iiinova — where your digital self keeps evolving

Reposted by Peter Carlton

Marie Held @makaefer.bsky.social · 28/09/2026

Want to enhance your image analysis skills with napari? We’re running a two-day training event on how to use napari to effectively analyse your bioimaging data. 🕒 Applications close on 15 September. Learn more and apply 👇 www.crick.ac.uk/whats-on/cbi...

crick.ac.uk

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Peter Carlton @carltonlab.org · 28/09/2026

Not real data here in this example but I am really enjoying interactive #terminal plotting… 2 tmux panes with ssh replicating ~90% of what I usually do with jupyter.

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Reposted by Peter Carlton

Christophe 🔬 Leterrier @christlet.bsky.social · 25/09/2026

Here's a balanced account of where the microscopy community stands on AI use by this year's Small World in Motion winner. My main issue is that no one seems to have seen the original data despite requests (no mention of it being reviewed by the organizers) www.the-scientist.com/allegations-...

the-scientist.com

Allegations of AI Use in Nikon Competition Spark Controversy | The Scientist

Microscopists raise concerns about inappropriate AI usage in Nikon's microscopy contest-winning video. Nikon stands their ground, citing no policy breach.

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Peter Carlton @carltonlab.org · 25/09/2026

Here is an amazing 1960's video from a company that once cared deeply about quality, starting with making their own glass www.youtube.com/watch?v=qwej...

youtube.com

科学の眼－ニコン－

YouTube video by NPO法人科学映像館

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Christophe 🔬 Leterrier @christlet.bsky.social · 22/09/2026

From the new info my bet is fluo labeling inference pushed to 11. Hallucinating nonsensical DAPI nuclei, mitochondria stain, membrane labeling from a kind of phase contrast image: wrong localization, wrong scale, wrong movement. Keeping this movie as SWiM winner is a disgrace to the competition

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Christophe 🔬 Leterrier @christlet.bsky.social · 20/09/2026

Human cilia disease specialist on the Small World in Motion winning movie

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André Marques @amarques.bsky.social · 16/09/2026

Out today in Nature: sex without crossovers. Rhynchospora tenuis makes pollen, fertilises and sets seed, yet 0 crossovers in 10,997 pollen nuclei. Chromosome drive and ~87% seed abortion rebuild the mother's genotype, so the offspring are clones. doi.org/10.1038/s415...

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Kazuhiro Maeshima @kazu-maeshima.bsky.social · 08/09/2026

Is euchromatin really “open”? 🧬 Using super-resolution imaging🔬 our new study @natgenet.nature.com reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing for proper transcriptional insulation🚧 🔗 www.nature.com/articles/s41... (1/2)

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Masa A. Shimazoe @masaashimazoe.bsky.social · 09/09/2026

Our paper on euchromatin and cohesin is now published!!🙌 Euchromatin forms condensed domains, and cohesin constrains their local mixing. This organization maintains transcriptional insulation. This work was truly a team effort, and I’m grateful to everyone who contributed to it.

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Peter Carlton @carltonlab.org · 09/09/2026

Back from an unforgettable trip to Indonesia! First, a weekend of discussing study opportunities with highly motivated students. Then, a few days waiting for a volcano to let us fly home. Glad to have spent 5 days in Jakarta, but have really just scratched the surface of an amazing city and country.

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Peter Carlton @carltonlab.org · 08/09/2026

Anak Krakatau has calmed down enough to let us slip out of Jakarta tonight; hopefully it will stay that way for a long time.

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Reposted by Peter Carlton

Anton Goloborodko @golobor.bsky.social · 03/09/2026

1/ out in @science.org! We found a new asymmetry in large-scale chromosome structure: sister chromatids are shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! A close collaboration w/ @gerlichlab.bsky.social , led by @flaviacorsi.bsky.social www.science.org/doi/10.1126/...

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Peter Carlton @carltonlab.org · 03/09/2026

modern terminals are amazing, it hasn't been this good since Tektronix emulation in xterm.

a screenshot of a terminal window running teemux (tmux) showing an interactive ipython session in the left pane and a semi-interactive plot in the right pane.

