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Thomas Gregor

@thomasgregor.bsky.social
588 followers 229 following 5 posts

Scientist — Biophysicist tglab.princeton.edu research.pasteur.fr/en/team/physics…

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Reposted by Thomas Gregor
bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · 22/06/2025
An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning www.biorxiv.org/content/10.1101/202…
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Santa Fe Institute @sfiscience.bsky.social · 23/05/2025
Catch up on our recent Community Lecture with Blaise Agüera y Arcas! The lecture, Computing, Life, and Intelligence, is available on SFI’s YouTube channel: www.youtube.com/live/75PAyV8... @blaiseaguera.bsky.social
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Alfonso Martinez Arias @amartinezarias.bsky.social · 23/05/2025
In which we discuss the homologies between amphibian and mammalian organizers from the perspective of #gastruloids with special relevance to recently described A and C gastruloids as containing Spemann/Mangold and Trunk/Tail organizers www.sciencedirect.com/science/arti...
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Jesse Veenvliet @jesseveenvliet.bsky.social · 19/05/2025
Check out our "In Preprints" @dev-journal.bsky.social w/ Yonit Maroudas-Sacks & Marc Trani Bustos @mpi-cbg.de @poldresden.bsky.social, putting recent #gastruloid work from @viktri08.bsky.social @thomasgregor.bsky.social @amartinezarias.bsky.social labs in broader perspective: doi.org/10.1242/dev....
doi.org
In preprints: exploring developmental robustness and timing with gastruloids
How developmental processes are coordinated in time and space to ensure the robust formation of complex, functional patterns during embryogenesis remains an outstanding question. Investigating this in...
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André Nadler @nadlerlab.bsky.social · 06/05/2025
Why are biological membranes asymmetric, with different lipids in the two bilayer leaflets? Discovered in the 70s, lipid asymmetry is linked to many cellular processes, but why the cell needs it is largely unclear. @pavelbarahtjan.bsky.social addresses this question: www.biorxiv.org/content/10.1...
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Lionel Christiaen, PhD (he/him/his) @lionlchristiaen.bsky.social · 05/05/2025
It is also good to get some perspective, such as given by ballpark numbers and recent policies, since announcements were made. With the help of Perplexity. (1) The two systems start on different scales:
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Jesse Veenvliet @jesseveenvliet.bsky.social · 19/04/2025
😱 A very hungry #PacManoid ate the original post 🍬🍬🍬 Here’s the 🧵 on our latest in @cp-cellstemcell.bsky.social again! Gastruloids w/ a sweet tooth better model natural embryos: doi.org/10.1016/j.st... Spearheaded by @cryaaa.bsky.social & Alba Villaronga-Luque @mpi-cbg.de @poldresden.bsky.social
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Waggoner Lab @labwaggoner.bsky.social · 09/04/2025
Spatial multi-omics reveals cell-type-specific nuclear compartments @nature.com www.nature.com/articles/s41...
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bioRxiv Biophysics @biorxiv-biophys.bsky.social · 10/04/2025
A methodology to reduce the localization error in multi-loci microscopy provides new insights into enhancer biology www.biorxiv.org/content/10.1101/202…
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Physics Magazine @physicsmagazine.aps.org · 28/03/2025
The Dark Energy Spectroscopic Instrument (DESI) has determined the distances to enough galaxies by now to conclude that the cosmological constant is not in fact constant.
physics.aps.org
The Standard Cosmology Model May Be Breaking
Measurements of millions of galaxies suggest that dark energy changes over time and is more complicated than previously thought.
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Nadine Vastenhouw @nvastenhouw.bsky.social · 28/03/2025
Martino Ugolini and I wrote a review on how useful embryos are to understand the role of transcription bodies in gene expression. I am sure @mirlab.bsky.social, @harrisonflylab.bsky.social, @lennarthilbert.bsky.social and others would agree. Enjoy the read! portlandpress.com/biochemsoctr....
portlandpress.com
The role of transcription bodies in gene expression: what embryos teach us
Transcription does not occur diffusely throughout the nucleus but is concentrated in specific areas. Areas of accumulated transcriptional machinery have been called clusters, hubs, or condensates, whi...
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Biology Open @biologyopen.bsky.social · 25/03/2025
We are excited to be launching the next phase of our Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. #fastandfairpeerreview Read the Editorial by EiC Daniel Gorelick @danielgorelick.bsky.social at: bit.ly/4kYD1mL
Fast & Fair peer review

A new initiative offering high-quality peer review within 7 working days of submission

