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Sreeparna Pradhan

@sreeparnap.bsky.social
842 followers 1.1K following 98 posts

K. Lisa Yang Brain-Body Center Postdoctoral Fellow at Steve Flavell's Lab @Picower Inst, MIT | PhD from Michael Hendricks' Lab @IPN, McGill Univ | Animal behavior | Neuroscience | Open science

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Reposted by Sreeparna Pradhan
Sweta Agrawal @hokuba.bsky.social · 16/09/2026
The Agrawal lab has published its first paper! "Sticking the landing: leg mechanosensory feedback coordinates the transition from flight to landing" www.biorxiv.org/content/10.6... This project was led by a technician in the lab, Tse-Wei (Wayne) Kuo. Brief 🧵on what we found
agrawal-lab-workspace.slack.com
Slack
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Misha Ahrens @mishaahrens.bsky.social · 09/09/2026
Whole-body cellular activity imaging in zebrafish, headed by Virginie Ruetten @vmsruetten.bsky.social - new paper is out: www.nature.com/articles/s41...
nature.com
Imaging cellular activity across all organs reveals body-wide circuits - Nature
An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits.
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ZooCELL MSCA-Doctoral Network @zoocell.bsky.social · 21/07/2026
5️⃣ What do you wish more people knew about science? "I wish more people would come to the lab and look down a microscope. Science starts with fascination, followed by questions."
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Ben Hayden @benhayden.bsky.social · 16/07/2026
And, of course, Eb Fetz was the prophet of this whole direction, with this paper from 1992, but that reads like it was written 30 years later: depts.washington.edu/fetzweb/asse...
depts.washington.edu
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Kevin Mitchell @wiringthebrain.bsky.social · 13/05/2026
All neuromodulators are more spatially and temporally specific than was often believed!
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The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · 20/04/2026
How neurons sense bacteria in the gut: To understsand the mechanisms that enable the bacterial microbiome to influence brain function, a new study examines the mechanisms at work in a model “bacterial specialist,” C. elegans. picower.mit.edu/news/how-neu... #neuroscience @mitbcs.bsky.social
Little worms wriggle through a red-tinted gel.
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Sreeparna Pradhan @sreeparnap.bsky.social · 11/04/2026
Early morning meal for this Cooper's hawk
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Sreeparna Pradhan @sreeparnap.bsky.social · 10/04/2026
A detailed mapping of olfactory navigation. Pleased to have contributed to this landmark study led by Talya Kramer!
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The Picower Institute for Learning and Memory at MIT @picowerinstitute.bsky.social · 10/04/2026
How do nervous systems produce behaviors? A new MIT study provides a detailed mechanistic mapping of exactly what happens in the brains of C. elegans worms when they “follow their nose” to savor attractive odors or avoid unappealing ones. picower.mit.edu/news/navigat... #neuroscience
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Piali Sengupta @senguptalab.bsky.social · 01/04/2026
Another paper from our awesome lab out today @nature.com. Led by 🌟 PD Jihye Yeon with fantastic collaborators. We show how an ionotropic receptor (related to insect sensory IRs) in a single pharyngeal enteric neuron senses ingested salts and protects the worm from high salt stress. rdcu.be/fbd4a
rdcu.be
An enteric neuron ionotropic receptor regulates salt stress resistance
Nature - The I3 pharyngeal enteric neuron in Caenorhabditis elegans detects high-salt conditions, and the GLR-9 ionotropic salt receptor expressed specifically in I3 regulates genes related to salt...
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Hannah Haberkern @hannah-haberkern.bsky.social · 19/03/2026
How does an animal choose between exploring for a better food source and taking advantage of a known one? Our recent work in Current Biology demonstrates how recent feeding and metabolic state dynamically influence fly local search. bit.ly/3PfrIv3 #Science #Neurosky #Foraging #Drosophila
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Bratislav Misic @misicbata.bsky.social · 17/03/2026
Organization of neuropeptide systems in the human brain | doi.org/10.1038/s415... Neuropeptides are functionally diverse signaling molecules in the brain and body. @cebric.bsky.social curates an atlas of neuropeptide receptors and relates it to brain function @natneuro.nature.com 🧩 🧠 ⤵️
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Sreeparna Pradhan @sreeparnap.bsky.social · 12/03/2026
The MIT BCS Postdoc Association is looking for a Rising Star 🌟 Showcase your work and meet folks in the department! Deadline 31st May 2026! @picowerinstitute.bsky.social
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Piali Sengupta @senguptalab.bsky.social · 28/01/2026
Our first 2026 paper is out @currentbiology.bsky.social! 👏 to @nathancsharris.bsky.social (now Asst Prof, GA State) and PD Priya Dutta. Here we show how transcriptional and trafficking pathways coordinate thermoreceptor levels to precisely modulate response plasticity www.cell.com/current-biol...
cell.com
Experience-dependent reconfiguration of thermoreceptors regulates neuronal response plasticity
Harris, Dutta, et al. find that experience-dependent plasticity in the activation threshold of the AFD thermosensory neurons is mediated by modulating warm and cold thermoreceptor levels at the sensor...