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Peter Carlton @carltonlab.org · 29/08/2026

I spent 16 years in the SF Bay Area, and have lived 16 more in Kansai, Japan where I'll most likely stay for the rest of my life, but this picture depicts one uniquely representative frame from my permanently imprinted birthplace (Seattle/Salish Sea)

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Peter Carlton @carltonlab.org · 28/08/2026

🇦🇺↔🇯🇵 for undergrad/masters students studying in Australia and interested in short-term research opportunities this summer (Jan 7 – Feb 18 2027) - please check out Kyoto University's KU-STAR program: www.kugd.k.kyoto-u.ac.jp/en/ku-star-p... ! Application deadline is Sep. 25, happy to take questions.

kugd.k.kyoto-u.ac.jp

KU-STAR Program AUS

What’s the KU-STAR Program? KU-STAR Program, Kyoto University Short-Term Academic Research Pro

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Peter Carlton @carltonlab.org · 26/08/2026

My brain entertaining me this morning

Screenshot of a text passage describing my dream:

5am this morning after returning to sleep:
I was walking along a sidewalk in daytime, and crossed paths with… a guy who was just a head riding on a skateboard?! with a mounted computer keyboard, and the context was that in this dream world a person could detach their head and use it to control things; there was nothing distressing the guy, an early tech-adopter; the keyboard keys were clacking up and down, controlling the skateboard while controlled by his head.
After I walked along a bit more, I heard a sound that made me look back, and his skateboard had gotten stuck on a broken slab of pavement, and I felt disappointed and angry about how bad the sidewalk infrastructure had gotten despite the amazing head-dislocation tech we had… my last dream thought just upon waking was “Heads should roll for this!” --
was the whole dream a setup for that punchline??

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Reposted by Peter Carlton

Joumana Medlej @majnouna.com · 13/08/2026

Is Claude, let alone his pal Jimmy "Trust me bro" the Feckless, out there deciphering hundreds of pages of unconventionally-spelled scrawl and vanished words across a dozen text variants that require chemistry experiments to fully settle?

Passage from an Arabic manuscript with unconventional spelling and several letters written with the same shape, requiring previous understanding o teh subject matter before reading is possible

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Mariko Sasaki @marikosasakiatnig.bsky.social · 06/08/2026

The Sasaki lab at the National Institute of Genetics in Japan are seeking for highly motivated PhD students to work on extrachromosomal circular DNA, gene amplification, genome stability, and cancer genome dynamics, starting in October 2027. Please see below and apply by August 31.

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Reposted by Peter Carlton

Josef Uyeda @pseudacris.bsky.social · 11/08/2026

Really nice article laying out the semantics of sex/sexes that causes persistent confusion and arguing in our community. It lays out the undisputed patterns in biology and makes clear any "lack of consensus" on sex/sexes is arguing across different levels. academic.oup.com/icb/article/...

academic.oup.com

Evolution, Development, and the Incoherence of Sex: A Framework for Multiple Sex Concepts

Synopsis. The word sex can refer to at least seven distinct, evolutionarily related biological phenomena (0–6 below). Bacteria and archaea use mechanisms f

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Peter Carlton @carltonlab.org · 03/08/2026

Our latest publication is on bioRχiv! — a study of the meiotic double-strand break machinery, focused on C. elegans but using the extensive genomic resources available for the whole genus to learn more about how SPO-11 and its cofactors work together to break DNA www.biorxiv.org/content/10.6...

biorxiv.org

Multifaceted and evolutionarily dynamic interactions between Caenorhabditis elegans SPO-11 and its cofactors ensure proper formation of meiotic DNA double-strand breaks

DNA double-strand breaks (DSBs) generated during meiotic prophase by the topoisomerase-like protein SPO11 are essential to create crossovers between homologous chromosomes. Since crossovers are requir...

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Reposted by Peter Carlton

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 27/07/2026

ZHP-2/HEI10 generates CO precursors and triggers procrossover factor coarsening and CO formation through Polo kinase recruitment www.biorxiv.org/content/10.64898/20…

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Peter Carlton @carltonlab.org · 27/07/2026

Since it's entered the zeitgeist again, I will take a moment to thank Carolyn Dewald who taught me the Odýsseia at USC and inspired me to memorize its first stanzas in Greek, which I still remember. That class continued into the modern age and pretty much established my tastes as a reader.

