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François Leulier

@francoisleulier.bsky.social
1.6K followers 568 following 258 posts

Scientist, Biologist @CNRS Director and Group leader @IGFLyon @ENSLyon We study how the #Microbiome together with #Nutrition influence #Juvenile #Physiology using #InMice and #Drosophila as models.

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François Leulier @francoisleulier.bsky.social · 11h
Join us in Valparaiso, Chile next year in April for the 8th International Insect Hormone Workshop (IIHW) 4id.network/event/iihw-2...
4id.network
4ID Platforms
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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 02/10/2026
Mais, mais, et du coup toutes les aides publiques, dont le #CIR, ça a servi à quoi ? 🫣 #ESR #veilleESR En panne d’innovation, Sanofi puise dans la R&D de l’américain Regeneron pour se relancer www.lemonde.fr/economie/art...
lemonde.fr
En panne d’innovation, Sanofi puise dans la R&D de l’américain Regeneron pour se relancer
En annonçant jeudi un important accord de collaboration avec la société Regeneron, Sanofi met la main sur des anticorps appelés à prendre le relais de son médicament vedette, le Dupixent, dont le brev...
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Michalis Averof @michalis-averof.bsky.social · 01/10/2026
A cost-effective method for finding cis-regulatory elements in a large genome (Parhyale, 3.6 Gb), combining info from chromatin accessibility (bulk & single-nucleus ATACseq) and cross-species sequence conservation (low coverage sequencing from 3 additional Parhyale species) Now published in eLife!
elifesciences.org
Genome-wide discovery of cis-regulatory elements in a large genome
Integrating genome-wide maps of chromatin accessibility and sequence conservation provides an accessible low-cost approach for identifying cis-regulatory elements in large genomes, validated in the em...
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CNRS Biologie @cnrsbiologie.bsky.social · 07/09/2026
#ResultatScientifique🔎| Comment les gènes trouvent-ils leur place dans le noyau, et quel rôle cette position joue-t-elle dans leur activité ? ✍️ Samir Merabet 🔬 @igflyon.bsky.social 👋 @cnrs-rhoneauvergne.bsky.social @ensdelyon.bsky.social @inrae-france.bsky.social buff.ly/Si3srFN
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Filipe De Vadder @filipedevadder.bsky.social · 30/09/2026
Sex is often handled as a nuisance variable, something to hold constant or to average out. Our results say it is a variable in its own right, and one that responds to the environment. Using both sexes is not a box to tick. It is where the biology is.
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Filipe De Vadder @filipedevadder.bsky.social · 30/09/2026
Here is the part I would like people to take away. Had we studied males only, we would have written: low protein stunts growth. Females only: low protein delays puberty. Both true. Neither is the finding. The finding is the distance between them.
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EMBL @embl.org · 30/09/2026
Sickness is a whole-brain state. EMBL scientists recently found that more evolved sections of the brain, not just primal ones, activate to alert us when we fall sick. Full article 👉https://www.embl.org/news/science-technology/sickness-is-a-whole-brain-state/
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Helena Cocheme @cochemelab.bsky.social · 30/09/2026
✨Excited to share our latest paper in Aging Cell!✨ "Direct Pharmacological Activation of AMPK Extends Lifespan in Yeast, Worms and Flies" Thanks to all the collaborators who made this multi-organism study possible! 💊🪱🪰🐁⏳ #TeamScience #Drosophila #C.elegans #S.pombe #Ageing doi.org/10.1111/acel...
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Filipe De Vadder @filipedevadder.bsky.social · 30/09/2026
This work was led by two brilliant (former and current) PhD students @ameliejoly.bsky.social and @lucasrebiffe.bsky.social, co-led with @francoisleulier.bsky.social. We're grateful to all colleagues who helped us achieve this milestone. Preprint, data and code are open. Happy to answer questions.
doi.org
Data and code for: Juvenile protein restriction compresses sexual dimorphism in mice
This deposit contains the curated wet-lab measurements, the R analysis pipeline, and the supplementary-data build outputs supporting the manuscript "Juvenile protein restriction compresses sexual dimo...
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François Leulier @francoisleulier.bsky.social · 30/09/2026
Lab latest preprint! Have a look, it is super cool (but I am biased)!
