Bacteria infecting the intestinal epithelium are recognized by epithelial and immune cells, however the role of intestinal stem cells (ISCs) remains unclear. This study shows that adult Drosophila mid...

Bacterial ribosomes can synthesize proteins encoded within their own RNA.

Arc genes evolved from Ty3 retrotransposons and encode proteins that self-assemble into virus-like capsids that package and transfer RNA between cells. This capsid-forming property may mediate a form ...

Author summary The most common genetic cause of both familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is an expanded G4C2 repeat in the first intron of the gene C9orf72. ...

How genes determine the development of chiral structures is a fascinating question. The reciprocal placement of female and male organs on opposite sides of mirror-image flowers promotes efficient cros...

Early immune surveillance promotes effective antifungal defense. Here, the authors show that a secreted lectin, IML1, binds diverse fungal spores on the cuticle, but immunity is triggered only upon cl...

Abstract. Robinow Syndrome is a genetically heterogeneous, rare skeletal disorder characterized by craniofacial and limb defects. All 7 causative genes lie

This study reveals how muscle diversity arises in flies, enabling the complex movements that drive animal behavior.

Structural analysis of Cas12a2, a CRISPR-associated nuclease that nonspecifically cleaves ssRNA, ssDNA and dsDNA, reveals a complete activation pathway involved in the abortive infection system protec...

Three fundamental classes of gene regulatory elements were identified in Escherichia coli in the 1960s: operators bound by repressor proteins, promoters bound by the basic transcription machinery, and...

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In Drosophila, changing the expression of a small set of cell-surface proteins in just one type of olfactory neuron rewires its connections almost entirely to a new postsynaptic partner neuron type, altering the fly’s odour response and courtship behaviour.

Abstract. Heterozygous missense variants in CDK19 have been found in patients diagnosed with Developmental and Epileptic Encephalopathy-87 (DEE87) who pres