iiinova — where your digital self keeps evolving

Reposted by Sarah H. Shahmoradian

Jeremy Berg @jeremymberg.bsky.social · 13/03/2026

Good story from Vox on falling numbers of new and competitive renewal R01 grants. [Gift Link] www.vox.com/future-perfe... 1/5

vox.com

The US slashed research for cancer, Alzheimer’s, mental health — and nearly everything else

Revealed in one chart.

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Reposted by Sarah H. Shahmoradian

Henne lab @hennelab.bsky.social · 06/11/2025

New paper in Science identifying adipogenin as a critical seipin regulator in LD biogenesis. So glad our lab could help a little in this monumental study. Congrats to all authors! www.science.org/doi/10.1126/...

science.org

Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex

The microprotein adipogenin (Adig) is predominantly expressed in adipose tissues. Here, we found that Adig interacts with seipin to form a stable, rigid complex. We present the structure of the seipin...

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Reposted by Sarah H. Shahmoradian

David W. Sanders! @davidwsanders.bsky.social · 08/10/2025

Humbled to announce that we received a New Innovator award. I thank the NIH’s civil servants for their hard work during a stressful funding cycle. I thank the leadership (and chair, Marc Diamond) at UTSW for betting on my lab’s high risk, high reward research. www.utsouthwestern.edu/newsroom/art...

utsouthwestern.edu

UT Southwestern researcher receives NIH Director’s New Innovator Award

David Sanders, Ph.D., Assistant Professor in the Center for Alzheimer’s and Neurodegenerative Diseases and Molecular Biology at UT Southwestern Medical Center, has been awarded $2.4 million over five ...

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Reposted by Sarah H. Shahmoradian

Misha Kudryashev @mishakudryashev.bsky.social · 08/06/2025

We have a preprint for you EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...

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Reposted by Sarah H. Shahmoradian

Misha Kudryashev @mishakudryashev.bsky.social · 19/06/2025

Building atomic models to cryo-EM maps of huge molecules is intimidating: crowded, uncertain copy numbers, variable resolution ... Fan Liu and team incl us, show how cross-linking MS can be used to build novel models of unknown complexes, like a giant Melbourne virus biorxiv.org/content/10.1...

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Reposted by Sarah H. Shahmoradian

Ricardo Henriques @henriqueslab.bsky.social · 27/06/2025

🧑‍🔬📰🚀 #RxivMaker is here! A framework automating the creation of publication-ready scientific #preprints from simple Markdown. Goodbye manual formatting, and hello gorgeous manuscripts! A great adventure with @guijacquemet.bsky.social's lab 📜: zenodo.org/records/1575... 👨‍💻: github.com/HenriquesLab...

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Reposted by Sarah H. Shahmoradian

LizdelaGarzaG @lizdelagarzag.bsky.social · 29/06/2025

Full video here, originally shared by DW. What Jeremy says is exactly right—clear, urgent, and deeply important. Cuts to science affect everyone, sooner or later, everywhere. Illness knows no ideology, no borders. This concerns us all. Watch, reflect, share, discuss. bsky.app/profile/deni...

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60 Minutes @60minutes.bsky.social · 28/04/2025

The National Institutes of Health, the largest funder of biomedical research in the world, has fired 1,300 employees and cancelled more than $2 billion in federal research grants. cbsn.ws/4daiCrv

cbsn.ws

How cuts at the National Institutes of Health could impact Americans' health

Cuts and layoffs to the National Institutes of Health threaten medical research around the U.S., agency insiders warn.

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Reposted by Sarah H. Shahmoradian

Jeremy Berg @jeremymberg.bsky.social · 17/03/2025

Bluetorial: Non-Competitive Renewal (Continuation) Awards Normally, multiyear NIH grants are paid with awards each year, pending administratively reviewed progress reports. “NIH” has been slow in making these awards. This has led to $1.83 B being withheld from institutions through February 2025.

media.tenor.com

a cartoon of homer simpson holding a card

ALT: a cartoon of homer simpson holding a card

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Reposted by Sarah H. Shahmoradian

Don Moynihan @donmoyn.bsky.social · 18/03/2025

They are going to make it harder for the scientists to stop, or even record, what comes next.

