Bacteria infecting the intestinal epithelium are recognized by epithelial and immune cells, however the role of intestinal stem cells (ISCs) remains unclear. This study shows that adult Drosophila mid...

Bacterial ribosomes can synthesize proteins encoded within their own RNA.

Arc genes evolved from Ty3 retrotransposons and encode proteins that self-assemble into virus-like capsids that package and transfer RNA between cells. This capsid-forming property may mediate a form ...

Author summary The most common genetic cause of both familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is an expanded G4C2 repeat in the first intron of the gene C9orf72. ...

How genes determine the development of chiral structures is a fascinating question. The reciprocal placement of female and male organs on opposite sides of mirror-image flowers promotes efficient cros...

Early immune surveillance promotes effective antifungal defense. Here, the authors show that a secreted lectin, IML1, binds diverse fungal spores on the cuticle, but immunity is triggered only upon cl...

Abstract. Robinow Syndrome is a genetically heterogeneous, rare skeletal disorder characterized by craniofacial and limb defects. All 7 causative genes lie

This study reveals how muscle diversity arises in flies, enabling the complex movements that drive animal behavior.

Three fundamental classes of gene regulatory elements were identified in Escherichia coli in the 1960s: operators bound by repressor proteins, promoters bound by the basic transcription machinery, and...

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In Drosophila, changing the expression of a small set of cell-surface proteins in just one type of olfactory neuron rewires its connections almost entirely to a new postsynaptic partner neuron type, altering the fly’s odour response and courtship behaviour.

Abstract. Heterozygous missense variants in CDK19 have been found in patients diagnosed with Developmental and Epileptic Encephalopathy-87 (DEE87) who pres

Adult intestinal plasticity and tissue repair involves complex and reciprocal multicellular interactions. Medina, Perochon, et al. report a signaling axis between hormone-producing cells in the intest...

The peptide hormone Capa is responsible for regulating extracellular fluid Ca2+ levels in the fruit fly Drosophila melanogaster.

This study reveals that transcription factors DAF-16/FOXO and HLH-30/TFEB promote healthy aging in C. elegans, in part, by activating lipid metabolism genes that remodel lysosomes into tubular network...

The role of peroxisomes in skeletal muscle remains largely unexplored. Here, the authors show that peroxisomal dysfunction and disrupted crosstalk with mitochondria drive age-related muscle decline, u...

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Mariana Wolfner has spent her life studying a creature so small it could rest on the tip of her finger. In her hands, the fruit fly Drosophila melanogaster becomes something extraordinary, a key to understanding how life is shaped, sustained, and passed on. On a windy fall afternoon at Cornell, she sat surrounded by papers, notes, and journals. The light came through the window in soft bands as she lifted a golden model of a fly and smiled.

The peptide hormone Capa is responsible for regulating extracellular fluid Ca2+ levels in the fruit fly Drosophila melanogaster.

Effective tissue adaptation to damage requires precise coordination among diverse cell types. In skeletal muscle, injury-responsive cells play a pivotal role in repair, yet the molecular and cellular ...

Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...