Abstract. Efficient purification of specific RNAs from lysates remains a major challenge. Existing methods, such as MS2 tagging or oligonucleotide hybridiz

GOP leaders are supporting a spending bill that would prevent the White House from asserting greater control over hundreds of billions of dollars in federal grants.

Nature - Somatic mutations reveal the ontogeny of microglia in human aging

A deep learning method quantitatively decodes nucleolar, nuclear speckle, and viral condensate morphology to reveal underlying biochemical states. Applying this framework reveals a previously unrecogn...

CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...

Nuclear speckles are key subnuclear structures that regulate gene expression in GC-rich regions. This work shows that the evolution and expansion of core speckle proteins were crucial for the increase...

Langstein-Skora, Schmid, Huth et al. propose that intrinsically disordered region functionality can be driven by the interplay between linear binding motifs and contextual chemical characteristics suc...

Texas voters approved funding the Dementia Prevention and Research Institute of Texas (DPRIT), the nation's largest state-funded dementia research initiative. OG image: press release

Photobleaching of fluorescent proteins often limits the acquisition of high-quality images in microscopy. StayGold, a novel dimeric green fluorescent protein recently monomerised through sequence engi...

Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...

David Sanders, Ph.D., Assistant Professor in the Center for Alzheimer’s and Neurodegenerative Diseases and Molecular Biology at UT Southwestern Medical Center, has been awarded $2.4 million over five ...

Japan’s Keio University awards the prize annually to honor contributions in medicine and life sciences. Brangwynne is being recognized for groundbreaking work that has opened up a new field of cell bi...

The Liver Tumor Program at UT Southwestern Medical Center’s Harold C. Simmons Comprehensive Cancer Center has been selected by the National Cancer Institute as a Specialized Program of Research Excell...

YouTube video by Albert and Mary Lasker Foundation

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed) PAR-25-322. OD

Our understanding of how post-translational modification—protein phosphorylation—impacts the complexity of eukaryotic signalling pathways is continuously expanding. Now, protein oligophosphorylation h...

Biomolecular condensates compartmentalize the interior of living cells to spatiotemporally organize complex functions, yet linking molecular interactions within condensates to their mesoscale organiza...

Polyglutamine (polyQ) diseases, including Huntington’s disease and several spinocerebellar ataxias, are caused by abnormally expanded CAG nucleotide repeats, which encode aggregation-prone polyQ tract...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the progressive degeneration of motor neurons. ALS pathology primarily involves the failure of protein qualit...

Mis-splicing of autophagy genes contributes to diverse pathologies including cancer. Mathavarajah et al. report that depletion of tumor suppressor and splicing kinase PRP4K leads to impaired autophagy...