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François Leulier @francoisleulier.bsky.social · 29/09/2026
Chenxu’s show starts now. Latest Ph’D candidate from the lab supervised by @renatafcmatos.bsky.social
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Zongzhao Zhai @immuno-physiology.bsky.social · 25/09/2026
Excited to share our work reporting that fly Lsp2 acts as a nutrient-induced physiological factor that amplifies mTORC1 output in TOP mRNA translation and regulates lifespan. www.nature.com/articles/s41...
nature.com
Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila - Nature
In Drosophila, the protein Lsp2, which is induced by dietary essential amino acids, is a key physiological effector of mTORC1, and mutant flies that lack the Lsp2 gene exhibit reduced translation of T...
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Fumiaki Obata @obataf-lab.bsky.social · 25/09/2026
Our new study just out @nature.com Together with Koshi Imami @RIKEN IMS, Hina Kosakamoto found out the key molecule mediating lifespan extension by early life dietary restriction! www.nature.com/articles/s41...
nature.com
Lsp2 links early-life diet to adult translation and lifespan in Drosophila - Nature
Isotope tracing is used to determine the fate of larval dietary amino acids in adult flies, and identifies Lsp2 as a key regulator of translation and lifespan that forms the molecular basis of the eff...
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Igor Iatsenko @iatsenkolab.bsky.social · 18/09/2026
🚨 Job alert! I am hiring a long-term postdoc (up to 6 years) to work on host–microbe interactions using the #Drosophila model. A great opportunity to develop your own research program in a wonderful scientific environment @uni-graz.at 🦠🔬 www.linkedin.com/jobs/view/44...
linkedin.com
University of Graz hiring University Assistant with doctorate (m/f/d) in Graz, Styria, Austria | LinkedIn
Posted 4:24:01 AM. Your ResponsibilitiesIndependent research in the field of host-microbe and microbe-microbe…See this and similar jobs on LinkedIn.
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CNRS Rhône Auvergne @cnrs-rhoneauvergne.bsky.social · 17/09/2026
🌊 Parmi les 6 projets lauréats de l'appel international, découvrez celui de l'Institut de génomique fonctionnelle de Lyon avec le Japon 👇
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Mark D. Garfinkel, Ph.D. @mdgarfinkel.bsky.social · 17/09/2026
Here's an important head's up: Today is Sept. 17, 2026... Registration and abstract submission for the 2027 #Drosophila research conference both open in two weeks, on Thursday, 1 October 2026. I hope to see you in Philadelphia! genetics-gsa.org/drosophila-2... #Dros27
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Development @dev-journal.bsky.social · 17/09/2026
Pathway to Independence – an interview with Jessica Perochon In this interview, Jessica discusses her research at the intersection of developmental biology and regenerative medicine, as well as her future plans. doi.org/10.1242/dev....
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CNRS @cnrs.fr · 17/09/2026
🏅The physicist Jacqueline Bloch, a specialist in polaritons, has been awarded the CNRS 2026 Gold Medal, in recognition of her work and major achievements in quantum physics and non linear optics.
news.cnrs.fr
Jacqueline Bloch, magician of light
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François Leulier @francoisleulier.bsky.social · 14/09/2026
La résignation certainement… car ces règles ne servent qu’à une chose: maintenir artificiellement un taux de sélection similaire aux années passées malgré des coupes et sous-investissement dans la recherche publique…1/3
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DMM Journal @dmmjournal.bsky.social · 11/09/2026
In #Drosophila, the intestine releases the cytokine Upd3, which signals to the fat body and oenocytes to drive systemic hypoxia tolerance Read and share the article by Kate Ding & co for free: doi.org/10.1242/dmm....
Female flies expressing GFP under control of a upd3 promoter (upd3-Gal4, UAS-GFP) were exposed to hypoxia (1% oxygen) or maintained in normoxia for 16 h.
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François Leulier @francoisleulier.bsky.social · 09/09/2026
Latest collaborative work from @renatafcmatos.bsky.social 👏👏👏
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Levayer Lab @levayerr.bsky.social · 08/09/2026
Institut Curie, Paris, symposium: Where Form Takes Shape October 27-28th 2026 (after the yearly International Developmental Biology course) Registration before October 10th (for free !): docs.google.com/forms/d/e/1F... There will be short talks and posters selected from abstracts.
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CNRS Rhône Auvergne @cnrs-rhoneauvergne.bsky.social · 07/09/2026
👀 Une étude qui implique des scientifiques de l'Institut de génomique fonctionnelle de Lyon @igflyon.bsky.social 👇
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Libération @liberation.fr · 05/09/2026
Aux assises des sociétés savantes à Paris, des chercheurs ont lancé une série de colloques, partout en France, avec l’objectif de lutter contre le déclin de la recherche et le désengagement de l’Etat. ➡️ l.liberation.fr/vCP
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Janelia FlyEM @janelia-flyem.bsky.social · 04/09/2026
We're thrilled with the publication of the Male CNS Connectome! www.cell.com/cell/fulltex... Also check out this (growing) collection of companion papers: www.cell.com/consortium/m...