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Marianne Roca @marianneroca.bsky.social · 28/01/2026
How does a predator sense its prey? 🪱The nematode Pristionchus pacificus preys on other nematodes, but how it detects them in its environment? That is what we have been exploring : www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Javier Apfeld @javierapfeld.bsky.social · 28/01/2026
Friends! I am so happy to share our new preprint! Hydrogen peroxide has been the most common reactive chemical threat to life forms since the Great Oxygenation Event 2.5 billion years ago. How do animals like C. elegans sense it fast and escape? www.biorxiv.org/content/10.6... Thread 1/
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James Lightfoot @jameslightfoot.bsky.social · 21/01/2026
Why do some worms graze on bacteria while others hunt and kill? Our study, published today in Nature, reveals how predatory aggression evolved in nematodes. Led by @gunizgozeeren.bsky.social and @leoboeger.bsky.social across the @jameslightfoot.bsky.social and @monikakscholz.bsky.social labs.
nature.com
Predatory aggression evolved through adaptations to noradrenergic circuits - Nature
Noradrenergic circuits support and balance aggressive behavioural states in predatory nematodes, distinguish predatory from non-predatory nematode species and are associated with the evolution of comp...
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Alejandro Aballay, PhD @aaballay.bsky.social · 02/01/2026
Circadian timing shapes infection outcomes. In our new paper, we show that baseline inflammatory state—measurable before infection—strongly predicts which individuals will survive a bacterial challenge. www.science.org/doi/10.1126/...
science.org
Circadian-shaped immune variability predicts infection outcome
Basal immune state under circadian control predicts infection outcome, and clock gene perturbation shifts survival patterns.
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Mackenzie Weygandt Mathis @trackingactions.bsky.social · 31/12/2025
Interested in the latest advances in neuroscience (neural dynamics and internal models) and how they can be leveraged to build smarter, adaptive AI? ➡️ My first real solo piece 🖤🫶 @natneuro.nature.com rdcu.be/eWVmA
rdcu.be
Leveraging insights from neuroscience to build adaptive artificial intelligence
Nature Neuroscience - Adaptive intelligence envisions AI that, like animals, learns online, generalizes and adapts quickly. This Perspective reviews biological foundations, progress in AI and...
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Sreeparna Pradhan @sreeparnap.bsky.social · 31/12/2025
Moments that brought joy in this otherwise rollercoaster of a year. All spotted in the greater Boston area.
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Jan M. Ache @jan-ache.bsky.social · 19/12/2025
How do animals channel sensory information into motor pathways to generate flexible behavioral output? Excited to share a new preprint addressing this question by leveraging the new #maleCNS connectome, behavioral experiments, and in-vivo recordings: doi.org/10.64898/202.... A long🧵...
Landing and takeoff sensorimotor pathways illustrated alongside fly drawings showing behavioral responses.
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Carlos Ribeiro @ribeirocarlitos.bsky.social · 26/11/2025
Thrilled to share our new paper! With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste. Link @nature.com: www.nature.com/articles/s41...
nature.com
Evolution of taste processing shifts dietary preference - Nature
Calcium imaging of taste neurons and the ventral brain provides insight into evolutionary divergence of food choice in Drosophila species, supporting a role of sensorimotor processing in addition to p...
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Ishmail Abdus-Saboor @ishmailsaboor.bsky.social · 21/11/2025
Ive seen this work from Prof Liqun Luo’s presented a few times now and its stunning and heroic.
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Alexey Amunts @amunts.bsky.social · 31/10/2025
What a gem from @dudinlab.bsky.social @gautamdey.bsky.social @centriolelab.bsky.social in Cell! Expansion microscopy atlas of >200 eukaryotes comparing cytoskeletal architectures revealing structures not seen before. Stunning visualisation! Exactly the kind of transformative cell biology we need.
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Greg Jefferis @jefferis.bsky.social · 15/10/2025
Excited to share our new #biorxivpreprint: “Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1... We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
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Steven Cook @dumpyunc.bsky.social · 08/10/2025
Our group at the Allen Institute is recruiting a technician and postdoc to work on light microscopy-based connectomics. Please DM me or share with anyone you think may be interested in this NIH BRAIN CONNECTS funded project.
