Centered on the transcription factor NRF2 and its E3 ligase CUL3KEAP1, the oxidative stress response protects cells from damage by reactive oxygen spe…

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Nature Structural & Molecular Biology - Better SIFI than sorry

Nature - Molecular basis of SIFI activity in the integrated stress response

Philosopher Hannah Ginsborg will use the award to write a book about the relation between norms and reasons, while chemical engineer Markita del Carpio Landry will try to find molecules in little-stud...

Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

The Creative Promise Prizes are awarded to young immigrant professionals who have demonstrated outstanding achievement early in their careers.

Congratulations to Xavier Darzacq on his promotion to MCB Professor of Molecular Therapeutics! The Darzacq Lab studies transcription regulation during cellular differentiation. Read more about the Dar...

Many environmental toxins damage proteins, which then must be removed to avoid dangerous protein aggregation and disease. How cells dispose of chemically modified proteins has been unclear, but a discovery offers some clues. How the stress-response machinery eliminates damaged proteins.

A byproduct of mitochondrial energy production is the generation of reactive oxygen species (ROS). Too much ROS is toxic, but ROS deficiency is equall…

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A cohort study of over 15,000 US adults found that the lifetime risk of developing dementia from ages 55 to 95 is 42%, with the highest risk in APOE ε4 carriers, women and Black adults, and projected ...

Lipid droplets (LDs) are organelles that store and supply lipids based on cellular needs. While mechanisms preventing oxidative damage to membrane phospholipids are established, the vulnerability of L...

The cohort includes early career scientists working in research areas ranging from treatment-resistant cancers to how animals evolved to live on land. The HHMI Hanna H. Gray Fellows Program provides e...

Today, President Biden announced the latest recipients of the National Medal of Science and the National Medal of Technology and Innovation—our nation’s

Keiji Tanaka, a beloved scientist and a pioneering leader in the field of intracellular protein degradation, passed away unexpectedly from ischemic heart disease on July 23, 2024 at the age of 75. His unparalleled dedication to proteasome research has left an indelible legacy; without his contributions, the field would scarcely be where it is today. His untimely departure marks a profound loss to life sciences and will be deeply mourned by colleagues and researchers worldwide.

A mutant gene is coming to steal Linde Jacobs’s mind. Can she find a way to stop it?

Cryo-electron microscopy and biochemical studies elucidate the read–write mechanisms of non-canonical PRC1-containing RYBP in histone H2A lysine 119 monoubiquitination and their roles in maintaining e...