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CNRS Rhône Auvergne @cnrs-rhoneauvergne.bsky.social · 04/09/2026
Une graine de fleur est un monde complexe... Le laboratoire Reproduction et développement des plantes @ENSL @cnrsbiologie.bsky.social a découvert comment l'Arabette des dames contrôlait l'environnement immédiat des embryons et maximisait ses chances de survie. www.insb.cnrs.fr/fr/cnrsinfo/...
Arabette des dames
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Pedro Beltrao @pedrobeltrao.bsky.social · 03/09/2026
8.8% success rate for the ERC Starting Grant is not acceptable. It is a lottery at this point with so many great scientists and ideas left to be funded. We keep talking about the competitiveness of Europe and we can't agree to properly fund our best instrument for scientific innovation.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 03/09/2026
The complete #connectome of the adult Drosophila male CNS has allowed researchers, inc @jefferis.bsky.social’s group, to compare male & female brains at synaptic-resolution for the first time. Read more here: mrclmb.ac.uk/news-events/... #LMBResearch 1/2
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Robert Arkowitz @robertarkowitz.bsky.social · 30/08/2026
A transient RNP compartment boosts translation and growth of mammalian oocytes | Science Advances www.science.org/doi/10.1126/...
science.org
A transient RNP compartment boosts translation and growth of mammalian oocytes
Mammalian oocytes undergo an extended growth phase, during which transcription gradually declines. To sustain meiotic divisions and early embryonic development, growing oocytes must accumulate materna...
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Martial Marbouty @mmarbout.bsky.social · 30/08/2026
🚨 ‼️ NEW PUBLICATION ‼️ While we start to know a lot about how bacterial genomes are organized in 3D, almost nothing is known about phage genome once it enters a bacterial cell. read the paper here: www.science.org/doi/10.1126/...
science.org
Bacteriophage PAK_P3 genome structuration and dynamics during infection of Pseudomonas aeruginosa reveal specific interaction patterns
While the dynamic changes in genome organization in cellular organisms have been well described, the three-dimensional (3D) folding of phage genomes during the infection of their host is extremely lim...
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François Leulier @francoisleulier.bsky.social · 29/08/2026
Ne nous inquiétons pas, les nouvelles règles de l’appel générique de l’@agencerecherche.bsky.social et les coupes budgétaires du @cnrs.fr vont nous permettre de redresser tout cela… #TimeForaPoliticalChange
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Anne Mascret @annemascret.bsky.social · 28/08/2026
De l'intérêt d'une infographie ! #ESR
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CIRI Lyon @ciri-lyon.bsky.social · 27/08/2026
Félicitations à Lucie Etienne et son équipe, soutenue par le CNRS IRP RAPIDvBAT, le CNRS IRC Univ. Arizona et le CNRS MITI, pour leurs travaux sur la longévité et l’adaptation induite par les virus à partir des génomes de chauves-souris Myotis. 💡: www.nature.com/articles/s41....
nature.com
Insights into longevity and virus-driven adaptation from Myotis bat genomes - Nature
Comparative and functional analyses of Myotis bats uncover unique patterns of adaptation in virus-interacting proteins and longevity-associated pathways, linking two hallmarks of bat biology.
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PLOS Biology @plosbiology.org · 21/08/2026
Erebosis is a non-apoptotic, non-autophagic & non-necrotic #CellDeath process in the #Drosophila gut. This study shows that a decrease in cytoplasmic heme is a critical step in initiating #enterocyte erebosis & coordinating cell proliferation @plosbiology.org 🧪 plos.io/4hFGl72
This image shows the Drosophila gut. Green indicates GFP, yellow indicates nuclear RFP, and magenta indicates phosphorylated Mad. Mad phosphorylation is reduced in GFP-negative erebotic cells compared with GFP-positive normal enterocytes. Image credit: Motohiro Morikawa.
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Waggoner Lab @labwaggoner.bsky.social · 22/08/2026
The language of the immune system: Part 1: Cytokine conversations and conversationalists @immunohorizons.bsky.social academic.oup.com/immunohorizo...