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Alex Nelson @alxnelson.bsky.social · 04/10/2025
Roseate spoonbills will splash their wings through the water as part of their beauty routine. Here's one doing so mid-splash, facing straight ahead towards the camera. I really love this shot. #birds
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Kyle Horton @kyle-horton.bsky.social · 25/09/2025
Truly impressive number of birds migrating tonight. More than 800 MILLION birds up in the air right now❗ #BirdMigration
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Matt Rockman @wormsrock.bsky.social · 24/09/2025
C. elegans is a real animal and we set out to understand how it comes to have its distinctive biogeography. Its ancestral center of diversity is in the higher elevation forests of Hawaii. Its closest relatives are spread across east Asia. Did they travel from Asia? [Preprint 🧵]
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Surojit Sural @surojitsural.bsky.social · 24/09/2025
Very excited to share this finding from my postdoctoral work that is now published in #ScienceAdvances. We show how the gut’s epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes. www.science.org/doi/10.1126/... Thread ⬇️ (1/n)
science.org
Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes
Gut epithelium modulates output from distinct enteric circuits by altering secretion of insulin and noninsulin peptides.
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Sreeparna Pradhan @sreeparnap.bsky.social · 16/09/2025
Such a "cheesy" story!
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Miriam B. Goodman, PhD @wormsense.bsky.social · 06/09/2025
Please help me to celebrate Mei Zhen, an innovator and tremendous collaborator, named to the Royal Society of Canada Academy of Science on September 4, 2025
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Ann Kennedy @antihebbiann.bsky.social · 22/08/2025
Can't wait to read this preprint from Misha Ahrens and team. Calcium imaging in larval zebrafish, in every cell in the body! Amazing. www.biorxiv.org/content/10.1...
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Greg Jefferis @jefferis.bsky.social · 21/08/2025
Neuronal diversity is written in transcriptional codes 🧬. But what is the logic of these codes that define cell types and wiring patterns? To find out we built a #scRNAseq developmental atlas of the Drosophila nerve cord and linked it to the #connectome 🪰🧠 #preprint thread ⬇️1/8
ALT text: A UMAP representation of a single cell RNAseq dataset from the Drosophila ventral nerve cord as well as images of the Drosophila nerve cord connectome and different stages of fly development.
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Philipp Brand @pbrand.bsky.social · 21/08/2025
Exciting new Ruta lab preprint by @annaryba.bsky.social et al. on the neural underpinnings of intraspecific behavioral variation: Strain variation identifies a neural substrate for behavioral evolution Drosophila www.biorxiv.org/content/10.1...
biorxiv.org
Strain variation identifies a neural substrate for behavioral evolution in Drosophila
Sexual selection acts on heritable differences within species, driving the parallel diversification of signal production in one sex and behavioral responses in the other. This coevolution implies that...
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Michael Hendricks 🇨🇦 @michaelhendricks.bsky.social · 20/08/2025
New preprint: Scientists, how many times has this happened to you? You collect all kinds of data from a camera or microscope. But then you are faced with an analysis pipeline that threatens to take 100x longer than collecting the data did!
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Michael Hendricks 🇨🇦 @michaelhendricks.bsky.social · 20/08/2025
The pipeline is hardware-agnostic, scales to system capabilities, and will improve along with the underlying foundation models. Very little fine tuning is required to tailor it to a large range of use cases. www.biorxiv.org/content/10.1...
biorxiv.org
Large vision model framework for automated C. elegans analysis: From static morphometry to dynamic neural activity
Quantitative phenotyping of Caenorhabditis elegans is essential across numerous fields, yet data extraction remains a significant analytical bottleneck. Traditional segmentation methods, typically rel...
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Javier Apfeld @javierapfeld.bsky.social · 13/08/2025
The funds are approved! We're hiring a postdoc to build a CRISPRa toolkit to identify new aging mechanisms in C. elegans. Email or DM me to find out more. Please share & repost!
media.tenor.com
a man in a suit has a name tag on his jacket that says dennis
Alt: a man in a suit has a name tag on his jacket that says dennis
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Steven Cook @dumpyunc.bsky.social · 31/07/2025
Happy to share our publication - Comparative connectomics of two distantly related nematode species reveals patterns of nervous system evolution www.science.org/doi/10.1126/...
science.org
Comparative connectomics of two distantly related nematode species reveals patterns of nervous system evolution
Understanding the evolution of the bilaterian brain requires a detailed exploration of the precise nature of cellular and subcellular differences between related species. We undertook an electron micr...