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Reposted by Sarah H. Shahmoradian

Aaron Rupar @atrupar.com · 13/03/2025

Walz: "The idea that the secretary of education would not know what IDEA is -- individuals with disability in education act -- that's like your mechanic not knowing how to put air in your tire. And she's in charge of this nation's education progress. It is catastrophic."

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Reposted by Sarah H. Shahmoradian

@LaBonneLaB @labonnelab.bsky.social · 13/03/2025

Dear all, Because of your help shining light on this all 15 were reinstated today. This is a huge win for science - When We Fight We Win!!!

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Reposted by Sarah H. Shahmoradian

Sherry Pagoto, PhD @drsherrypagoto.bsky.social · 12/03/2025

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024. That's not to mention the countless lives that biomedical research has saved. Show me a better investment than that. www.forbes.com/sites/michae...

forbes.com

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report

National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

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Reposted by Sarah H. Shahmoradian

Jeremy Berg @jeremymberg.bsky.social · 09/03/2025

Bluetorial: Women, courage, and leadership What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.

media.tenor.com

a cartoon says hey everybody an old man 's talking while bart simpson looks on

ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

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Reposted by Sarah H. Shahmoradian

Denis Wirtz @deniswirtz.bsky.social · 03/03/2025

Some good news: The Federal Register has just posted NIH study sections, which are to meet in late March. NIH announces some key grant-review meetings will restart in late March | Science | AAAS www.science.org/content/arti...

science.org

NIH announces some key grant-review meetings will restart in late March

Trump policy blocking required notices has frozen reviews of thousands of grants

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Reposted by Sarah H. Shahmoradian

Matthew Taliaferro @jmtali.bsky.social · 03/03/2025

Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.

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Reposted by Sarah H. Shahmoradian

Emily Mullin @emilymullin.bsky.social · 04/03/2025

DOGE's crackdown on agency spending means that federal researchers can't do vital experiments, order liquid nitrogen tanks to preserve samples, or refill basic but necessary lab equipment. My story with @zoeschiffer.bsky.social: www.wired.com/story/doge-e...

wired.com

Elon Musk’s $1 Spending Limit Is Paralyzing Federal Agencies

The DOGE-mandated credit card freeze is delaying shipments of critical supplies, stalling travel, and stopping employees from doing their jobs.

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Reposted by Sarah H. Shahmoradian

Max Kozlov @maxkozlov.bsky.social · 27/02/2025

Today's update: ICs will be barred from publishing Federal Register notices for at least TWO MORE WEEKS, according to an email to NIH staff. In other (likely related) news, Jay Bhattacharya's confirmation hearing to become NIH director has been scheduled for March 5.

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Reposted by Sarah H. Shahmoradian

John Wallingford @jbwallingford.bsky.social · 24/02/2025

NIH money directly pays for >29,000 jobs in Texas, but the overall economic impact is MUCH bigger: >5 BILLION DOLLARS annually in Texas. NIH funding cuts hurt the bottom line for anyone who sells your lab anything. 2/3 Data for Texas are here: www.unitedformedicalresearch.org/nih-in-your-...

unitedformedicalresearch.org

Texas - United For Medical Research

the economic impact of NIH funded research in Texas

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Reposted by Sarah H. Shahmoradian

Rejji Kuruvilla @rkuruvi1.bsky.social · 22/02/2025

Beautiful thread of scientific discovery that led to a non-addictive pain medication. Built on decades of painstaking NIH funded basic research on sodium channels in peripheral neurons, using animal models. Not developed by private companies but driven by govt investing in scientific curiosity

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Reposted by Sarah H. Shahmoradian

Shannon Mattern @shannonmattern.bsky.social · 22/02/2025

“The professor said that their department — which submitted its choices for admits to its graduate program on Feb. 14 — will be forced to rescind the acceptances of 10 of the 17 students.”…

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Reposted by Sarah H. Shahmoradian

Mark Peifer (He, him) @peiferlabunc.bsky.social · 21/02/2025

Ok scientists & those who love science 🧪: here is another exhortation. Call Congress TODAY about the freeze on NIH Council Meetings and Study Sections. Emphasize that this means NO new grants are being funded & labs will soon start to shut down and fire employees. Phone numbers are at: 5calls.org

5calls.org

5 Calls

Spend 5 minutes. Make 5 calls. Make your voice heard.