Biology Open
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jared toettcher @toettch.bsky.social · 25/03/2025
I'm so happy to report that our preprint on light-induced collective cell migration has now been published in Cell Systems! This project was a lot of fun and will be the basis for a lot of our ongoing & future work.
cell.com
Large-scale control over collective cell migration using light-activated epidermal growth factor receptors
Programmable control over tissue movement is a fundamental challenge for tissue engineering and wound healing. Suh, Thornton, et al. discovered that a light-controlled EGF receptor controls long-range...
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Eszter Posfai @eposfai.bsky.social · 22/03/2025
How many cells do you need to establish PCP? The magic number is 3! Beautiful work by Lena Basta in Danelle Devenport's lab. Happy to have contributed. www.science.org/doi/10.1126/...
science.org
Epithelial polarization by the planar cell polarity complex is exclusively non–cell autonomous
For cells to polarize collectively along a tissue plane, asymmetrically localized planar cell polarity (PCP) complexes must form intercellular contacts between neighboring cells. Yet, it is unknown wh...
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Alfonso Martinez Arias @amartinezarias.bsky.social · 21/03/2025
The Barcelona #gastruloid meeting has been a blast. A witness to a field that is maturing and a statement of a promise that lurks in its horizon. Thank you @joshifrenster.bsky.social @dias-andre.bsky.social and Ulla Fiuza for the organization, @EMBO, @ERC and the community for support.
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Cees Dekker @ceesdekker.bsky.social · 20/03/2025
still possible to apply: phygenome.sciencesconf.org
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Thomas Lecuit @thomaslecuit.bsky.social · 20/03/2025
⭐️ Please Fwd. Are you in Paris on 16th May? See👇 poster of symposium on « Information processing in biological systems » @collegedefrance.bsky.social Fantastic line of speakers 🤩. It is free, w/o registration, and it will be exciting.m! Follows from my series of lectures at CdF last fall.
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bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · 17/03/2025
N2B27 media formulations influence gastruloid development www.biorxiv.org/content/10.1101/202…
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Alfonso Martinez Arias @amartinezarias.bsky.social · 19/03/2025
There's increasing evidence that in organoid/embryoids conditions of cells at start of experiments is crucial/ determines outcome. Much to be learnt still. Taking advantage of mouse #gastruloids, two groups explore this here. Important work to calibrate the field www.biorxiv.org/content/10.1...
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micamer.bsky.social @micamer.bsky.social · 11/03/2025
We would love feedback on a new NCBI-BLAST service we are launching today: sky-blast.com Under the hood it's the same BLAST executable and databases provided by NCBI, with a replica of the NIH's interface - providing an alternative to the US gov service that's less congested, faster & more reliable
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Zechner Lab @zechnerlab.bsky.social · 12/02/2025
Excited to share our new work with Frank Jülicher on noise control & concentration buffering in intracellular condensates! There has been confusion about these concepts, which we aim to address in this paper. www.cell.com/cell-systems...
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Thomas Gregor @thomasgregor.bsky.social · 06/02/2025
Shocking: a pioneer in quantitative developmental biology passed... one of my all-time heroes! He had a dominant influence on many in the early 2000s when this field started to take off. What a loss! Obituary written by two of his former students: biologicalsciences.uchicago.edu/news/john-re...
biologicalsciences.uchicago.edu
John Reinitz, systems biologist, 1958-2025
Reinitz helped pioneer a data-driven, systems approach to developmental biology that is now widely used in the field today.
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Alfonso Martinez Arias @amartinezarias.bsky.social · 30/01/2025
January has been a plentiful month for #gastruloid #preprints. Here @thomasgregor.bsky.social @denisduboule.bsky.social & colleagues introduce a new family of #hydrogels and probe the effect of mechanical constrains on morphogenesis www.biorxiv.org/content/10.1... #NotInTheGenes #InNumbersWeTrust
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Pierre Osteil @pierreosteil.bsky.social · 30/01/2025
Check out this new paper from @thomasgregor.bsky.social 's lab on hydrogel embedding of mouse gastruloids to control gene expression and patterning.
Gastruloids embedded in hydrogel of different concentration stained for DAPI (blue), BRACHYURY (pink) and SOX2 (yellow).
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Marc Robinson-Rechavi @marcrr.bsky.social · 21/01/2025
Does anyone know of a search engine which searches all preprint archives, and only preprint archives (i.e., not Google Scholar)? In @europepmc.bsky.social I find @biorxivpreprint.bsky.social and EcoEvoRxiv , but not arXiv-Qbio.
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Arnaud Krebs @arnaudkr.bsky.social · 15/01/2025
Single molecule approaches across the central dogma! Genomics, imaging and theory! Very excited to host the first edition of Gene regulation, one molecule at a time this July @embl.org! Great lineup and many abstract selected talks!
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Institut Pasteur | 130 years of biomedical research @pasteur.fr · 16/01/2025
The Institut Pasteur has decided to leave X (formerly Twitter) to join BlueSky! 🦋 The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...
pasteur.fr
Institut Pasteur decides to leave X
