Neurons face unique challenges in maintaining protein homeostasis due to their tortuous morphology and extended processes. Proteolytic organelles are typically transported retrogradely towards their s...

Thirteen of the agency’s advisory councils, which must review grant applications before funding is awarded, are on track to have no voting members.

Neurons are the largest and most long-lived class of cells, necessitating specialized mechanisms for their survival, growth and maintenance. Axons are the longest extensions of a neuron, reaching len…

“We can no longer lend our credibility to an organization that has lost its integrity,” write four scientists and administrators who recently resigned from the NIH.

In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.

The Nobel Prize rewards science, humanism and peace efforts. This is one of the central concepts in the will of Alfred Nobel, and it also permeates the outreach activities that have been developed for...

Ionescu, Ankol et al. show that, in ALS mouse and iPSC models, TDP-43 aggregation at NMJs stems from aberrant axonal translation, normally repressed by muscle EV-derived miR126. Loss of miR126 in ALS increases TDP-43 buildup, impairs local synthesis and triggers degeneration.

The human peripheral nervous system (PNS) consists of many ganglia, including sympathetic ganglia (SG) and dorsal root ganglia (DRG), that house the cell bodies of many constituent neuron types and no...

Replaying history with less NIH funding shows widespread impacts on drug-linked research

TRYPTYR is a prescription eye drop used for the treatment of the signs and symptoms of dry eye disease. See prescribing information, how to save, and more.