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Reposted by Sarah H. Shahmoradian

Violeta J. Rodriguez, PhD, MSEd @vjrp.bsky.social · 21/02/2025

In my latest article for @science.org, I reflect on the current challenges faced by early-career researchers, including delays in grant reviews, uncertainty around NIH funding freezes and changes, and the critical need for continued support and advocacy. www.science.org/content/arti...

science.org

I’m an NIH-funded researcher, drowning in uncertainty

“I’ll keep doing what I can to move my research forward. But I, and so many others, can’t do this indefinitely,” this assistant professor writes

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Reposted by Sarah H. Shahmoradian

Lauer Lab @lauerlab.bsky.social · 21/02/2025

“The terminated federal workers included veterans who became disabled during their military service. For many of them, federal work was another way to continue serving the public after a career in the military, said one veteran who has PTSD from their service.” How low can they go?😡

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Reposted by Sarah H. Shahmoradian

AlwaysACivilServant @drneuro.bsky.social · 21/02/2025

So. It has officially happened. I have been officially let go from my position at CDC. I wasn’t a probationary employee. I had stellar performance reviews every year. I’ll be ok. But please understand that many worked HARD to get into these positions and were doing great public health work.

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Reposted by Sarah H. Shahmoradian

Michael Baym @baym.lol · 21/02/2025

Legitmately thrilled to share our latest work, in which @fernpizza.bsky.social solved an experimental challenge in plasmid biology as old as the field: measuring how plasmids compete and evolve within individual cells!

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Reposted by Sarah H. Shahmoradian

samuel mehr @mehr.nz · 21/02/2025

I chatted with a program director at NIH for a half hour just now It's clear that the people who make American science happen are doing everything they can to keep making it happen in a very difficult environment They deserve our respect and gratitude

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Morgan Carter @morgancarterphd.bsky.social · 21/02/2025

I have 31 students applying for 3 undergraduate research spots in my lab for the summer. It's heartbreaking to know we already aren't able to provide enough opportunities for research training, and that it will only be harder with the fallout from the current attacks on science. 🧪

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Celeste Karch @karchlab.bsky.social · 22/02/2025

In January, we were closer than ever before to finding life changing treatments for Alzheimer’s disease. The funding stoppage has slowed this progress.

nytimes.com

Trump Administration Stalls Scientific Research Despite Court Ruling

Using an arcane law, officials have effectively delayed funding from the National Institutes of Health, leaving medical studies in jeopardy.

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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 19/02/2025

PO's message for NINDS R01 that scored 9%. Science is crippled and America doesn't care.

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Jeremy Berg @jeremymberg.bsky.social · 20/02/2025

Nature Story "Revealed: NIH research grants still frozen despite lawsuits challenging Trump order" (with non-paywalled link) archive.ph/7h6Im

archive.ph

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Rick Huganir @rhuganir.bsky.social · 20/02/2025

Reaching out to all Americans through the media to explain how decreasing funding of the NIH will have irreversible harm for developing therapies for all diseases. Please spread the word to your families and friends and contact your congressional representatives. www.nbcnews.com/science/scie...

nbcnews.com

Science under siege: Trump cuts threaten to undermine decades of research

Sweeping layoffs, funding freezes and executive orders have provoked outcry among federal researchers and their university partners, who fear that science itself is under siege.

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Reposted by Sarah H. Shahmoradian

Jana Kroll @janakroll.bsky.social · 12/02/2025

Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" www.biorxiv.org/content/10.1... We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️

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Alexis Rohou @alexisrohou.bsky.social · 02/12/2024

Oh my. This is just gorgeous from Misha Kudryashev's lab (I don't think he's here yet?). Love to see it. V ATPase resolved directly in synaptic vesicles 🤤 Lots of other neat observations in there also. Congrats to all involved! www.pnas.org/doi/10.1073/...

Section through the 3D cryoET map of V-ATPase embedded in synaptic vesicle membrane at 17 Å resolution, as published in PNAS recently.

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