The Institut Pasteur, a research organization which for more than 130 years has been committed to tackling infectious diseases, sharing knowledge and defending science, has decided to leave X because ...
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Marieke Oudelaar @mariekeoudelaar.bsky.social · 17/01/2025
Two great articles in Mol Cell about enhancer cooperativity & long-range enhancer activation by @chribue.bsky.social & Wysocka labs: www.sciencedirect.com/science/arti... www.sciencedirect.com/science/arti... Dimitra and I had the pleasure to write a Preview: www.sciencedirect.com/science/arti...
sciencedirect.com
Bridging the gap: How enhancers cooperate to regulate gene expression over large genomic distances
By building synthetic regulatory landscapes, Jensen et al.1 and Thomas et al.2 demonstrate in this issue of Molecular Cell that gene expression levels…
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Mehmet Can Uçar @mehmetcanucar.bsky.social · 09/01/2025
Self-generated gradients guide collective cell movement -but often different cell types must move together, e.g. in immune response. We develop a theory of self-generated chemotaxis in mixed populations -are there optimal principles for this cooperation?🤔 www.biorxiv.org/content/10.1...
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Nikolai Slavov @slavov-n.bsky.social · 23/12/2024
UMAP applied to 100 randomly generated points from a multivariate normal distribution simplystatistics.org/posts/2024-1...
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James Briscoe @jamesbriscoe.bsky.social · 18/12/2024
New preprint from my colleagues in Naomi Moris's lab at the Crick Human trunk-like structures that model interactions between forming somites & neural tube Nice work showing how tissues talk to each other as they develop www.biorxiv.org/content/10.1...
biorxiv.org
Modelling co-development between somites and neural tube with human Trunk-like Structures (hTLS)
Human stem cell-based embryo models have opened new avenues of research in development by providing experimentally amenable in vitro systems. One of the features of embryo models is their multilineage...
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Alfonso Martinez Arias @amartinezarias.bsky.social · 17/12/2024
We've wondered for a while why #gastruloids are so sensitive to initial cell numbers. Here www.biorxiv.org/content/10.1... led by U, Fiuza, we explore this & observe effects of a number of variables on final structure and think what this tells us @ embryogenesis #IInNumbersWeTrust #NotInTheGenes
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Alfonso Martinez Arias @amartinezarias.bsky.social · 17/12/2024
Registration is open for the 12th Advances in Stem Cell Biology Course #ASCBcourse at the @pasteur.fr Hands-on training in different models, embryonic stem cells, iPS cells and much more on #StemCells. 🕘June23-July04, 2025 👉https://qrfy.io/VEcoKQpGfV
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Ricard Solé @ricardsole.bsky.social · 13/12/2024
How can randomness be a source of living order? Can physics explain how an embryo emerges out of chaos? In this new paper in Science, Bernat Corominas-Murtra, @ehannezo.bsky.social & cols. show how embryos solve their own Rubik’s cube ist.ac.at/en/news/from...
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Shelby Blythe @shelbyflies.bsky.social · 12/12/2024
Very proud to share the latest preprint from my lab by Ellie Degen and co. Here Ellie shows that a concentration threshold in the Bcd morphogen gradient is determined by competition with nucleosomes. Great mix of math, imaging, and genomics!
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Zeynep Baharoglu @zeynepbaharoglu.bsky.social · 11/12/2024
Très honorée et émue de faire partie des 2 lauréats 2024 du prix Agnes Ullmann, pionnière de la recherche sur la régulation de l'expression des gènes des bactéries. Toute ma gratitude à l'Institut Pasteur, au comité de sélection, et toutes mes collaboratrices et collaborateurs x.com/institutpast...
x.com
x.com
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🦋Plastic Free Frontline🌎🚯🌊 @plasticwars.bsky.social · 09/12/2024
"The greatest threat to our planet is the belief that someone else will save it." - Robert Swan 🌊The ocean floor is becoming a graveyard for plastic waste! ⚠️It's time to act!♻️ scitechdaily.com/world-first-...
scitechdaily.com
World-First Study Reveals That There Is up to 100x More Plastic on the Ocean Floor Than the Surface
New research conducted by CSIRO, Australia’s national science agency, and the University of Toronto in Canada, estimates up to 11 million tons of plastic pollution is sitting on the ocean floor. Every...
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Loïc A. Royer 💻🔬🧪 @loicaroyer.bsky.social · 09/12/2024
Continuing to go through my trove of cool videos... here is a classic from my work with Philipp Keller's team at @hhmijanelia.bsky.social A developing fly embryo imaged with a SiMView #lightsheet microscope augmented with our Autopilot self-alignment system. www.nature.com/articles/nbt... 🧪🔬🪰💻
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Jop Kind @jopkind.bsky.social · 29/11/2024
I am really happy to announce the first Hubrecht Symposium on March 13th 2025! We will organize these yearly events on a specific topic in molecular and developmental biology to emphasize the importance of fundamental research for Dutch science. Free of charge! www.hubrecht.eu/hubrecht-sym...
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Didier Mazel @amazeld.bsky.social · 08/12/2024
We are opening a call for applications 2025 – Creation of new junior research groups at the Institut Pasteur in Paris @pasteur.fr all details on our web site : research.pasteur.fr/en/call/call...
research.pasteur.fr
Call for applications 2025 – Creation of new research groups at the Institut Pasteur | Research - Institut Pasteur
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