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Peter Carlton @carltonlab.org · 22/07/2026

This is what they took from us (ok, I still have the album, but !) #nusrat #ustadnusratfatehalikhan

A screenshot of a Spotify menu with two out of six tracks from an album shown in a darker color, meaning they are unavailable to listen to — one of the two being a superlative ghazal, Kehna ghalat ghalat to chhupana sahi sahi, a favorite of mine and I think a few million others

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Reposted by Peter Carlton

Tressie McMillan Cottom @tressiemcphd.bsky.social · 21/07/2026

I just had this conversarion with an editor yesterday. If you start hedging for imagined bad faith readers, you have stopped writing and started journaling a fan fic to them.

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Peter Carlton @carltonlab.org · 21/07/2026

by Jove, I think that's all of them… 30+ more genomes on the way sometime soon, I do hope, but for now here are 54 Caenorhabditis SPO-11s

A screenshot of a terminal window showing a slice of a multiple sequence alignment through 54 SPO-11 protein sequences, all from the genus Caenorhabditis; a phylogenetic tree is shown at left, and protein names are next to it. Two conserved motifs are highlighted in green and blue.

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Peter Carlton @carltonlab.org · 18/07/2026

Does anyone else have songs or albums you can't listen to until a certain obligation is done with? anyway, really eager to submit something to bioRχiv next week.

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Reposted by Peter Carlton

preLights @prelights.bsky.social · 15/07/2026

Crossover: hanging by a COSA-2 thread @ethanewe.bsky.social highlights work from @celjauebel.bsky.social & colleagues demonstrating the complex molecular machinery required to maintain the fidelity of meiotic recombination. #preprint #DevBio #preLight ⬇️ prelights.biologists.com/highlights/d...

prelights.biologists.com

Disordered protein COSA-2 maintains crossover-specific repair compartments to ensure meiotic crossover maturation - preLights

Crossover: hanging by a COSA-2 thread

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Peter Carlton @carltonlab.org · 11/07/2026

During my 書道 class I heard from down the hall the unmistakable sound of a group of 20 or so people going through Carmina Burana, and felt a surprisingly strong urge to put down the brush and go join them. Vade retro, for now

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Reposted by Peter Carlton

Marine Biological Laboratory @mblscience.bsky.social · 10/07/2026

Tadasu Nozaki of UMass Amherst and an MBL Whitman Fellow is trying to better understand the complex movements that allow chromosomes to pair. 🔗 Read the full story here: go.mbl.edu/nozaki

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Peter Carlton @carltonlab.org · 08/07/2026

Probably too many nuclei are generated in total, but the eggs/apoptosis numbers look good. Here is some simple stem cell lineage tracing - I wonder if this picture is correct, that after a few days all the meiotic cells in a gonad arm descend from a single progenitor?

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Peter Carlton @carltonlab.org · 07/07/2026

Messing around with C. elegans gonad arm simulation, with a goal in mind to reproduce things like RAD-51 focus distribution through the germline

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Peter Carlton @carltonlab.org · 03/07/2026

The vast array of Unicode glyphs should get more attention in command line tools; this is one good use I've found for the box-drawing characters:

A screenshot of a terminal window, showing a python command at top executing the file "newick2box.py" on a nematode lineage tree file and producing in the terminal a display of a phylogenetic tree of most of the sequenced Caenorhabditis species we know, with unicode box-drawing characters (showing straight lines, 90 degree angles, and places where lines join each other) used to create the tree diagram.

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Reposted by Peter Carlton

Konrad Chudzik @konrad-chudzik.bsky.social · 30/06/2026

My first PhD paper is out in Nucleic Acids Research! We describe "Ab-trapping" - an antibody artifact that distorts assays relying on antibody diffusion (microscopy, CUT&Tag, CUT&RUN). The revisions made the story much stronger. Check it out! doi.org/10.1093/nar/...

doi.org

Antibody-trapping presents a widespread pitfall for microscopy and genomics in the nucleus

Abstract. Chromatin has a complex 3D structure and diverse binding proteins that coordinate the genome’s most essential functions. Many microscopy and geno

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Peter Carlton @carltonlab.org · 25/06/2026

Per fess argent and vert, a gypsy moth larva rampant guardant, armed and langued gules

A gypsy moth (Lymantria dispar) caterpillar rearing up in a pretty successful attempt to intimidate me, on a field of aluminum siding.