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European Drosophila Society @fly-eds.bsky.social · 21/08/2026
A very important point about how we view - and fund - the knowledge bases ALL biological sciences rely on. Funders take note! Please share widely. 👇🏻👇🏻👇🏻
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FlyBase @flybase.bsky.social · 20/08/2026
Treat biological databases as infrastructure, not projects www.nature.com/articles/d41...
nature.com
Treat biological databases as infrastructure, not projects
Letter to the Editor
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CNRS Biologie @cnrsbiologie.bsky.social · 12/08/2026
#ResultatScientifique🔎| Chez la drosophile, l’intestin détecte le manque de nutriments et produit une hormone qui ralentit la croissance. Une nouvelle voie de communication entre organes 🧬 ▶️ buff.ly/i1SxrP5 ✍️ @francoisleulier.bsky.social 📕 @plosbiology.org
buff.ly
Quand l’intestin informe l’organisme : une nouvelle voie endocrine ajuste la croissance
La croissance
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PLOS Biology @plosbiology.org · 20/08/2026
Wherever we look, insect numbers are declining... but most insect life on Earth is found in locations we aren't actively monitoring. @justinmcrocker.bsky.social discusses the #insect decline and how can we build the planetary observatory that #biodiversity requires @plosbiology.org 🧪 plos.io/4qzS2yv
Long-term insect monitoring sites and global pesticide use intensity. Total pesticide use per area of cropland (kg ha−1), most recent year available per country (2015–2023), from the FAOSTAT Pesticides Use domain; gray indicates no reported data. FAOSTAT totals exclude seed-applied systemic pesticides and so understate exposure to the neonicotinoids emphasized in the text. White points mark representative long-term insect monitoring programs. Base map: Natural Earth (public domain).
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François Leulier @francoisleulier.bsky.social · 17/08/2026
Smooth, reactive and timely handling by senior & academic editors @plosbiology.org as well as by the 3 reviewers. Reviewer 3 was very constructive this time 😂. The manuscript much improved from v1 and v2 posted on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
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@bilderlab @bilderlab.bsky.social · 17/08/2026
Now out in Annu Rev Cancer Biol: "Beyond Mice and Men." We think of cancer as a disease of humans, as well as pets 🐈‍⬛ 🐕 & lab mice. But cancer is found across the animal tree of life, including clams and fruit flies. Comparative oncology has a lot to teach us. 🧵 www.annualreviews.org/content/jour...
annualreviews.org
Beyond Mice and Men: Alternative Vertebrate and Invertebrate Models in Cancer Biology
While cancer looms large in the public and scientific minds, this can result in a quite narrow view of its range and manifestations. The centering of human clinical investigations and the popularity o...
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Longwei Bai @longweibai.bsky.social · 13/08/2026
Many thanks for this Prime article! I still vividly remember the summer school in Spetses two years ago and your generous guidance during the entire poster session for over an hour—it was an unforgettable experience. Looking forward very much to our next reunion.
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François Leulier @francoisleulier.bsky.social · 12/08/2026
A must read (and teach!) Congrats to all!
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corderolab.bsky.social @corderolab.bsky.social · 12/08/2026
Thoroughly enjoyed writing the Prime article for it! journals.plos.org/plosbiology/... Well done Longwei, Francois and the rest of the team.
journals.plos.org
The gut takes it all: Enteroendocrine control of developmental growth
How do developing animals sense nutritional shortages and adjust their growth accordingly? A new study in PLOS Biology shows that the developing intestine is a central regulator of a multi-organ signa...
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François Leulier @francoisleulier.bsky.social · 12/08/2026
Thank you so much @corderolab.bsky.social
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François Leulier @francoisleulier.bsky.social · 12/08/2026
Nice metaphore if you feel like a little maggot 😉
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François Leulier @francoisleulier.bsky.social · 12/08/2026
Latest from the lab in its final form. We revisit the #Decretin concept in the light of growth adaptation to protein intake. PhD work of @longweibai.bsky.social at @igflyon.bsky.social #Drosophila
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François Leulier @francoisleulier.bsky.social · 12/08/2026
Notre dernier article qui revisite le concept de #Decretin ou comment adapter la production des hormones de croissance au regard des entrants protéiques. Travaux de thèse de @longweibai.bsky.social à @igflyon.bsky.social
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François Leulier @francoisleulier.bsky.social · 30/07/2026
Seen in Roscoff! 😉 Congrats!
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François Leulier @francoisleulier.bsky.social · 29/07/2026
Dis #ESR et le call Labex pour site non-IDEX non-iSite, tjrs pas? Des infos ici ou là?
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