Because all known living organisms are made from at least 20 canonical amino acids, the feasibility of life using a more simplified alphabet remains unclear. In this work, we leveraged computational d...

The Columbia University Department of Systems Biology brings together researchers specializing in computational biology, experimental biology, and technology development to discover how biological traits emerge from complex molecular networks.

Engineered probiotic delivers bacterial peptide that enhances GLP-1 and restores barrier integrity in diet-modulated colitis.

Profiling host RNA shed in feces reveals disease states in the gut.

Profiling host RNA shed in feces reveals disease states in the gut.

Although metagenomic sequencing has revealed a rich microbial biodiversity in the mammalian gut, methods to genetically alter specific species in the microbiome are highly limited. Here, we introduce ...

Although metagenomic sequencing has revealed a rich microbial biodiversity in the mammalian gut, methods to genetically alter specific species in the microbiome are highly limited. Here, we introduce ...

Discover how immigrant scientist Harris Wang, PhD, uses synthetic biology to reprogram gut bacteria in this manga by Hiroki Otsuka.

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD

Split-And-pool Metagenomic Plot-sampling sequencing (SAMPL-seq) can be applied to complex microbial communities to reveal spatial co-localization of microbes at the micron scale.

Fecal microbiota transplantation (FMT) therapies hold promise but suffer from variable transplantation efficiencies. Here, we examine microbiome spatiotemporal dynamics post-FMT with a super-colonizin...