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Le Neuro (Institut-Hôpital neurologique de Montréal) @theneuro.bsky.social · 15/07/2025
Happy 107th Birthday, Brenda Milner! Her contributions to neuropsychology shaped the way we understand the human brain. From surviving two world wars and two pandemics, to paving the way for future generations of researchers, Milner’s legacy continues. @mcgill.ca @cusm-muhc.bsky.social
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Katherine Brown @katherine-brown.bsky.social · 01/07/2025
Hard to remember that just 12 years ago there was no @biorxivpreprint.bsky.social and almost no one in the biology community preprinted their work. What a long way we’ve come. @reinierprosee.bsky.social and I wrote a thing about how @biologists.bsky.social embraced the preprint world
journals.biologists.com
Staying ahead of the curve: a decade of preprints in biology
When Cold Spring Harbor Laboratory announced the launch of bioRxiv in November 2013, only the braver or more radical amongst us would have predicted that it heralded a lasting change within the scienc...
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Meital Oren @meital.bsky.social · 25/06/2025
C. elegans enthusiasts - join me and @stern-lab.bsky.social ‪‪for a pre #worm25 meeting online workshop on *Monitoring inter-individual diversity across multiple levels and timescales* - Jun 26, 2025 12:30 PM Eastern Time us06web.zoom.us/j/8544967372... please share!
us06web.zoom.us
Join our Cloud HD Video Meeting
Zoom is the leader in modern enterprise cloud communications.
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callista yee @csybio.bsky.social · 25/06/2025
I will be opening my new lab in September at UBC! if you’re coming to #Worm25 and are looking for graduate studies or a postdoc position, let’s meet! Vancouver + worms = perfect vibes. www.zoology.ubc.ca/~yeecs/labsi... Please share! 🙌
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Jennifer Biddle @jenbiddle.bsky.social · 19/06/2025
This is so cool - octopus can sense microbiomes: sending a gift link www.nytimes.com/2025/06/17/s...
nytimes.com
Eight Arms to Taste Your Microbiome
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Aakanksha Singhvi @singhvilabglia.bsky.social · 16/06/2025
Happy to present a single cell atlas of ALL glia, in BOTH sexes of an animal (in vivo validated!)! Fab work by postdoc @glia-maria.bsky.social, team, & collaboration with @manusetty.bsky.social . Find insights into glia, new analytics and ML models, and browse our companion website (wormglia.org)
wormglia.org
React App
Web site created using create-react-app
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Aakanksha Singhvi @singhvilabglia.bsky.social · 16/06/2025
www.sciencedirect.com/science/arti...
sciencedirect.com
Molecular profiling of adult C. elegans glia across sexes by single-nuclear RNA-seq
A comprehensive understanding of nervous system function requires molecular insight into the diversity and sex dimorphism of both its component cell t…
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Max Heiman @heiman.bsky.social · 09/06/2025
In 1975 "Bohemian Rhapsody" and "Space Oddity" were on the UK top 100, and Ward, Thomson, White, and Brenner published the first reconstruction of the C. elegans sensory anatomy. A short 50 years later, we reconstructed the same neurons and glia in the embryo: doi.org/10.1101/2025...
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Max Planck Institute of Animal Behavior @mpi-animalbehav.bsky.social · 05/06/2025
Move over, starling murmurations. There’s a slimier, squirmier collective behavior in town. It's a living, twisting tower of worms. Everybody, meet the wormuration 🪱🪱 Latest paper by Daniela Perez, Serena Ding and team @uni-konstanz.de Paper: doi.org/10.1016/j.cu... youtube.com/shorts/F8QVc...
youtube.com
Have you ever seen a worm tower?
YouTube video by Max Planck Institute of Animal Behavior
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Greg Stephens @gjstephens.bsky.social · 30/05/2025
A vital and very enjoyable component of my academic work is teaching students at all levels how to extend the frontiers of knowledge. So I’m pleased to announce a set of Jupyter notebooks organized around our ideas for “physics of behavior”. You can find them here: github.com/oist/Physics...
github.com
GitHub - oist/Physics-of-Behavior-Tutorials
Contribute to oist/Physics-of-Behavior-Tutorials development by creating an account on GitHub.
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PessoaBrain @pessoabrain.bsky.social · 19/05/2025
𝗣𝗮𝗿𝗮𝗹𝗹𝗲𝗹 𝗱𝗶𝘀𝘁𝗿𝗶𝗯𝘂𝘁𝗲𝗱 𝗯𝗿𝗮𝗶𝗻 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻, 𝗵𝗼𝘄 𝗱𝗼𝗲𝘀 𝗶𝘁 𝘄𝗼𝗿𝗸? Don't expect simple mappings between mind and brain. Check out this piece I wrote for Aeon. aeon.co/essays/how-t...
aeon.co
How the human brain is like a murmuration of starlings | Aeon Essays
The brain is much less like a machine than it is like the murmurations of a flock of starlings or an orchestral symphony
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