Scientists share help and advice on how they got their research discussions flowing.

This article features recent preLights that discuss preprints relevant to this ‘Cell Biology of the Nucleus’ special issue.preLighterPierre Caron, CNRS researcher at the Institute of Structural Biolog...

Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints. The preprints this month are hosted on bioRxiv.

Concise preprint highlights from the October preprint list, prepared by the preLighter community. Quick reads from early-career researchers to help working scientists spot the month’s most exciting bi...

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

Multicellular organisms generate organizational complexity through morphogenesis, in which mechanical forces orchestrate the movements and deformations of cells and tissues, while chemical signals re...

Cancer cells that survive, thrive: capillary constrictions as a trigger of mechanotransduction in cancer progression

Summary: Dynamical systems theory provides a powerful quantitative and intuitive framework to understand developmental processes. This Primer brings key concepts of this framework to the ever-growing ...

We previously developed the CellPhe toolkit, an open-source R package for automated cell phenotyping from ptychography time-lapse videos. To align with the growing adoption of python-based image anal...

Nature Physics - Blood flow through a vessel deforms vessel walls. Cells lining these walls sense the changes in pressure as blood flows and reorient their actin fibres in the direction of largest...

The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...

YouTube video by The Company of Biologists

Membrane fluidity is a crucial feature in understanding cellular physiology. This protocol describes a robust pipeline for measuring plasma membrane fluidity using confocal imaging and new environment...

Bioimage analysis is a powerful tool for investigating complex biological processes, but its robustness depends on both technical precision and rigorous experimental design. In particular, the use of ...

In their recent paper, Maia-Gil and colleagues explored whether and how nuclear properties can influence nuclear positioning in vivo. Their work revealed

Microscopy preprints - bioimage analysis - News

Cambridge Core - Philosophy of Science - Explanation in Biology

A decade in, expansion microscopy is unlocking insights across biology and medicine.

Hoffmann et al. describe within cells how the Dictyostelium discoideum nuclear pore complex structure constricts and dilates as a consequence of osmotic stress. Based on their experimental findings, they propose a hydrodynamics model and quantify fluid flow across nuclear pore complexes under conditions when nuclei change their volume rapidly.

Extra, extra! Read the latest on how journalists interpret and report on scientific research.

Probes 101 – How to choose a fluorescent probe for your imaging experiment - Tools

During morphogenesis, epithelial folding is irreversible, ensuring that the process proceeds in one direction. Here, the authors report that, given sufficient curvature or duration of a fold, these ce...