly abundant in the myelin sheath that surrounds nerve fibers. Its production is catalyzed by SM synthases SMS1 and SMS...
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tafesselab.bsky.social @tafesselab.bsky.social · 04/06/2025
Excited to share our latest preprint! Using integrated global lipidomics and proteomics, we show that SARS-CoV-2 variants induce conserved changes in host lipid metabolism pathways. Congrats to Scotty for leading the work. @ohsummi.bsky.social @ohsunews.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Multi-Omic Profiling Identifies Conserved Metabolic Pathways Critical for SARS-CoV-2 Variants Infection
The rapid evolution of SARS-CoV-2 has led to the emergence of numerous variants with en-hanced transmissibility and immune evasion. Despite widespread vaccination, infections persist, and the mechanis...
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OHSU-MMI @ohsummi.bsky.social · 24/05/2025
This cool study on compounds that can kill Plasmodium inside mosquitoes and can be applied to bed-nets was contributed to by the Riscoe lab at MMI!
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tafesselab.bsky.social @tafesselab.bsky.social · 19/05/2025
Have you ever wondered how repeated vaccination shapes our immune responses, and whether timing between doses matters? Check out our latest work! @ohsunews.bsky.social @ohsummi.bsky.social www.nature.com/articles/s43...
nature.com
Immune imprinting and vaccine interval determine antibody responses to monovalent XBB.1.5 COVID-19 vaccination - Communications Medicine
Wrynla et al. assess humoral immunity elicited by the monovalent XBB.1.5 COVID-19 vaccine in participants who did or did not previously receive the bivalent Wuhan-Hu-1/BA.4-5 vaccine. They find that i...
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OHSU-MMI @ohsummi.bsky.social · 30/04/2025
Congratulations to the groups of Eric Barklis and @tafesselab.bsky.social for reporting an analysis of factors that regulate HIV-1 fusion in reverse pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
Analysis of Factors That Regulate HIV-1 Fusion in Reverse
Based on observations that HIV-1 envelope (Env) proteins on the surfaces of cells have the capacity to fuse with neighboring cells or enveloped viruses that express CD4 receptors and CXCR4 co-receptor...
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tafesselab.bsky.social @tafesselab.bsky.social · 01/04/2025
Excellent work!
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tafesselab.bsky.social @tafesselab.bsky.social · 04/03/2025
I had an amazing time visiting University of Victoria @uvic.ca It was wonderful meeting students and faculty- thank you so much, John Burke @jburkevic.bsky.social, for hosting me! #lipids and #nanobodies
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Sphingolipid Biology @slbiology.bsky.social · 04/02/2025
The early bird deadline may have passed but there is still plenty of time to register and submit abstracts for the 2025 FEBS/ICC! Come to historic Varna for sun, sea, and sphingolipid science!!
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Sphingolipid Biology @slbiology.bsky.social · 20/02/2025
The Obeid award was created to honor the legacy of the late, great Lina Obeid, a giant of the Sphingolipid field and a strong proponent of women in science. We are privileged to present this award at FEBS/ICC 2025 and are very grateful to CaymanChemical for their sponsorship.
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