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Reposted by Peter Carlton

Ryan Moulton @moultano.bsky.social · 19/06/2026

I spent the last month obsessed with finding colors that can't be displayed on a conventional screen. This is what I found. moultano.wordpress.com/2026/06/19/w...

moultano.wordpress.com

Where to Find the Colors Your Screen Can’t Show You

An atlas of the vibrance of the real world

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Mara Duncan @mcduncanlab.bsky.social · 16/06/2026

Just got a notice of award for an R01. I will be hiring. I'll be looking for either a staff scientist or postdoctoral researcher. The project explores the conserved HEATR5 family of proteins. Their roles in AP1 mediated traffic, and links to motors.🎉

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Peter Carlton @carltonlab.org · 29/05/2026

Slack webhooks for phenix refinement of alphafold structures, with a unique personality (IYKYK)

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Maureen Barr @barrlab.bsky.social · 14/05/2026

The International C. elegans meeting #worm27 is going to Kobe, Japan in 2027! genetics-gsa.org/celegans/ Organizers: Erik Andersen @erikandersen.bsky.social, Johns Hopkins University Kavita Babu @kavita-babu.bsky.social, IISc Bangalore Suhong Xu, Zhejiang University @genetics-gsa.bsky.social

Genetics Society of America. 26th International Worm Meeting
July 18-22, 2027
Kobe, Japan
Kobe Convention Center

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Peter Carlton @carltonlab.org · 11/05/2026

Experimenting with pulling N nearest neighbors (128 here) to a protein of interest in embedding space closer together in 2D UMAP space —the red human dot that approaches SYP-1 is SIX6OS1. The UMAP puts it quite far away to begin with, presumably under the influence of its nearest human neighbors

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Peter Carlton @carltonlab.org · 08/05/2026

Which would you want on a desert island: 1 - the mixtape a friend (not even your best friend) made for you when you were young 2 - a "Tailored to your listening history!!" playlist by current AI in 2026 3 - the Ultimate_Agentic_AI "I know EVERYTHING about you and you WILL LOVE THIS" playlist in 2027

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Gerlich Lab @gerlichlab.bsky.social · 06/05/2026

New preprint out!🧬 How do cells keep replicated sister chromatids linked for DNA repair while folding 3D loops for gene expression? Extrusion folds DNA but separates sisters, while cohesion connects them, risking mutual interference. How do they coexist?🧵👇 🔗 doi.org/10.64898/2026.05.02.722390 1/6

doi.org

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Peter Carlton @carltonlab.org · 30/04/2026

This is a great opportunity for anyone interested!

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Peter Carlton @carltonlab.org · 30/04/2026

I've done it again, the computer equivalent of running a gel the wrong way

A screenshot showing what I intended to be a DNA sequence input to AlphaFold3 but was interpreted as a protein consisting only of Cysteine, Alanine, Glycine, and Threonine

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Reposted by Peter Carlton

Wyoming Wormboy @wyomingwormboy.bsky.social · 25/04/2026

Please repost! This comes from the good people at ChimeraX, who produce powerful up-to-date software to study protein (etc) structures, which are FREE to the community. 🙏 To stay viable and serve us, they need an experienced structural biologist to assume the leadership role on a funded project.

aprecruit.ucsf.edu

Faculty Position – In-Residence

University of California, San Francisco is hiring. Apply now!

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Jeff VanderMeer @jeffvandermeer.bsky.social · 10/04/2026

Thrilled that my first new short story in several years, "Constellations," about astronauts crashlanding on a distant planet, has been published by the @technologyreview.com. Acquiring editor Rachel Cortland. Art by Rogan Brown. Free link to avoid the paywall: ter.li/r3tbrsgr

a complex biosphere in vivid color in an illustrative style inside a circle and outside all white with shadow, with suggestion of complex ferns and other vegetation; art by rogan brown

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Peter Carlton @carltonlab.org · 17/04/2026

Is someone ever going to put on a real, well-controlled, no-holds-barred Turing Test for the leading LLMs one of these days? Where the judges are philosophers of mind, AI critics, white-hat hackers, some of whom you and I follow here—the very people who are best equipped for the challenge.

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