ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.

ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.

What OMB’s Proposed Federal Financial Assistance Rule Means in Practice

Progress in the use of artificial intelligence (AI) to advance scientific discovery has made it increasingly realistic to envision automated “end-to-end science” (ETES) systems: integrated pipelines t...

Gene syntax—the order and arrangement of genes and their regulatory elements—shapes the dynamic coordination of both natural and synthetic gene circuits. Transcription at one locus perturbs the transc...

Natural behavior unfolds as coordinated sequences of body movements. This organization suggests that behavior may be built from discrete motor patterns, yet how such arrangements are implemented by neural circuits remains unknown. Here, we combined kinematic analysis, muscle recordings, genetically identified cell types, and closed-loop optogenetic perturbations to examine the organizational logic of natural gap-crossing jumps in mice. Jumping was characterized by a series of precisely defined phases and their associated modular motor patterns. The core phases, propulsion and flight, exhibited distinct signatures of neural control, including unique bursts of coordinated hindlimb muscle activity, differential tuning strategies for jump distance, and active requirements for spinal neural drive. Mapping activity across lumbar interneuron populations and functionally screening candidate cell types for their ability to drive coordinated movement revealed that a population of dorsal excitatory dILB6 neurons can autonomously evoke coordinated multi-joint hindlimb flexion characteristic of the jumping flight phase, across behavioral contexts. These findings provide a specific cellular substrate for the long-standing concept of spinal modular motor control: a flexible, preconfigured motor template that the mammalian CNS can recruit and modulate to meet the demands of natural behavior. ### Competing Interest Statement The authors have declared no competing interest. Intramural Research Program of the National Institutes of Health (NIH)

Members must go beyond reinstating US government research spending and re-establish decentralized governance at the National Institutes of Health and other agencies.

Trace protein and phosphoprotein dynamics during neuronal differentiation in the iPSC-derived cell line model are described.

CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...

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CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4 ubiquitinates tau, that CUL5 expression is correlated with resilience in human Alzheimer’s disease, and that electr...

TDP-43 is an RNA and DNA binding protein that plays major roles in regulating RNA processing. In particular, TDP-43 dysfunction leads to the accumulation of cryptic splice isoforms that result from im...

Pairing imaging and sequencing to simultaneously measure gene expression and morphological phenotypes in diverse genetically perturbed cells in mosaic animals, Perturb-Multimodal enables systematic ex...

A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.

A global map of human subcellular architecture yields protein complex structures, reveals protein functions, identifies assemblies with multiple localizations or cell-type specificity and decodes paed...

This is something I’m still trying to get my head around –...

An NIH insider explains what Republicans are likely to do next, and what we can do

Subcellular RNA organization can affect critical cellular functions. However, our understanding of RNA microenvironments, particularly biomolecular condensates, remains limited, largely due to a lack ...

A global map of human subcellular architecture yields protein complex structures, reveals protein functions, identifies assemblies with multiple localizations or cell-type specificity and decodes paed...

While high and stable transgene expression can be achieved in undifferentiated pluripotent stem cells, conventional transgene expression systems are often silenced upon differentiation. Silencing occu...

While high and stable transgene expression can be achieved in undifferentiated pluripotent stem cells, conventional transgene expression systems are often silenced upon differentiation. Silencing occu...

Most phenotype-associated genetic variants map to noncoding regulatory regions of the human genome, but their mechanisms remain elusive in most cases. We developed a highly efficient strategy, Perturb...